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A pilot study of screening for neuroblastoma in the north of England

Lookup NU author(s): Emeritus Professor Alan Craft, Professor Louise Parker, Mike Cole, Julian Smith


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A pilot study has been carried out to assess the feasibility of screening for neuroblastoma in 6-month-old infants in the north of England. A total of 20,829 infants were screened. Two true-positive cases were found, along with eight false-positive and three false-negative cases. It was shown that the concentrations of catecholamine metabolites in the urine are dependent on the creatinine content; centiles have been established to allow this relationship to be taken into account. Five of the eight false-positive cases would have been correctly assessed as normal if the new centiles had been used. Preliminary results lend support to the need for a well-designed study of neuroblastoma screening to be carried out, with death from this disease as the only end point.

Publication metadata

Author(s): Craft, A. W., Parker, L., Dale, G., McGill, A. C., Seviour, J. A., Bell, S., Cole, M., Smith, J.

Publication type: Article

Publication status: Published

Journal: American Journal of Pediatric Hematology / Oncology

Year: 1992

Volume: 14

Issue: 4

Pages: 337-341

Print publication date: 01/11/1992

ISSN (print): 0192-8562

ISSN (electronic): 1536-3678


DOI: 10.1097/00043426-199211000-00010

PubMed id: 1456400


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