Browse by author
c-MYC gene abnormalities in high grade and centroblastic-centrocytic Non-Hodgkins Lymphoma
Lookup NU author(s): Dr Mark Levasseur, Dr Peter Middleton, Dr Brian Angus, Professor Stephen Proctor, Jean Norden
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
Fifty nine cases of high grade and centroblastic-centrocytic (cc) Non Hodgkins Lymphoma (NHL) were investigated for mutations and gross gene rearrangements in the 5' region of the c-MYC gene. Mutations in this region, and the presence of hypermutated c-MYC genes, have been associated with poor prognostic groups. All cases showed normal c-MYC gene organisation on Southern blot analysis indicating absence of gross gene rearrangements, PCR amplification and restriction digest analysis of the exon 1/intron 1 region revealed point mutations in 7 cases. No evidence for hypermutation was found. Mutations were relatively more common in high grade NHL (6/39) than in cc-NHL (1/20). There was no correlation with disease status at presentation or relapse or the presence of extranodal disease. The cc-NHL case with a c-MYC mutation subsequently transformed to high grade disease. These data suggest that hypermutation of the c-MYC gene is a relatively rare event in cc-NHL and high grade NHL and does not contribute to the aetiology in the majority of cases. Mutation of c-MYC in cc-NHL may predict transformation to high grade disease.
Author(s): Levasseur, M., Middleton, P. G., Angus, B., Proctor, S. J., Norden, J., Howard, M. R.
Publication type: Article
Publication status: Published
Journal: Leukemia and Lymphoma
Year: 1995
Volume: 18
Issue: 1 & 2
Pages: 131-136
Print publication date: 01/06/1995
ISSN (print): 1042-8194
ISSN (electronic): 1026-8022
URL: http://dx.doi.org/10.3109/10428199509064933
DOI: 10.3109/10428199509064933
Altmetrics provided by Altmetric
