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Alpha interferon gene deletions in adults, children and infants with acute lymphoblastic leukemia

Lookup NU author(s): Dr Peter Middleton, Dr Penelope Taylor, Dr Michael Reid, Professor Graham Jackson, Professor Stephen Proctor


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DNA from 76 cases of acute lymphoblastic leukemia (ALL) was tested with a cDNA probe encoding the alpha-2B interferon (IFN) gene transcript. Deletions were found in three of ten pre-B, three of 21 T-cell, four of 22 common and one of 23 null ALL cases. Amongst those with null ALL were 20 infants, most with characteristic translocations, none of whom had deletion of alpha-IFN genes. The results confirm that alpha-IFN gene deletions may occur without visible abnormalities of chromosome 9p and show that they occur across a wide range of ALL phenotypes. The results suggest that alpha-IFN gene deletions may be rare events in null ALL of infants but their incidence and cellular consequences remain unknown.

Publication metadata

Author(s): Middleton, P. G., Prince, R. A., Williamson, I. K., Taylor, P. R. A., Reid, M. M., Jackson, G. H., Katz, F., Chessells, J. M., Proctor, S. J.

Publication type: Article

Publication status: Published

Journal: Leukemia

Year: 1991

Volume: 5

Issue: 8

Pages: 680-682

Print publication date: 01/08/1991

ISSN (print): 0887-6924

ISSN (electronic): 1476-5551

PubMed id: 1886420