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Browsing publications by Professor Bruce Westley.

Newcastle AuthorsTitleYearFull text
Dr Felicity May
Professor Bruce Westley
TFF3 is a valuable predictive biomarker of endocrine response in metastatic breast cancer2015
Ahmed Ahmed
Andrew Griffiths
Professor Bruce Westley
Dr Felicity May
TFF3 Is a Normal Breast Epithelial Protein and Is Associated with Differentiated Phenotype in Early Breast Cancer but Predisposes to Invasion and Metastasis in Advanced Disease2012
Dr Zoe Davison
Dr Gail De Blaquiere
Professor Bruce Westley
Dr Felicity May
Insulin-like Growth Factor-Dependent Proliferation and Survival of Triple-Negative Breast Cancer Cells: Implications for Therapy2011
Dr Felicity May
Professor Bruce Westley
Trefoil Factor 1 Stimulates Both Pancreatic Cancer and Stellate Cells and Increases Metastasis2011
Paul Wright
Dr Felicity May
Dr Steven Darby
Rehan Saif
Professor Thomas Lennard
et al.
Estrogen regulates vesicle trafficking gene expression in EFF-3, EFM-19 and MCF-7 breast cancer cells2009
Dr Gail De Blaquiere
Dr Felicity May
Professor Bruce Westley
Increased expression of both insulin receptor substrates 1 and 2 confers increased sensitivity to IGF-1 stimulated cell migration2009
Dr Felicity May
Professor Michael Griffin
Professor Bruce Westley
The trefoil factor interacting protein TFIZ1 binds the trefoil protein TFF1 preferentially in normal gastric mucosal cells but the co-expression of these proteins is deregulated in gastric cancer2009
Dr Felicity May
Professor Bruce Westley
Helicobacter pylori Lipopolysaccharide Interacts With TFF1 in a pH-Dependent Manner2008
Professor Bruce Westley
Dr Felicity May
Decreased expression of gastrokine 1 and the trefoil factor interacting protein TFIZ1/GKN2 in gastric cancer: Influence of tumor histology and relationship to prognosis2008
Dr Felicity May
Professor Bruce Westley
Increased TFF1 trefoil protein expression in Opisthorchis viverrini-associated cholangiocarcinoma is important for invasive promotion2007
Dr Felicity May
Professor Bruce Westley
Rough-form lipopolysaccharide of Helicobacter pylori promotes adhesion to trefoil protein TFF1 - a pH regulated interaction2007
Professor Julia Newton
Professor Bruce Westley
Dr Felicity May
Human pancreatic polypeptide has a marked diurnal rhythm that is affected by ageing and is associated with the gastric TFF2 circadian rhythm2006
Professor Bruce Westley
Dr Felicity May
Identification of steroid hormone-regulated genes in breast cancer2006
Dr Gail De Blaquiere
Dr Felicity May
Professor Bruce Westley
Insulin-like growth factor signalling in oestrogen nonresponsive breast cancer cells2006
Professor Bruce Westley
Dr Felicity May
Identification of human urinary trefoil factor 1 as a novel calcium oxalate crystal growth inhibitor2005
Paul Wright
Dr Felicity May
Professor Bruce Westley
Professor Thomas Lennard
Identification of oestrogen-regulated genes in breast cancer using DNA microarrays2005
Paul Wright
Dr Felicity May
Professor Bruce Westley
Professor Thomas Lennard
Identification of oestrogen-regulated genes in breast cancer using DNA microarrays2005
Professor Bruce Westley
Professor Michael Griffin
Dr Felicity May
Interaction between TFF1, a gastric tumor suppressor trefoil protein, and TFIZ1, a brichos domain-containing protein with homology to SP-C2005
Dr Emma Johns
Professor Julia Newton
Professor Bruce Westley
Dr Felicity May
The diurnal rhythm of the cytoprotective human trefoil protein TFF2 is reduced by factors associated with gastric mucosal damage: Ageing, Helicobacter pylori Infection, and sleep deprivation2005
Professor Bruce Westley
Dr Felicity May
Trefoil factor family mRNA and protein expression in pterygium2005
Dr Emma Johns
Professor Julia Newton
Professor Bruce Westley
Dr Felicity May
