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Lookup NU author(s): Emeritus Professor Alan Craft,
Professor Louise Parker,
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A pilot study has been carried out to assess the feasibility of screening for neuroblastoma in 6-month-old infants in the north of England. A total of 20,829 infants were screened. Two true-positive cases were found, along with eight false-positive and three false-negative cases. It was shown that the concentrations of catecholamine metabolites in the urine are dependent on the creatinine content; centiles have been established to allow this relationship to be taken into account. Five of the eight false-positive cases would have been correctly assessed as normal if the new centiles had been used. Preliminary results lend support to the need for a well-designed study of neuroblastoma screening to be carried out, with death from this disease as the only end point.
Author(s): Craft, A. W., Parker, L., Dale, G., McGill, A. C., Seviour, J. A., Bell, S., Cole, M., Smith, J.
Publication type: Article
Publication status: Published
Journal: American Journal of Pediatric Hematology / Oncology
Print publication date: 01/11/1992
ISSN (print): 0192-8562
ISSN (electronic): 1536-3678
PubMed id: 1456400
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