Toggle Main Menu Toggle Search

Open Access padlockePrints

Lifecourse influences on health among British adults: Effects of region of residence in childhood and adulthood

Lookup NU author(s): Dr UNKNOWN Gibb


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Background It has been suggested that early life exposures are important determinants of geographical variations in adult diseases. We examined inter-regional migrants in Britain to evaluate the relative importance of early and recent exposures for adult cardiorespiratory risk factors, mental ill-health and sensory function. Methods A total of 9023 persons born throughout England, Scotland and Wales during I week in 1958 were followed periodically through childhood into adulthood. At 44 45 years, height, body mass index (BMI), blood pressure (BP), glycosylated haemoglobin, total and high-density lipoprotein (HDL) cholesterol, triglycerides, fibrinogen, total immunoglobulin E (IgE), one-second forced expiratory volume (FEV1), hearing threshold at 4kHz, visual impairment, symptoms of depression and anxiety, and chronic widespread pain were measured. Analysis of migration between 12 regions included 3125 cohort members who were examined in a region different to their birthplace. Results Height, BMI, diastolic BP (DBP), FEV1, log-transformed IgE and hearing threshold varied by region among non-migrants (each P < 0.05). Among inter-regional migrants, the spatial associations with current region, independent of birthplace, followed closely the geographical pattern shown among non-migrants for BMI, DBP and FEV1 (each P < 0.001). In contrast, of the 15 outcomes, only adult height was related to region of birth, after adjustment for region of examination (P = 0.002) Conclusions Although individual disease risk is predicted by early life factors, early exposures do not explain regional variations in cardiovascular and respiratory risk factors among middle-aged adults in Britain. Geographical inequalities in cardiorespiratory health are more strongly related to factors associated with region of examination that influence obesity, BP and ventilatory function.

Publication metadata

Author(s): Strachan DP, Rudnicka AR, Power C, Shepherd P, Fuller E, Davis A, Gibb I, Kumari M, Rumley A, Macfarlane GJ, Rahi J, Rodgers B, Stansfeld S

Publication type: Article

Publication status: Published

Journal: International Journal of Epidemiology

Year: 2007

Volume: 36

Issue: 3

Pages: 522-531

ISSN (print): 0300-5771

ISSN (electronic): 1464-3685

Publisher: Oxford University Press


DOI: 10.1093/ije/dyl309


Altmetrics provided by Altmetric


Funder referenceFunder name
G0000934Medical Research Council