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Screening for wilms' tumor in patients with aniridia, Beckwith syndrome, or hemihypertrophy

Lookup NU author(s): Emeritus Professor Alan Craft


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The role of screening for early detection of Wilms' tumour (WT) in patients with aniridia (A), Beckwith-Weidemann syndrome (BWS) and hemihypertrophy (HH) has been explored. Of the 1,622 Wilms' tumour patients registered with the National Childhood Cancer Registry from 1971 to 1991, 41 were recorded as having A, BWS or HH. Twenty-eight of these had their anomaly diagnosed before the WT and 13 had screening procedures carried out, mainly abdominal ultrasound. in 8 patients the screening procedure detected the WT. There was no significant difference in stage distribution or outcome for any of the th ree subgroups who were not screened, screen-positive or screen-negative. We conclude that regular screening with abdominal ultrasound is not of proven value. Parents should be taught abdominal palpation and advised to seek appropriate advice for untoward symptoms. (C) 1995 Wiley-Liss, Inc.

Publication metadata

Author(s): Craft, A. W., Parker, L., Stiller, C., Cole, M.

Publication type: Article

Publication status: Published

Journal: Medical and Pediatric Oncology

Year: 1995

Volume: 24

Issue: 4

Pages: 231-234

Print publication date: 01/04/1995

ISSN (print): 0098-1532

ISSN (electronic): 1545-5017


DOI: 10.1002/mpo.2950240404

PubMed id: 7700167


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