Publications by Professor Mark Walker - ePrints

Browsing publications by Professor Mark Walker.

Newcastle Authors	Title	Year
Dr Ana Viñuela Dr Alison Heggie Donna McEvoy Professor Mark Walker	Author Correction: Discovery of drug–omics associations in type 2 diabetes with generative deep-learning models (Nature Biotechnology, (2023), 41, 3, (399-408), 10.1038/s41587-022-01520-x)	2023
Dr Ana Viñuela Dr Alison Heggie Donna McEvoy Professor Mark Walker	Discovery of drug–omics associations in type 2 diabetes with generative deep-learning models	2023
Professor Mark Walker	Pharmacogenomics of GLP-1 receptor agonists: a genome-wide analysis of observational data and large randomised controlled trials	2023
Professor Mark Walker	A saturated map of common genetic variants associated with human height	2022
Dr Ana Viñuela Dr Alison Heggie Donna McEvoy Professor Mark Walker	Four groups of type 2 diabetes contribute to the etiological and clinical heterogeneity in newly diagnosed individuals: An IMI DIRECT study	2022
Professor Mark Walker	Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis	2022
Xuefei Yu Dr Catherine Arden Dr Rolando Berlinguer Palmini Dr Chun Chen Carla Bradshaw et al.	Mitochondrial complex I subunit deficiency promotes pancreatic α-cell proliferation	2022
Dr Ana Viñuela Professor Mark Walker	Correction to: The role of physical activity in metabolic homeostasis before and after the onset of type 2 diabetes: an IMI DIRECT study (Diabetologia, (2020), 63, 4, (744-756), 10.1007/s00125-019-05083-6)	2021
Professor Mark Walker Dr Ibrahim Ibrahim Dr Muthu Jayapaul Dorothy Carman Charlotte Ryan et al.	Gamma-glutamyltransferase, arterial remodeling and prehypertension in a healthy population at low cardiometabolic risk	2021
Dr Harshal Deshmukh Dr Ana Viñuela Dr Alison Heggie Professor Mark Walker	Genome-Wide Association Analysis of Pancreatic Beta-Cell Glucose Sensitivity	2021
Dr Helen Porteous Dr Cara Tomas Dr Satomi Miwa Professor Mark Walker	Peroxisomes and pancreatic beta-cell lipo-dysfunction	2021
Dr Alison Heggie Donna McEvoy Dr Ana Viñuela Professor Mark Walker	Processes Underlying Glycemic Deterioration in Type 2 Diabetes: An IMI DIRECT Study	2021
Professor Mark Walker	The trans-ancestral genomic architecture of glycemic traits	2021
Dr Ana Viñuela Professor Mark Walker	Dietary metabolite profiling brings new insight into the relationship between nutrition and metabolic risk: An IMI DIRECT study	2020
Professor Mark Walker Dr Georg Homuth	Genetic studies of leptin concentrations implicate leptin in the regulation of early adiposity	2020
Professor Mark Walker Dr Alison Heggie Dr Ana Viñuela	Post-load glucose subgroups and associated metabolic traits in individuals with type 2 diabetes: An IMI-DIRECT study	2020
Dr Ana Viñuela Dr Alison Heggie Donna McEvoy Professor Mark Walker	Predicting and elucidating the etiology of fatty liver disease: A machine learning modeling and validation study in the IMI DIRECT cohorts	2020
Dr Cara Tomas-Smith Dr Joanna Elson Emerita Professor Julia Newton Professor Mark Walker	Substrate utilisation of cultured skeletal muscle cells in patients with CFS	2020
Dr Cara Tomas Dr Joanna Elson Vicki Strassheim Emerita Professor Julia Newton Professor Mark Walker et al.	The effect of myalgic encephalomyelitis/ chronic fatigue syndrome (ME/CFS) severity on cellular bioenergetic function	2020
Dr Ana Viñuela Professor Mark Walker	The role of physical activity in metabolic homeostasis before and after the onset of type 2 diabetes: an IMI DIRECT study	2020
Dr Alison Heggie Donna McEvoy Dr Ana Viñuela Professor Mark Walker	Whole blood co-expression modules associate with metabolic traits and type 2 diabetes: an IMI-DIRECT study	2020
Ushma Shah Professor Mark Walker Professor Caroline Relton Dr Hannah Elliott	Differential methylation of the type 2 diabetes susceptibility locus KCNQ1 is associated with insulin sensitivity and is predicted by CpG site specific genetic variation	2019
Professor Mark Walker	Disentangling the genetics of lean mass	2019
Dr Harshal Deshmukh Dr Alison Heggie Professor Mark Walker Dr Ana Viñuela	Genetic studies of abdominal MRI data identify genes regulating hepcidin as major determinants of liver iron concentration	2019
Ali Al-Bayati Dr Audrey Brown Professor Mark Walker	Impaired enhancement of insulin action in cultured skeletal muscle cells from insulin resistant type 2 diabetic patients in response to contraction using electrical pulse stimulation	2019
Professor Mark Walker	Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution	2019
Professor Mark Walker Professor Emma Stevenson Dr Daniel West	A small dose of whey protein co-ingested with mixed-macronutrient breakfast and lunch meals improves postprandial glycemia and suppresses appetite in men with type 2 diabetes: a randomized controlled trial	2018
Professor Mark Walker	Not quite type 1 or type 2, what now? Review of monogenic, mitochondrial, and syndromic diabetes	2018
Dr Audrey Brown Beth Dibnah Emerita Professor Julia Newton Professor Mark Walker	Pharmacological activation of AMPK and glucose uptake in cultured human skeletal muscle cells from patients with ME/CFS	2018
Professor Mark Walker	Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity	2018
Professor Mark Walker	A genome-wide association study of IVGTT-based measures of first-phase insulin secretion refines the underlying physiology of type 2 diabetes variants	2017
Professor Mark Walker Dr Daniel West	An additional bolus of rapid-acting insulin to normalise postprandial cardiovascular risk factors following a high-carbohydrate high-fat meal in patients with type 1 diabetes: A randomised controlled trial	2017
Professor Mark Walker	Data Descriptor: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls	2017