Ageing and H pylori infection alter the diurnal rhythm of the gastric cytoprotective trefoil protein TFF22004
Dr Meiyi Pu
Dr Felicity May
Dr Marie-Helene Ruchaud
Professor Bruce Westley
Development of a two-site ELISA assay for the dimeric form of human TFF12004
Dr Felicity May
Dr Sara Prest
Professor Bruce Westley
Expression and motogenic activity of TFF2 in human breast cancer cells2004
Dr Felicity May
Professor Bruce Westley
Helicobacter pylori interacts with the human single-domain trefoil protein TFF12004
Dr Meiyi Pu
Professor Bruce Westley
Dr Felicity May
Synergistic effects of systemic trefoil factor family 1 (TFF1) peptide and epidermal growth factor in a rat model of colitis2004
Dr Marie-Helene Ruchaud
Professor Bruce Westley
Dr Felicity May
The trefoil protein TFF1 is bound to MUC5AC in human gastric mucosa2004
Dr Felicity May
Professor Bruce Westley
Trefoil factor family peptide 3 prevents the development and promotes healing of ischemia-reperfusion injury in weanling rats2004
Dr Emma Johns
Professor Julia Newton
Professor Bruce Westley
Dr Felicity May
Expression of the cytoprotective trefoil protein TFF2 in human gastric and duodenal biopsies2003
Professor Bruce Westley
Dr Felicity May
Selective abrogation of the proinvasive activity of the trefoil peptides pS2 and spasmolytic polypeptide by disruption of the EGF receptor signaling pathways in kidney and colonic cancer cells2003
Dr Felicity May
Professor Bruce Westley
Solution Structure of the Disulfide-Linked Dimer of Human Intestinal Trefoil Factor (TFF3): The Intermolecular Orientation and Interactions Are Markedly Different from Those of Other Dimeric Trefoil Proteins2003
Dr Felicity May
Dr Stephen Church
Professor Bruce Westley
The closely related estrogen-regulated trefoil proteins TFF1 and TFF3 have markedly different hydrodynamic properties, overall charge, and distribution of surface charge2003
Professor Bruce Westley
Dr Felicity May
Trefoil peptides as proangiogenic factors in vivo and in vitro: Implication of cyclooxygenase-2 and EGF receptor signaling2003
Dr Sara Prest
Dr Felicity May
Professor Bruce Westley
The estrogen-regulated protein, TFF1, stimulates migration of human breast cancer cells2002
Professor Bruce Westley
Dr Felicity May
Activation of cellular invasion by trefoil peptides and src is mediated by cyclooxygenase- and thromboxane A2 receptor-dependent signaling pathways2001
Professor Julia Newton
Professor Bruce Westley
Dr Felicity May
Dramatic diurnal variation in the concentration of the human trefoil peptide TFF2 in gastric juice2001
Moira Crosier
Dr Debbie Scott
Dr Felicity May
Professor Bruce Westley
High expression of the trefoil protein TFF1 in interval breast cancers2001
Dr Felicity May
Professor Bruce Westley
Induction of scattering and cellular invasion by trefoil peptides in src- and RhoA-transformed kidney and colonic epithelial cells2001
Professor Bruce Westley
Dr Felicity May
The solution structure of the disulphide-linked homodimer of the human trefoil protein TFF12001
Dr Felicity May
Professor Bruce Westley
Insulin receptor substrate-1 expression is regulated by estrogen in the MCF-7 human breast cancer cell line2000
Professor Julia Newton
Professor Bruce Westley
Dr Felicity May
The human trefoil peptide, TFF1, is present in different molecular forms that are intimately associated with mucus in normal stomach2000
Professor Bruce Westley
Dr Felicity May
High-resolution solution structure of human pNR-2/pS2: A single trefoil motif protein1997
Professor Debra Bevitt
Professor Geoff Toms
Professor Thomas Lennard
Professor Bruce Westley
Dr Brian Angus
et al.
New monoclonal antibodies to oestrogen and progesterone receptors effective for paraffin section immunohistochemistry1997
Dr Mary Carr
Dr Felicity May
Professor Thomas Lennard
Professor Bruce Westley

