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Secondary acute lymphoblastic leukaemia with 4:11 translocation following treatment for Hodgkin's disease

Lookup NU author(s): Dr Anne Lennard, Professor Graham Jackson, Dr Peter Carey, Dr Peter Middleton, Professor Stephen Proctor


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It is apparent that treatment of Hodgkin's disease can be complicated by the development of secondary leukaemia. Most such leukaemias are of the non-lymphocytic type. We describe here a patient treated for Hodgkin's disease with chemo- and radiotherapy who developed secondary acute lymphoblastic leukaemia with a non-random chromosomal abnormality t(4;11). The frequency of such cases is assessed by a literature review and evidence for their pluripotent cell origin is discussed.

Publication metadata

Author(s): Lennard, A. L., Jackson, G. H., Carey, P. J., Bown, N., Middleton, P. G., Proctor, S. J.

Publication type: Article

Publication status: Published

Journal: Leukemia

Year: 1991

Volume: 5

Issue: 7

Pages: 624-627

Print publication date: 01/07/1991

ISSN (print): 0887-6924

ISSN (electronic): 1476-5551

PubMed id: 2072750