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Browsing publications by Professor Bernard Golding.

Newcastle AuthorsTitleYearFull text
Islam Al-Khawaldeh
Dr Christine Basmadjian
Dr Cinzia Bordoni
Dr Suzannah Harnor
Amy Heptinstall
et al.
An alkynylpyrimidine-based covalent inhibitor that targets a unique cysteine in NF-κB-inducing kinase (NIK)2021
Edwige Picazo
Amy Heptinstall
Dr Celine Cano
Professor Bernard Golding
Professor Mike Waring
et al.
Cyclisations and fragmentations in the alkylation of 6-chloro-5-hydroxy-4-aminopyrimidines with aminoalkyl chlorides2021
Dr Marta Drozdowska
Jay Tromans
Dr Bian Zhang
Professor Bernard Golding
Defining Pathways of Anaerobic Alkane Oxidation: Synthesis of Enantiomers of 4-Methylalkanoic Acids and (2-Methylalkyl)malonic Acids2021
Miriam Fsadni
Amy Roberts
Professor Majid Sadeghi
Professor Bernard Golding
Enantiopure 2,9-Dideuterodecane – Preparation and Proof of Enantiopurity2021
Christopher Matheson
Christopher Coxon
Dr Benoit Carbain
Dr Ian Hardcastle
Dr Suzannah Harnor
et al.
2-Arylamino-6-ethynylpurines are cysteine-targeting irreversible inhibitors of Nek2 kinase2020
Dr Ahmad Al-Sheikh
Masuma Begum
Dr Bian Zhang
Dr Richard Lewis
Dr Nicholas Allenby
et al.
Molecular Diversity via Tetrasubstituted Alkenes Containing a Barbiturate Motif: Synthesis and Biological Activity2020
Stephanie Myers
Duncan Miller
Dr Lauren Molyneux
Dr Mercedeh Arasta
Dr Ruth Bawn
et al.
Identification of a novel orally bioavailable ERK5 inhibitor with selectivity over p38α and BRD42019
Dr Alistair Henderson
Professor Bernard Golding
Photochemistry of 2-butenedial and 4-oxo-2-pentenal under atmospheric boundary layer conditions2019
Richard Espiritu
Professor Bernard Golding
Emeritus Professor Keith Scott
Dr Mohamed Mamlouk
Degradation of radiation grafted anion exchange membranes tethered with different amine functional groups via removal of vinylbenzyl trimethylammonium hydroxide2018
Professor Bernard Golding
Hydrogen Sulfide: A Reagent for pH-Driven Bioinspired 1,2-Diol Mono-deoxygenation and Carbonyl Reduction in Water2018
Duncan Miller
Dr Mathew Martin
Santosh Adhikari
Alfie Brennan
Professor Jane Endicott
et al.
Identification of a novel ligand for the ATAD2 bromodomain with selectivity over BRD4 through a fragment growing approach2018
Professor Bernard Golding
Professor Mike Waring
The consequences of ‘Brexit’ for drug discovery and development, and the regulatory implications2018
John Mullaney
Dr Chris Medcraft
Professor Bernard Golding
Dr Nick Walker
Professor Anthony Legon
et al.
Cooperative Hydrogen Bonds Form a Pseudocycle Stabilizing an Isolated Complex of Isocyanic Acid with Urea2017
Christopher Coxon
Dr Suzannah Harnor
Dr Mathew Martin
Dr Benoit Carbain
Professor Bernard Golding
et al.
Cyclin-Dependent Kinase (CDK) Inhibitors; Structure-Activity Relationships and Insights into the CDK-2 Selectivity of 6-Substituted 2-Arylaminopurines2017
Professor David Rees
Professor Bernard Golding
Dr Ian Hardcastle
Dr Celine Cano
Duncan Miller
et al.
ISOINDOLINONE INHIBITORS OF THE MDM2-P53 INTERACTION HAVING ANTICANCER ACTIVITY2017
Professor David Rees
Professor Bernard Golding
Dr Ian Hardcastle
Dr Celine Cano
Duncan Miller
et al.
Preparation of isoindolinones as inhibitors of the MDM2-​p53 interaction having anticancer activity2017
Professor David Rees
Professor Bernard Golding
Dr Ian Hardcastle
Dr Celine Cano
Duncan Miller
et al.
Preparation of isoindolinones as inhibitors of the MDM2-​p53 interaction having anticancer activity;WO 20170558602017
Dr Christopher Wong
Dr Ian Hardcastle
Christopher Matheson
Professor Herbie Newell
Dr Mangaleswaran Sivaprakasam
et al.
Structure-guided design of purine-based probes for selective Nek2 inhibition2017
Professor Bernard Golding
The impact of Brexit on British science: Also Sprach Zunderland2017
Christopher Coxon
Dr Celine Cano
Professor Bernard Golding
Professor Roger Griffin
A new tool for the chemical genetic investigation of the Plasmodium falciparum Pfnek-2 NIMA-related kinase2016
Professor Bernard Golding
Anaerobic Degradation of p-Alkylated Benzoates and Toluenes2016
Professor Bernard Golding
Anaerobic Microbial Degradation of Hydrocarbons: From Enzymatic Reactions to the Environment2016
Dr Gary Beale
Dr Emma Haagensen
Huw Thomas
Lan Wang
Charlotte Revill
et al.
Combined PI3K and CDK2 inhibition induces cell death and enhances in vivo anti-tumour activity in colorectal cancer2016
Dr Victorovich Zaytsev
James Pickles
Dr Suzannah Harnor
Dr Alistair Henderson
Mohammed Al Yasiri
et al.
Concise syntheses of bridged morpholines2016
Professor Bernard Golding
COST Action CM1201 "Biomimetic Radical Chemistry": free radical chemistry successfully meets many disciplines2016
Tristan Reuillon
Dr Sari Alhasan
Dr Gary Beale
Annalisa Bertoli
Alfie Brennan
et al.
Design and synthesis of biphenyl and biphenyl ether inhibitors of sulfatases2016
Dr Peter Friedrich
Professor Bernard Golding
Elucidating the stereochemistry of enzymatic benzylsuccinate synthesis with chirally labeled toluene2016
Stephanie Myers
Dr Ruth Bawn
Betty Cottyn
Dr Lauren Molyneux
Dr Celine Cano
et al.
High-throughput screening and hit validation of extracellular-related kinase 5 (ERK5) inhibitors2016
Professor Bernard Golding
Metabolism of Hydrocarbons in n-Alkane-Utilizing Anaerobic Bacteria2016
Professor Roger Griffin
Professor Bernard Golding
New derivatives of the antimalarial drug Pyrimethamine in the control of melanoma tumor growth: an in vitro and in vivo study2016
Xu Wang
Professor Bernard Golding
Professor Eileen Yu
Emeritus Professor Keith Scott
Preparation of a Chemically Stable Polysulfone-based Anion Exchange Membrane Using DABCO as the Quaternization Agent2016
Tristan Reuillon
Duncan Miller
Stephanie Myers
Dr Lauren Molyneux
Dr Celine Cano
et al.
