Publications by Julian Leathart - ePrints

Browsing publications by Julian Leathart.

Newcastle Authors	Title	Year
Dr Yang-Lin Liu Dr Gillian Patman Julian Leathart Professor Alastair Burt Professor Chris Day et al.	Carriage of the PNPLA3 rs738409 C>G Polymorphism Confers an Increased Risk of Non-Alcoholic Fatty Liver Disease Associated Hepatocellular Carcinoma	2014
Julian Leathart Professor Ann Daly Professor Chris Day Professor Quentin Anstee	Gene Polymorphisms of Cellular Senescence Marker P21 and Disease Progression in Non-Alcohol-Related Fatty Liver Disease	2014
Dr Yang-Lin Liu Professor Helen Reeves Professor Alastair Burt Dr Dina Tiniakos Professor Stuart McPherson et al.	TM6SF2 rs58542926 Influences Hepatic Fibrosis Progression in Patients with Non-Alcoholic Fatty Liver Disease	2014
Professor Quentin Anstee Dr Rebecca Darlay Julian Leathart Yilei Liu Professor Alastair Burt et al.	A candidate-gene approach to validation of genetic modifier associations using a large cohort with histologically characterised non-alcoholic fatty liver disease	2013
Dr Patrick Kesteven Julian Leathart Professor Ann Daly Professor Farhad Kamali	A Randomized Trial of Genotype-Guided Dosing of Warfarin	2013
Dr Yang-Lin LIU Dr Gillian Patman Julian Leathart Professor Alastair Burt Professor Chris Day et al.	Carriage of PNPLA3 I148M is Associated with an Increased Risk of Non-Alcoholic Fatty Liver Disease Associated Hepatocellular Carcinoma	2013
Professor Quentin Anstee Dr Rebecca Darlay Julian Leathart Professor Helen Reeves Professor Alastair Burt et al.	Genome-Wide Association Analysis Confirms Importance of PNPLA3 and Identifies Novel Variants Associated With Histologically Progressive Steatohepatitis in NAFLD	2012
Ahmad Alserri Professor Quentin Anstee Julian Leathart Julia Patch Professor Chris Day et al.	The SOD2 C₄₇T polymorphism influences NAFLD fibrosis severity: Evidence from case-control and intra-familial allele association studies	2012
Dr Tina Biss Dr Peter Avery Julian Leathart Professor Farhad Kamali	VKORC1 and CYP2C9 genotype is associated with over-anticoagulation during initiation of warfarin therapy in children	2012
Dr Tina Biss Dr Peter Avery Julian Leathart Professor Farhad Kamali	Warfarin dose prediction in children using pharmacogenetics information	2012
Dr Tina Biss Dr Peter Avery Julian Leathart Dr John Hanley Professor Ann Daly et al.	VKORC1 and CYP2C9 genotype and patient characteristics explain a large proportion of the variability in warfarin dose requirement among children	2011
Dr Gul Ozhan Rajiv Lochan Jayadeva Julian Leathart Richard Charnley Professor Ann Daly et al.	Cyclooxygenase-2 polymorphisms and pancreatic cancer susceptibility	2011
Julian Leathart Professor Ann Daly	Genotyping for CYP2C9 and VKORC1 alleles by a novel point of care assay with HyBeacon(R) probes	2011
Dr Nimantha De Alwis Julian Leathart Professor Gavin Hudson Dr Angela Pyle Dr Catherine Mowbray et al.	Mitochondrial DNA does not contribute to the heritability of non-alcoholic fatty liver disease	2011
Julian Leathart Professor Ann Daly Professor Chris Day	The APOC3 T-455C and C-482T promoter region polymorphisms are not associated with the severity of liver damage independently of PNPLA3 I148M genotype in patients with nonalcoholic fatty liver	2011
Professor Ann Daly Julian Leathart Professor Alastair Burt Professor Chris Day	Genetic variants regulating insulin receptor signalling are associated with the severity of liver damage in patients with non-alcoholic fatty liver disease	2010
