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Browsing publications by Professor Mark Walker.

Newcastle AuthorsTitleYearFull text
Dr Ana Viñuela
Dr Alison Heggie
Donna McEvoy
Professor Mark Walker
Four groups of type 2 diabetes contribute to the etiological and clinical heterogeneity in newly diagnosed individuals: An IMI DIRECT study2022
Xuefei Yu
Dr Catherine Arden
Dr Rolando Berlinguer Palmini
Dr Chun Chen
Carla Bradshaw
et al.
Mitochondrial complex I subunit deficiency promotes pancreatic α-cell proliferation2022
Dr Ana Viñuela
Professor Mark Walker
Correction to: The role of physical activity in metabolic homeostasis before and after the onset of type 2 diabetes: an IMI DIRECT study (Diabetologia, (2020), 63, 4, (744-756), 10.1007/s00125-019-05083-6)2021
Professor Mark Walker
Dr Ibrahim Ibrahim
Dr Muthu Jayapaul
Dorothy Carman
Charlotte Ryan
et al.
Gamma-glutamyltransferase, arterial remodeling and prehypertension in a healthy population at low cardiometabolic risk2021
Dr Harshal Deshmukh
Dr Ana Viñuela
Dr Alison Heggie
Professor Mark Walker
Genome-Wide Association Analysis of Pancreatic Beta-Cell Glucose Sensitivity2021
Dr Helen Porteous
Dr Cara Tomas
Dr Satomi Miwa
Professor Mark Walker
Peroxisomes and pancreatic beta-cell lipo-dysfunction2021
Dr Alison Heggie
Donna McEvoy
Dr Ana Viñuela
Professor Mark Walker
Processes Underlying Glycemic Deterioration in Type 2 Diabetes: An IMI DIRECT Study2021
Professor Mark Walker
The trans-ancestral genomic architecture of glycemic traits2021
Dr Ana Viñuela
Professor Mark Walker
Dietary metabolite profiling brings new insight into the relationship between nutrition and metabolic risk: An IMI DIRECT study2020
Professor Mark Walker
Dr Georg Homuth
Genetic studies of leptin concentrations implicate leptin in the regulation of early adiposity2020
Professor Mark Walker
Dr Alison Heggie
Dr Ana Viñuela
Post-load glucose subgroups and associated metabolic traits in individuals with type 2 diabetes: An IMI-DIRECT study2020
Dr Ana Viñuela
Dr Alison Heggie
Donna McEvoy
Professor Mark Walker
Predicting and elucidating the etiology of fatty liver disease: A machine learning modeling and validation study in the IMI DIRECT cohorts2020
Dr Cara Tomas-Smith
Dr Joanna Elson
Professor Julia Newton
Professor Mark Walker
Substrate utilisation of cultured skeletal muscle cells in patients with CFS2020
Dr Cara Tomas
Dr Joanna Elson
Vicki Strassheim
Professor Julia Newton
Professor Mark Walker
et al.
The effect of myalgic encephalomyelitis/ chronic fatigue syndrome (ME/CFS) severity on cellular bioenergetic function2020
Dr Ana Viñuela
Professor Mark Walker
The role of physical activity in metabolic homeostasis before and after the onset of type 2 diabetes: an IMI DIRECT study2020
Dr Alison Heggie
Donna McEvoy
Dr Ana Viñuela
Professor Mark Walker
Whole blood co-expression modules associate with metabolic traits and type 2 diabetes: an IMI-DIRECT study2020
Ushma Shah
Professor Mark Walker
Professor Caroline Relton
Dr Hannah Elliott
Differential methylation of the type 2 diabetes susceptibility locus KCNQ1 is associated with insulin sensitivity and is predicted by CpG site specific genetic variation2019
Professor Mark Walker
Disentangling the genetics of lean mass2019
Dr Harshal Deshmukh
Dr Alison Heggie
Professor Mark Walker
Dr Ana Viñuela
Genetic studies of abdominal MRI data identify genes regulating hepcidin as major determinants of liver iron concentration2019
Ali Al-Bayati
Dr Audrey Brown
Professor Mark Walker
Impaired enhancement of insulin action in cultured skeletal muscle cells from insulin resistant type 2 diabetic patients in response to contraction using electrical pulse stimulation2019
Professor Mark Walker
Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution2019
Professor Mark Walker
Professor Emma Stevenson
Dr Daniel West
A small dose of whey protein co-ingested with mixed-macronutrient breakfast and lunch meals improves postprandial glycemia and suppresses appetite in men with type 2 diabetes: a randomized controlled trial2018
Professor Mark Walker
Not quite type 1 or type 2, what now? Review of monogenic, mitochondrial, and syndromic diabetes2018
Dr Audrey Brown
Beth Dibnah
Professor Julia Newton
Professor Mark Walker
Pharmacological activation of AMPK and glucose uptake in cultured human skeletal muscle cells from patients with ME/CFS2018
Professor Mark Walker
Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity2018
Professor Mark Walker
A genome-wide association study of IVGTT-based measures of first-phase insulin secretion refines the underlying physiology of type 2 diabetes variants2017
Professor Mark Walker
Dr Daniel West
An additional bolus of rapid-acting insulin to normalise postprandial cardiovascular risk factors following a high-carbohydrate high-fat meal in patients with type 1 diabetes: A randomised controlled trial2017
Professor Mark Walker
Data Descriptor: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls2017
Professor Mark Walker
Erratum: Large meta-analysis of genome-wide association studies identifies five loci for lean body mass2017
Professor Mark Walker
Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults2017
Dr Christopher Stewart
Professor Mark Walker
Professor Emma Stevenson
Professor James Shaw
Dr Daniel West
et al.
Gut microbiota of Type 1 diabetes patients with good glycaemic control and high physical fitness is similar to people without diabetes: an observational study2017
Timothy Brock
Dr Mark Shirley
Michelle Bardgett
Professor Mark Walker
Professor David Deehan
et al.
