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Alzheimer's disease pathology influences severity and topographical distribution of cerebral amyloid angiopathy

Lookup NU author(s): Professor Johannes Attems


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Cerebral amyloid angiopathy (CAA) is defined by beta-amyloid peptide (Abeta) depositions in cerebral vessels and is associated with Alzheimer's disease (AD). The relationship between sporadic CAA and AD, and the origin of Abeta in CAA are poorly understood. The aim of our study was to investigate the relationship between CAA and AD. Autopsy brains (n=113, 61.1% female, 55.8% clinically demented, age range 54-102 years, mean +/- SE 83.5+/-0.93 years) underwent standardized neuropathological assessment. CAA was evaluated in frontal, frontobasal, hippocampal, and occipital regions. Using immunohistochemistry, the severity of Abeta deposition in vessels was assessed semiquantitatively for each region separately. Evaluation of APOE genotype in 53 cases using real-time PCR showed significant correlations with severe AD pathology and CAA. CAA was present in 77 cases (68.1%), with the occipital region being affected significantly more often and more severely than other regions (P

Publication metadata

Author(s): Attems J, Jellinger KA, Lintner F

Publication type: Article

Publication status: Published

Journal: Acta Neuropathologica

Year: 2005

Volume: 110

Issue: 3

Pages: 222-231

ISSN (print): 0001-6322

ISSN (electronic): 1432-0533

Publisher: Springer


DOI: 10.1007/s00401-005-1064-y

Notes: Attems, Johannes Jellinger, Kurt A Lintner, Felix Research Support, Non-U.S. Gov't Germany Acta neuropathologica Acta Neuropathol. 2005 Sep;110(3):222-31. Epub 2005 Aug 25.


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