Professor Mark Walker	Erratum: Large meta-analysis of genome-wide association studies identifies five loci for lean body mass	2017
Professor Mark Walker	Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults	2017
Dr Christopher Stewart Professor Mark Walker Professor Emma Stevenson Professor James Shaw Dr Daniel West et al.	Gut microbiota of Type 1 diabetes patients with good glycaemic control and high physical fitness is similar to people without diabetes: an observational study	2017
Timothy Brock Dr Mark Shirley Michelle Bardgett Professor Mark Walker Professor David Deehan et al.	Inadequate pre-operative glycaemic control in patients with diabetes mellitus adversely influences functional recovery after total knee arthroplasty: Patients with impaired glycaemic control exhibit poorer functional outcomes at 1-year post-arthroplasty	2017
Professor Mark Walker	Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance	2017
Professor Mark Walker	Large meta-analysis of genome-wide association studies identifies five loci for lean body mass	2017
Professor Mark Walker	Rare and low-frequency coding variants alter human adult height	2017
Dr Alison Heggie Professor Mark Walker	Sustained influence of metformin therapy on circulating glucagon-like peptide-1 levels in individuals with and without type 2 diabetes	2017
Professor Mark Walker	A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease	2016
Dr Alison Heggie Professor Mark Walker	A patient with a glucokinase mutation: a cautionary tale	2016
Professor Mark Walker Professor James Shaw Professor Emma Stevenson Dr Daniel West	Administering a small rapid-acting insulin bolus 3 h after eating a mixed macronutrient meal improves postprandial glucose control, without hypoglycaemia, in people with Type 1 diabetes	2016
Professor Mark Walker Dr Dean Allerton Professor Emma Stevenson Professor James Shaw Dr Daniel West et al.	Carbohydrate counting at meal time followed by a small secondary postprandial bolus injection at 3 hours prevents late hyperglycemia, without hypoglycemia, after a high-carbohydrate high-fat meal in Type 1 diabetes	2016
Professor Mark Walker	Determinants of glucagon-like peptide-1 (GLP-1) response in prediabetes and diabetes: an IMI-DIRECT study	2016
Ali Al-Bayati Dhanisha Lukka Dr Audrey Brown Professor Mark Walker	Effects of thrombin on insulin signalling and glucose uptake in cultured human myotubes	2016
Dr Audrey Brown Professor Mark Walker	Genetics of Insulin Resistance and the Metabolic Syndrome	2016
Professor Mark Walker	Genome-Wide Association Study of the Modified Stumvoll Insulin Sensitivity Index Identifies BCL2 and FAM19A2 as Novel Insulin Sensitivity Loci	2016
Professor Mark Walker	Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels	2016
Professor Mark Walker	The Association Between Sleep Duration, Insulin Sensitivity, and β-Cell Function: The EGIR-RISC Study	2016
Dr Helen Porteous Dr Audrey Brown Professor Mark Walker	The effect of Pex11 beta knockdown on peroxisome abundance and insulin secretion in MIN6 cells	2016
Professor Mark Walker	The genetic architecture of type 2 diabetes	2016
Professor Mark Walker Professor Mike Trenell Professor James Shaw Dr Daniel West	A combined basal-bolus insulin dose reduction strategy for preventing exercise-induced hypoglycaemia does not cause hormonal, metabolic or inflammatory disturbances in Type 1 diabetes	2015
Professor Mark Walker	A genome wide association study of IVGTT based measures of first phase insulin secretion reveals new physiology of known and novel variants	2015
Professor Mark Walker Professor Mike Trenell Professor James Shaw	A novel strategy that prevents early- and late-onset nocturnal hypoglycaemia following evening exercise in Type 1 diabetes	2015
Dr Audrey Brown Professor Mark Walker Emerita Professor Julia Newton	Abnormalities of AMPK Activation and Glucose Uptake in Cultured Skeletal Muscle Cells from Individuals with Chronic Fatigue Syndrome	2015
Professor Mark Walker	Association Analysis of 29,956 Individuals Confirms That a Low-Frequency Variant at CCND2 Halves the Risk of Type 2 Diabetes by Enhancing Insulin Secretion	2015
Professor Mark Walker Professor James Shaw Professor Emma Stevenson Dr Daniel West	Comparison of appetite responses to high- and low-glycemic index postexercise meals under matched insulinemia and fiber in type 1 diabetes	2015
Professor Mark Walker	Genetic studies of body mass index yield new insights for obesity biology	2015
Professor Mark Walker	Identification and Functional Characterization of G6PC2 Coding Variants Influencing Glycemic Traits Define an Effector Transcript at the G6PC2-ABCB11 Locus	2015
Professor Heather Cordell Professor Mark Walker	Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene	2015
Dr Daniel West Professor Mark Walker Professor James Shaw Dr Fahad Ahmed Stephanie Wijaya et al.	Inflammation and the acute endothelial progenitor cell response to submaximal running exercise in males with and without Type 1 diabetes	2015
Professor Mark Walker Professor Emma Stevenson Professor James Shaw Dr Daniel West	Insulin therapy and dietary adjustments to normalise glycaemia and prevent nocturnal hypoglycaemia after evening exercise in Type 1 diabetes: a randomized controlled trial	2015
Professor Mark Walker	Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility	2015
Professor Mark Walker	New genetic loci link adipose and insulin biology to body fat distribution	2015
Dr Audrey Brown Dr Peter Avery Emeritus Professor Steve Yeaman Professor Mark Walker	p38 MAPK activation upregulates proinflammatory pathways in skeletal muscle cells from insulin-resistant type 2 diabetic patients	2015
Dr Alison Heggie Professor Mark Walker	Presentation of new diabetes with severe hypertriglyceridaemia in two young Asian patients	2015
