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Incidence of cerebrovascular lesions in Alzheimer's disease: a postmortem study

Lookup NU author(s): Professor Johannes Attems


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Recent epidemiological and clinico-pathological data suggest overlaps between Alzheimer's disease (AD) and cerebrovascular lesions (CVL) that may show some synergistic effects, but the results of studies of the relationship between AD and stroke have been controversial. The objective of this study was to compare the frequency of cerebral infarcts, hemorrhages and minor cerebrovascular lesions in autopsy-confirmed AD and age-matched control brains. Using current routine and immunohistochemical methods 173 consecutive cases of autopsy-confirmed AD and 130 age-matched controls were compared. The total incidence of vascular pathology (56.5%) in AD was significantly less than in a previously reported smaller AD autopsy cohort (82.3%) (P

Publication metadata

Author(s): Attems J; Jellinger KA

Publication type: Article

Publication status: Published

Journal: Acta Neuropathologica

Year: 2003

Volume: 105

Issue: 1

Pages: 14-17

ISSN (print): 0001-6322

ISSN (electronic): 1432-0533

Publisher: Springer

Notes: Jellinger, Kurt A Attems, Johannes Germany Acta neuropathologica Acta Neuropathol. 2003 Jan;105(1):14-7. Epub 2002 Oct 22.