Inadequate pre-operative glycaemic control in patients with diabetes mellitus adversely influences functional recovery after total knee arthroplasty: Patients with impaired glycaemic control exhibit poorer functional outcomes at 1-year post-arthroplasty2017
Professor Mark Walker
Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance2017
Professor Mark Walker
Large meta-analysis of genome-wide association studies identifies five loci for lean body mass2017
Professor Mark Walker
Rare and low-frequency coding variants alter human adult height2017
Dr Alison Heggie
Professor Mark Walker
Sustained influence of metformin therapy on circulating glucagon-like peptide-1 levels in individuals with and without type 2 diabetes2017
Professor Mark Walker
A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease2016
Dr Alison Heggie
Professor Mark Walker
A patient with a glucokinase mutation: a cautionary tale2016
Professor Mark Walker
Professor James Shaw
Professor Emma Stevenson
Dr Daniel West
Administering a small rapid-acting insulin bolus 3 h after eating a mixed macronutrient meal improves postprandial glucose control, without hypoglycaemia, in people with Type 1 diabetes2016
Professor Mark Walker
Dr Dean Allerton
Professor Emma Stevenson
Professor James Shaw
Dr Daniel West
et al.
Carbohydrate counting at meal time followed by a small secondary postprandial bolus injection at 3 hours prevents late hyperglycemia, without hypoglycemia, after a high-carbohydrate high-fat meal in Type 1 diabetes2016
Professor Mark Walker
Determinants of glucagon-like peptide-1 (GLP-1) response in prediabetes and diabetes: an IMI-DIRECT study2016
Ali Al-Bayati
Dhanisha Lukka
Dr Audrey Brown
Professor Mark Walker
Effects of thrombin on insulin signalling and glucose uptake in cultured human myotubes2016
Dr Audrey Brown
Professor Mark Walker
Genetics of Insulin Resistance and the Metabolic Syndrome2016
Professor Mark Walker
Genome-Wide Association Study of the Modified Stumvoll Insulin Sensitivity Index Identifies BCL2 and FAM19A2 as Novel Insulin Sensitivity Loci2016
Professor Mark Walker
Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels2016
Professor Mark Walker
The Association Between Sleep Duration, Insulin Sensitivity, and β-Cell Function: The EGIR-RISC Study2016
Dr Helen Porteous
Dr Audrey Brown
Professor Mark Walker
The effect of Pex11 beta knockdown on peroxisome abundance and insulin secretion in MIN6 cells2016
Professor Mark Walker
The genetic architecture of type 2 diabetes2016
Professor Mark Walker
Professor Mike Trenell
Professor James Shaw
Dr Daniel West
A combined basal-bolus insulin dose reduction strategy for preventing exercise-induced hypoglycaemia does not cause hormonal, metabolic or inflammatory disturbances in Type 1 diabetes2015
Professor Mark Walker
A genome wide association study of IVGTT based measures of first phase insulin secretion reveals new physiology of known and novel variants2015
Professor Mark Walker
Professor Mike Trenell
Professor James Shaw
A novel strategy that prevents early- and late-onset nocturnal hypoglycaemia following evening exercise in Type 1 diabetes2015
Dr Audrey Brown
Professor Mark Walker
Professor Julia Newton
Abnormalities of AMPK Activation and Glucose Uptake in Cultured Skeletal Muscle Cells from Individuals with Chronic Fatigue Syndrome2015
Professor Mark Walker
Association Analysis of 29,956 Individuals Confirms That a Low-Frequency Variant at CCND2 Halves the Risk of Type 2 Diabetes by Enhancing Insulin Secretion2015
Professor Mark Walker
Professor James Shaw
Professor Emma Stevenson
Dr Daniel West
Comparison of appetite responses to high- and low-glycemic index postexercise meals under matched insulinemia and fiber in type 1 diabetes2015
Professor Mark Walker
Genetic studies of body mass index yield new insights for obesity biology2015
Professor Mark Walker
Identification and Functional Characterization of G6PC2 Coding Variants Influencing Glycemic Traits Define an Effector Transcript at the G6PC2-ABCB11 Locus2015
Professor Heather Cordell
Professor Mark Walker
Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene2015
Dr Daniel West
Professor Mark Walker
Professor James Shaw
Dr Fahad Ahmed
Stephanie Wijaya
et al.
Inflammation and the acute endothelial progenitor cell response to submaximal running exercise in males with and without Type 1 diabetes2015
Professor Mark Walker
Professor Emma Stevenson
Professor James Shaw
Dr Daniel West
Insulin therapy and dietary adjustments to normalise glycaemia and prevent nocturnal hypoglycaemia after evening exercise in Type 1 diabetes: a randomized controlled trial2015
Professor Mark Walker
Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility2015
Professor Mark Walker
New genetic loci link adipose and insulin biology to body fat distribution2015
Dr Audrey Brown
Dr Peter Avery
Emeritus Professor Steve Yeaman
Professor Mark Walker
p38 MAPK activation upregulates proinflammatory pathways in skeletal muscle cells from insulin-resistant type 2 diabetic patients2015
Dr Alison Heggie
Professor Mark Walker
Presentation of new diabetes with severe hypertriglyceridaemia in two young Asian patients2015
Professor Mark Walker
Professor James Shaw
Dr Daniel West
Subjective and hormonal appetite responses to high and low glycaemic index post-exercise meals, under matched insulinaemia and fibre in Type 1 diabetes2015
Professor Mark Walker
The association between sleep duration and insulin sensitivity: the EGIR-RISC study2015
Professor Mark Walker
Dr Fahad Ahmed
Stephanie Wijaya
Professor James Shaw
Dr Jolanta Weaver
et al.
The inflammation, vascular repair and injury responses to exercise in fit males with and without Type 1 diabetes: an observational study2015
Laura Pascoe
Professor Mark Walker
The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study2015
Professor Mark Walker
A Central Role for GRB10 in Regulation of Islet Function in Man2014
Professor Mark Walker
Professor Mike Trenell
Professor Emma Stevenson
Professor James Shaw
Dr Daniel West
et al.