Dr Stuart Kendrick Julian Leathart Elsbeth Henderson Dr Nimantha De Alwis Dr Stephen Stewart et al.	A 'loss-of-function' mutation in TIRAP, the gene encoding the Toll-like receptor adapter molecule MAL protects against fibrosis in NAFLD but not ALD	2008
Dr Peter Donaldson Dr Pallav Bhatnagar Julia Patch Jill Henderson Julian Leathart et al.	Flucloxacillin-induced liver injury: the extended MHC 57.1 haplotype as a major risk factor	2008
Dr Peter Donaldson Dr Pallav Bhatnagar Julia Patch Jill Henderson Julian Leathart et al.	Susceptibility to drug induced liver injury determined by HLA class II genotype	2008
Dr Luca Miele Dr Gary Beale Dr Gillian Patman Julian Leathart Professor Chris Day et al.	The Kruppel-like factor 6 genotype is associated with fibrosis in nonalcoholic fatty liver disease	2008
Dr Nimantha De Alwis Professor Ann Daly Julian Leathart Dr Sushma Saksena Professor Chris Day et al.	Genetic evidence that lipid trafficking plays a key role in fibrosis in non alcoholic fatty liver disease	2007
Professor Ann Daly Julian Leathart Richard Swainsbury Professor Chris Day	Genetic Susceptibility to Diclofenac-Induced Hepatotoxicity: Contribution of UGT2B7, CYP2C8, and ABCC2 Genotypes	2007
Dr Nimantha De Alwis Dr Catherine Mowbray Dr Angela Pyle Julian Leathart Professor Patrick Chinnery et al.	Mitochondrial DNA haplogroups associated with histological severity in non-alcoholic fatty liver disease (NAFLD)	2007
Dr Luca Miele Dr Gary Beale Julian Leathart Professor Chris Day Professor Helen Reeves et al.	The KLF6 (IVS1-27G > a) polymorphism is associated with non-progressive NAFLD	2007
Professor Ann Daly Ahmad Alserri Julian Leathart Julia Patch Professor Chris Day et al.	The mitochondrial superoxide dismutase 2 (SOD2) targeting sequence polymorphism is associated with fibrotic NAFLD: Consistent evidence from case-control and intra-familial allelic association studies	2007
Professor Chris Day Julian Leathart Professor Ann Daly	Genetic evidence for a role for gut flora in the pathogenesis of NASH in humans	2006
Professor Ann Daly Dr Barry King Julian Leathart	Genotyping for cytochrome P450 polymorphisms	2006
Dr David Price Dr Peter Donaldson Julian Leathart Professor Alastair Burt Dr Matthias Schmid et al.	Microsomal triglyceride transfer protein gene promoter polymorphism (493g allele) is associated with severity of hcv-associated steatosis	2006
Julian Leathart Professor Ann Daly	Polymorphic organic anion transporting polypeptide 1B1 is a major determinant of repaglinide pharmacokinetics	2005
Vanessa Gage Professor Peter Blain Julian Leathart Professor Ann Daly Professor Faith Williams et al.	Association of DNA damage to human peripheral lymphocytes with age and MnSOD and OGG1 genotype	2004
Professor Ann Daly Julian Leathart Professor Chris Day	Hepatic Adducts, Circulating Antibodies, and Cytokine Polymorphisms in Patients with Diclofenac Hepatotoxicity	2004
Professor Ann Daly Julian Leathart Professor Chris Day	A "loss-of-function" polymorphism in ICAM-1 protects heavy drinkers from alcoholic liver disease	2003
Dr Barry King Julian Leathart Dr Elaine Mutch Professor Faith Williams Professor Ann Daly et al.	CYP3A5 phenotype-genotype correlations in a British population	2003
Dr Elaine Mutch Professor Ann Daly Julian Leathart Professor Peter Blain Professor Faith Williams et al.	Do multiple cytochrome P450 isoforms contribute to parathion metabolism in man?	2003
Professor Ann Daly Julian Leathart Dr Beate Haugk Professor David Jones Professor Alastair Burt et al.	Evidence that alcoholic liver disease is due to immune mechanisms in genetically susceptible drinkers	2003