Pyrrolcarboxamide Derivatives for the Inhibition of ERK52016
Professor Bernard Golding
Structure and Function of 4-Hydroxyphenylacetate Decarboxylase and Its Cognate Activating Enzyme2016
Professor Bernard Golding
Structure and Function of Benzylsuccinate Synthase and Related Fumarate-Adding Glycyl Radical Enzymes2016
Professor Bernard Golding
Dr Celine Cano
Synthesis and Biological Evaluation of N2-Substituted 2,4-Diamino-6-cyclohexylmethoxy-5-nitrosopyrimidines and Related 5-Cyano-NNO-azoxy Derivatives as Cyclin-Dependent Kinase 2 (CDK2) Inhibitors2016
Professor Bernard Golding
Academic medicinal chemistry: no country for young men (or women)?2015
Professor Bernard Golding
Corrin Synthesis via A→D Ring Closure. The Construction of A/D-Secocorrin Chromophore Systems by the ‘Sulfide Contraction’ Method and the Photochemical A/B-Secocorrin→Corrin Cycloisomerization2015
Elisa Meschini
Dr Regina Mora Vidal
Dr Mathew Martin
Dr Will Stanley
Tristan Reuillon
et al.
Identification and characterization of an irreversible inhibitor of CDK22015
Professor Bernard Golding
Non-enzymatic Ribonucleotide Reduction in the Prebiotic Context2015
Duncan Miller
Dr Benoit Carbain
Dr Gary Beale
Dr Sari Alhasan
Professor Helen Reeves
et al.
Regioselective sulfamoylation at low temperature enables concise syntheses of putative small molecule inhibitors of sulfatases2015
Dr Andrey Zaytsev
Dr Barry Dodd
Professor Bernard Golding
Professor Roger Griffin
Dr Xiaohong Lu
et al.
Searching for Dual Inhibitors of the MDM2-p53 and MDMX-p53 Protein-Protein Interaction by a Scaffold-Hopping Approach2015
Bian Zhang
Professor Bernard Golding
Dr Ian Hardcastle
Small-molecule MDM2-p53 inhibitors: recent advances2015
Andrew Shouksmith
Laura Evans
Professor Deborah Tweddle
Duncan Miller
Dr Elaine Willmore
et al.
Synthesis and Activity of Putative Small-​Molecule Inhibitors of the F-​Box Protein SKP22015
Marta Drozdowska
Professor Bernard Golding
Versatile transformations of hydrocarbons in anaerobic bacteria: substrate ranges and regio- and stereo-chemistry of activation reactions2015
Dr Benoit Carbain
Dr Allyson Campbell
Dr Celine Cano
Professor Jane Endicott
Professor Bernard Golding
et al.
8-Substituted O-6-Cyclohexylmethylguanine CDK2 Inhibitors: Using Structure-Based Inhibitor Design to Optimize an Alternative Binding Mode2014
Professor Bernard Golding
Alkylcobyrinate from sucralose and mechanistic aspects of its Co-C bond cleavage2014
Alex Liu
Dr Catherine Drummond
Professor Jane Endicott
Professor Bernard Golding
Professor Roger Griffin
et al.
An X-ray crystal structure-based understanding of the inhibition of the MDM2-p53 protein-protein interaction by isoindolinones2014
Marta Drozdowska
Professor Bernard Golding
Anaerobic Activation of p-Cymene in Denitrifying Betaproteobacteria: Methyl Group Hydroxylation versus Addition to Fumarate2014
Honorine Lebraud
Professor Bernard Golding
Elisa Meschini
Dr Celine Cano
Lan Wang
et al.
Anticancer agents targeted against cyclin-dependent kinase 2 (CDK2): Structure-based design of irreversible and reversible inhibitors2014
Andrew Shouksmith
Laura Evans
Professor Roger Griffin
Professor Bernard Golding
Professor Herbie Newell
et al.
Design and synthesis of putative small-molecule inhibitors targeting the SCFSKP2 E3 ligase complex2014
Dr Ruth Bawn
Tristan Reuillon
Professor Bernard Golding
Professor Roger Griffin
Dr Ian Hardcastle
et al.
Development of extracellular signal-regulated kinase 5 (ERK5) inhibitors for anti-cancer therapy2014
Dr Mathew Martin
Elisa Meschini
Lan Wang
Dr Regina Mora Vidal
Tristan Reuillon
et al.
Identification and characterization of an irreversible inhibitor of CDK22014
Honorine Lebraud
Christopher Coxon
Vicky Archard
Carlo Bawn
Dr Benoit Carbain
et al.
Model system for irreversible inhibition of Nek2: thiol addition to ethynylpurines and related substituted heterocycles2014
Dr Susan Tudhope
Dr Yan Zhao
Dr Anita Wittner
Annalisa Bertoli
Santosh Adhikari
et al.
Profiling inhibitors of MDM2: p53 and MDMX: p53 in relation to MDMX protein levels2014
Professor Bernard Golding
Sir John Warcup Cornforth (1917-2013)2014
Dr Suzannah Harnor
Dr Tommy Rennison
Martin Galler
Dr Celine Cano
Professor Roger Griffin
et al.
Synthesis of 3 '-deoxy-3'-fluorothymidine (FLT) 5 '-O-glucuronide: a reference standard for imaging studies with [18F]FLT2014
Dr Benoit Carbain
Christopher Coxon
Honorine Lebraud
Dr Kris Elliott
Christopher Matheson
et al.
Trifluoroacetic Acid in 2,2,2-Trifluoroethanol Facilitates SNAr Reactions of Heterocycles with Arylamines2014
Annalisa Bertoli
Santosh Adhikari
Dr Suzannah Harnor
Dr Yan Zhao
Professor John Lunec
et al.
Validation studies with small-molecule modulators of the MDM2/MDMX-p53 binding interaction2014
Dr Celine Cano
Dr Kappusamy Saravanan
Professor Nicola Curtin
Professor Bernard Golding
Dr Ian Hardcastle
et al.
1-Substituted (Dibenzo[b,d]thiophen-4-yl)-2-morpholino-4H-chromen-4-ones Endowed with Dual DNA-PK PI3-K Inhibitory Activity2013
Professor Bernard Golding
ATP-dependent/-independent enzymatic ring reductions involved in the anaerobic catabolism of naphthalene2013
Dr Tommy Rennison
Sonsoles Rodriguez-Aristegui
Professor Nicola Curtin
Professor Bernard Golding
Dr Ian Hardcastle
et al.
Development of potent inhibitors of DNA-dependent protein kinase (DNA-PK)2013
Dr Tim Blackburn
Christopher Coxon
Dr Xiaohong Lu
Professor Bernard Golding
Professor Roger Griffin
et al.
Diaryl- and triaryl-pyrrole derivatives: inhibitors of the MDM2-p53 and MDMX-p53 protein-protein interactions2013
Professor Bernard Golding
Marta Drozdowska
Metagenomic analysis and metabolite profiling of deep-sea sediments from the Gulf of Mexico following the Deepwater Horizon oil spill2013
Sarah Cully
Dr Celine Cano
Professor Bernard Golding
Professor Roger Griffin
Professor John Lunec
et al.
Regiospecific synthesis of isoindolinones as MDM2 inhibitors2013
Honorine Lebraud
Dr Celine Cano
Dr Benoit Carbain
Dr Ian Hardcastle
Dr Ross Harrington
et al.
Trifluoroethanol solvent facilitates selective N-7 methylation of purines2013
Dr Kelly Coffey
Dr Tim Blackburn
Susan Cook
Professor Bernard Golding
Professor Roger Griffin
et al.