A Low-Glycemic Index Meal and Bedtime Snack Prevents Postprandial Hyperglycemia and Associated Rises in Inflammatory Markers, Providing Protection From Early but Not Late Nocturnal Hypoglycemia Following Evening Exercise in Type 1 Diabetes2014
Dr Audrey Brown
Meutia Kumaheri
Dr Helen Porteous
Dr Alison Heggie
Dr Satomi Miwa
et al.
Age-Related Mitochondrial DNA Depletion and the Impact on Pancreatic Beta Cell Function2014
Professor Mark Walker
Common Genetic Variants Highlight the Role of Insulin Resistance and Body Fat Distribution in Type 2 Diabetes, Independent of Obesity2014
Professor Mark Walker
Defining the role of common variation in the genomic and biological architecture of adult human height2014
Dr Alison Heggie
Professor Mark Walker
Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: rationale and design of the epidemiological studies within the IMI DIRECT Consortium2014
Professor Mark Walker
Functional Living in Older Adults With Type 2 Diabetes: Executive Functioning, Dual Task Performance, and the Impact on Postural Stability and Motor Control2014
Professor Mark Walker
Genetic Evidence for a Normal-Weight "Metabolically Obese" Phenotype Linking Insulin Resistance, Hypertension, Coronary Artery Disease, and Type 2 Diabetes2014
Professor Mark Walker
Professor Mike Trenell
Heavily reducing pre- and post-exercise rapid-acting insulin dose may cause hyperglycaemia, but does not augment ketonaemia or increase inflammatory cytokines in patients with Type 1 diabetes2014
Professor Mark Walker
Impact of Type 2 Diabetes Susceptibility Variants on Quantitative Glycemic Traits Reveals Mechanistic Heterogeneity2014
Professor Mark Walker
Professor Mike Trenell
Dr Daniel West
Metabolic Implications when Employing Heavy Pre- and Post-Exercise Rapid-Acting Insulin Reductions to Prevent Hypoglycaemia in Type 1 Diabetes Patients: A Randomised Clinical Trial2014
Professor Mark Walker
The DEXLIFE study methods: Identifying novel candidate biomarkers that predict progression to type 2 diabetes in high risk individuals2014
Professor Mark Walker
A genetic risk score comprising common variants associated with fasting insulin is associated with OGTT- and clamp-based indices of whole body insulin sensitivity2013
Dr Gus Brooks
Dr Ali Aldibbiat
Professor Mark Walker
Professor James Shaw
Attainment of Metabolic Goals in the Integrated UK Islet Transplant Program With Locally Isolated and Transported Preparations2013
Dr Andrew Schaefer
Professor Mark Walker
Emeritus Professor Doug Turnbull
Professor Robert Taylor
Endocrine disorders in mitochondrial disease2013
Professor Mark Walker
Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes2013
Charlotte Gordon
Professor Mark Walker
Dr Debbie Carrick-Sen
Exploring risk, prevention and educational approaches for the non-diabetic offspring of patients with type 2 diabetes - a qualitative study2013
Professor Heather Cordell
Professor Mark Walker
Genetic and Functional Analyses Identify NAT2 as a Human Insulin Sensitivity Gene2013
Professor Mark Walker
Genetic Variants Associated with Glycine Metabolism and their Role in Insulin Sensitivity and Type 2 Diabetes2013
Professor Mark Walker
Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders2013
Dr Linda Penn
Professor Martin White
Professor Mark Walker
Professor John Mathers
Importance of Weight Loss Maintenance and Risk Prediction in the Prevention of Type 2 Diabetes: Analysis of European Diabetes Prevention Study RCT2013
Professor Chris Day
Professor Mark Walker
Professor Helen Reeves
Krüppel Like Factor 6 (KLF6) Protects From NAFLD Progression through Regulation of Adipose Tissue Insulin Resistance2013
Professor Mark Walker
Professor Mike Trenell
Professor Djordje Jakovljevic
Large pre- and postexercise rapid-acting insulin reductions preserves glycemia and prevents early- but not late-onset hypoglycemia in patients with type 1 diabetes2013
Professor Mark Walker
Mendelian Randomization Studies Do Not Support a Causal Role for Reduced Circulating Adiponectin Levels in Insulin Resistance and Type 2 Diabetes2013
Professor Mark Walker
Professor Dianne Ford
Professor Ruth Valentine
Nutrigenetics and Nutrigenomics; the role of nutrition in gene expression2013
Professor Mark Walker
Professor Mike Trenell
Preventing hypoglycaemia by heavily reducing pre- and post-exercise rapid-acting insulin dose may cause hyperglycaemia, but not hyperketonaemia in type 1 diabetes patients2013
Dr Alison Heggie
Professor Mark Walker
Renal function in patients with Type 2 diabetes treated with glucagon-like peptide 1 (GLP-1) analogues2013
Dr Augustin Brooks
Dr Ali Aldibbiat
Professor Mark Walker
Professor James Shaw
Restoration of endogenous C-peptide by islet transplantation is associated with increased duration of normoglycaemia and reduced blood glucose variability in recipients with Type 1 diabetes2013
Professor Mark Walker
Professor Mike Trenell
Professor Djordje Jakovljevic
The preservation of glycaemia through large pre- and post-exercise rapid-acting insulin reductions prevents early, but not late-onset hypoglycaemia in individuals with Type 1 diabetes2013
Dr Matthew Thomas
Colin Wilson
Professor Derek Manas
Professor Mark Walker
Professor James Shaw
et al.
Endoscopic Botulinum Toxin Injection for the Treatment of Diabetic Gastropathy in Pancreas and Islet-cell Transplant Patients2012
Dr Gillian Patman
Laura Pascoe
Dr Luca Miele
Douglas Hui
Professor Alastair Burt
et al.
