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Concentration-dependent effects of 9-cis retinoic acid on neuroblastoma differentiation and proliferation in vitro

Lookup NU author(s): Professor Penny Lovat, Professor Andrew Pearson, Professor Archibald Malcolm, Dr Chris RedfernORCiD


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The observation that neuroblastoma cells differentiate in response to retinoic acid (RA) in vitro has led to clinical trials using either 13-cis or all-trans RA. Since 9-cis RA may also have important biological functions, we have compared the potential of RA isomers to induce differentiation and inhibit cell proliferation of SH SY 5Y neuroblastoma cells. 9-cis RA at high concentrations is better at inducing morphological differentiation than either all-trans or 13-cis RA and as effective at inhibiting proliferation. Hence, 9-cis RA or stable analogues may have important therapeutic potential in the treatment of neuroblastoma.

Publication metadata

Author(s): Lovat PE, Lowis SP, Pearson ADJ, Malcolm AJ, Redfern CPF

Publication type: Article

Publication status: Published

Journal: Neuroscience Letters

Year: 1994

Volume: 182

Issue: 1

Pages: 29-32

Print publication date: 01/11/1994

ISSN (print): 0304-3940

ISSN (electronic): 1872-7972


DOI: 10.1016/0304-3940(94)90197-X


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