Professor Mark Walker Professor James Shaw Dr Daniel West	Subjective and hormonal appetite responses to high and low glycaemic index post-exercise meals, under matched insulinaemia and fibre in Type 1 diabetes	2015
Professor Mark Walker	The association between sleep duration and insulin sensitivity: the EGIR-RISC study	2015
Professor Mark Walker Dr Fahad Ahmed Stephanie Wijaya Professor James Shaw Dr Jolanta Weaver et al.	The inflammation, vascular repair and injury responses to exercise in fit males with and without Type 1 diabetes: an observational study	2015
Laura Pascoe Professor Mark Walker	The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study	2015
Professor Mark Walker	A Central Role for GRB10 in Regulation of Islet Function in Man	2014
Professor Mark Walker Professor Mike Trenell Professor Emma Stevenson Professor James Shaw Dr Daniel West et al.	A Low-Glycemic Index Meal and Bedtime Snack Prevents Postprandial Hyperglycemia and Associated Rises in Inflammatory Markers, Providing Protection From Early but Not Late Nocturnal Hypoglycemia Following Evening Exercise in Type 1 Diabetes	2014
Dr Audrey Brown Meutia Kumaheri Dr Helen Porteous Dr Alison Heggie Dr Satomi Miwa et al.	Age-Related Mitochondrial DNA Depletion and the Impact on Pancreatic Beta Cell Function	2014
Professor Mark Walker	Common Genetic Variants Highlight the Role of Insulin Resistance and Body Fat Distribution in Type 2 Diabetes, Independent of Obesity	2014
Professor Mark Walker	Defining the role of common variation in the genomic and biological architecture of adult human height	2014
Dr Alison Heggie Professor Mark Walker	Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: rationale and design of the epidemiological studies within the IMI DIRECT Consortium	2014
Professor Mark Walker	Functional Living in Older Adults With Type 2 Diabetes: Executive Functioning, Dual Task Performance, and the Impact on Postural Stability and Motor Control	2014
Professor Mark Walker	Genetic Evidence for a Normal-Weight "Metabolically Obese" Phenotype Linking Insulin Resistance, Hypertension, Coronary Artery Disease, and Type 2 Diabetes	2014
Professor Mark Walker Professor Mike Trenell	Heavily reducing pre- and post-exercise rapid-acting insulin dose may cause hyperglycaemia, but does not augment ketonaemia or increase inflammatory cytokines in patients with Type 1 diabetes	2014
Professor Mark Walker	Impact of Type 2 Diabetes Susceptibility Variants on Quantitative Glycemic Traits Reveals Mechanistic Heterogeneity	2014
Professor Mark Walker Professor Mike Trenell Dr Daniel West	Metabolic Implications when Employing Heavy Pre- and Post-Exercise Rapid-Acting Insulin Reductions to Prevent Hypoglycaemia in Type 1 Diabetes Patients: A Randomised Clinical Trial	2014
Professor Mark Walker	The DEXLIFE study methods: Identifying novel candidate biomarkers that predict progression to type 2 diabetes in high risk individuals	2014
Professor Mark Walker	A genetic risk score comprising common variants associated with fasting insulin is associated with OGTT- and clamp-based indices of whole body insulin sensitivity	2013
Dr Gus Brooks Dr Ali Aldibbiat Professor Mark Walker Professor James Shaw	Attainment of Metabolic Goals in the Integrated UK Islet Transplant Program With Locally Isolated and Transported Preparations	2013
Dr Andrew Schaefer Professor Mark Walker Emeritus Professor Doug Turnbull Professor Robert Taylor	Endocrine disorders in mitochondrial disease	2013
Professor Mark Walker	Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes	2013
Charlotte Gordon Professor Mark Walker Dr Debbie Carrick-Sen	Exploring risk, prevention and educational approaches for the non-diabetic offspring of patients with type 2 diabetes - a qualitative study	2013
Professor Heather Cordell Professor Mark Walker	Genetic and Functional Analyses Identify NAT2 as a Human Insulin Sensitivity Gene	2013
Professor Mark Walker	Genetic Variants Associated with Glycine Metabolism and their Role in Insulin Sensitivity and Type 2 Diabetes	2013
Professor Mark Walker	Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders	2013
Dr Linda Penn Professor Martin White Professor Mark Walker Professor John Mathers	Importance of Weight Loss Maintenance and Risk Prediction in the Prevention of Type 2 Diabetes: Analysis of European Diabetes Prevention Study RCT	2013
Professor Chris Day Professor Mark Walker Professor Helen Reeves	Krüppel Like Factor 6 (KLF6) Protects From NAFLD Progression through Regulation of Adipose Tissue Insulin Resistance	2013
Professor Mark Walker Professor Mike Trenell Professor Djordje Jakovljevic	Large pre- and postexercise rapid-acting insulin reductions preserves glycemia and prevents early- but not late-onset hypoglycemia in patients with type 1 diabetes	2013
Professor Mark Walker	Mendelian Randomization Studies Do Not Support a Causal Role for Reduced Circulating Adiponectin Levels in Insulin Resistance and Type 2 Diabetes	2013
Professor Mark Walker Professor Dianne Ford Professor Ruth Valentine	Nutrigenetics and Nutrigenomics; the role of nutrition in gene expression	2013
Professor Mark Walker Professor Mike Trenell	Preventing hypoglycaemia by heavily reducing pre- and post-exercise rapid-acting insulin dose may cause hyperglycaemia, but not hyperketonaemia in type 1 diabetes patients	2013
Dr Alison Heggie Professor Mark Walker	Renal function in patients with Type 2 diabetes treated with glucagon-like peptide 1 (GLP-1) analogues	2013
Dr Augustin Brooks Dr Ali Aldibbiat Professor Mark Walker Professor James Shaw	Restoration of endogenous C-peptide by islet transplantation is associated with increased duration of normoglycaemia and reduced blood glucose variability in recipients with Type 1 diabetes	2013
