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The pharmacogenetics of chemical carcinogenesis

Lookup NU author(s): Professor Alan Boddy, Emerita Professor Suzanne Cholerton, Professor Ann Daly, Professor Janice Ellis, Julian Leathart

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Abstract

The human body is endowed with a large number of xenobiotic chemical metabolizing enzymes, a significant proportion of which are polymorphic and thus render one individual at greater or lesser risk than another of chemically-induced disease. All examples of genetic polymorphism of chemical metabolizing enzymes have been reviewed in relation to their potential to activate and detoxicate procarcinogens and promutagens. Many examples are cited whereby phenotype can act as a carcinogenic risk factor. With the availability of a large amount of DNA sequence data for chemical metabolizing enzymes there has emerged a number of polymerase chain reaction (PCR) strategies aimed at discerning one metabolic phenotype or another. This is seen as a very positive and democratic scientific development, widening the franchise for studies of disease risk. Nevertheless, it is argued that, at these early stages with many laboratory-based scientists scarcely familiar with epidemiological study design, a cautious approach should obtain when interpreting single studies.


Publication metadata

Author(s): Idle, J. R., Armstrong, M., Boddy, A. V., Boustead, C., Cholerton, S., Cooper, J., Daly, A. K., Ellis, J., Gregory, W., Hadidi, H., Hofer, C., Holt, J., Leathart, J., McCracken, N., Monkman, S. C., Painter, J. E., Taber, H., Walker, D., Yule, M.

Publication type: Article

Publication status: Published

Journal: Pharmacogenetics

Year: 1992

Volume: 2

Issue: 6

Pages: 246-258

Print publication date: 01/12/1992

ISSN (print): 0960-314X

ISSN (electronic):

URL: http://dx.doi.org/10.1097/00008571-199212000-00002

DOI: 10.1097/00008571-199212000-00002

Notes: Original format: conference proceeding.


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