Characterisation of a Tip60 specific inhibitor, NU9056, in prostate cancer2012
Tristan Reuillon
Annalisa Bertoli
Professor Roger Griffin
Duncan Miller
Professor Bernard Golding
et al.
Efficacious N-protection of O-aryl sulfamates with 2,4-dimethoxybenzyl groups2012
Dr Peter Friedrich
Dr Ulrich Baisch
Dr Ross Harrington
Frederick Lyatuu
Emeritus Professor William McFarlane
et al.
Experimental Study of Hydrogen Bonding Potentially Stabilizing the 5'-Deoxyadenosyl Radical from Coenzyme B122012
Dr Peter Friedrich
Professor Bernard Golding
Hydrogen Bonds Guide the Short-Lived 5 '-Deoxyadenosyl Radical to the Place of Action2012
Professor Bernard Golding
Professor Roger Griffin
Mechanism-based design, synthesis and biological studies of N-5-substituted tetrahydrofolate analogs as inhibitors of cobalamin-dependent methionine synthase and potential anticancer agents2012
Dr Tommy Rennison
Faye Craven
Professor Bernard Golding
Professor Roger Griffin
Dr Karen Haggerty
et al.
Potent enantioselective inhibition of DNA-dependent protein kinase (DNA-PK) by atropisomeric chromenone derivatives2012
Professor Bernard Golding
Revisiting the reaction of hydroxyl radicals with vicinal diols in water2012
Professor Majid Sadeghi
Marta Drozdowska
Dr Sven Lahme
Professor Bernard Golding
Stereochemical Investigations Reveal the Mechanism of the Bacterial Activation of n-Alkanes without Oxygen2012
Dr Richard Scott
Kristin Downey
Dr Keith Healy
Dr Alistair Henderson
Claire Robinson
et al.
Synthesis and stability of 3-hydroxyanagrelide, a biologically potent metabolite of anagrelide2012
Xu Wang
Professor Bernard Golding
Professor Majid Sadeghi
Dr Yuancheng Cao
Emeritus Professor Keith Scott
et al.
A novel phosphoric acid loaded quaternary 1,4-diazabicyclo-[2.2.2]-octane polysulfone membrane for intermediate temperature fuel cells2011
Professor Bernard Golding
Professor Majid Sadeghi
Dr Yuancheng Cao
Professor Eileen Yu
Emeritus Professor Keith Scott
et al.
A polytetrafluoroethylene-quaternary 1,4-diazabicyclo-[2.2.2]-octane polysulfone composite membrane for alkaline anion exchange membrane fuel cells2011
Hitesh Motwani
Professor Bernard Golding
Cob(I)alamin reacts with sucralose to afford an alkylcobalamin: Relevance to in vivo cobalamin and sucralose interaction2011
Dr Kate Smith
Professor Bernard Golding
Elizabeth Griffin
Professor Roger Griffin
Dr Ian Hardcastle
et al.
DNA-dependent protein kinase (DNA-PK) inhibitors: Structure–activity relationships for O-alkoxyphenylchromen-4-one probes of the ATP-binding domain2011
Dr Philip Butler
Professor Bernard Golding
Dr Gilles Laval
Dr Hosein Loghmani-Khouzani
Professor Majid Sadeghi
et al.
Fluorination and chlorination of nitroalkyl groups (vol 63, pg 11160, 2007) [Addendum]2011
Professor Bernard Golding
Identification and Characterization of 2 '-Deoxyadenosine Adducts Formed by Isoprene Monoepoxides in Vitro2011
Dr Ian Hardcastle
Alex Liu
Dr Eric Valeur
Anna Watson
Shafiq Ahmed
et al.
Isoindolinone Inhibitors of the Murine Double Minute 2 (MDM2)-p53 Protein-Protein Interaction: Structure-Activity Studies Leading to Improved Potency2011
Dr Karim Bennaceur
Dr Catherine Drummond
Professor Jane Endicott
Professor Bernard Golding
Professor Roger Griffin
et al.
MDM2-p53 protein-protein interaction inhibitors: A-ring substituted isoindolinones2011
Professor Bernard Golding
Molecular hijacking of siroheme for the synthesis of heme and d(1) heme2011
Dr Kappusamy Saravanan
Hannah Barlow
Marion Barton
Professor Hilary Calvert
Professor Bernard Golding
et al.
Nucleoside Transport Inhibitors: Structure-Activity Relationships for Pyrimido[5,4-d]pyrimidine Derivatives That Potentiate Pemetrexed Cytotoxicity in the Presence of α1-Acid Glycoprotein2011
Huw Thomas
Dr Celine Roche
Dr Johanne Bentley
Dr Ian Hardcastle
Professor Bernard Golding
et al.
Preclinical in vitro and in vivo evaluation of the potent and specific cyclin-dependent kinase 2 inhibitor NU6102 and a water soluble prodrug NU63012011
Sonsoles Rodriguez-Aristegui
Dr Lauren Molyneux
Dr Celine Cano
Dr Marine Desage-El-Murr
Professor Roger Griffin
et al.
Versatile Synthesis of Functionalised Dibenzothiophenes via Suzuki Coupling and Microwave-assisted Ring Closure2011
Dr Celine Cano
Professor Bernard Golding
Dr Karen Haggerty
Dr Ian Hardcastle
Professor Roger Griffin
et al.
Atropisomeric 8-arylchromen-4-ones exhibit enantioselective inhibition of the DNA-dependent protein kinase (DNA-PK)2010
Elisa Meschini
Professor Jane Endicott
Professor Bernard Golding
Dr Ian Hardcastle
Professor Herbie Newell
et al.
Design and synthesis of dual CDK2 and CDK7 inhibitors2010
Dr Kate Smith
Dr Tommy Rennison
Sonsoles Rodriguez-Aristegui
Professor Nicola Curtin
Professor Bernard Golding
et al.
Development of potent inhibitors of DNA-dependent protein kinase (DNA-PK)2010
Dr Celine Cano
Olivier Barbeau
Professor Nicola Curtin
Professor Bernard Golding
Dr Ian Hardcastle
et al.
DNA-Dependent Protein Kinase (DNA-PK) Inhibitors. Synthesis and Biological Activity of Quinolin-4-one and Pyridopyrimidin-4-one Surrogates for the Chromen-4-one Chemotype2010
Sara Payne
Sonsoles Rodriguez-Aristegui
Dr Celine Cano
Professor Bernard Golding
Dr Ian Hardcastle
et al.
Mapping the ATP-binding domain of DNA-dependent protein kinase (DNA-PK) with coumarin- and isocoumarin-derived inhibitors2010
Professor Bernard Golding
Martine Barnes
Dr Christine Bleasdale
Dr Alistair Henderson
Dong Jiang
et al.
Modeling the formation and reactions of benzene metabolites2010
Dr Benoit Carbain
Dr Celine Roche
Professor Bernard Golding
Dr Ian Hardcastle
Dr Celine Cano
et al.
Structure-based design of C8-substituted O6-alkylguanine CDK1 and 2 inhibitors2010
Dr Francesco Marchetti
Dr Celine Cano
Professor Nicola Curtin
Professor Bernard Golding
Professor Roger Griffin
et al.
Synthesis and biological evaluation of 5-substituted O4-alkylpyrimidines as CDK2 inhibitors2010
Dr Christopher Wong
Professor Roger Griffin
Dr Ian Hardcastle
Dr Julian Scott Northen
Lan Wang
et al.