Professor Mark Walker Professor Mike Trenell Professor Djordje Jakovljevic	The preservation of glycaemia through large pre- and post-exercise rapid-acting insulin reductions prevents early, but not late-onset hypoglycaemia in individuals with Type 1 diabetes	2013
Dr Matthew Thomas Colin Wilson Professor Derek Manas Professor Mark Walker Professor James Shaw et al.	Endoscopic Botulinum Toxin Injection for the Treatment of Diabetic Gastropathy in Pancreas and Islet-cell Transplant Patients	2012
Dr Gillian Patman Laura Pascoe Dr Luca Miele Douglas Hui Professor Alastair Burt et al.	Glucokinase links Krüppel-like factor 6 to the regulation of hepatic insulin sensitivity in nonalcoholic fatty liver disease	2012
Dr Linda Penn Professor Martin White Professor Mark Walker Professor John Mathers	Intensive lifestyle intervention for prevention of type 2 diabetes in adults with impaired glucose tolerance: the European Diabetes Prevention Study, a pooled analysis of three randomised controlled trials from Finland, The Netherlands and the UK	2012
Donna Hine Dr Audrey Brown Dr Lynsey Cree David Gunn Professor Patrick Chinnery et al.	Mitochondrial DNA depletion and insulin secretion	2012
Professor Mark Walker	No Interactions Between Previously Associated 2-Hour Glucose Gene Variants and Physical Activity or BMI on 2-Hour Glucose Levels	2012
Dr Peter Avery Dr Sheila Patel Dr Ibrahim Ibrahim Professor Mark Walker Professor Bernard Keavney et al.	Common variation in the adiponectin gene has an effect on systolic blood pressure	2011
Laura Pascoe Professor Mark Walker	Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile	2011
Laura Pascoe Professor Mark Walker	Genome-Wide Association Identifies Nine Common Variants Associated With Fasting Proinsulin Levels and Provides New Insights Into the Pathophysiology of Type 2 Diabetes	2011
Professor Mark Walker	Glucose tolerance, insulin sensitivity and insulin release in European non-diabetic carriers of a polymorphism upstream of CDKN2A and CDKN2B	2011
Professor Mark Walker	Influence of Hyperinsulinemia and Insulin Resistance on In Vivo beta-Cell Function: Their Role in Human beta-Cell Dysfunction	2011
Professor Mark Walker	Insulin-induced stimulation of insulin secretion, its relation to insulin sensitivity and impact on impaired glucose regulation	2011
Dr Roslyn Simms Professor John Sayer Dr Richard Quinton Professor Mark Walker Professor Tim Goodship et al.	Monogenic diabetes, renal dysplasia and hypopituitarism: a patient with a HNF1A mutation	2011
Professor Mark Walker	Physical Activity Attenuates the Influence of FTO Variants on Obesity Risk: A Meta-Analysis of 218,166 Adults and 19,268 Children	2011
Professor Mark Walker	Sequencing PDX1 (insulin promoter factor 1) in 1788 UK individuals found 5% had a low frequency coding variant, but these variants are not associated with Type 2 diabetes	2011
Dr Linda Penn Professor John Mathers Professor Mark Walker Professor Martin White	Translating research evidence to service provision for prevention of type 2 diabetes: development and early outcomes of the ‘New life, New you’ intervention	2011
Professor Mark Walker	Detailed Physiologic Characterization Reveals Diverse Mechanisms for Novel Genetic Loci Regulating Glucose and Insulin Metabolism in Humans	2010
Dr Louise Hayes Professor Mark Pearce Dr Michael Firbank Professor Mark Walker Professor Roy Taylor et al.	Do obese but metabolically normal women differ in intra-abdominal fat and physical activity levels from those with the expected metabolic abnormalities? A cross-sectional study	2010
Professor Mark Walker	Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes	2010
Laura Pascoe Professor Mark Walker	Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge	2010
Emeritus Professor Nicol Ferrier Professor John Isaacs Dr John Mansfield Professor Mark Walker	Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls	2010
Dr Nicola Leech Dr John O'Sullivan Dr Peter Avery Laura Pascoe Professor Mark Walker et al.	Increased maternal Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) associated with older age at diagnosis of Type 1 diabetes in offspring	2010
Professor Mark Walker	Insulin Sensitivity and beta-Cell Function in the Offspring of Type 2 Diabetic Patients: Impact of Line of Inheritance	2010
Dr Linda Penn Professor John Mathers Professor Mark Walker Michael White	Towards the translation of research evidence to service provision: experience from North East England, UK	2010
Professor Mark Walker	Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis	2010
Dr Angela Pyle Professor Mark Walker Professor Patrick Chinnery Dr Simon Baudouin	A common UCP2 polymorphism predisposes to stress hyperglycaemia in severe sepsis	2009
Professor Mark Walker	Adiposity-Related Heterogeneity in Patterns of Type 2 Diabetes Susceptibility Observed in Genome-Wide Association Data	2009
Laura Pascoe Professor Mark Walker	Common genetic variation in the melatonin receptor 1B gene (MTNR1B) is associated with decreased early-phase insulin response	2009
Professor Mark Walker	Correlation of the leptin:adiponectin ratio with measures of insulin resistance in non-diabetic individuals	2009
Dr Audrey Brown Professor Mark Walker	Insulin-like growth factor I (IGF-I) is a more potent regulator of gene expression than insulin in primary human myoblasts and myotubes	2009
Professor Mark Walker	Parental origin of sequence variants associated with complex diseases	2009
Dr Linda Penn Professor Martin White Professor Mark Walker Emeritus Professor Sir George Sir George Alberti Professor John Mathers et al.	Prevention of type 2 diabetes in adults with impaired glucose tolerance: the European Diabetes Prevention RCT in Newcastle upon Tyne, UK	2009
Dr Gary Beale Laura Pascoe Dr Luca Miele Professor Mark Walker Professor Chris Day et al.	The Kruppel-Like Factor 6 (KLF6) Genotype Which is Associated With NAFLD Progression is Associated with Higher Fasting Serum Glucose Levels in Healthy Individuals	2009
