Toggle Main Menu Toggle Search

Open Access padlockePrints

Regulation of glycogen synthesis in human muscle cells

Lookup NU author(s): Emeritus Professor Steve Yeaman, Dr Jane Renwick, Dr Sylvie Bonavaud, Darren Poinasamy, Dr Laura Rush, Dr Reza Halse


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Glucose uptake into muscle and its subsequent storage as glycogen is a crucial factor in energy homeostasis in skeletal muscle. This process is stimulated acutely by insulin and is impaired in both insulin-resistant states and in type 2 diabetes mellitus. A signalling pathway involving protein kinase B and glycogen synthase kinase 3 seems certain to have a key role in stimulating glycogen synthesis but other signalling pathways also contribute, including a rapamycin-sensitive pathway stimulated by amino acids. Although glycogen synthesis is one of the classical insulin-regulated pathways, it is also regulated in an insulin-independent manner; for example glycogen synthesis in muscle is stimulated significantly after strenuous exercise, with much of this stimulation being independent of the involvement of insulin. Evidence suggests that glucose and the glycogen content of the muscle have a key role in this stimulation but the molecular mechanism has vet to be fully explained.

Publication metadata

Author(s): Yeaman SJ, Armstrong JL, Bonavaud SM, Poinasamy D, Pickersgill L, Halse R

Publication type: Article

Publication status: Published

Journal: Biochemical Society Transactions

Year: 2001

Volume: 29

Issue: part 4

Pages: 537-541

ISSN (print): 0300-5127

ISSN (electronic): 1470-8752

Publisher: Portland Press Ltd.


DOI: 10.1042/BST0290537

PubMed id: 11498024


Altmetrics provided by Altmetric