Synthesis of sulfonamide-based kinase inhibitors from sulfonates by exploiting the abrogated SN2 reactivity of 2,2,2-trifluoroethoxysulfonates2010
Diana Suarez
Dr Gilles Laval
Shang-Min Tu
Dong Jiang
Claire Robinson
et al.
Benzylic Brominations with N-Bromosuccinimide in (Trifluoromethyl)benzene2009
Hitesh Motwani
Professor Bernard Golding
Cob(I)alamin for Trapping Butadiene Epoxides in Metabolism with Rat S9 and for Determining Associated Kinetic Parameters2009
Professor Bernard Golding
Antonius Pierik
Crystal Structure and Putative Mechanism of 3-Methylitaconate-Delta-isomerase from Eubacterium barkeri2009
Huw Thomas
Dr Kappusamy Saravanan
Lan Wang
Mei Lin
Dr Julian Scott Northen
et al.
Preclinical evaluation of a novel pyrimidopyrimidine for the prevention of nucleoside and nucleobase reversal of antifolate cytotoxicity2009
Professor Herbie Newell
Huw Thomas
Lan Wang
Dr Celine Roche
Dr Ian Hardcastle
et al.
[abstract] Preclinical in vitro and in vivo evaluation of the cyclin dependent kinase 2 inhibitor NU6102 and a water pro-drug NU63012008
Dr Celine Cano
Professor Bernard Golding
Dr Ian Hardcastle
Professor Nicola Curtin
Professor Roger Griffin
et al.
8-Biarylchromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK)2008
Professor Jane Endicott
Stuart Kemp
Dr Lucy Smyth
Dr Eric Valeur
Professor Bernard Golding
et al.
Analysis of Chemical Shift Changes Reveals the Binding Modes of Isoindolinone Inhibitors of the MDM2-p53 Interaction2008
Professor Bernard Golding
Biologically relevant small radicals2008
Antonius Pierik
Professor Bernard Golding
But-3-ene-1,2-diol: A Mechanism-Based Active Site Inhibitor for Coenzyme B-12-Dependent Glycerol Dehydratase2008
Dr Celine Cano
Professor Nicola Curtin
Professor Bernard Golding
Dr Karen Haggerty
Dr Ian Hardcastle
et al.
Development of Potent Water-soluble Inhibitors of DNA-Dependent Protein Kinase (DNA-PK)2008
Dr Kappusamy Saravanan
Dr Celine Cano
Professor Nicola Curtin
Professor Bernard Golding
Dr Karen Haggerty
et al.
Identification of potent water-soluble DNA-dependent protein kinase (DNA-PK) inhibitors using a small-molecule library approach [abstract]2008
Dr Xiaomei Lu
Alex Liu
Dr Ian Hardcastle
Professor Roger Griffin
Professor Bernard Golding
et al.
MDM2 and MDMX status as a determinant of in vitro cellular sensitivity to MDM2 antagonists in human tumour cell lines2008
Professor Bernard Golding
Mechanism of Enzymatic Birch Reduction: Stereochemical Course and Exchange Reactions of Benzoyl-CoA Reductase2008
Professor Bernard Golding
Professor Roger Griffin
Dr Claire Hutton
Professor John Lunec
Professor Herbie Newell
et al.
MEDI 147-Isoindolinone-based inhibitors of the MDM2-p53 protein-protein interaction2008
Professor Bernard Golding
The Complete Stereochemistry of the Enzymatic Dehydration of 4-Hydroxybutyryl Coenzyme A to Crotonyl Coenzyme A2008
Sonja Seeberger
Professor Roger Griffin
Dr Ian Hardcastle
Professor Bernard Golding
A new strategy for the synthesis of taurine derivatives using the 'safety-catch' principle for the protection of sulfonic acids2007
Dr Tony Munter
Rikas Ghai
Professor Bernard Golding
Professor William Watson
Erratum to "The metabolism and molecular toxicology of chloroprene" [Chem. Biol. Interact. 166 (1-3) (2007) 323-331] (DOI:10.1016/j.cbi.2006.05.017)2007
Philip Butler
Professor Bernard Golding
Dr Gilles Laval
Dr Hosein Loghmani-Khouzani
Professor Majid Sadeghi
et al.
Fluorination and chlorination of nitroalkyl groups2007
Jonathan Hollick
Dr Laurent Rigoreau
Dr Celine Cano
Professor Nicola Curtin
Professor Bernard Golding
et al.
Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependent protein kinase inhibition, and identification of the first potent and selective inhibitor of the ataxia telangiectasia mutated kinase2007
Olivier Barbeau
Dr Celine Cano
Professor Roger Griffin
Dr Ian Hardcastle
Emeritus Professor Bill Clegg
et al.
Quinolinone and pyridopyrimidinone inhibitors of DNA-dependent protein kinase2007
Dr Francesco Marchetti
Kerry Louise Sayle
Dr Johanne Bentley
Emeritus Professor Bill Clegg
Professor Nicola Curtin
et al.
Structure-based design of 2-arylamino-4-cyclohexylmethoxy-5-nitroso-6- aminopyrimidine inhibitors of cyclin-dependent kinase 22007
Dr Tony Munter
Rikas Ghai
Professor Bernard Golding
Professor William Watson
The metabolism and molecular toxicology of chloroprene2007
Professor Majid Sadeghi
Dr Hosein Loghmani-Khouzani
Professor Bernard Golding
Erratum to "Sonochemical fluorination of heterocyclic nitro compounds with Selectfluor™ (F-TEDA-BF4)". [Tetrahedron Lett. 47 (2006) 2455]2006
Professor Majid Sadeghi
Dr Hosein Loghmani-Khouzani
Dr Philip Butler
Professor Bernard Golding
Erratum: Sonochemical fluorination of heterocyclic nitro compounds with Selectfluor2006
Professor Bernard Golding
Insights into the hydrogen-abstraction reactions of diol dehydratase: Relevance to the catalytic mechanism and suicide inactivation2006
Professor Bernard Golding
Professor Roger Griffin
Dr Ian Hardcastle
Judicious application of allyl protecting groups for the synthesis of 2-morpholin-4-yl-4-oxo-4H-chromen-8-yl triflate, a key precursor of DNA-dependent protein kinase inhibitors2006
Professor Bernard Golding
Lars Ehrenberg (1921-2005) - Obituary2006
Antonius Pierik
Diana Suarez
Shang-Min Tu
Professor Bernard Golding
Mechanism-based inactivation of coenzyme B12-dependent 2-methyleneglutarate mutase by (Z)-glutaconate and buta-1,3-diene-2,3- dicarboxylate2006
Professor Bernard Golding
Radical enzymes in anaerobes2006
Professor Roger Griffin
Andrew Henderson
Professor Nicola Curtin
Professor Jane Endicott
Dr Ian Hardcastle
et al.
Searching for cyclin-dependent kinase inhibitors using a new variant of the cope elimination2006
Dr Ian Hardcastle
Dr Shafiq Ahmed
Helen Atkins
Gillian Farnie
Professor Bernard Golding
et al.