Dr Lynsey Cree Dr Sheila Patel Dr Angela Pyle Dr Stephen Lynn Emeritus Professor Doug Turnbull et al.	Age-related decline in mitochondrial DNA copy number in isolated human pancreatic islets	2008
Laura Pascoe Professor Mark Walker	Beta cell glucose sensitivity is decreased by 39% in non-diabetic individuals carrying multiple diabetes-risk alleles compared with those with no risk alleles	2008
Emeritus Professor Doug Turnbull Professor Mark Walker Anne Hattersley	Clinical features, diagnosis and management of maternally inherited diabetes and deafness (MIDD) associated with the 3243A>G mitochondrial point mutation	2008
Dr Audrey Brown Dr Matthias Elstner Emeritus Professor Steve Yeaman Emeritus Professor Doug Turnbull Professor Mark Walker et al.	Does impaired mitochondrial function affect insulin signaling and action in cultured human skeletal muscle cells?	2008
Professor Mark Walker Dr Colin Miles	Effects on kidney disease, fertility and development in mice inheriting a protein-truncating Denys-Drash syndrome allele (Wt1 tmT396)	2008
Anne Hattersley Dr John Hudson Professor Mark Walker	Extreme phenotypic diversity and nonpenetrance in families with the LMNA gene mutation R644C	2008
Dr Sheila Patel Professor Mark Walker	Influence of polymorphism I/D of the ACE gene on insulin sensitivity and the risk of glucose intolerance in healthy European subjects	2008
Dr Sheila Patel Professor Mark Walker	Influence of the ACE gene insertion/deletion polymorphism on insulin sensitivity and impaired glucose tolerance in healthy subjects	2008
Professor Mark Walker	Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes	2008
Professor Mark Walker	Optimization of human plasma H-1 NMR spectroscopic data processing for high-throughput metabolic phenotyping studies and detection of insulin resistance related to type 2 diabetes	2008
Professor Mark Walker	Population-Specific Risk of Type 2 Diabetes Conferred by HAT4A P2 Promoter Variants: A Lesson for Replication Studies	2008
Professor Mark Walker Dr Muthu Jayapaul	Type 2 diabetes in families and diabetes prevention	2008
Dr Sheila Patel Dr Ibrahim Ibrahim Dr Peter Avery Professor Mark Walker	Variation in the ADIPOQ gene promoter is associated with carotid intima media thickness independent of plasma adiponectin levels in healthy subjects	2008
Professor Mark Walker	A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity	2007
Professor Mark Walker	An association analysis of the HLA gene region in latent autoimmune diabetes in adults	2007
Dr Sheila Patel Professor Mark Walker	Association between the ACE gene I/D polymorphism and insulin sensitivity in healthy subjects	2007
Professor Mark Walker	Association between the T-381C polymorphism of the brain natriuretic peptide gene and risk of type 2 diabetes in human populations	2007
Professor Allan Young Emeritus Professor Nicol Ferrier Dr Stephen Ball Professor Mark Walker Professor Simon Pearce et al.	Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants	2007
Professor Mark Walker	Common variants in WFS1 confer risk of type 2 diabetes	2007
Laura Pascoe Dr Sheila Patel Dr Ibrahim Ibrahim Professor Mark Walker	Common variants of the novel type 2 diabetes genes CDKAL1 and HHEX/IDE are associated with decreased pancreatic β-cell function	2007
Professor Mark Walker	Common variation in the LMNA gene (encoding lamin A/C) and type 2 diabetes: Association analyses in 9,518 subjects	2007
Dr Audrey Brown Dr Matthias Elstner Emeritus Professor Steve Yeaman Emeritus Professor Doug Turnbull Professor Mark Walker et al.	Decreased mitochondrial respiration impairs insulin action in cultured human skeletal muscle cells	2007
Professor Roger Whittaker Dr Andrew Schaefer Professor Bobby McFarland Professor Robert Taylor Professor Mark Walker et al.	Diabetes and deafness: Is it sufficient to screen for the mitochondrial 3243A>G mutation alone?	2007
Dr Audrey Brown Emeritus Professor Steve Yeaman Professor Mark Walker	Direct effect of inhibition of TCF7L2 expression on insulin action in cultured human skeletal muscle cells	2007
Professor Mark Walker	Evaluation of common variants in the six known maturity-onset diabetes of the young (MODY) genes for association with type 2 diabetes	2007
Professor Mark Walker	Examining the candidacy of ghrelin as a gene responsible for variation in adult stature in a United Kingdom population with type 2 diabetes	2007
Professor Allan Young Emeritus Professor Nicol Ferrier Mohamed Mohiuddin Dr Catherine Todhunter Dr John Mansfield et al.	Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls	2007
Dr Muthu Jayapaul Professor Mark Walker	Hyperglucagonaemia is not a primary metabolic defect in non-diabetic first-degree relatives from Type 2 diabetic families	2007
Professor Mark Walker	Insulin resistance, insulin response, and obesity as indicators of metabolic risk	2007
Dr Laura Rush Dr Gary Litherland Professor Mark Walker Emeritus Professor Steve Yeaman	Key role for ceramides in mediating insulin resistance in human muscle cells	2007
Professor Allan Young Emeritus Professor Nicol Ferrier Professor Mark Walker	Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A	2007
Professor Patrick Chinnery Dr Catherine Mowbray Dr Sheila Patel Dr Joanna Elson Anne Hattersley et al.	Mitochondrial DNA haplogroups and type 2 diabetes: a study of 897 cases and 1010 controls	2007
Professor Roger Whittaker Dr Andrew Schaefer Professor Bobby McFarland Professor Robert Taylor Professor Mark Walker et al.	Prevalence and progression of diabetes in mitochondrial disease	2007
Professor Mark Walker Professor John Isaacs	Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes	2007
Dr Gary Litherland Dr Nick Morris Professor Mark Walker Emeritus Professor Steve Yeaman	Role of glycogen content in insulin resistance in human muscle cells	2007