Glucokinase links Krüppel-like factor 6 to the regulation of hepatic insulin sensitivity in nonalcoholic fatty liver disease2012
Dr Linda Penn
Professor Martin White
Professor Mark Walker
Professor John Mathers
Intensive lifestyle intervention for prevention of type 2 diabetes in adults with impaired glucose tolerance: the European Diabetes Prevention Study, a pooled analysis of three randomised controlled trials from Finland, The Netherlands and the UK2012
Donna Hine
Dr Audrey Brown
Dr Lynsey Cree
David Gunn
Professor Patrick Chinnery
et al.
Mitochondrial DNA depletion and insulin secretion2012
Professor Mark Walker
No Interactions Between Previously Associated 2-Hour Glucose Gene Variants and Physical Activity or BMI on 2-Hour Glucose Levels2012
Dr Peter Avery
Dr Sheila Patel
Dr Ibrahim Ibrahim
Professor Mark Walker
Professor Bernard Keavney
et al.
Common variation in the adiponectin gene has an effect on systolic blood pressure2011
Laura Pascoe
Professor Mark Walker
Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile2011
Laura Pascoe
Professor Mark Walker
Genome-Wide Association Identifies Nine Common Variants Associated With Fasting Proinsulin Levels and Provides New Insights Into the Pathophysiology of Type 2 Diabetes2011
Professor Mark Walker
Glucose tolerance, insulin sensitivity and insulin release in European non-diabetic carriers of a polymorphism upstream of CDKN2A and CDKN2B2011
Professor Mark Walker
Influence of Hyperinsulinemia and Insulin Resistance on In Vivo beta-Cell Function: Their Role in Human beta-Cell Dysfunction2011
Professor Mark Walker
Insulin-induced stimulation of insulin secretion, its relation to insulin sensitivity and impact on impaired glucose regulation2011
Dr Roslyn Simms
Professor John Sayer
Dr Richard Quinton
Professor Mark Walker
Professor Tim Goodship
et al.
Monogenic diabetes, renal dysplasia and hypopituitarism: a patient with a HNF1A mutation2011
Professor Mark Walker
Physical Activity Attenuates the Influence of FTO Variants on Obesity Risk: A Meta-Analysis of 218,166 Adults and 19,268 Children2011
Professor Mark Walker
Sequencing PDX1 (insulin promoter factor 1) in 1788 UK individuals found 5% had a low frequency coding variant, but these variants are not associated with Type 2 diabetes2011
Dr Linda Penn
Professor John Mathers
Professor Mark Walker
Professor Martin White
Translating research evidence to service provision for prevention of type 2 diabetes: development and early outcomes of the ‘New life, New you’ intervention2011
Professor Mark Walker
Detailed Physiologic Characterization Reveals Diverse Mechanisms for Novel Genetic Loci Regulating Glucose and Insulin Metabolism in Humans2010
Dr Louise Hayes
Professor Mark Pearce
Dr Michael Firbank
Professor Mark Walker
Professor Roy Taylor
et al.
Do obese but metabolically normal women differ in intra-abdominal fat and physical activity levels from those with the expected metabolic abnormalities? A cross-sectional study2010
Professor Mark Walker
Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes2010
Laura Pascoe
Professor Mark Walker
Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge2010
Emeritus Professor Nicol Ferrier
Professor John Isaacs
Dr John Mansfield
Professor Mark Walker
Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls2010
Dr Nicola Leech
Dr John O'Sullivan
Dr Peter Avery
Laura Pascoe
Professor Mark Walker
et al.
Increased maternal Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) associated with older age at diagnosis of Type 1 diabetes in offspring2010
Professor Mark Walker
Insulin Sensitivity and beta-Cell Function in the Offspring of Type 2 Diabetic Patients: Impact of Line of Inheritance2010
Dr Linda Penn
Professor John Mathers
Professor Mark Walker
Michael White
Towards the translation of research evidence to service provision: experience from North East England, UK2010
Professor Mark Walker
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis2010
Dr Angela Pyle
Professor Mark Walker
Professor Patrick Chinnery
Dr Simon Baudouin
A common UCP2 polymorphism predisposes to stress hyperglycaemia in severe sepsis2009
Professor Mark Walker
Adiposity-Related Heterogeneity in Patterns of Type 2 Diabetes Susceptibility Observed in Genome-Wide Association Data2009
Laura Pascoe
Professor Mark Walker
Common genetic variation in the melatonin receptor 1B gene (MTNR1B) is associated with decreased early-phase insulin response2009
Professor Mark Walker
Correlation of the leptin:adiponectin ratio with measures of insulin resistance in non-diabetic individuals2009
Dr Audrey Brown
Professor Mark Walker
Insulin-like growth factor I (IGF-I) is a more potent regulator of gene expression than insulin in primary human myoblasts and myotubes2009
Professor Mark Walker
Parental origin of sequence variants associated with complex diseases2009
Dr Linda Penn
Professor Martin White
Professor Mark Walker
Emeritus Professor Sir George Sir George Alberti
Professor John Mathers
et al.
Prevention of type 2 diabetes in adults with impaired glucose tolerance: the European Diabetes Prevention RCT in Newcastle upon Tyne, UK2009
Dr Gary Beale
Laura Pascoe
Dr Luca Miele
Professor Mark Walker
Professor Chris Day
et al.
The Kruppel-Like Factor 6 (KLF6) Genotype Which is Associated With NAFLD Progression is Associated with Higher Fasting Serum Glucose Levels in Healthy Individuals2009
Dr Lynsey Cree
Dr Sheila Patel
Dr Angela Pyle
Dr Stephen Lynn
Emeritus Professor Doug Turnbull
et al.
