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Is complement factor H a susceptibility factor for IgA nephropathy?

Lookup NU author(s): Dr Matthew Edey, Dr Lisa Turnbull, Professor Tim Goodship


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There is substantial evidence to suggest that complement activation plays a pivotal role in the pathogenesis of IgA nephropathy. Mesangial 0 deposition is seen in similar to 90% of patients and polymeric IgA has been shown to activate the alternative and lectin pathways. In addition there have been reports of deficiency and mutations in the serum complement regulator factor H (CFH) in association with IgA nephropathy. In this study we have examined the hypothesis that CFH is a susceptibility factor for IgA nephropathy. In 46 IgA nephropathy patients we undertook genotyping of three CFH SNPS (rs3753394, rs3753396 and rs1065489). There was no significant difference in the allele frequency of these 3 SNPs between the patients and normal controls. In the same group of patients we undertook mutation screening of CFH exons 18-23 using direct sequencing and found no abnormalities. All the patients had a normal serum factor H concentration. In this small cohort of IgA nephropathy patients we have not found evidence to support the hypothesis that factor H is a major susceptibility factor for the disease. (C) 2008 Elsevier Ltd. All rights reserved.

Publication metadata

Author(s): Edey M, Strain L, Ward R, Ahmed S, Thomas T, Goodship TH

Publication type: Article

Publication status: Published

Journal: Molecular Immunology

Year: 2009

Volume: 46

Issue: 7

Pages: 1405-1408

ISSN (print): 0161-5890

ISSN (electronic): 1872-9142

Publisher: Pergamon


DOI: 10.1016/j.molimm.2008.12.002


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