Dr Audrey Brown Emeritus Professor Steve Yeaman Professor Mark Walker	Targeted suppression of calpain-10 expression impairs insulin-stimulated glucose uptake in cultured primary human skeletal muscle cells	2007
Professor Mark Walker	[abstract] Physical activity and sensitivity to insulin	2006
Professor Mark Walker	Assessment of the role of common genetic variation in the transient neonatal diabetes mellitus (TNDM) region in type 2 diabetes: A comparative genomic and tagging single nucleotide polymorphism approach	2006
Professor Mark Walker	Association analysis of 6,736 U.K. subjects provides replication and confirms TCF7L2 as a type 2 diabetes susceptibility gene with a substantial effect on individual risk	2006
Professor Mark Walker Dr Sheila Patel Dr Ibrahim Ibrahim	Association between the C-11377G promoter variant of the ACDC gene and carotid intima thickness in healthy subjects	2006
Professor Nigel Unwin Dorothy McLarty Dr Terry Aspray Dr Leslie Carlin Dr Sheila Patel et al.	Changes in blood pressure and lipids associated with rural to urban migration in Tanzania	2006
Professor Mark Walker	Combining information from common type 2 diabetes risk polymorphisms improves disease prediction	2006
Dr Sheila Patel Professor Mark Walker	Common variations in the ALMS1 gene do not contribute to susceptibility to type 2 diabetes in a large white UK population	2006
Dr Audrey Brown Dr Matthias Elstner Emeritus Professor Steve Yeaman Emeritus Professor Doug Turnbull Professor Mark Walker et al.	Decreased mitochondrial respiration impairs insulin action in cultured human skeletal muscle cells	2006
Professor Mark Walker	Epistasis between type 2 diabetes susceptibility loci on chromosomes 1q21-25 and 10q23-26 in Northern Europeans	2006
Professor Mark Walker Dr Muthu Jayapaul Dr Stuart Bennett	Erratum: Impaired beta cell glucose sensitivity and whole-body insulin sensitivity as predictors of hyperglycaemia in non-diabetic subjects (Diabetologia http://dx.doi.org/10.1007/s00125-005-0004-7)	2006
Professor Mark Walker	Functional variation in VEGF is not associated with type 2 diabetes in a United Kingdom Caucasian population	2006
Professor Mark Walker Dr Bijayeswar Vaidya	GAD antibodies in probands and their relatives in a cohort clinically selected for Type 2 diabetes	2006
Professor Mark Walker Dr Muthu Jayapaul Dr Stuart Bennett	Impaired beta cell glucose sensitivity and whole-body insulin sensitivity as predictors of hyperglycaemia in non-diabetic subjects (vol 49, pg 1131, 2006)	2006
Professor Mark Walker	Insulin sensitivity and fasting insulin: association with indicators of cardiovascular disease in healthy subjects. The RISC Study	2006
Professor Mark Walker	Large scale case-control and family-based analyses of TCF7L2 variants in > 6000 UK subjects demonstrates an almost two-fold difference in relative risk between homozygote classes	2006
Professor Mark Walker	No evidence of association of ENPP1 variants with type 2 diabetes or obesity in a study of 8,089 U.K. Caucasians	2006
Professor Mark Walker	Pitfalls of the disposition index as an index of beta cell function	2006
Dr Peter Avery Professor Mark Walker	Reduced beta cell function in offspring of mothers with young-onset type 2 diabetes	2006
Professor Mark Walker	Significant linkage of BMI to chromosome 10p in the U.K. population and evaluation of GAD2 as a positional candidate	2006
Professor Mark Walker	Syndromic obesity and diabetes: Changes in body composition with age and mutation analysis of ALMS1 in 12 United Kingdom kindreds with Alström syndrome	2006
Dr Sheila Patel Professor Mark Walker	The A-11426G and G-11391A promoter variants of the ACDC gene influence adiponectin levels in healthy subjects	2006
Professor Mark Walker	The functional "KL-VS" variant of KLOTHO is not associated with type 2 diabetes in 5028 UK Caucasians	2006
Professor Mark Walker	The variable number of tandem repeats upstream of the insulin gene is a susceptibility locus for latent autoimmune diabetes in adults	2006
Professor Mark Walker	Variation within the gene encoding the upstream stimulatory factor 1 does not influence susceptibility to type 2 diabetes in samples from populations with replicated evidence of linkage to chromosome 1q	2006
Professor Mark Walker	A large-scale association analysis of common variation of the HNF1α gene with type 2 diabetes in the U.K. Caucasian population	2005
Professor Mark Walker	An evaluation of HapMap sample size and tagging SNP performance in large-scale empirical and simulated data sets	2005
Professor Mark Walker	Assessment of the role of genetic variation in the transient neonatal diabetes (TNDM) region on chromosome 6q24 in type 2 diabetes: a comparative genomic and haplotype approach	2005
Dr Audrey Brown Emeritus Professor Steve Yeaman Professor Mark Walker	Calpain inhibition and insulin action in cultured human muscle cells	2005
Professor Mark Walker	Carotid artery stiffness decreases with habitual physical activity in a healthy adult population	2005
Professor Mark Walker Professor Alastair Burt	Distinctive pattern of liver histology in poorly controlled type I diabetes	2005
Professor Mark Walker	Examining the relationships between the Pro12Ala variant in PPARG and Type 2 diabetes-related traits in UK samples	2005
Professor Mark Walker	Genetic variations in the gene encoding TFAP2B are associated with type 2 diabetes mellitus	2005
Professor Mark Walker Dr Muthu Jayapaul Dr Stuart Bennett	Impaired beta cell glucose sensitivity and whole-body insulin sensitivity as predictors of hyperglycaemia in non-diabetic subjects	2005
Dr Audrey Brown Emeritus Professor Steve Yeaman Professor Mark Walker	Investigation of the effects of calpain-10 inhibition on insulin action in cultured skeletal muscle cells	2005
