Toggle Main Menu Toggle Search

Open Access padlockePrints

Multidrug resistance markers P-glycoprotein, multidrug resistance protein 1, and lung resistance protein in non-small cell lung cancer: prognostic implications

Lookup NU author(s): Professor Johannes Attems


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


PURPOSE: The aim of this retrospective study was to comparatively investigate the expression of the three drug-resistance genes P-glycoprotein (P-gp), multidrug-resistance protein 1 (MRP1), and lung resistance protein (LRP), in non-small cell lung cancer (NSCLC) tissues, and to assess possible associations with clinicopathologic features. METHODS: Tumor specimens from 126 patients were analyzed by immunohistochemistry and, in selected cases, by reverse transcriptase polymerase chain reaction (RT-PCR), and data were statistically analyzed by SPSS. RESULTS: The mean expression levels of tumor tissues in the case of P-gp and LRP did not exceed the one of normal epithelia, while MRP1 was significantly enhanced in NSCLC. A weak association was observed between higher grading and P-glycoprotein expression (p

Publication metadata

Author(s): Berger W, Setinek U, Hollaus P, Zidek T, Steiner E, Elbling L, Cantonati H, Attems J, Gsur A, Micksche M

Publication type: Article

Publication status: Published

Journal: Journal of Cancer Research and Clinical Oncology

Year: 2005

Volume: 131

Issue: 6

Pages: 355-363

ISSN (print): 0171-5216

ISSN (electronic): 1432-1335

Publisher: Springer


DOI: 10.1007/s00432-004-0653-9

Notes: Berger, Walter Setinek, Ulrike Hollaus, Peter Zidek, Thomas Steiner, Elisabeth Elbling, L Cantonati, H Attems, Johannes Gsur, Andrea Micksche, Michael Comparative Study Research Support, Non-U.S. Gov't Germany Journal of cancer research and clinical oncology J Cancer Res Clin Oncol. 2005 Jun;131(6):355-63. Epub 2005 Jan 27.


Altmetrics provided by Altmetric