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INT-2 amplification in breast cancer: association with decreased survival and relationship to amplification of C-ERBB-2 and C-MYC

Lookup NU author(s): Diana Levett, Professor Thomas Lennard, Professor Bruce Westley, Dr Felicity May


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Amplification of the int-2 oncogene was measured in a series of breast tumours and related to amplification of the c-myc and c-erbB-2 oncogenes, histopathological features and relapse-free and overall survival. int-2 was amplified in 11%, c-myc in 20% and c-erbB-2 in 27% of the tumours assessed. int-2 amplification was associated with large tumour size (p < 0.05) and reduced relapse-free (p < 0.05) and overall (p < 0.0005) survival. c-myc amplification was associated with poor tumour differentiation (p < 0.05) but had no association with prognosis. c-erbB-2 amplification was associated with low levels of expression of oestrogen receptor mRNA (p < 0.05), poor tumour differentiation (p < 0.05) and shortened relapse-free (p < 0.0001) and overall survival (p < 0.0001). This is the first report of an association between amplification of the int-2 oncogene in breast tumours and a significantly increased risk of death from breast cancer, and suggests that int-2 may be useful for identifying breast-cancer patients having a poor prognosis.

Publication metadata

Author(s): Henry JA, Hennessy C, Levett DL, Lennard TWJ, Westley BR, May FEB

Publication type: Article

Publication status: Unknown

Journal: International Journal of Cancer

Year: 1993

Volume: 53

Issue: 5

Pages: 774-780

Print publication date: 01/03/1993

ISSN (print): 0020-7136

ISSN (electronic): 1097-0215


DOI: 10.1002/ijc.2910530512


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