Determination of estrogen responsiveness of breast cancer by competitive reverse transcription polymerase chain reaction

1995
Professor Bruce Westley
Dr Felicity May

Insulin like growth factors: the unrecognised oncogenes

1995
Professor Bruce Westley
Dr Felicity May

In-vitro development of tamoxifen resistance

1995
Dr Felicity May
Professor Bruce Westley

Mutations at position-11 and postition-60 of insulin like growth factor 1 reveal differences between its interactions with the type-I insulin like growth factor receptor and insulin receptor

1995
Dr Felicity May
Professor Bruce Westley

Production and comparison of mature single domain trefoil peptides PNR-2/PS2 CYS(58) and PNR-2/PS2 SER(58)

1995
Dr Felicity May
Professor Bruce Westley

Mitogenic activity of procathepsin-D purified from conditioned medium of breast cancer cells by affinity chromatography on pepstatinyl agarose

1994
Professor Bruce Westley
Dr Felicity May

Role of insulin like growth factors in steroid modulated proliferation

1994
Diana Levett
Professor Thomas Lennard
Professor Bruce Westley
Dr Felicity May

INT-2 amplification in breast cancer: association with decreased survival and relationship to amplification of C-ERBB-2 and C-MYC

1993
Professor Bruce Westley
Dr Felicity May

Isolation and characterization of an estrogen responsice breast cancer cell line, EFF-3

1993
Dr Felicity May
Dave Smith
Professor Bruce Westley

The human cathepsin d-encoding is transcribed from an estrogen regulated and a constitutive start point

1993
Dr Felicity May
Professor Bruce Westley

Type-I IGF receptor and acquired tamoxifen resistance in estrogen responsive human breast cancer cells

1993
Professor Bruce Westley
Dr Felicity May

Modulation of the proliferative response of breast cancer cells to growth factors by estrogen

1992
Dr Mark Bennett
Diana Levett
Dr Felicity May
Professor Bruce Westley

Expresison of the PNR-2 PS2 protein in diverse human epithelial tumors

1991
Dr Felicity May
Professor Bruce Westley
Dr Brian Angus
Professor Thomas Lennard

Expression of antimetastatic gene NM23

1991
Dr Felicity May
Professor Bruce Westley
Dr Brian Angus
Professor Thomas Lennard

Expression of the antimetastatic gene NM23 in human breast cancer: an association with good prognosis

1991
Dr Ujjal Mallick
Professor Bruce Westley
Dr Felicity May

PNR-2 PS2 immunohistochemical staining in breast cancer: correlation with prognostic factors and endocrine response

1991
Dr Brian Angus
Diana Levett
Dr Sarah Johnson
Professor Thomas Lennard
Dr Felicity May
et al.

The prognostic significance of the lysosomal protease cathepsin-D in human breast cancer - an immunohistochemical study

1991
Dr Felicity May
Professor Bruce Westley
Antipeptide antibodies against the PNR-2-estrogen regulated protein of human breast cancer cells and detection of PNR-2 expression in norman tissue by immunohistochemistry1991
Dr Brian Angus
Professor Bruce Westley
Dr Felicity May
Prognostic significance of the estrogen-regulated protein, cathepsin D, in breast cancer. An immunohistochemical study.
1990
Professor Thomas Lennard
Dr Felicity May
Professor Bruce Westley