Professor Mark Walker	Large-scale studies of the association between variation at the TNF/LTA locus and susceptibility to type 2 diabetes	2005
Professor Mark Walker	Metabolic syndrome definitions in relation to intima media thickness and insulin senstivity in healthy adult men and women	2005
Professor Mark Walker Professor Robert Taylor Emeritus Professor Doug Turnbull	Mitochondrial diabetes	2005
Dr Peter Avery Professor Mark Walker Anne Hattersley	Reduced beta cell function in offspring of mothers with young onset type 2 diabetes	2005
Professor Patrick Chinnery Dr Hannah Elliott Dr Sheila Patel Claire Lambert Dr Steve Durham et al.	Role of the mitochondrial DNA 16184-16193 poly-C tract in type 2 diabetes	2005
Dr Carmela Ciardullo Dr Stuart Bennett Professor Mark Walker	Rosiglitazone improves insulin sensitivity, glucose tolerance and ambulatory blood pressure in subjects with impaired glucose tolerance: Does it really work? If yes, is it a novelty?	2005
Professor Mark Walker Dr Heather Dickinson	Surgical resection and whole brain radiation therapy versus whole brain radiation therapy for single brain metastases	2005
Dr Ibrahim Ibrahim Dr Sheila Patel Professor Mark Walker	The Pro12Ala variant of the peroxisome proliferator-activated receptor gamma2 gene influences insulin sensitivity in healthy subjects participating in the RISC study	2005
Professor Mark Walker	Analysis of the contribution to type 2 diabetes susceptibility of sequence variation in the gene encoding stearoyl-CoA desaturase, a key regulator of lipid and carbohydrate metabolism	2004
Professor Mark Walker	Association studies of insulin receptor substrate 1 gene (IRS1) variants in type 2 diabetes samples enriched for family history and early age of onset	2004
Professor Mark Walker	Cocaine users differ from normals on cognitive tasks showing declines during abstinence. Similar research can be conducted in recreational 'ecstasy' users	2004
Professor Mark Walker	Common variants of the hepatocyte nuclear factor-4α P2 promoter are associated with type 2 diabetes in the U.K. population	2004
Dr Elizabeth McIntyre Dr Reza Halse Emeritus Professor Steve Yeaman Professor Mark Walker	Cultured muscle cells from insulin-resistant type 2 diabetes patients have impaired insulin, but normal 5-amino-4-imidazolecarboxamide riboside-stimulated, glucose uptake	2004
Professor Mark Walker	Evidence from A Large U.K. Family Collection That Genes Influencing Age of Onset of Type 2 Diabetes Map to Chromosome 12p and to the MODY3/NIDDM2 Locus on 12q24	2004
Professor Bobby McFarland Dr Andrew Schaefer Dr Julie Murphy Dr Stephen Lynn Christine Hayes et al.	Familial Myopathy: New Insights into the T14709C Mitochondrial tRNA Mutation	2004
Mr GW William Mills Dr Peter Avery Professor Mark Walker	Heritability estimates for beta cell function and features of the insulin resistance syndrome in UK families with an increased susceptibility to Type 2 diabetes	2004
Professor Mark Walker Anne Hattersley	Large-scale association studies of candidate genes and their interactions in Type 2 diabetes	2004
Dr Muthu Jayapaul Professor Mark Walker	Mechanisms contributing to the development of type 2 diabetes	2004
Professor Mark Walker	Role of the D76N polymorphism of insulin promoter factor-1 in predisposing to Type 2 diabetes	2004
Dr Stuart Bennett Professor Mark Walker	Rosiglitazone improves insulin sensitivity, glucose tolerance and ambulatory blood pressure in subjects with impaired glucose tolerance	2004
Professor Mark Walker	The EGIR-RISC Study (the European group for the study of insulin resistance: Relationship between insulin sensitivity and cardiovascular disease risk): I. Methodology and Objectives	2004
Marcus Wilson Dr Kathleen Scougall Dr Elizabeth McIntyre Emeritus Professor Steve Yeaman Professor Mark Walker et al.	Towards muscle-targeted gene therapy for diabetes: Tetracycline-repressible transcriptional regulation of (pro)insulin secretion in human muscle	2004
Professor Mark Walker Anne Hattersley	Association and haplotype analysis of the insulin-degrading enzyme (IDE) gene, a strong positional and biological candidate for type 2 diabetes susceptibility	2003
Dr Andrew Schaefer Professor Bobby McFarland Dr Julie Murphy Dr Stephen Lynn Christine Hayes et al.	Familial mitochondrial myopathy: New insights into the T14709C mitochondrial tRNA mutation	2003
Professor Mark Walker	Genetic variation in the small heterodimer partner gene and young-onset type 2 diabetes, obesity, and birth weight in U.K. subjects	2003
Dr Stephen Lynn Dr Gillian Borthwick Richard Charnley Professor Mark Walker Emeritus Professor Doug Turnbull et al.	Heteroplasmic ratio of the A3243G mitochondrial DNA mutation in single pancreatic beta cells	2003
Professor Mark Walker Anne Hattersley	Large-scale association studies of variants in genes encoding the pancreatic β-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes	2003
Professor Mark Walker	Meta-Analysis and a Large Association Study Confirm a Role for Calpain-10 Variation in Type 2 Diabetes Susceptibility	2003
Magdalene Wilson Dr Elizabeth McIntyre Dr Kathleen Scougall Professor Mark Walker Emeritus Professor Steve Yeaman et al.	Tetracycline-regulated (pro)insulin secretion and processing to mature insulin following plasmid-mediated transfection of human muscle	2003
Professor Mark Walker Anne Hattersley	Young-onset type 2 diabetes families are the major contributors to genetic loci in the Diabetes UK Warren 2 genome scan and identify putative novel loci on chromosomes 8q21, 21q22, and 22q11	2003
Professor Mark Walker	Analysis of the imprinted transient neonatal diabetes critical region (ZAC/HYMAI) locus in Type 2 diabetes parent-offspring trios	2002
Professor Mark Walker	Association studies of genetic variation in the WFS1 gene and type 2 diabetes in UK populations	2002
