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Cerebral amyloid angiopathy in Lewy body disease

Lookup NU author(s): Professor Johannes Attems

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Abstract

While Alzheimer and Lewy body pathologies are discussed as major substrates of dementia in Parkinson's disease (PD/Lewy body disease of brainstem type), the incidence and impact of cerebral amyloid angiopathy (CAA) and its association with cognitive decline in PD and dementia with Lewy bodies (DLB) are unknown. The severity of CAA and other Alzheimer lesions were assessed in 68 cases of autopsy-confirmed PD, 32 of them with dementia (PDD), and in 20 cases of DLB. PDD patients were significantly older than those without dementia (mean age 84.5 vs 77.6 years; p

Publication metadata

Author(s): Jellinger KA, Attems J

Publication type: Article

Publication status: Published

Journal: Journal of Neural Transmission

Year: 2008

Volume: 115

Issue: 3

Pages: 473-482

ISSN (print): 0300-9564

ISSN (electronic): 1435-1463

Publisher: Springer Wien

URL: http://dx.doi.org/10.1007/s00702-007-0856-8

DOI: 10.1007/s00702-007-0856-8

Notes: Jellinger, K A Attems, J Research Support, Non-U.S. Gov't Austria Journal of neural transmission (Vienna, Austria : 1996) J Neural Transm. 2008;115(3):473-82. Epub 2008 Feb 26.

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