Small-molecule inhibitors of the MDM2-p53 protein-protein interaction based on an isoindolinone scaffold2006
Professor Majid Sadeghi
Dr Hosein Loghmani-Khouzani
Professor Bernard Golding
Sonochemical fluorination of heterocyclic nitro compounds with Selectfluor (TM) (F-TEDA-BF4) (vol 47, pg 2455, 2006)2006
Professor Majid Sadeghi
Dr Hosein Loghmani-Khouzani
Professor Bernard Golding
Sonochemical fluorination of heterocyclic nitro compounds with Selectfluor™ (F-TEDA-BF4)2006
Professor Bernard Golding
Stabilisation of methylene radicals by Cob(II)alamin in coenzyme B12 dependent mutases2006
Olivier Barbeau
Professor Bernard Golding
Professor Roger Griffin
Dr Ian Hardcastle
Design and synthesis of novel DNA-dependent protein kinase (DNA-PK) inhibitors2005
Professor Roger Griffin
Olivier Barbeau
Professor Bernard Golding
Dr Ian Hardcastle
Design and synthesis of novel pyridopyrimidin-4-one and quinolin-4-one DNA-dependent protein kinase (DNA-PK) inhibitors2005
Dr Ian Hardcastle
Professor Nicola Curtin
Justin John James Leahy
Martin Stockley
Professor Bernard Golding
et al.
Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach2005
Olivier Barbeau
Professor Roger Griffin
Dr Ian Hardcastle
Professor Bernard Golding
Efficient synthesis of 8-substituted 2-morpholine-4-yl-quinolin-4-ones: Potent inhibitors of DNA-dependent protein kinase2005
Dr Alistair Henderson
Dr Christine Bleasdale
Professor Bernard Golding
Evidence for the formation of Michael adducts from reactions of (E,E)-muconaldehyde with glutathione and other thiols2005
Professor Bernard Golding
Facile cobalt(III) template synthesis of novel branched hexadentate polyamine monocarboxylates2005
Dr Alistair Henderson
Professor Bernard Golding
In vitro studies of the influence of glutathione transferases and epoxide hydrolase on the detoxification of acrylamide and glycidamide in blood2005
Dr Ian Hardcastle
Shafiq Ahmed
Professor Bernard Golding
Professor Roger Griffin
Dr Claire Hutton
et al.
Inhibitors of the MDM2-p53 protein-protein interaction based on an isoindolinone scaffold2005
Stuart Kemp
Dr Ian Hardcastle
Dr Shafiq Ahmed
Professor Bernard Golding
Professor Roger Griffin
et al.
Isoindolinone based inhibitors of the MDM2-p53 protein-protein interaction2005
Dr Ian Hardcastle
Dr Shafiq Ahmed
Professor Alan Calvert
Professor Nicola Curtin
Gillian Farnie
et al.
Isoindolinone-based inhibitors of the MDM2-p53 protein-protein interaction2005
Professor Roger Griffin
Dr YuZhu Cheng
Professor Nicola Curtin
Professor Bernard Golding
Dr Ian Hardcastle
et al.
Potent CDK2 inhibitors generated using a variant of the cope elimination2005
Dr Allyson Campbell
Dr YuZhu Cheng
Lan Wang
Professor Nicola Curtin
Professor Bernard Golding
et al.
Potentiation of paclitaxel-induced apoptosis by the novel cyclin-dependent kinase inhibitor NU6140: A possible role for survivin down-regulation2005
Dr Alastair Hayes
Professor Bernard Golding
Preclinical pharmacokinetics and metabolism of a novel prototype DNA-PK inhibitor NU70262005
Professor Bernard Golding
Radical-mediated dehydration reactions in anaerobic bacteria2005
Dr Virginia Silvari
Professor Bernard Golding
Reaction-kinetic parameters of glycidamide as determinants of mutagenic potency2005
Martine Barnes
Dr Christine Bleasdale
Emeritus Professor Bill Clegg
Professor William Watson
Professor Bernard Golding
et al.
Reactions of benzene oxide with thiols including glutathione2005
Antonius Pierik
Daniele Ciceri
Professor Bernard Golding
Searching for intermediates in the carbon skeleton rearrangement of 2-methyleneglutarate to (R)-3-methylitaconate catalyzed by coenzyme B 12-dependent 2-methyleneglutarate mutase from Eubacterium barkeri2005
Professor Bernard Golding
Dr Ian Hardcastle
Professor Roger Griffin
Searching for potent CDK inhibitors using a new variant of the Cope elimination2005
Andrew Henderson
Dr YuZhu Cheng
Professor Nicola Curtin
Professor Bernard Golding
Professor Roger Griffin
et al.
Searching for potent CDK2 inhibitors using a variant of the Cope elimination2005
Professor Roger Griffin
Professor Bernard Golding
Sophie Guiard
Dr Ian Hardcastle
Justin John James Leahy
et al.
Selective benzopyranone and pyrimido[2,1-alpha]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: Synthesis, structure-activity studies, and radiosensitization of a human tumor cell line in vitro2005
Antonius Pierik
Professor Bernard Golding
Synthesis of 13C-labeled γ-hydroxybutyrates for EPR studies with 4-hydroxybutyryl-CoA dehydratase2005
Emeritus Professor Bill Clegg
Professor Bernard Golding
Dr Ross Harrington
Dr Richard Scott
1-{2-[4-(2,4-Dinitrophenyl)piperazin-1 -yl]ethyl}-4-aza-1-azoniabicyclo[2. 2.2]octane chloride2004
Dr Alistair Henderson
Dr Christine Bleasdale
Emeritus Professor Bill Clegg
Professor Bernard Golding
2,6-Diarylaminotetrahydropyrans from Reactions of Glutaraldehyde with Anilines: Models for Biomolecule Cross-Linking2004
Professor William Watson
Dr Tony Munter
Professor Bernard Golding
A new role for glutathione: Protection of vitamin B12 from depletion by xenobiotics2004
Dr Alistair Henderson
Professor Bernard Golding
Adducts of N-terminal valines in hemoglobin with isoprene diepoxide, a metabolite of isoprene2004
Professor Bernard Golding
Coenzyme B12-dependent enzymatic dehydration of 1,2-diols: Simple reaction, complex mechanism!2004
Dr Christopher Calabrese
Professor Nicola Curtin
Suzanne Kyle
Huw Thomas
Lan Wang
et al.
Design, synthesis, and evaluation of 3,4-dihydro-2H-[1,4]diazepino[6,7,1- hi]indol-1-ones as inhibitors of poly(ADP-ribose) polymerase2004
Dr Tony Munter
Professor Bernard Golding
Professor William Watson
DNA reactivity and detoxication pathways of chloroprene metabolites in vitro2004
Dr Raghuram Chetty
Professor Paul Christensen
Professor Bernard Golding
Emeritus Professor Keith Scott
Fundamental and applied studies on the electrochemical hydrodehalogenation of halogenated phenols at a palladised titanium electrode2004
Justin John James Leahy
Professor Bernard Golding
Professor Roger Griffin
Dr Ian Hardcastle
Dr Laurent Rigoreau
et al.
Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries2004
Dr Richard Scott
Professor Bernard Golding
Improved synthesis of enantiomerically pure Etomoxir and its 2,4-dinitrophenyl analogue2004
Dr Ian Hardcastle
Dr Christine Arris
Dr Johanne Bentley
Professor Nicola Curtin
Professor Jane Endicott
et al.