Age-related decline in mitochondrial DNA copy number in isolated human pancreatic islets2008
Laura Pascoe
Professor Mark Walker
Beta cell glucose sensitivity is decreased by 39% in non-diabetic individuals carrying multiple diabetes-risk alleles compared with those with no risk alleles2008
Emeritus Professor Doug Turnbull
Professor Mark Walker
Anne Hattersley
Clinical features, diagnosis and management of maternally inherited diabetes and deafness (MIDD) associated with the 3243A>G mitochondrial point mutation2008
Dr Audrey Brown
Dr Matthias Elstner
Emeritus Professor Steve Yeaman
Emeritus Professor Doug Turnbull
Professor Mark Walker
et al.
Does impaired mitochondrial function affect insulin signaling and action in cultured human skeletal muscle cells?2008
Professor Mark Walker
Dr Colin Miles
Effects on kidney disease, fertility and development in mice inheriting a protein-truncating Denys-Drash syndrome allele (Wt1 tmT396)2008
Anne Hattersley
Dr John Hudson
Professor Mark Walker
Extreme phenotypic diversity and nonpenetrance in families with the LMNA gene mutation R644C2008
Dr Sheila Patel
Professor Mark Walker
Influence of polymorphism I/D of the ACE gene on insulin sensitivity and the risk of glucose intolerance in healthy European subjects2008
Dr Sheila Patel
Professor Mark Walker
Influence of the ACE gene insertion/deletion polymorphism on insulin sensitivity and impaired glucose tolerance in healthy subjects2008
Professor Mark Walker
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes2008
Professor Mark Walker
Optimization of human plasma H-1 NMR spectroscopic data processing for high-throughput metabolic phenotyping studies and detection of insulin resistance related to type 2 diabetes2008
Professor Mark Walker
Population-Specific Risk of Type 2 Diabetes Conferred by HAT4A P2 Promoter Variants: A Lesson for Replication Studies2008
Professor Mark Walker
Dr Muthu Jayapaul
Type 2 diabetes in families and diabetes prevention2008
Dr Sheila Patel
Dr Ibrahim Ibrahim
Dr Peter Avery
Professor Mark Walker
Variation in the ADIPOQ gene promoter is associated with carotid intima media thickness independent of plasma adiponectin levels in healthy subjects2008
Professor Mark Walker
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity2007
Professor Mark Walker
An association analysis of the HLA gene region in latent autoimmune diabetes in adults2007
Dr Sheila Patel
Professor Mark Walker
Association between the ACE gene I/D polymorphism and insulin sensitivity in healthy subjects2007
Professor Mark Walker
Association between the T-381C polymorphism of the brain natriuretic peptide gene and risk of type 2 diabetes in human populations2007
Professor Allan Young
Emeritus Professor Nicol Ferrier
Dr Stephen Ball
Professor Mark Walker
Professor Simon Pearce
et al.
Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants2007
Professor Mark Walker
Common variants in WFS1 confer risk of type 2 diabetes2007
Laura Pascoe
Dr Sheila Patel
Dr Ibrahim Ibrahim
Professor Mark Walker
Common variants of the novel type 2 diabetes genes CDKAL1 and HHEX/IDE are associated with decreased pancreatic β-cell function2007
Professor Mark Walker
Common variation in the LMNA gene (encoding lamin A/C) and type 2 diabetes: Association analyses in 9,518 subjects2007
Dr Audrey Brown
Dr Matthias Elstner
Emeritus Professor Steve Yeaman
Emeritus Professor Doug Turnbull
Professor Mark Walker
et al.
Decreased mitochondrial respiration impairs insulin action in cultured human skeletal muscle cells2007
Professor Roger Whittaker
Dr Andrew Schaefer
Professor Bobby McFarland
Professor Robert Taylor
Professor Mark Walker
et al.
Diabetes and deafness: Is it sufficient to screen for the mitochondrial 3243A>G mutation alone?2007
Dr Audrey Brown
Emeritus Professor Steve Yeaman
Professor Mark Walker
Direct effect of inhibition of TCF7L2 expression on insulin action in cultured human skeletal muscle cells2007
Professor Mark Walker
Evaluation of common variants in the six known maturity-onset diabetes of the young (MODY) genes for association with type 2 diabetes2007
Professor Mark Walker
Examining the candidacy of ghrelin as a gene responsible for variation in adult stature in a United Kingdom population with type 2 diabetes2007
Professor Allan Young
Emeritus Professor Nicol Ferrier
Mohamed Mohiuddin
Dr Catherine Todhunter
Dr John Mansfield
et al.
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls2007
Dr Muthu Jayapaul
Professor Mark Walker
Hyperglucagonaemia is not a primary metabolic defect in non-diabetic first-degree relatives from Type 2 diabetic families2007
Professor Mark Walker
Insulin resistance, insulin response, and obesity as indicators of metabolic risk2007
Dr Laura Rush
Dr Gary Litherland
Professor Mark Walker
Emeritus Professor Steve Yeaman
Key role for ceramides in mediating insulin resistance in human muscle cells2007
Professor Allan Young
Emeritus Professor Nicol Ferrier
Professor Mark Walker
Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A2007
Professor Patrick Chinnery
Dr Catherine Mowbray
Dr Sheila Patel
Dr Joanna Elson
Anne Hattersley
et al.
Mitochondrial DNA haplogroups and type 2 diabetes: a study of 897 cases and 1010 controls2007
Professor Roger Whittaker
Dr Andrew Schaefer
Professor Bobby McFarland
Professor Robert Taylor
Professor Mark Walker
et al.
Prevalence and progression of diabetes in mitochondrial disease2007
Professor Mark Walker
Professor John Isaacs
Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes2007
Dr Gary Litherland
Dr Nick Morris
Professor Mark Walker
Emeritus Professor Steve Yeaman
Role of glycogen content in insulin resistance in human muscle cells2007
Dr Audrey Brown
Emeritus Professor Steve Yeaman
Professor Mark Walker
Targeted suppression of calpain-10 expression impairs insulin-stimulated glucose uptake in cultured primary human skeletal muscle cells2007
Professor Mark Walker
[abstract] Physical activity and sensitivity to insulin2006
Professor Mark Walker
Assessment of the role of common genetic variation in the transient neonatal diabetes mellitus (TNDM) region in type 2 diabetes: A comparative genomic and tagging single nucleotide polymorphism approach2006
Professor Mark Walker
Association analysis of 6,736 U.K. subjects provides replication and confirms TCF7L2 as a type 2 diabetes susceptibility gene with a substantial effect on individual risk2006
Professor Mark Walker
Dr Sheila Patel
Dr Ibrahim Ibrahim
Association between the C-11377G promoter variant of the ACDC gene and carotid intima thickness in healthy subjects2006
Professor Nigel Unwin
Dorothy McLarty
Dr Terry Aspray
Dr Leslie Carlin
Dr Sheila Patel
et al.
