Publications by Dr Ian Cowell - ePrints

Browsing publications by Dr Ian Cowell.

Newcastle Authors	Title	Year
Dr Ian Cowell Professor Caroline Austin	Myeloperoxidase inhibition protects bone marrow mononuclear cells from DNA damage induced by the TOP2 poison anti-cancer drug etoposide	2024
Dr Ian Cowell Professor Caroline Austin	DNA fragility at the KMT2A/MLL locus: insights from old and new technologies	2023
Dr Ian Cowell John Casement Professor Caroline Austin	To Break or Not to Break: The Role of TOP2B in Transcription	2023
Elise Ling Dr Arnaud Basle Dr Ian Cowell Professor Bert van den Berg Professor Caroline Austin et al.	A comprehensive structural analysis of the ATPase domain of Human DNA topoisomerase II Beta bound to AMPPNP, ADP and the bisdioxopiperazine, ICRF193	2022
Dr Ian Cowell Professor Caroline Austin	Disease-associated Mutations in Topoisomerase IIβ Result in Defective NK cells	2022
Rebecca Swan Dr Ian Cowell Professor Caroline Austin	Mechanisms to Repair Stalled Topoisomerase II-DNA Covalent Complexes	2022
Mushtaq Khazeem John Casement Dr Niall Kenneth Jade McGow Dr Ian Cowell et al.	TOP2B Is Required to Maintain the Adrenergic Neural Phenotype and for ATRA‑Induced Differentiation of SH‑SY5Y Neuroblastoma Cells	2022
Dr Katja Menger Dr James Chapman Mushtaq Khazeem Dr Dasha Deen John Casement et al.	Two type I topoisomerases maintain DNA topology in human mitochondria	2022
Rebecca Swan Dr Ian Cowell Professor Caroline Austin	A role for VCP/p97 in the processing of drug-stabilized TOP2-DNA covalent complexes	2021
Professor Caroline Austin Dr Ian Cowell Mushtaq Khazeem Dawn Lok Huei Teng Ng et al.	TOP2B’s contributions to transcription	2021
Rebecca Swan Luke Poh Dr Ian Cowell Professor Caroline Austin	Small molecule inhibitors confirm ubiquitin-dependent removal of TOP2-DNA covalent complexes	2020
Mushtaq Khazeem Dr Ian Cowell Lauren Harkin John Casement Professor Caroline Austin et al.	Transcription of carbonyl reductase 1 is regulated by DNA topoisomerase II beta	2020
Dr Mandeep Atwal Rebecca Swan Ka Lee Dr David Lee Professor Lyle Armstrong et al.	Intercalating TOP2 poisons attenuate topoisomerase action at higher concentrations	2019
Dr Ian Cowell Professor Caroline Austin	Mutations in topoisomerase IIβ result in a B cell immunodeficiency	2019
Dr Ian Cowell Elise Ling Becky Swan Professor Caroline Austin	The Deubiquitinating Enzyme Inhibitor PR-619 is a Potent DNA Topoisomerase II Poison s	2019
Becky Swan Dr Zbyslaw Sondka Dr Ian Cowell Professor Caroline Austin	Effect of TDP2 on the level of TOP2-DNA complexes and SUMOylated TOP2-DNA complexes	2018
Professor Caroline Austin Ka Lee Becky Swan Mushtaq Khazeem Catriona Manville et al.	TOP2B: The first thirty years	2018
Dr Ian Cowell Professor Caroline Austin	Topoisomerase II chromatin immunoprecipitation	2018
Dr Ian Cowell Professor Caroline Austin	Visualization and quantification of topoisomerase–DNA covalent complexes using the trapped in agarose immunostaining (TARDIS) assay	2018
Dr Mandeep Atwal Emma Lishman-Walker Professor Caroline Austin Dr Ian Cowell	Myeloperoxidase Enhances Etoposide and Mitoxantrone-Mediated DNA Damage: A Target for Myeloprotection in Cancer Chemotherapy	2017
Ka Lee Becky Swan Dr Ian Cowell Professor Graham Jackson Professor Caroline Austin et al.	Proteasomal inhibition potentiates drugs targeting DNA topoisomerase II	2016
Dr Ian Cowell Professor Caroline Austin	Brief Reports: Controlling the Survival of Human Pluripotent Stem Cells by Small Molecule-Based Targeting of Topoisomerase II Alpha	2015
Catriona Manville Kayleigh Smith Dr Zbyslaw Sondka Holly Rance Dr Ian Cowell et al.	Genome-wide ChIP-seq analysis of human TOP2B occupancy in MCF7 breast cancer epithelial cells	2015
Andy Best Caroline Dalgliesh Elaine Hong Mahsa Kheirollahi Kouhestani Dr Yaobo Xu et al.	Human Tra2 proteins jointly control a CHEK1 splicing switch among alternative and constitutive target exons	2014
Kayleigh Smith Dr Ian Cowell Dr Zbyslaw Sondka Professor Caroline Austin	The role of topoisomerase II beta on breakage and proximity of RUNX1 to partner alleles RUNX1T1 and EVI1	2014
Dr Ian Cowell Professor Caroline Austin	Do transcription factories and TOP2B provide a recipe for chromosome translocations in therapy-related leukemia?	2012
Dr Ian Cowell Professor Caroline Austin	Mechanism of Generation of Therapy Related Leukemia in Response to Anti-Topoisomerase II Agents	2012
Dr Ian Cowell Dr Zbyslaw Sondka Kayleigh Smith Ka Lee Catriona Manville et al.	Model for MLL translocations in therapy-related leukemia involving topoisomerase IIβ-mediated DNA strand breaks and gene proximity	2012