N2-substituted O6-cyclohexylmethylguanine derivatives: Potent inhibitors of cyclin-dependent kinases 1 and 22004
Professor Bernard Golding
Optimisation of the synthesis of guanidines from amines via nitroguanidines using 3,5-dimethyl-N-nitro-1H-pyrazole-1-carboxamidine2004
Professor Nicola Curtin
Professor Bernard Golding
Suzanne Kyle
Professor Roger Griffin
Potentiation of cytotoxic drug activity in human tumour cell lines, by amine-substituted 2-arylbenzimidazole-4-carboxamide PARP-1 inhibitors2004
Professor Nicola Curtin
Hannah Barlow
Professor Alan Calvert
Richard Davison
Professor Bernard Golding
et al.
Resistance-modifying agents. 11. Pyrimido[5,4-d]pyrimidine modulators of antitumor drug activity. Synthesis and structure-activity relationships for nucleoside transport inhibition and binding to α1-acid glycoprotein2004
Professor Bernard Golding
Stereochemistry of hydrogen removal from the 'unactivated' C-3 position of 4-hydroxybutyryl-CoA catalysed by 4-hydroxybutyryl-CoA dehydratase2004
Daping Zhang
Professor Bernard Golding
Synthesis, characterization, and identification of N7-guanine adducts of isoprene monoepoxides in vitro2004
Dr Kieren Carey
Emeritus Professor Bill Clegg
Dr Mark Elsegood
Professor Bernard Golding
1,2-Bis[bis(4-methoxyphenyl)hydroxymethyl]benzene2003
Dr Kieren Carey
Emeritus Professor Bill Clegg
Dr Mark Elsegood
Professor Bernard Golding
1,2-Bis[bis(4-methoxyphenyl)hydroxymethyl]benzene2003
Jonathan Hollick
Professor Bernard Golding
Dr Ian Hardcastle
Dr Laurent Rigoreau
Professor Roger Griffin
et al.
2,6-disubstituted pyran-4-one and thiopyran-4-one inhibitors of DNA-dependent protein kinase (DNA-PK)2003
Dr Veronique Mesguiche
Rachel Parsons
Dr Christine Arris
Dr Johanne Bentley
Professor Nicola Curtin
et al.
4-Alkoxy-2,6-diaminopyrimidine derivatives: Inhibitors of cyclin dependent kinases 1 and 22003
Antonius Pierik
Professor Bernard Golding
Acryloyl-CoA reductase from Clostridium propionicum: An enzyme complex of propionyl-CoA dehydrogenase and electron-transferring flavoprotein2003
Dr Tony Munter
Professor Bernard Golding
Professor William Watson
Detoxication Pathways Involving Glutathione and Epoxide Hydrolase in the in Vitro Metabolism of Chloroprene2003
Hayley Whitfield
Professor Roger Griffin
Dr Ian Hardcastle
Dr Alistair Henderson
Dr Jerome Meneyrol
et al.
Facilitation of addition-elimination reactions in pyrimidines and purines using trifluoroacetic acid in trifluoroethanol2003
Professor Bernard Golding
Identification of adducts formed by the reaction of isoprene monoepoxides with 2'-deoxyadenosine2003
Dr Raghuram Chetty
Professor Paul Christensen
Professor Bernard Golding
In situ FTIR studies on the electrochemical reduction of halogenated phenols2003
Dr Alistair Henderson
Professor Bernard Golding
Induction of micronuclei in mouse and rat by glycidamide, genotoxic metabolite of acrylamide2003
Dr Alistair Henderson
Professor Bernard Golding
Measurements of photo-oxidation products from the reaction of a series of alkyl-benzenes with hydroxyl radicals during EXACT using comprehensive gas chromatography2003
Professor Bernard Golding
Professor William Watson
Stereochemical and kinetic comparisons of mono- and diepoxide formation in the in vitro metabolism of isoprene by liver microsomes from rats, mice, and humans2003
Emeritus Professor Bill Clegg
Dr Ross Harrington
Professor Bernard Golding
Stereocontrolled Synthesis of (2R,3S)-2-Methylisocitrate, a Central Intermediate in the Methylcitrate Cycle2003
Kerry Louise Sayle
Dr Johanne Bentley
Professor Alan Calvert
Dr YuZhu Cheng
Professor Nicola Curtin
et al.
Structure-based design of 2-arylamino-4-cyclohexylmethyl-5-nitroso-6-aminopyrimidine inhibitors of cyclin-dependent kinases 1 and 22003
Professor Nicola Curtin
Professor Herbie Newell
Professor Alan Calvert
Professor Roger Griffin
Professor Bernard Golding
et al.
Tricyclic benzimidazoles as potent poly(ADP-ribose) polymerase-1 inhibitors2003
Kerry Louise Sayle
Dr Veronique Mesguiche
Rachel Parsons
Professor Jane Endicott
Professor Martin Noble
et al.
4-Alkoxy-2,6-diaminopyrimidine derivatives: inhibitors of cyclin dependent kinases 1 and 22002
Daniele Ciceri
Professor Bernard Golding
A novel reaction between adenosylcobalamin and 2-methyleneglutarate catalyzed by glutamate mutase2002
Jonathan Hollick
Professor Bernard Golding
Professor Roger Griffin
Dr Ian Hardcastle
Justin John James Leahy
et al.
Application of combinatorial chemistry for the identification of pyran-4-one and thiopyran-4-one inhibitors of DNA-dependent protein kinase2002
Dr Gilles Laval
Emeritus Professor Bill Clegg
Professor Bernard Golding
Assembly of polyamines via amino acids from three components using cobalt(III) template methodology2002
Professor Roger Griffin
Dr Ian Hardcastle
Dr Laurent Rigoreau
Martin Stockley
Justin John James Leahy
et al.
Cassette dosing iv and ip of novel DNA dependent protein kinase inhibitors2002
Dr Julian Scott Northen
Emeritus Professor Bill Clegg
Professor Nicola Curtin
Professor Roger Griffin
Professor Bernard Golding
et al.
Controlled stepwise conversion of 2,4,6,8-tetrachloropyrimido-[5,4-d ]pyrimidine into 2,4,6,8-tetrasubstituted pyrimido[5,4-d]pyrimidines2002
Dr Ian Hardcastle
Professor Bernard Golding
Professor Roger Griffin
Designing inhibitors of cyclin-dependent kinases2002
Dr Alistair Henderson
Professor Bernard Golding
Evidence for phosphate adducts in DNA from mice treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK)2002
Professor Roger Griffin
Dr Ian Hardcastle
Dr Laurent Rigoreau
Martin Stockley
Justin John James Leahy
et al.
High throughput pharmacokinetics of novel DNA-dependent protein kinase inhibitors2002
Dr Tony Munter
Professor William Watson
Professor Bernard Golding
Identification of adducts derived from reactions of (1-chloroethenyl)oxirane with nucleosides and calf thymus DNA2002
Dr Christopher Calabrese
Professor Nicola Curtin
Suzanne Kyle
Huw Thomas
Lan Wang
et al.
Novel tricyclic poly(ADP-ribose) polymerase-1 inhibitors with potent anticancer chemopotentiating activity: Design, synthesis, and X-ray cocrystal structure2002
Dr Ashleigh Gibson
Dr Christine Arris
Dr Johanne Bentley
Professor Nicola Curtin
Professor Jane Endicott
et al.
