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Intratumoral IGF-I protein expression is selectively upregulated in breast cancer patients with BRCA1/2 mutations

Lookup NU author(s): Professor Johannes Attems


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BRCA1/2 mutations predispose to early onset breast and ovarian cancers. The phenotypic expression of mutant alleles, however, is thought to be modified by factors that are also involved in the pathogenesis of sporadic breast cancer. One such protein is IGF-I, one of the strongest mitogens to breast cancer cells in vitro. We have utilized immunohistochemistry to compare the intratumoral IGF-I and IGF-I receptor (IGF-IR) protein expression in 57 BRCA1/2 mutation carriers and 102 matched breast cancer patients without a family history in a nested case-control study. BRCA1 silencing by siRNA was used to investigate the effect of BRCA mutations on IGF-I protein expression. IGF-I protein expression was detected in tumoral epithelium and surrounding stroma, and was significantly upregulated in tumors of BRCA mutation carriers when compared with matched sporadic tumors (epithelial: 87.7% vs 61.8%, P=0.001; stromal: 73.7% vs 34.3%, P

Publication metadata

Author(s): Hudelist G, Wagner T, Rosner M, Fink-Retter A, Gschwantler-Kaulich D, Czerwenka K, Kroiss R, Tea M, Pischinger K, Kostler WJ, Attems J, Mueller R, Blaukopf C, Kubista E, Hengstschlager M, Singer CF

Publication type: Article

Publication status: Published

Journal: Endocrine-Related Cancer

Year: 2007

Volume: 14

Issue: 4

Pages: 1053-1062

ISSN (print): 1351-0088

ISSN (electronic): 1479-6821

Publisher: Society for Endocrinology


DOI: 10.1677/ERC-06-0075


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