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Prevalence and impact of cerebrovascular pathology in Alzheimer's disease and parkinsonism

Lookup NU author(s): Professor Johannes Attems


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OBJECTIVE: To study the prevalence and impact of cerebrovascular lesions (CVL) in Alzheimer's disease (AD) and their effects on cognitive impairment. MATERIAL AND METHODS: In study I, the prevalence of vascular lesions in a prospective series of 244 autopsy-proved AD cases (mean age 83.1+/-8.4 years) and 230 age-matched non-demented controls was examined using immunochemistry and current morphological diagnostic criteria. In study II, in 100 consecutive autopsy cases (mean age 84.3+/-9.3 years), the incidence of general and capillary cerebral amyloid angiopathy (CAA, CapCAA) was examined. RESULTS: In study I, AD cases showed significantly more frequent CVL than age-matched controls without differences in the Braak stages, but the severity of CAA was significantly higher in AD brain with associated vascular lesions. In study II, CAA was more frequent in demented than in non-demented patients, but did neither correlate with high-grade AD pathology nor with clinical dementia, whereas CapCAA correlated with both dementia and high Braak stages; the severity of both types of CAA showed only low correlation with each other. CONCLUSIONS: The present data and other studies confirm the importance of CVL in AD and Parkinson's disease without considerable impact on cognitive impairment in progressed stages of AD, and the close association of CapCAA but not of general CAA with clinical dementia and AD pathology.

Publication metadata

Author(s): Jellinger KA, Attems J

Publication type: Article

Publication status: Published

Journal: Acta Neurologica Scandinavica

Year: 2006

Volume: 114

Issue: 1

Pages: 38-46

ISSN (print): 0001-6314

ISSN (electronic): 1600-0404

Publisher: Wiley-Blackwell Publishing, Inc.


DOI: 10.1111/j.1600-0404.2006.00665.x

Notes: Jellinger, K A Attems, J Research Support, Non-U.S. Gov't Denmark Acta neurologica Scandinavica Acta Neurol Scand. 2006 Jul;114(1):38-46.


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