Professor Mark Walker Emeritus Professor Sir George Sir George Alberti	Biochemical measures in a population-based study: effect of fasting duration and time of day	2002
Dr Stephen Lynn Geoffrey Taylor Dr Theresa Wardell Professor Patrick Chinnery Emeritus Professor Doug Turnbull et al.	Defining the importance of mitochondrial gene defects in maternally inherited diabetes by sequencing the entire mitochondrial genome	2002
Professor Mark Walker	Evidence for linkage of stature to chromosome 3p26 in a large UK family data set ascertained for type 2 diabetes	2002
Dr Elizabeth McIntyre Professor Mark Walker	Genetics of type 2 diabetes and insulin resistance: knowledge from human studies	2002
Dr Sheila Patel Professor Nigel Unwin Professor Mark Walker	Investigation of the role of the T to G SNP in the adiponectin (AMP1) gene in abdominal obesity using parent-offspring trios	2002
Professor Mark Walker	Linkage studies of the Type 2 diabetes susceptibility locus on chromosome 1q: Combined analysis of 1200 UK and French affected sibpairs	2002
Glenn Renforth Dr Neil Hanley Dr Karen Piper Hanley Dr Vincent Connolly Professor Mark Walker et al.	Mutation of ALMS1, a large gene with a tandem repeat encoding 47 amino acids, causes Alstrom syndrome	2002
Emeritus Professor Doug Turnbull Professor Mark Walker	Variation in the calpain-10 gene affects blood glucose levels in the British population	2002
Professor Mark Walker	A genomewide scan for loci predisposing to type 2 diabetes in a UK population (the Diabetes UK Warren 2 repository): Analysis of 573 pedigrees provides independent replication of a susceptibility locus on chromosome 1q	2001
Dr Clive Ballard Professor John O'Brien Alastair Gray Francesca Cormack Dr Elise Rowan et al.	Attention and fluctuating attention in patients with dementia with lewy bodies and alzheimer disease	2001
Dr Tim Butler Dr Luis Barriocanal Professor Mark Walker	Elevated plasma non-esterified fatty acid levels and insulin secretion in non-diabetic relatives of type 2 diabetic patients	2001
Dr Colin Fischbacher Professor Raj Bhopal CBE Professor Nigel Unwin Professor Mark Walker	Maternal transmission of Type 2 diabetes varies by ethnic group: Cross-sectional survey of Europeans and South Asians	2001
Dr Stuart Bennett Professor Mark Walker	Rosiglitazone improves glycaemic and insulinaemic responses in subjects with impaired glucose tolerance	2001
Dr Stuart Bennett Professor Mark Walker	Rosiglitazone improves insulin sensitivity and 24-hour ambulatory blood pressure in subjects with IGT	2001
Professor Mark Walker	Studies of association between the gene for calpain-10 and type 2 diabetes mellitus in the United Kingdom	2001
Professor Mark Walker	Studies of Association between the Gene for Calpain-10 and Type 2 Diabetes Mellitus in the United Kingdom	2001
Professor Mark Walker Professor John Mathers	Acute fuel selection in response to high-sucrose and high-starch meals in healthy men	2000
Professor Mark Walker	Analysis of parent-offspring trios provides evidence for linkage and association between the insulin gene and type 2 diabetes mediated exclusively through paternally transmitted class III variable number tandem repeat alleles	2000
Professor Mark Walker Sarah Jackson Emeritus Professor Steve Yeaman Emeritus Professor Doug Turnbull	Decreased glucose uptake in myoblasts from insulin resistant non-diabetic relatives of type 2 diabetic families	2000
Emeritus Professor Steve Yeaman Professor Mark Walker	Decreased insulin responsiveness of glucose uptake in cultured human skeletal muscle cells: From insulin-resistant nondiabetic relatives of type 2 diabetic families	2000
Professor Mark Walker	Evidence that single nucleotide polymorphism in the uncoupling protein 3 (UCP3) gene influences fat distribution in women of European and Asian origin	2000
Professor Mark Walker	Insulin resistance: a problem for clinicians and scientists	2000
Professor Rudy Bilous Professor Mark Walker	Insulin sensitivity in hypertensive Type 2 diabetic patients after 1 and 19 days' treatment with trandolapril	2000
Dr Stephen Lynn Emeritus Professor Doug Turnbull Professor Mark Walker	Intermediate expansions of a X25/frataxin gene GAA repeat and Type II diabetes: Assessment using parent-offspring trios [1]	2000
Professor Mark Walker	No evidence for linkage at candidate type 2 diabetes susceptibility loci on chromosomes 12 and 20 in United Kingdom Caucasians	2000
Emeritus Professor Elaine Perry Professor Mark Walker Emeritus Professor Robert Perry	Acetylcholine in mind: a neurotransmitter correlate of consciousness?	1999
Emeritus Professor Elaine Perry Professor Mark Walker Emeritus Professor Robert Perry	Consciousness in mind: a correlate for ACh? Reply to Hölscher	1999
Dr Stephen Lynn Anne Hattersley Emeritus Professor Doug Turnbull Professor Mark Walker	Intermediate GAA repeat expansions of the X25/frataxin gene in type 2 diabetes	1999
Professor Patrick Chinnery Professor Mark Walker Professor Robert Taylor Professor Robert Lightowlers Professor Laurence Bindoff et al.	Nonrandom tissue distribution of mutant mtDNA	1999
Professor Patrick Chinnery Professor Mark Walker Professor Robert Taylor Professor Robert Lightowlers Professor Laurence Bindoff et al.	Non-random tissue distribution of mutant mtDNA	1999
Professor Mark Walker Anne Hattersley	Parent-offspring trios - A resource to facilitate the identification of type 2 diabetes genes	1999
Dr Stuart Bennett Professor Mark Walker	Physical activity in non-diabetic relatives of type 2 diabetic patients	1999
Professor Mark Walker Emeritus Professor Sir George Sir George Alberti	Twenty-four-hour insulin secretion rates, circulating concentrations of fuel substrates and gut incretin hormones in healthy offspring of Type II (non-insulin-dependent) diabetic parents: evidence of several aberrations	1999