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Browsing publications by Dr Laura Greaves.

Newcastle AuthorsTitleYearFull text
Dr Ashwin Sachdeva
Dr Christopher Carey
Dr Amy Vincent
Dr Laura Greaves
Professor Rakesh Heer
et al.
Automated quantitative high‑throughput multiplex immunofuorescence pipeline to evaluate OXPHOS defects in formalin‑fxed human prostate tissue2022
Xuefei Yu
Dr Catherine Arden
Dr Rolando Berlinguer Palmini
Dr Chun Chen
Carla Bradshaw
et al.
Mitochondrial complex I subunit deficiency promotes pancreatic α-cell proliferation2022
Dr Craig Stamp
Dr Julia Whitehall
Anna Smith
Dr David Houghton
Carla Bradshaw
et al.
Age-associated mitochondrial complex I deficiency is linked to increased stem cell proliferation rates in the mouse colon2021
Amy Fuller
Dr Nduka Okwose
Jadine Scragg
Dr Christopher Eggett
Peter Luke
et al.
The effect of age on mechanisms of exercise tolerance: Reduced arteriovenous oxygen difference causes lower oxygen consumption in older people2021
Dr Julia Whitehall
Dr Laura Greaves
Aberrant mitochondrial function in ageing and cancer2020
Anna Smith
Dr Julia Whitehall
Carla Bradshaw
Dr Fiona Robertson
Dr Alasdair Blain
et al.
Age-associated mitochondrial DNA mutations cause metabolic remodeling that contributes to accelerated intestinal tumorigenesis2020
Dr Philip Dobson
Dr Ella Dennis
Dan Hipps
Dr Amy Reeve
Dr Alex Laude
et al.
Mitochondrial dysfunction impairs osteogenesis, increases osteoclast activity, and accelerates age related bone loss2020
Dr Conor Lawless
Dr Laura Greaves
Dr Amy Reeve
Emeritus Professor Doug Turnbull
Dr Amy Vincent
et al.
The rise and rise of mitochondrial DNA mutations2020
Hannah Paish
Lee Reed
Helen Brown
Mark Bryan
Dr Olivier Govaere
et al.
A bioreactor technology for modelling fibrosis in human and rodent precision-cut liver slices2019
Dr Fiona Malcomson
Stella Breininger
Khalil ElGendy
Aj Joel
Thilanka Ranathunga
et al.
Design and baseline characteristics of the Biomarkers Of Risk In Colorectal Cancer (BORICC) Follow-Up study: A 12+ years follow-up2019
Stella Breininger
Dr Fiona Malcomson
Dr Sonny Afshar
Emeritus Professor Doug Turnbull
Dr Laura Greaves
et al.
Effects of obesity and weight loss on mitochondrial structure and function and implications for colorectal cancer risk2019
Rhys Anderson
Anthony Lagnado
Damien Maggiorani
Dr Anna Walaszczyk
Emily Dookun
et al.
Length‐independent telomere damage drives post‐mitotic cardiomyocyte senescence2019
Dr Laura Greaves
Professor Robert Taylor
Dr Jim Stewart
A novel histochemistry assay to assess and quantify focal cytochrome c oxidase deficiency2018
Dr Dave Houghton
Dr Christopher Stewart
Dr Craig Stamp
Professor Anil Wipat
Professor Mike Trenell
et al.
Age-related mitochondrial dysfunction influences the mouse intestinal microbiome composition2018
Tianhong Su
Dr John Grady
Sorena Afshar
Professor Robert Taylor
Emeritus Professor Doug Turnbull
et al.
Inherited pathogenic mitochondrial DNA mutations and gastrointestinal stem cell populations2018
Dr Craig Stamp
Dr Anze Zupanic
Ashwin Sachdeva
Dr Elizabeth Stoll
Dr Daryl Shanley
et al.