Changes in blood pressure and lipids associated with rural to urban migration in Tanzania2006
Professor Mark Walker
Combining information from common type 2 diabetes risk polymorphisms improves disease prediction2006
Dr Sheila Patel
Professor Mark Walker
Common variations in the ALMS1 gene do not contribute to susceptibility to type 2 diabetes in a large white UK population2006
Dr Audrey Brown
Dr Matthias Elstner
Emeritus Professor Steve Yeaman
Emeritus Professor Doug Turnbull
Professor Mark Walker
et al.
Decreased mitochondrial respiration impairs insulin action in cultured human skeletal muscle cells2006
Professor Mark Walker
Epistasis between type 2 diabetes susceptibility loci on chromosomes 1q21-25 and 10q23-26 in Northern Europeans2006
Professor Mark Walker
Dr Muthu Jayapaul
Dr Stuart Bennett
Erratum: Impaired beta cell glucose sensitivity and whole-body insulin sensitivity as predictors of hyperglycaemia in non-diabetic subjects (Diabetologia http://dx.doi.org/10.1007/s00125-005-0004-7)2006
Professor Mark Walker
Functional variation in VEGF is not associated with type 2 diabetes in a United Kingdom Caucasian population2006
Professor Mark Walker
Dr Bijayeswar Vaidya
GAD antibodies in probands and their relatives in a cohort clinically selected for Type 2 diabetes2006
Professor Mark Walker
Dr Muthu Jayapaul
Dr Stuart Bennett
Impaired beta cell glucose sensitivity and whole-body insulin sensitivity as predictors of hyperglycaemia in non-diabetic subjects (vol 49, pg 1131, 2006)2006
Professor Mark Walker
Insulin sensitivity and fasting insulin: association with indicators of cardiovascular disease in healthy subjects. The RISC Study2006
Professor Mark Walker
Large scale case-control and family-based analyses of TCF7L2 variants in > 6000 UK subjects demonstrates an almost two-fold difference in relative risk between homozygote classes2006
Professor Mark Walker
No evidence of association of ENPP1 variants with type 2 diabetes or obesity in a study of 8,089 U.K. Caucasians2006
Professor Mark Walker
Pitfalls of the disposition index as an index of beta cell function2006
Dr Peter Avery
Professor Mark Walker
Reduced beta cell function in offspring of mothers with young-onset type 2 diabetes2006
Professor Mark Walker
Significant linkage of BMI to chromosome 10p in the U.K. population and evaluation of GAD2 as a positional candidate2006
Professor Mark Walker
Syndromic obesity and diabetes: Changes in body composition with age and mutation analysis of ALMS1 in 12 United Kingdom kindreds with Alström syndrome2006
Dr Sheila Patel
Professor Mark Walker
The A-11426G and G-11391A promoter variants of the ACDC gene influence adiponectin levels in healthy subjects2006
Professor Mark Walker
The functional "KL-VS" variant of KLOTHO is not associated with type 2 diabetes in 5028 UK Caucasians2006
Professor Mark Walker
The variable number of tandem repeats upstream of the insulin gene is a susceptibility locus for latent autoimmune diabetes in adults2006
Professor Mark Walker
Variation within the gene encoding the upstream stimulatory factor 1 does not influence susceptibility to type 2 diabetes in samples from populations with replicated evidence of linkage to chromosome 1q2006
Professor Mark Walker
A large-scale association analysis of common variation of the HNF1α gene with type 2 diabetes in the U.K. Caucasian population2005
Professor Mark Walker
An evaluation of HapMap sample size and tagging SNP performance in large-scale empirical and simulated data sets2005
Professor Mark Walker
Assessment of the role of genetic variation in the transient neonatal diabetes (TNDM) region on chromosome 6q24 in type 2 diabetes: a comparative genomic and haplotype approach2005
Dr Audrey Brown
Emeritus Professor Steve Yeaman
Professor Mark Walker
Calpain inhibition and insulin action in cultured human muscle cells2005
Professor Mark Walker
Carotid artery stiffness decreases with habitual physical activity in a healthy adult population2005
Professor Mark Walker
Professor Alastair Burt
Distinctive pattern of liver histology in poorly controlled type I diabetes2005
Professor Mark Walker
Examining the relationships between the Pro12Ala variant in PPARG and Type 2 diabetes-related traits in UK samples2005
Professor Mark Walker
Genetic variations in the gene encoding TFAP2B are associated with type 2 diabetes mellitus2005
Professor Mark Walker
Dr Muthu Jayapaul
Dr Stuart Bennett
Impaired beta cell glucose sensitivity and whole-body insulin sensitivity as predictors of hyperglycaemia in non-diabetic subjects2005
Dr Audrey Brown
Emeritus Professor Steve Yeaman
Professor Mark Walker
Investigation of the effects of calpain-10 inhibition on insulin action in cultured skeletal muscle cells2005
Professor Mark Walker
Large-scale studies of the association between variation at the TNF/LTA locus and susceptibility to type 2 diabetes2005
Professor Mark Walker
Metabolic syndrome definitions in relation to intima media thickness and insulin senstivity in healthy adult men and women2005
Professor Mark Walker
Professor Robert Taylor
Emeritus Professor Doug Turnbull
Mitochondrial diabetes2005
Dr Peter Avery
Professor Mark Walker
Anne Hattersley
Reduced beta cell function in offspring of mothers with young onset type 2 diabetes2005
Professor Patrick Chinnery
Dr Hannah Elliott
Dr Sheila Patel
Claire Lambert
Dr Steve Durham
et al.
