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Protein-protein interaction between the transcriptional repressor E4BP4 and the TBP-binding protein Dr1

Lookup NU author(s): Dr Ian Cowell


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We have previously mapped a repression domain from the active transcriptional repressor E4BP4 to a 65 amino acid segment near the C-terminus of the polypeptide. Here we show that the E4BP4 repression domain interacts specifically with the TBP binding repressor protein Drl. Mutants that affect the ability of E4BP4 to bring about transcriptional repression are also deficient in their binding of Drl. The results are discussed in the light of evidence for squelching of a 'global' repressor by a DNA binding defective E4BP4 mutant.

Publication metadata

Author(s): Cowell IG, Hurst HC

Publication type: Article

Publication status: Published

Journal: Nucleic Acids Research

Year: 1996

Volume: 24

Issue: 18

Pages: 3607-3613

Print publication date: 01/09/1996

ISSN (print): 0305-1048

ISSN (electronic): 1362-4962

Publisher: Oxford University Press


DOI: 10.1093/nar/24.18.3607


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