Predominant Asymmetrical Stem Cell Fate Outcome Limits the Rate of Niche Succession in Human Colonic Crypts2018
Tianhong Su
Emeritus Professor Doug Turnbull
Dr Laura Greaves
Roles of mitochondrial DNA mutations in stem cell ageing2018
Dr Dave Houghton
Dr Christopher Stewart
Dr Craig Stamp
Professor Anil Wipat
Professor Mike Trenell
et al.
Impact of Age-Related Mitochondrial Dysfunction and Exercise on Intestinal Microbiota Composition2017
Alex Bury
Dr Angela Pyle
Dr Joanna Elson
Dr Laura Greaves
Dr Christopher Morris
et al.
Mitochondrial DNA changes in pedunculopontine cholinergic neurons in Parkinson disease2017
Dr Mohammad Moad
Laura Wilson
Rob Pickard
Emeritus Professor Doug Turnbull
Professor Robert Taylor
et al.
Multipotent Basal Stem Cells, Maintained in Localized Proximal Niches, Support Directed Long-Ranging Epithelial Flows in Human Prostates2017
Holly Baines
Dr Craig Stamp
Dr Laura Greaves
Dr Jim Stewart
A Phenotype-Driven Approach to Generate Mouse Models with Pathogenic mtDNA Mutations Causing Mitochondrial Disease2016
Ashwin Sachdeva
Dr Amira El-Sherif
Emeritus Professor Doug Turnbull
Dr Laura Greaves
Professor Rakesh Heer
et al.
Development of prostate intra-epithelial neoplasia in an aging series of PolgA mutator mice suggests a role for mitochondrial DNA mutations in prostate carcinogenesis2016
Dr Ellen Tullo
Dr Laura Greaves
Dr Luisa Wakeling
Involving older people in the design, development, and delivery of an innovative module on aging for undergraduate students2016
Dr Clara Correia Melo
Francisco Marques
Rhys Anderson
Dr Graeme Hewitt
Dr Bernadette Carroll
et al.
Mitochondria are required for pro-ageing features of the senescent phenotype2016
Dr Philip Dobson
Dr Mariana Rocha
Dr John Grady
Alexia Chrysostomou
Sharon Watson
et al.
Unique quadruple immunofluorescence assay demonstrates mitochondrial respiratory chain dysfunction in osteoblasts of aged and PolgA -/- mice2016
Professor Grainne Gorman
Dr Hue Hornig - Do
Dr Helen Tuppen
Dr Laura Greaves
Dr Langping He
et al.
Novel MTND1 mutations cause isolated exercise intolerance, complex I deficiency and increased assembly factor expression2015
Dr Laura Greaves
Dr Anne Grunewald
SCNT-Derived ESCs with Mismatched Mitochondria Trigger an Immune Response in Allogeneic Hosts2015
Dr Joanna Elson
Dr Paul Smith
Dr Laura Greaves
Professor Robert Lightowlers
Professor Zofia Chrzanowska-Lightowlers
et al.
The presence of highly disruptive 16S rRNA mutations in clinical samples indicates a wider role for mutations of the mitochondrial ribosome in human disease2015
Dr Laura Greaves
Professor Robert Taylor
Bmi1 enhances skeletal muscle regeneration through MT1-mediated oxidative stress protection in a mouse model of dystrophinopathy2014
Dr Diana Jurk
Dr Caroline Wilson
Dr Joao Passos
Professor Fiona Oakley
Clara Correia Melo
et al.
Chronic inflammation induces telomere dysfunction and accelerates ageing in mice2014
Dr Laura Greaves
Marco Nooteboom
Dr Joanna Elson
Dr Helen Tuppen
Geoffrey Taylor
et al.
Clonal Expansion of Early to Mid-Life Mitochondrial DNA Point Mutations Drives Mitochondrial Dysfunction during Human Ageing2014
Dr Stuart Williamson
Laura Wilson
Graeme Williamson
Dr Laura Greaves
Dr Helen Tuppen
et al.
Finding a niche. The location of human prostate stem cells2014
Holly Baines
Emeritus Professor Doug Turnbull
Dr Laura Greaves
Human stem cell aging: do mitochondrial DNA mutations have a causal role?2014
Holly Baines
Dr Jim Stewart
Craig Stamp
Dr Anze Zupanic
Emeritus Professor Thomas Kirkwood
et al.