Probing the ATP ribose-binding domain of cyclin-dependent kinases 1 and 2 with O6-substituted guanine derivatives2002
Antonius Pierik
Daniele Ciceri
Emeritus Professor William McFarlane
John Winter
Professor Bernard Golding
et al.
Rotation of the exo-methylene group of (R)-3-methylitaconate catalyzed by coenzyme B12-dependent 2-methyleneglutarate mutase from Eubacterium barkeri2002
Dr Johanne Bentley
Dr Christine Arris
Professor Nicola Curtin
Professor Jane Endicott
Dr Ashleigh Gibson
et al.
Structure-based design of a potent purine-based cyclin-dependent kinase inhibitor2002
Dr Philip Butler
Professor Bernard Golding
Synthesis of 2-(nitromethyl)ornithine from ornithine mediated by cobalt(III)2002
Dr Kieren Carey
Emeritus Professor Bill Clegg
Dr Mark Elsegood
Professor Bernard Golding
Dr Maurice Hill
et al.
Synthesis of highly hindered oxepins and an azepine from bis-trityl carbenium ions: structural characterisation by NMR and X-ray crystallography2002
Dr Alistair Henderson
Esra Mutlu
Dr Christine Bleasdale
Emeritus Professor Bill Clegg
Professor Richard Henderson
et al.
Trapping of benzene oxide-oxepin and methyl-substituted derivatives with 4-phenyl- and 4-pentafluorophenyl-1,2,4-triazoline-3,5-dione2002
Professor Nicola Curtin
Dr Stephen Barton
Michael Batey
Dr Christopher Calabrese
Professor Alan Calvert
et al.
Anti-cancer chemosensitization in vitro and in vivo by a novel potent poly(ADP-ribose) polymerase (PARP1) inhibitor, TBI-361.2001
Dr Alistair Henderson
Professor Bernard Golding
Crossed acyloin condensation of aliphatic aldehydes2001
Peter Smith
Huw Thomas
Hannah Barlow
Professor Roger Griffin
Professor Bernard Golding
et al.
In vitro and in vivo properties of novel nucleoside transport inhibitors with improved pharmacological properties that potentiate antifolate activity2001
Professor Bernard Golding
Dr Tony Munter
Professor William Watson
In vitro metabolism of chloroprene: Species differences, epoxide stereochemistry and a de-chlorination pathway2001
Professor Alan Calvert
Professor Nicola Curtin
Professor Bernard Golding
Professor Roger Griffin
Dr Ian Hardcastle
et al.
Inhibiting the MDM2-p53 interaction using low molecular weight compounds2001
Professor Bernard Golding
Interconversion of (S)-glutamate and (2S,3S)-3-methylaspartate: A distinctive B-12-dependent carbon-skeleton rearrangement2001
Professor William Watson
Professor Bernard Golding
Metabolism and molecular toxicology of isoprene2001
Dr Stephany Veuger
Professor barbara Durkacz
Professor Bernard Golding
Professor Roger Griffin
Professor Herbie Newell
et al.
Radiosensitization by novel inhibitors of PARP, PI, and DNA-PK, NU7026, in vitro2001
Professor Martin Noble
Dr Christine Arris
Professor Alan Calvert
Professor Nicola Curtin
Dr Ashleigh Gibson
et al.
Structural and thermodynamic validation of inactive cdk2 as a template for structure-based drug design2001
Professor Martin Noble
Dr Christine Arris
Professor Alan Calvert
Professor Nicola Curtin
Professor Bernard Golding
et al.
Structure based design of a potent inhibitor of cdk22001
Professor Bernard Golding
Study on synthesis of ethyl 3-oxo-(S)-(+)-6,7-di-O-isopropylidene-6,7-dihydroxyheptanoate2001
Martin Stockley
Emeritus Professor Bill Clegg
Professor Bernard Golding
Nicola Martin
Dr Laurent Rigoreau
et al.
Synthesis, crystal structure determination, and biological properties of the DNA-dependent protein kinase (DNA-PK) inhibitor 3-cyano-6-hydrazonomethyl-5-(4-pyridyl)pyrid-[1H]-2-one (OK-1035)2001
Peter Smith
Huw Thomas
Hannah Barlow
Professor Roger Griffin
Professor Bernard Golding
et al.
In vitro activity and in vivo pharmacology of two novel nucleoside transport inhibitors, NU3108 and NU31212000
Dr Minyan Wang
Professor Bernard Golding
A convenient preparation of p-methoxybenzyl esters2000
Professor Bernard Golding
Atmospheric chemistry of toluene-1,2-oxide/2-methyloxepin2000
Professor Nicola Curtin
Professor Alan Calvert
Professor barbara Durkacz
Professor Roger Griffin
Professor Bernard Golding
et al.
Chemopotentiation studies with two classes of potent (polyADP-ribose) polymerase (PARP) inhibitors in human lung and colon carcinoma cell lines.2000
Dr Christopher Calabrese
Professor Nicola Curtin
Michael Batey
Huw Thomas
Suzanne Kyle
et al.
Design and evaluation of novel potent inhibitors of poly (ADP-ribose) polymerase2000
Professor Roger Griffin
Dr Christine Arris
Professor Alan Calvert
Professor Nicola Curtin
Dr Ashleigh Gibson
et al.
Design, synthesis, and biological evaluation of O-6-alkylguanine and O-4-alkylpyrimidine cyclin-dependent kinase inhibitors2000
Dr Christine Arris
Professor Alan Calvert
Professor Nicola Curtin
Dr Ashleigh Gibson
Professor Bernard Golding
et al.
Identification of novel purine and pyrimidine cyclin-dependent kinase inhibitors with distinct molecular interactions and tumor cell growth inhibition profiles2000
Dr Christine Arris
Professor Alan Calvert
Professor Nicola Curtin
Professor Jane Endicott
Professor Bernard Golding
et al.
Identification of novel purine and pyrimidine cyclin-dependent kinase inhibitors with distinct molecular interactions and tumor cell growth inhibition profiles2000
Professor Bernard Golding
Intramolecular functionalisation by a methylene radical of a 1,2-diol and a vicinal amino alcohol: Models for coenzyme B12-dependent diol dehydratase and ethanolamine ammonia lyase2000
Dr Christine Arris
Professor Alan Calvert
Professor Nicola Curtin
Professor Bernard Golding
Professor Roger Griffin
et al.
O6-substituted guanines and 4-substituted pyrimidines: a novel class of antiproliferative cyclin dependent kinase inhibitors with distinct molecular interactions and tumor cell growth inhibition profiles.2000
Professor Roger Griffin
Dr Christine Arris
Dr Christine Bleasdale
Professor Alan Calvert
Professor Nicola Curtin
et al.
Resistance-modifying agents. 8. Inhibition of O6-alkylguanine-DNA alkyltransferase by O6-alkenyl-, O6-cycloalkenyl-, and O6-(2-oxoalkyl)guanines and potentiation of temozolomide cytotoxicity in vitro by O6-(1-cyclopentenylmethyl) guanine2000
Alex White
Professor Alan Calvert
Professor Nicola Curtin
Professor Roger Griffin
Professor Herbie Newell
et al.
Resistance-modifying agents. 9. Synthesis and biological properties of benzimidazole inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase2000
Hannah Barlow
Professor Nicola Curtin
Professor Alan Calvert
Professor Bernard Golding
Professor Herbie Newell
et al.
