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Immunoreactivity of calcium binding protein secretagogin in the human hippocampus is restricted to pyramidal neurons

Lookup NU author(s): Professor Johannes Attems


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Disturbed calcium homeostasis plays a crucial role in the aetiology of Alzheimer's disease (AD) and the aging process. We evaluated immunoreactivity of secretagogin, a recently cloned calcium binding protein, in hippocampus and adjacent entorhinal cortex of 30 neuropathologically examined post mortem brains (m:f=12:18; mean age, 79.8+/-15.1 years). The study group consisted of 15 cases fulfilling the criteria for high probability of AD according to the NIA-Reagan Institute Criteria and 15 cases with no to medium probability. Sections were incubated with secretagogin-specific antibodies and the number of immunoreactive neurons as well as staining intensities in both neurons and neuropil were assessed. Both cellular and neuropil immunoreactivity were restricted to subiculum and Ammons horn. Cellular immunoreactivity was further restricted to pyramidal neurons and showed a hierarchical distribution: the mean percentage of immunoreactive neurons was highest in sector CA3 (64.41%), followed by CA2 (44.09%), CA4 (34.38%), CA1 (10.9%), and the subiculum (2.92%; P0.05), while it did not differ significantly between groups with different degrees of AD pathology. The pattern of secretagogin immunoreactivity resembles that of calcium sensor proteins as it is restricted to a subset of neurons and therefore secretagogin could serve highly specialized tasks in neuronal calcium signalling.

Publication metadata

Author(s): Attems J, Quass M, Gartner W, Nabokikh A, Wagner L, Steurer S, Arbes S, Lintner F, Jellinger K

Publication type: Article

Publication status: Published

Journal: Experimental Gerontology

Year: 2007

Volume: 42

Issue: 3

Pages: 215-222

ISSN (print): 0531-5565

ISSN (electronic): 1873-6815

Publisher: Elsevier Inc.


DOI: 10.1016/j.exger.2006.09.018

Notes: Attems, Johannes Quass, Magdalena Gartner, Wolfgang Nabokikh, Anastasiya Wagner, Ludwig Steurer, Stefan Arbes, Stefanie Lintner, Felix Jellinger, Kurt Research Support, Non-U.S. Gov't England Experimental gerontology Exp Gerontol. 2007 Mar;42(3):215-22. Epub 2006 Nov 20.


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