Role of the mitochondrial DNA 16184-16193 poly-C tract in type 2 diabetes2005
Dr Carmela Ciardullo
Dr Stuart Bennett
Professor Mark Walker
Rosiglitazone improves insulin sensitivity, glucose tolerance and ambulatory blood pressure in subjects with impaired glucose tolerance: Does it really work? If yes, is it a novelty?2005
Professor Mark Walker
Dr Heather Dickinson
Surgical resection and whole brain radiation therapy versus whole brain radiation therapy for single brain metastases2005
Dr Ibrahim Ibrahim
Dr Sheila Patel
Professor Mark Walker
The Pro12Ala variant of the peroxisome proliferator-activated receptor gamma2 gene influences insulin sensitivity in healthy subjects participating in the RISC study2005
Professor Mark Walker
Analysis of the contribution to type 2 diabetes susceptibility of sequence variation in the gene encoding stearoyl-CoA desaturase, a key regulator of lipid and carbohydrate metabolism2004
Professor Mark Walker
Association studies of insulin receptor substrate 1 gene (IRS1) variants in type 2 diabetes samples enriched for family history and early age of onset2004
Professor Mark Walker
Cocaine users differ from normals on cognitive tasks showing declines during abstinence. Similar research can be conducted in recreational 'ecstasy' users2004
Professor Mark Walker
Common variants of the hepatocyte nuclear factor-4α P2 promoter are associated with type 2 diabetes in the U.K. population2004
Dr Elizabeth McIntyre
Dr Reza Halse
Emeritus Professor Steve Yeaman
Professor Mark Walker
Cultured muscle cells from insulin-resistant type 2 diabetes patients have impaired insulin, but normal 5-amino-4-imidazolecarboxamide riboside-stimulated, glucose uptake2004
Professor Mark Walker
Evidence from A Large U.K. Family Collection That Genes Influencing Age of Onset of Type 2 Diabetes Map to Chromosome 12p and to the MODY3/NIDDM2 Locus on 12q242004
Professor Bobby McFarland
Dr Andrew Schaefer
Dr Julie Murphy
Dr Stephen Lynn
Christine Hayes
et al.
Familial Myopathy: New Insights into the T14709C Mitochondrial tRNA Mutation2004
Mr GW William Mills
Dr Peter Avery
Professor Mark Walker
Heritability estimates for beta cell function and features of the insulin resistance syndrome in UK families with an increased susceptibility to Type 2 diabetes2004
Professor Mark Walker
Anne Hattersley
Large-scale association studies of candidate genes and their interactions in Type 2 diabetes2004
Dr Muthu Jayapaul
Professor Mark Walker
Mechanisms contributing to the development of type 2 diabetes2004
Professor Mark Walker
Role of the D76N polymorphism of insulin promoter factor-1 in predisposing to Type 2 diabetes2004
Dr Stuart Bennett
Professor Mark Walker
Rosiglitazone improves insulin sensitivity, glucose tolerance and ambulatory blood pressure in subjects with impaired glucose tolerance2004
Professor Mark Walker
The EGIR-RISC Study (the European group for the study of insulin resistance: Relationship between insulin sensitivity and cardiovascular disease risk): I. Methodology and Objectives2004
Marcus Wilson
Dr Kathleen Scougall
Dr Elizabeth McIntyre
Emeritus Professor Steve Yeaman
Professor Mark Walker
et al.
Towards muscle-targeted gene therapy for diabetes: Tetracycline-repressible transcriptional regulation of (pro)insulin secretion in human muscle2004
Professor Mark Walker
Anne Hattersley
Association and haplotype analysis of the insulin-degrading enzyme (IDE) gene, a strong positional and biological candidate for type 2 diabetes susceptibility2003
Dr Andrew Schaefer
Professor Bobby McFarland
Dr Julie Murphy
Dr Stephen Lynn
Christine Hayes
et al.
Familial mitochondrial myopathy: New insights into the T14709C mitochondrial tRNA mutation2003
Professor Mark Walker
Genetic variation in the small heterodimer partner gene and young-onset type 2 diabetes, obesity, and birth weight in U.K. subjects2003
Dr Stephen Lynn
Dr Gillian Borthwick
Richard Charnley
Professor Mark Walker
Emeritus Professor Doug Turnbull
et al.
Heteroplasmic ratio of the A3243G mitochondrial DNA mutation in single pancreatic beta cells2003
Professor Mark Walker
Anne Hattersley
Large-scale association studies of variants in genes encoding the pancreatic β-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes2003
Professor Mark Walker
Meta-Analysis and a Large Association Study Confirm a Role for Calpain-10 Variation in Type 2 Diabetes Susceptibility2003
Magdalene Wilson
Dr Elizabeth McIntyre
Dr Kathleen Scougall
Professor Mark Walker
Emeritus Professor Steve Yeaman
et al.
Tetracycline-regulated (pro)insulin secretion and processing to mature insulin following plasmid-mediated transfection of human muscle2003
Professor Mark Walker
Anne Hattersley
Young-onset type 2 diabetes families are the major contributors to genetic loci in the Diabetes UK Warren 2 genome scan and identify putative novel loci on chromosomes 8q21, 21q22, and 22q112003
Professor Mark Walker
Analysis of the imprinted transient neonatal diabetes critical region (ZAC/HYMAI) locus in Type 2 diabetes parent-offspring trios2002
Professor Mark Walker
Association studies of genetic variation in the WFS1 gene and type 2 diabetes in UK populations2002
Professor Mark Walker
Emeritus Professor Sir George Sir George Alberti
Biochemical measures in a population-based study: effect of fasting duration and time of day2002
Dr Stephen Lynn
Geoffrey Taylor
Dr Theresa Wardell
Professor Patrick Chinnery
Emeritus Professor Doug Turnbull
et al.