Similar patterns of clonally expanded somatic mtDNA mutations in the colon of heterozygous mtDNA mutator mice and ageing humans2014
Dr Paul Smith
Dr Joanna Elson
Dr Laura Greaves
Professor Robert Lightowlers
Professor Zofia Chrzanowska-Lightowlers
et al.
The role of the mitochondrial ribosome in human disease: Searching for mutations in 12S mitochondrial rRNA with high disruptive potential2013
Dr Laura Greaves
Dr Joanna Elson
Dr John Grady
Geoffrey Taylor
Professor Robert Taylor
et al.
Comparison of Mitochondrial Mutation Spectra in Ageing Human Colonic Epithelium and Disease: Absence of Evidence for Purifying Selection in Somatic Mitochondrial DNA Point Mutations2012
Dr John Blackwood
Dr Laura Greaves
Laura Wilson
Rob Pickard
Professor Majlinda Lako
et al.
Lineage tracking in situ: Where are the prostate stem cells? What are they doing?2012
Dr Laura Greaves
Dr Amy Reeve
Professor Robert Taylor
Emeritus Professor Doug Turnbull
Mitochondrial DNA and disease2012
Dr John Blackwood
Dr Stuart Williamson
Dr Laura Greaves
Laura Wilson
Dr Anastasia Hepburn
et al.
In situ lineage tracking of human prostatic epithelial stem cell fate reveals a common clonal origin for basal and luminal cells2011
Dr Laura Greaves
Dr Martin Barron
Emeritus Professor Thomas Kirkwood
Emeritus Professor Doug Turnbull
Differences in the accumulation of mitochondrial defects with age in mice and humans2011
Marco Nooteboom
Professor Robert Taylor
Professor Robert Lightowlers
Emeritus Professor Thomas Kirkwood
Professor John Mathers
et al.
Age-associated mitochondrial DNA mutations lead to small but significant changes in cell proliferation and apoptosis in human colonic crypts2010
Dr Laura Greaves
Dr Martin Barron
Dr Stefan Plusa
Emeritus Professor Thomas Kirkwood
Professor John Mathers
et al.
Defects in multiple complexes of the respiratory chain are present in ageing human colonic crypts2010
Dr Laura Greaves
Dr Martin Barron
Dr Stefan Plusa
Emeritus Professor Thomas Kirkwood
Professor John Mathers
et al.
Defects in multiple complexes of the respiratory chain are present in ageing human colonic crypts2010
Dr Laura Greaves
Dr Patrick Yu Wai Man
Kim Krishnan
Nina Beadle
Dr Martin Barron
et al.
Mitochondrial DNA Defects and Selective Extraocular Muscle Involvement in CPEO2010
Dr Patrick Yu Wai Man
Dr Gillian Borthwick
Dr Langping He
Geoffrey Taylor
Dr Laura Greaves
et al.
Somatic Mitochondrial DNA Deletions Accumulate to High Levels in Aging Human Extraocular Muscles2010
Dr Nimantha De Alwis
Emeritus Professor Doug Turnbull
Professor Robert Taylor
Dr Laura Greaves
Professor Patrick Chinnery
et al.
A Methodological Approach to Tracing Cell Lineage in Human Epithelial Tissues2009
Dr Don Mahad
Dr Iryna Ziabreva
Graham Campbell
Dr Julie Murphy
Dr Amy Reeve
et al.
Detection of cytochrome c oxidase activity and mitochondrial proteins in single cells2009
Emeritus Professor Doug Turnbull
Professor Robert Taylor
Dr Laura Greaves
Professor Patrick Chinnery
Locating the Stem Cell Niche and Tracing Hepatocyte Lineages in Human Liver2009
Dr Laura Greaves
Emeritus Professor Doug Turnbull
Mitochondrial DNA mutations and ageing2009
Dr Laura Greaves
Professor John Mathers
Professor Robert Taylor
Emeritus Professor Doug Turnbull
Modelling mitochondrial DNA mutations in bacterial cytochrome c oxidase: Link to colon cancer?2009
Dr Laura Greaves
Nina Beadle
Geoffrey Taylor
Dr Daniel Commane
Professor John Mathers
et al.