Resistance-modifying agents. Part 7: 2,6-Disubstituted-4,8-dibenzylaminopyrimido[5,4-d]pyrimidines that inhibit nucleoside transport in the presence of α1-acid glycoprotein (AGP)2000
Daniele Ciceri
Antonius Pierik
Professor Bernard Golding
Stereochemistry of the methyl group in (R)-3-methylitaconate derived by rearrangement of 2-methylideneglutarate catalysed by a coenzyme B12-dependent mutase2000
Dr Johanne Bentley
Dr Christine Arris
Professor Alan Calvert
Professor Nicola Curtin
Professor Jane Endicott
et al.
Structure-activity relationships and cellular effects of novel purine- and pyrimidine-based cyclin dependent kinase inhibitors2000
Professor Bernard Golding
Studies on catalytic mechanism of methionine synthase IV. Synthesis of 5-amino-6-(3-butenyl) uracil2000
Daping Zhang
Dr Christine Bleasdale
Professor Bernard Golding
Professor William Watson
Synthesis of enantiopure isoprene epoxides from (s)-lactic acid via 'dispoke' intermediates2000
Adnan Rafiq
Professor Bernard Golding
Transalkylation of phosphotriesters using cob(I)alamin: Toward specific determination of DNA-phosphate adducts2000
Professor Roger Griffin
Hannah Barlow
Professor Nicola Curtin
Professor Alan Calvert
Professor Bernard Golding
et al.
2,6-Disubstituted-4,8-dibenzylaminopyrimido[5,4-d]pyrimidines as nucleoside transport inhibitors: Structure-activity relationships for binding to alpha(1)-acid glycoprotein (AGP)1999
Professor Herbie Newell
Dr Christine Arris
Professor Alan Calvert
Professor Nicola Curtin
Dr Ashleigh Gibson
et al.
Antiproliferative cyclin dependent kinase inhibitors with distinct molecular interactions and tumor cell growth inhibition profiles.1999
Professor Bernard Golding
B-12-mediated reactions: A theoretical examination1999
Professor Bernard Golding
Facilitation of enzyme-catalyzed reactions by partial proton transfer: Application to coenzyme-B12-dependent methylmalonyl-CoA mutase1999
Dr Christine Arris
Professor Alan Calvert
Professor Nicola Curtin
Dr Ashleigh Gibson
Professor Bernard Golding
et al.
In vitro growth activity of novel purine- and pyrimidine-based CDK1 and CDK2 inhibitors.1999
Peter Smith
Hannah Barlow
Professor Alan Calvert
Professor Nicola Curtin
Professor Bernard Golding
et al.
Novel dipyridamole analogues potentiate the in vitro activity of MTA (LY231514) in the presence of alpha(1)-acid glycoprotein.1999
Professor Bernard Golding
On the Mechanism of Action of Vitamin B12: Theoretical Studies of the 2-Methyleneglutarate Mutase Catalyzed Rearrangement1999
Professor Bernard Golding
Professor William Watson
Possible mechanisms of carcinogenesis after exposure to benzene1999
Professor Nicola Curtin
Suzanne Kyle
Lan Wang
Professor barbara Durkacz
Professor Roger Griffin
et al.
Potentiation of temozolomide and topotecan growth inhibition by novel potent benzimidazole poly(ADP-ribose) polymerase (PARP) inhibitors1999
Professor Nicola Curtin
Professor Alan Calvert
Professor Bernard Golding
Professor Roger Griffin
Professor Herbie Newell
et al.
Potentiation of the cytotoxicity of thymidylate synthase (TS) inhibitors by dipyridamole analogues with reduced α1-acid glycoprotein binding1999
Dr Christopher Calabrese
Huw Thomas
Michael Batey
Professor Nicola Curtin
Professor Roger Griffin
et al.
Preclinical pharmacology of novel substituted benzimidazoles - potent inhibitors of poly (ADP-ribose) polymerase1999
Professor Bernard Golding
Emeritus Professor Bill Clegg
Dr Mark Elsegood
Professor Roger Griffin
Protecting-group strategies for the synthesis of N4-substituted, and N1,N8-disubstituted spermidines, exemplified by hirudonine1999
Emeritus Professor Bill Clegg
Dr Mark Elsegood
Professor Roger Griffin
Professor Bernard Golding
Synthesis of 3-alkoxy- and 3-alkylamino-2-alkyl-3-arylisoindolinones1999
Professor Bernard Golding
Toward a consistent mechanism for diol dehydratase catalyzed reactions: an application of the partial-proton-transfer concept1999
Professor Bernard Golding
Understanding the mechanism of B12-dependent methylmalonyl-CoA mutase: partial proton transfer in action1999
Professor Alan Calvert
Professor Nicola Curtin
Professor Bernard Golding
Professor Roger Griffin
Professor Herbie Newell
et al.
2-phenylbenzimidazole-4-carboxamides are potent inhibitors of the DNA repair enzyme poly(ADP-ribose)-polymerase (PARP)1998
Professor Jane Endicott
Professor Martin Noble
Professor Alan Calvert
Professor Nicola Curtin
Professor Bernard Golding
et al.
Insights into CDK inhibitor design from X-ray crystallographic studies1998
Professor Alan Calvert
Professor Nicola Curtin
Professor Jane Endicott
Professor Bernard Golding
Professor Roger Griffin
et al.
O-6-alkylguanines as selective inhibitors of cyclin dependent kinases1998
Alex White
Professor Bernard Golding
Professor Roger Griffin
Professor Nicola Curtin
Potentiation of anti-cancer agent cytotoxicity by the potent poly(ADP-ribose) polymerase inhibitors NU1025 and NU10641998
Professor Roger Griffin
Professor Alan Calvert
Professor Nicola Curtin
Professor Herbie Newell
Professor Bernard Golding
et al.
Resistance-modifying agents. 5.1 Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP)1998
Dr Christine Arris
Dr Christine Bleasdale
Professor Alan Calvert
Professor Nicola Curtin
Professor Bernard Golding
et al.
Mechanism-based inhibition of O-6-methylguanine-DNA methyltransferase.1996
Professor Roger Griffin
Alex White
Kenneth Bowman
Professor Alan Calvert
Professor Nicola Curtin
et al.
Novel benzimidazole and quinazolinone inhibitors of the DNA repair enzyme Poly(ADP-ribose)polymerase1996
Professor Roger Griffin
Professor Nicola Curtin
Professor Herbie Newell
Professor Bernard Golding
Professor barbara Durkacz
et al.
The Role of Inhibitors of Poly(Adp-Ribose) Polymerase as Resistance-Modifying Agents in Cancer-Therapy1995
Professor Bernard Golding
Professor Roger Griffin
Discrimination of spermidine amino functions by a new protecting group strategy; application to the synthesis of guanidinylated polyamines, including hirudonine1994
Dr Christine Arris
Dr Christine Bleasdale
Professor Alan Calvert
Professor Nicola Curtin
Professor Bernard Golding
et al.
Probing the active site and mechanism of action of O-6-methylguanine-DNA methyltransferase with substrate-analogs to (O-6-substituted guanines)1994
Professor Herbie Newell
Dr Ross Maxwell
Professor Bernard Golding
Invivo and exvivo magnetic resonance spectroscopy as applied to pharmacokinetic studies with anticancer agents: a review1992