Defining the importance of mitochondrial gene defects in maternally inherited diabetes by sequencing the entire mitochondrial genome2002
Professor Mark Walker
Evidence for linkage of stature to chromosome 3p26 in a large UK family data set ascertained for type 2 diabetes2002
Dr Elizabeth McIntyre
Professor Mark Walker
Genetics of type 2 diabetes and insulin resistance: knowledge from human studies2002
Dr Sheila Patel
Professor Nigel Unwin
Professor Mark Walker
Investigation of the role of the T to G SNP in the adiponectin (AMP1) gene in abdominal obesity using parent-offspring trios2002
Professor Mark Walker
Linkage studies of the Type 2 diabetes susceptibility locus on chromosome 1q: Combined analysis of 1200 UK and French affected sibpairs2002
Glenn Renforth
Dr Neil Hanley
Dr Karen Piper Hanley
Dr Vincent Connolly
Professor Mark Walker
et al.
Mutation of ALMS1, a large gene with a tandem repeat encoding 47 amino acids, causes Alstrom syndrome2002
Emeritus Professor Doug Turnbull
Professor Mark Walker
Variation in the calpain-10 gene affects blood glucose levels in the British population2002
Professor Mark Walker
A genomewide scan for loci predisposing to type 2 diabetes in a UK population (the Diabetes UK Warren 2 repository): Analysis of 573 pedigrees provides independent replication of a susceptibility locus on chromosome 1q2001
Dr Clive Ballard
Professor John O'Brien
Alastair Gray
Francesca Cormack
Dr Elise Rowan
et al.
Attention and fluctuating attention in patients with dementia with lewy bodies and alzheimer disease2001
Dr Tim Butler
Dr Luis Barriocanal
Professor Mark Walker
Elevated plasma non-esterified fatty acid levels and insulin secretion in non-diabetic relatives of type 2 diabetic patients2001
Dr Colin Fischbacher
Professor Raj Bhopal CBE
Professor Nigel Unwin
Professor Mark Walker
Maternal transmission of Type 2 diabetes varies by ethnic group: Cross-sectional survey of Europeans and South Asians2001
Dr Stuart Bennett
Professor Mark Walker
Rosiglitazone improves glycaemic and insulinaemic responses in subjects with impaired glucose tolerance2001
Dr Stuart Bennett
Professor Mark Walker
Rosiglitazone improves insulin sensitivity and 24-hour ambulatory blood pressure in subjects with IGT2001
Professor Mark Walker
Studies of association between the gene for calpain-10 and type 2 diabetes mellitus in the United Kingdom2001
Professor Mark Walker
Studies of Association between the Gene for Calpain-10 and Type 2 Diabetes Mellitus in the United Kingdom2001
Professor Mark Walker
Professor John Mathers
Acute fuel selection in response to high-sucrose and high-starch meals in healthy men2000
Professor Mark Walker
Analysis of parent-offspring trios provides evidence for linkage and association between the insulin gene and type 2 diabetes mediated exclusively through paternally transmitted class III variable number tandem repeat alleles2000
Professor Mark Walker
Sarah Jackson
Emeritus Professor Steve Yeaman
Emeritus Professor Doug Turnbull
Decreased glucose uptake in myoblasts from insulin resistant non-diabetic relatives of type 2 diabetic families2000
Emeritus Professor Steve Yeaman
Professor Mark Walker
Decreased insulin responsiveness of glucose uptake in cultured human skeletal muscle cells: From insulin-resistant nondiabetic relatives of type 2 diabetic families2000
Professor Mark Walker
Evidence that single nucleotide polymorphism in the uncoupling protein 3 (UCP3) gene influences fat distribution in women of European and Asian origin2000
Professor Mark Walker
Insulin resistance: a problem for clinicians and scientists2000
Professor Rudy Bilous
Professor Mark Walker
Insulin sensitivity in hypertensive Type 2 diabetic patients after 1 and 19 days' treatment with trandolapril2000
Dr Stephen Lynn
Emeritus Professor Doug Turnbull
Professor Mark Walker
Intermediate expansions of a X25/frataxin gene GAA repeat and Type II diabetes: Assessment using parent-offspring trios [1]2000
Professor Mark Walker
No evidence for linkage at candidate type 2 diabetes susceptibility loci on chromosomes 12 and 20 in United Kingdom Caucasians2000
Emeritus Professor Elaine Perry
Professor Mark Walker
Emeritus Professor Robert Perry
Acetylcholine in mind: a neurotransmitter correlate of consciousness?1999
Emeritus Professor Elaine Perry
Professor Mark Walker
Emeritus Professor Robert Perry
Consciousness in mind: a correlate for ACh? Reply to Hölscher1999
Dr Stephen Lynn
Anne Hattersley
Emeritus Professor Doug Turnbull
Professor Mark Walker
Intermediate GAA repeat expansions of the X25/frataxin gene in type 2 diabetes1999
Professor Patrick Chinnery
Professor Mark Walker
Professor Robert Taylor
Professor Robert Lightowlers
Professor Laurence Bindoff
et al.
Nonrandom tissue distribution of mutant mtDNA1999
Professor Patrick Chinnery
Professor Mark Walker
Professor Robert Taylor
Professor Robert Lightowlers
Professor Laurence Bindoff
et al.
Non-random tissue distribution of mutant mtDNA1999
Professor Mark Walker
Anne Hattersley
Parent-offspring trios - A resource to facilitate the identification of type 2 diabetes genes1999
Dr Stuart Bennett
Professor Mark Walker
Physical activity in non-diabetic relatives of type 2 diabetic patients1999
Professor Mark Walker
Emeritus Professor Sir George Sir George Alberti
Twenty-four-hour insulin secretion rates, circulating concentrations of fuel substrates and gut incretin hormones in healthy offspring of Type II (non-insulin-dependent) diabetic parents: evidence of several aberrations1999