Expression of the estrogen regulated PNR-2 messenger RNA in human breast cancer: relation to estrogen receptor messenger RNA levels and response to tamoxifen therapy

1990
Dr Mark Bennett
Dr Felicity May
Professor Bruce Westley

Expression of the PNR-2/PS2 in nonmammary human cancer: an immunohistochemical study

1990
Dr Ian Corbett
Dr Brian Angus
Dr Felicity May
Professor Bruce Westley

NCL-CB11 anto c-erbb-2 monoclonal antibody characterization and correlation with gene amplification

1990
Dr Ian Corbett
Dr Brian Angus
Dr Felicity May
Professor Bruce Westley

NCL-CB11, a new monoclonal antibody recognizing the internal domain of the c-erbb-2 oncogene protein effective for use on formalin fixed, paraffin embedded tissue

1990
Dr Felicity May
Professor Bruce Westley

Role of insulin like growth factors and the type I insulin like growth factor receptor in the estrogen stimulated proliferation of human breast cancer cells

1990
Dr Felicity May
Professor Bruce Westley
Dr Brian Angus
Professor Thomas Lennard

The antimetastatic gene NM23: its expression in human breast cancers

1990
Professor Bruce Westley
Dr Felicity May

Effects of estrogen and the antioestrogens, tamoxifen and LY117018, on 4 estrogen regulated RNAs in the EFM-19 breast cancer cell line

1989
Professor Bruce Westley
Dr Felicity May

Estrogenic activity of tamoxifen and its metabolites on gene regulation and cell proliferation in MCF-7 breast cancer cells

1989
Dr Felicity May
Professor Bruce Westley

Regulation of progesterone receptor messenger RNA by estradiol and antioestrogens in breast cancer cell lines

1989
Dr Felicity May
Professor Bruce Westley
Characterization of sequences related to the mouse mammary tumor virus that are specific to MCF-7 breast cancer cells1989
Dr Felicity May
Professor Bruce Westley
Effects of the antiestrogen, ICI-164,384 on estrogen enduced RNAS in MCF-7 cells1989
Dr Felicity May
Professor Bruce Westley

Effects of the antioestrogen ICI-164,384 on estrogen induced RNAs in MCF-7 cells

1988
Professor Bruce Westley
Dr Felicity May

Estimation of estrogen receptor messenger RNA levels in human breast tumors

1988
Professor Bruce Westley
Dr Felicity May

Estrogen regulates estrogen receptor messenger RNA levels in an estrogen responsive human breast cancer cell line

1988
Dr Felicity May
Professor Bruce Westley

Expression of estrogen regulated PNR-2 messenger RNA in human breast cancer

1988
Dr Felicity May
Professor Bruce Westley

Expression of human sequences related to those of mouse mammary tumor virus

1988
Dr Felicity May
Professor Bruce Westley

Identification and characterization of estrogen regulated RNAs in human breast cancer cells

1988
Professor Bruce Westley
Dr Felicity May

Measurement of estrogen receptor messenger RNA levels in human breast tumors

1988
Professor Bruce Westley
Dr Felicity May

The effect of the antiestrogen tamoxifen and its metabolites on the expression of estrogen regulated genes in human breast cancer cells

1987
Professor Bruce Westley
Dr Felicity May

The expression of human DNA sequences related to mouse mammary tumor virus

1987
Dr Felicity May
Professor Bruce Westley
Effects of tamoxifen and 4-hydroxytamoxifen on the PNR-1 and PNR-2 estrogen regulated RNAs in human breast cancer cells1987
Professor Bruce Westley
Dr Felicity May
Estrogen regulates cathepsin-D messenger RNA levels in edtrogen responsive human breast cancer cells1987
Dr Felicity May
Professor Bruce Westley

Structure of a human retroviral sequence related to mouse mammary tumor virus

1986
Dr Felicity May
Professor Bruce Westley
Cloning of estrogen regulated messenger RNA sequences from human breast cancer cells1986