Dr Stephen Stewart Professor Ann Daly Professor David Jones Julian Leathart Professor Chris Day et al.	Genetic and epigenetic factors in autoimmune reactions toward cytochrome P4502E1 in alcoholic liver disease	2003
Dr Sushma Saksena Julian Leathart Professor Alastair Burt Emeritus Professor Oliver James Professor Ann Daly et al.	Genetic evidence supporting the two-hit model of NASH pathogenesis	2003
Dr Sushma Saksena Julian Leathart Professor Ann Daly Professor Chris Day	Manganese dependent superoxide dismutase (SOD2) targeting sequence polymorphism is associated with advanced fibrosis in patients with non-alcoholic fatty liver disease	2003
Julian Leathart Professor Ann Daly	Polymorphism in CYP2C8 is associated with reduced plasma concentrations of repaglinide	2003
Julian Leathart Professor Chris Day Professor Ann Daly	Relationship of UGT2B7 genotype with diclofenac hepatotoxicity	2003
Julian Leathart Professor Chris Day Professor Ann Daly	Association of udp-glucuronosyltransferase (UGT) 2B7 genotype with diclofenac-induced hepatotoxicity	2002
Dr Namrata Bahadur Julian Leathart Dr Elaine Mutch Dr Stuart Dunn Professor Faith Williams et al.	CYP2C8 polymorphisms in Caucasians and their relationship with paclitaxel 6α-hydroxylase activity in human liver microsomes	2002
Professor Ann Daly Julian Leathart Dr Beate Haugk Professor David Jones Professor Alastair Burt et al.	Evidence that alcoholic liver disease is due to immune mechanisms in genetically susceptible drinkers	2002
Professor Chris Day Dr Sushma Saksena Julian Leathart Professor Alastair Burt Emeritus Professor Oliver James et al.	Genetic evidence supporting the two-hit model of NASH pathogenesis	2002
Professor Chris Day Julian Leathart Professor Ann Daly	Genetic evidence that fatty liver is involved in the pathogenesis of advanced alcoholic liver disease	2002
Dr Stephen Stewart Julian Leathart Professor Ann Daly Professor Chris Day	Valine-alanine manganese superoxide dismutase polymorphism is not associated with alcohol-induced oxidative stress or liver fibrosis	2002
Dr Stephen Stewart Professor Ann Daly Julian Leathart Professor David Jones Professor Chris Day et al.	A polymorphism in CTLA-4 is associated with the presence of anti-CYP2E1 antibody titres in patients with alcoholic liver disease	2001
Julian Leathart Sally Keegan Jeffrey Pearson Dr Adrian Bint	Analysis of Escherichia coli strains causing bacteriuria during pregnancy	2001
Julian Leathart Sally Keegan Dr Adrian Bint	Analysis of Escherichia coli strains causing bacteriuria during pregnancy: Selection for strains that do not express type 1 fimbriae	2001
Professor Chris Day Julian Leathart Professor Ann Daly Dr Mark Hudson	Association of a 5'-flanking region polymorphism in the interleukin-4 gene with Crohn’s disease in a British population.	2001
Professor Chris Day Julian Leathart Professor Ann Daly Dr Mark Hudson	Association of single nucleotide polymorphisms in the interleukin-4 gene and interleukin-4 receptor gene with Crohn's disease in a British population	2001
Dr Kaushik Agarwal Professor Ann Daly Julian Leathart Dr Mark Hudson Professor Chris Day et al.	Polymorphisms of immunoregulatory genes: A step towards individually tailored immunosuppression?	2001
Professor Chris Day Julian Leathart Professor Ann Daly	Relationship of polymorphism in CYP2C9 to genetic susceptibility to diclofenac-induced hepatitis	2000
Professor Alan Boddy Emerita Professor Suzanne Cholerton Professor Ann Daly Professor Janice Ellis Julian Leathart et al.	The pharmacogenetics of chemical carcinogenesis	1992