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c-MYC gene abnormalities in high grade and centroblastic-centrocytic Non-Hodgkins Lymphoma

Lookup NU author(s): Dr Mark Levasseur, Dr Peter Middleton, Dr Brian Angus, Professor Stephen Proctor, Jean Norden


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Fifty nine cases of high grade and centroblastic-centrocytic (cc) Non Hodgkins Lymphoma (NHL) were investigated for mutations and gross gene rearrangements in the 5' region of the c-MYC gene. Mutations in this region, and the presence of hypermutated c-MYC genes, have been associated with poor prognostic groups. All cases showed normal c-MYC gene organisation on Southern blot analysis indicating absence of gross gene rearrangements, PCR amplification and restriction digest analysis of the exon 1/intron 1 region revealed point mutations in 7 cases. No evidence for hypermutation was found. Mutations were relatively more common in high grade NHL (6/39) than in cc-NHL (1/20). There was no correlation with disease status at presentation or relapse or the presence of extranodal disease. The cc-NHL case with a c-MYC mutation subsequently transformed to high grade disease. These data suggest that hypermutation of the c-MYC gene is a relatively rare event in cc-NHL and high grade NHL and does not contribute to the aetiology in the majority of cases. Mutation of c-MYC in cc-NHL may predict transformation to high grade disease.

Publication metadata

Author(s): Levasseur, M., Middleton, P. G., Angus, B., Proctor, S. J., Norden, J., Howard, M. R.

Publication type: Article

Publication status: Published

Journal: Leukemia and Lymphoma

Year: 1995

Volume: 18

Issue: 1 & 2

Pages: 131-136

Print publication date: 01/06/1995

ISSN (print): 1042-8194

ISSN (electronic): 1026-8022


DOI: 10.3109/10428199509064933


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