Quantification of mitochondrial DNA mutation load2009
Professor Robert Taylor
Dr Laura Greaves
Dr Martin Barron
Philip Griffiths
Emeritus Professor Doug Turnbull
et al.
A histochemical and molecular genetic investigation of the selective, extraocular muscle involvement in chronic progressive external ophthalmoplegia2008
Dr Laura Greaves
Professor Robert Taylor
Emeritus Professor Doug Turnbull
Mechanisms of Field Cancerization in the Human Stomach: The Expansion and Spread of Mutated Gastric Stem Cells2008
Dr Laura Greaves
Dr Amy Reeve
Emeritus Professor Doug Turnbull
Mitochondrial DNA mutations and aging2007
Dr Laura Greaves
Dr Amy Reeve
Emeritus Professor Doug Turnbull
Mitochondrial DNA mutations and aging2007
Dr Laura Greaves
Dr Daniel Commane
Dr Hazel Greetham
Professor Robert Taylor
Emeritus Professor Doug Turnbull
et al.
Novel preliminary findings of mitochondrial DNA mutations in colonic crypts of patients with diverticular disease (the Boricc study)2007
Dr Laura Greaves
Dr Amy Reeve
Emeritus Professor Doug Turnbull
The ageing mitochondrial genome2007
Dr Laura Greaves
Emeritus Professor Doug Turnbull
Clonal expansion in the human gut - Mitochondrial DNA mutations show us the way2006
Dr Simon Wilkinson
Dr Laura Greaves
Professor Faith Williams
Interactions of skin thickness and physicochemical properties of test compounds in percutaneous penetration studies2006
Dr Ramesh Arasaradnam
Dr Laura Greaves
Dr Daniel Commane
Professor John Mathers
Professor Robert Taylor
et al.
Mitochondrial DNA (MTDNA) mutations in human colonic crypts: A novel biomarker of colorectal cancer.2006
Dr Laura Greaves
Professor Robert Taylor
Dr Martin Barron
Emeritus Professor Doug Turnbull
Mitochondrial DNA mutations are established in human colonic stem cells, and mutated clones expand by crypt fission2006
Dr Laura Greaves
Professor Robert Taylor
Mitochondrial DNA mutations in human disease2006
Dr Laura Greaves
Emeritus Professor Doug Turnbull
Modelling of the expansion of normal human colonic crypts2006
Dr Laura Greaves
Emeritus Professor Doug Turnbull
Clusters of phenotypically related human colonic crypts develop through crypt fission: Implications for colorectal carcinogenesis2005
Dr Laura Greaves
Emeritus Professor Doug Turnbull
Clusters of phenotypically-related human colonic crypts develop through crypt fission: Implications for colorectal carcinogenesis2005
Professor Robert Taylor
Dr Langping He
Dr Laura Greaves
Geoffrey Taylor
Dr Martin Barron
et al.
Mitochondrial DNA mutations in human colonic crypt stem cells2004
Dr Laura Greaves
Dr Martin Barron
Professor Robert Taylor
Emeritus Professor Doug Turnbull
Mitochondrial DNA mutations in human colonic crypt stem cells - implications for function2004
Professor Robert Taylor
Dr Martin Barron
Dr Gillian Borthwick
Professor Patrick Chinnery
Dr David Samuels
et al.
Mitochondrial DNA mutations and aging in human colonic crypts and stem cells2003
Professor Robert Taylor
Dr Martin Barron
Dr Gillian Borthwick
Professor Patrick Chinnery
Dr David Samuels
et al.
Mitochondrial DNA mutations in human colonic crypt stem cells2003
Dr Laura Greaves
Dr Simon Wilkinson
Professor Faith Williams
Factors affecting percutaneous absorption of caffeine in vitro2002