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Lookup NU author(s): Professor Penny Lovat,
Dr Chris RedfernORCiD,
Professor Andrew Pearson
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Background and Procedure. The CD95/ CD95 ligand (CD95L) system is a key regulator of apoptosis. To evaluate a possible role of the CD95/CD95L system in human neuroblastoma (NB) cells, we investigated the constitutive and interferon gamma (INF gamma)-induced expression of CD95 and CD95L, and CD95-mediated cell death in the SK-N-BE(2) cell line. Results. Modulation of CD95/CD95L expression and triggering of an autocrine apoptotic mechanism by IFN gamma suggest a potential role for INF gamma as a therapeutic agent for NE. Conclusions. The evidence that retinoids induce apoptosis via tissue transglutaminase (tTC) and that N-methyl-D-aspartate (NMDA) and gp120 act through the nitric oxide synthase (NOS) activation pathway, indicates the existence of different molecular mechanisms of action, whose pharmacological exploitation might be used in an additive fashion. Med. Pediatr. Oncol. 36:115-117, 2001. (C) 2001 Wiley-Liss, inc.
Author(s): Annicchiarico-Petruzzelli, M., Bernassola, F., Lovat, P.E., Redfern, C.P.F., Pearson, A.D.J., Melino, G.
Publication type: Article
Publication status: Unknown
Journal: Medical and Pediatric Oncology
ISSN (print): 1545-5009
ISSN (electronic): 1545-5017
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