Dr Kay Padget Hannah Curtis Dr Ian Cowell Dr Zbyslaw Sondka Dr Nick Morris et al.	MRE11 facilitates the removal of human topoisomerase II complexes from genomic DNA	2012
Dr Ian Cowell Dr Michael Tilby Professor Caroline Austin	An overview of the visualisation and quantitation of low and high MW DNA adducts using the trapped in agarose DNA immunostaining (TARDIS) assay	2011
Dr Ian Cowell Dr Nikolaos Papageorgiou Dr Kay Padget Professor Caroline Austin	Histone deacetylase inhibition redistributes topoisomerase IIβ from heterochromatin to euchromatin	2011
Dr Nicola Sunter Dr Ian Cowell Dr Elaine Willmore Gary Watters Professor Caroline Austin et al.	Role of Topoisomerase IIbeta in DNA Damage Response following IR and Etoposide	2010
Professor Caroline Austin Dr Ian Cowell Dr Michael Tilby	Visualisation and quantitation of DNA adducts using the Trapped in Agarose DNA immunostaining (TARDIS) assay	2010
Dr Elaine Willmore Dr sarah Johnson Dr Tryfonia Mainou-Fowler Professor Graham Jackson Dr Celine Cano et al.	DNA-dependent protein kinase is a therapeutic target and an indicator of poor prognosis in B-cell chronic lymphocytic leukemia	2008
Dr Ian Cowell Professor Caroline Austin	NK314, a Topoisomerase II inhibitor that specifically targets the α isoform	2008
Dr Ian Cowell Dr Nicola Sunter Professor Caroline Austin Professor barbara Durkacz Dr Michael Tilby et al.	γH2AX foci form preferentially in euchromatin after ionising-radiation	2007
Dr Yan Zhao Huw Thomas Michael Batey Dr Ian Cowell Professor Roger Griffin et al.	Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441	2006
Dr Ian Cowell Professor barbara Durkacz Dr Michael Tilby	Sensitization of breast carcinoma cells to ionizing radiation by small molecule inhibitors of DNA-dependent protein kinase and ataxia telangiectsia mutated	2005
Dr Ian Cowell	Composite cis-acting epigenetic switches in eukaryotes: lessons from Drosophila Fab-7 for the Igf2-H19 imprinted domain	2003
Dr Ian Cowell	E4BP4/NFIL3, a PAR-related bZIP factor with many roles	2002
Dr Ian Cowell Heather Morrison	Heterochromatin, HP1 and methylation at lysine 9 of histone H3 in animals	2002
Dr Ian Cowell	Loss of Heterochromatin Protein 1 (HP1) chromodomain function in mammalian cells by intracellular antibodies causes cell death	2002
Dr Ian Cowell	The Ki-67 protein interacts with members of the heterochromatin protein 1 (HP1) family: a potential role in the regulation of higher-order chromatin structure	2002
Dr Ian Cowell	The gene and pseudogenes of Cbx3/mHP1 gamma	2001
Dr G Wang Dr Ian Cowell	Conservation of heterochromatin protein 1 function	2000
Dr Ian Cowell	Dynamic associations of heterochromatin protein 1 with the nuclear envelope	2000
Dr Ian Cowell	Mammalian chromodomain proteins: their role in genome organisation and expression	2000
Dr Ian Cowell	Yeast two-hybrid library screening	2000
Dr Ian Cowell Dr Elaine Willmore Dr David Allen Chalton Professor Caroline Austin	Nuclear distribution of human DNA topoisomerase IIβ: A nuclear targeting signal resides in the 116-residue C-terminal tail	1998
Dr Ian Cowell Professor Caroline Austin	cDNA library protocols	1997
Dr Ian Cowell Professor Caroline Austin	Self-association of chrome domain peptides	1997
Dr Ian Cowell Professor Caroline Austin	Self-association of chromo domain peptides	1997
Dr Ian Cowell	Protein-protein interaction between the transcriptional repressor E4BP4 and the TBP-binding protein Dr1	1996
Dr Ian Cowell	Cloning DNA binding proteins from cDNA expression libraries using oligonucleotide binding site probes	1994
Dr Ian Cowell	Repression versus activation in the control of gene transcription	1994
Dr Ian Cowell	Transcriptional repression by the human bZIP factor E4BP4: Definition of a minimal repression domain	1994
Dr Ian Cowell	Cloning transcription factors from a cDNA expression library	1993
Dr Ian Cowell	The human mitochondrial NADH: Ubiquinone oxidoreductase 51-kDa subunit maps adjacent to the glutathione S-transferase p1-1 gene on chromosome 11q13	1992
Dr Ian Cowell	Transcriptional repression by a novel member of the bZIP family of transcription factors	1992
Dr Ian Cowell	Glutathione transferase pi its minimal promoter and downstream cis- acting element	1991
Dr Ian Cowell	Control of expression of the human glutathione S-transferase Pi gene differs from its rat homologue	1989
Dr Ian Cowell	The structure of the human glutathione-Pi gene	1988
Dr Ian Cowell	Characterisation of a human genomic sequence homologous to rat GSH transferase subunit 7 cDNA	1987
Dr Ian Cowell	Molecular biology of the glutathione transferases	1986