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Nocardichelins A and B, siderophores from Nocardia strain Acta 3026

Lookup NU author(s): Amanda Jones, Professor Michael Goodfellow

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Abstract

An actinomycete, strain Acta 3026, isolated from mangrove soil was characterized and found to belong to the genus Nocardia. The strain produces two new cytotoxic metabolites, nocardichelins A (1) and B (2). Each of the compounds strongly inhibited human cell lines from gastric adenocarcinoma, breast carcinoma, and hepatocellular carcinoma with GI(50) values in a low micromolar to nanomolar range. The structural characterization of the compounds was performed by mass spectrometry and NMR spectroscopy. The nocardichelins represent a new group of siderophores that combine the structural elements of mycobactin-type siderophores from mycobacteria and hydroxamate-type siderophores (desferrioxamine B) produced by streptomycetes. The chromazurol S assay, characteristic for iron(III) complexation, was positive, confirming the role as a siderophore.

Publication metadata

Author(s): Schneider K, Rose I, Vikineswary S, Jones AL, Goodfellow M, Nicholson G, Beil W, Sussmuth RD, Fiedler HP

Publication type: Article

Publication status: Published

Journal: Journal of Natural Products

Year: 2007

Volume: 70

Issue: 6

Pages: 932-935

ISSN (print): 0163-3864

ISSN (electronic): 1520-6025

Publisher: American Chemical Society

URL: http://dx.doi.org/10.1021/np060612i

DOI: 10.1021/np060612i

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