Publications by Professor Tim Goodship - ePrints

Browsing publications by Professor Tim Goodship.

Newcastle Authors	Title	Year
Professor Kevin Marchbank Dr Isabel Pappworth Harriet Denton Kate Cooke Grant Richardson et al.	C3 Glomerulopathy and Related Disorders in Children.	2021
Dr Suren Kanagasundaram Dr Simon Baudouin Sarah Rowling Professor John Dark Professor Tim Goodship et al.	Mitochondrial Haplogroup and the Risk of Acute Kidney Injury Following Cardiac Bypass Surgery	2019
Dr Rebecca Darlay Aisling Stewart Dr Yaobo Xu Dr Heather Lambert Dr Mauro Santibanez Koref et al.	Erratum: Publisher Correction: Genome-wide linkage and association study implicates the 10q26 region as a major genetic contributor to primary nonsyndromic vesicoureteric reflux (Scientific reports (2017) 7 1 (14595))	2018
Professor David Kavanagh Dr Valerie Wilson Professor Tim Goodship	Statistical Validation of Rare Complement Variants Provides Insights into the Molecular Basis of Atypical Hemolytic Uremic Syndrome and C3 Glomerulopathy	2018
Professor Tim Goodship	Atypical hemolytic uremic syndrome and C3 glomerulopathy: conclusions from a “Kidney Disease: Improving Global Outcomes” (KDIGO) Controversies Conference	2017
Dr Vicky Brocklebank Dr Sally Johnson Dr Patrick Walsh Dr Edwin Wong Dr Larissa Kerecuk et al.	Factor H autoantibody is associated with atypical hemolytic uremic syndrome in children in the United Kingdom and Ireland	2017
Dr Rebecca Darlay Aisling Stewart Dr Yaobo Xu Dr Mauro Santibanez Koref Professor John Sayer et al.	Genome-wide linkage and association study implicates the 10q26 region as a major genetic contributor to primary nonsyndromic vesicoureteric reflux	2017
Rachel Challis Dr Edwin Wong Dr Vicky Brocklebank Dr Valerie Wilson Professor Kevin Marchbank et al.	Thrombotic Microangiopathy in Inverted Formin 2-Mediated Renal Disease	2017
Rachel Challis Dr Edwin Wong Dr Holly Anderson Dr Valerie Wilson Dr Vicky Brocklebank et al.	A De Novo Deletion in the Regulators of Complement Activation Cluster Producing a Hybrid Complement Factor H/Complement Factor H–Related 3 Gene in Atypical Hemolytic Uremic Syndrome	2016
Professor Neil Sheerin Professor David Kavanagh Professor Tim Goodship Dr Sally Johnson	A national specialised service in England for atypical haemolytic uraemic syndrome – the first year’s experience	2016
Professor Tim Goodship	An unusual case of haemolytic uraemic syndrome following endoscopic retrograde cholangiopancreatography rapidly improved with eculizumab	2016
Dr Valerie Wilson Tom Cox Dr Kate Smith-Jackson Professor David Kavanagh Professor Tim Goodship et al.	Chromosomal rearrangement – a rare cause of complement factor I associated atypical haemolytic uraemic syndrome	2016
Dr Veronique Fremaux-Bacchi Professor Tim Goodship	Database of Complement Gene Variants: A comprehensive database providing insights on function, structure and allele frequency for genetic variants identified in complement-mediated diseases	2016
Professor Tim Goodship Professor Neil Sheerin	Management of Recurrent aHUS After Adult Kidney transplantation Despite Eculizumab Prophylaxis.	2016
Professor Tim Goodship	Prevention of recurrence of atypical hemolytic uremic syndrome post renal transplant with the use of higher-dose eculizumab	2016
Dr Vicky Brocklebank Dr Edwin Wong Professor Kevin Marchbank Professor Tim Goodship Professor David Kavanagh et al.	The role of ADAMTS-13 activity and complement mutational analysis in differentiating acute thrombotic microangiopathies	2016
Dr Veronique Fremaux-Bacchi Professor Tim Goodship Professor David Kavanagh	Atypical aHUS: State of the art	2015
Rachael Horbury Dr Karim Bennaceur Catriona Barker Professor David Kavanagh Professor Tim Goodship et al.	Autoantibodies to CD59, CD55, CD46 or CD35 are not associated with atypical haemolytic uraemic syndrome (aHUS)	2015
Professor Tim Goodship	Case Report: Benefits and Challenges of Long-term Eculizumab in Atypical Hemolytic Uremic Syndrome	2015
Dr Edwin Wong Dr Vicky Brocklebank Professor Tim Goodship Professor David Kavanagh Dr Anna Richards et al.	Characterisation of a C3 Mutation with Increased Resistance to Complement Regulation in an Individual with Recurrent C3GN in a Renel Transplant	2015
Professor Tim Goodship Professor Neil Sheerin	Efficacy and safety of eculizumab in atypical hemolytic uremic syndrome from 2-year extensions of phase 2 studies	2015
Dr Valerie Wilson Professor Tim Goodship Dr Veronique Fremaux-Bacchi	Mapping interactions between complement C3 and regulators using mutations in atypical hemolytic uremic syndrome	2015
Professor Judith Goodship Professor Tim Goodship	Mutations in TBX18 Cause Dominant Urinary Tract Malformations via Transcriptional Dysregulation of Ureter Development	2015
Dr Edwin Wong Rachel Challis Professor Neil Sheerin Dr Sally Johnson Professor David Kavanagh et al.	Patient stratification and therapy in atypical haemolytic uraemic syndrome (aHUS)	2015
Dr Mustafa Sevinc Dr Vicky Brocklebank Professor Tim Goodship Professor David Kavanagh	Plasma resistant atypical hemolytic uremic syndrome associated with a CFH mutation treated with eculizumab: A case report	2015
Dr Edwin Wong Dr Isabel Pappworth Professor Claire Harris Professor Tim Goodship Dr Sally Johnson et al.	The national study of membranoproliferative glomerulonephrtis and C3 glomerulopathy - characterisation of the paediatric cohort	2015
Professor Tim Goodship Dr Sally Johnson Dr Veronique Fremaux-Bacchi	The role of complement in C3 glomerulopathy	2015
Professor Tim Goodship Dr Alison Brown Professor Neil Sheerin	Thrombotic microangiopathy as a cause of chronic kidney transplant dysfunction: a case report demonstrating successful treatment with Eculizumab	2015
Professor Judith Goodship Professor Tim Goodship Dr Heather Lambert Professor Heather Cordell	Urinary Tract Effects of HPSE2 Mutations	2015
Professor Tim Goodship	Use of eculizumab in crescentic IgA nephropathy: Proof of principle and conundrum?	2015
Professor Tim Goodship Professor Kevin Marchbank	A novel method for direct measurement of complement convertases activity in human serum	2014
Professor Tim Goodship Professor Kevin Marchbank	A novel method for direct measurement of complement convertases activity in human serum	2014
Dr Vicky Brocklebank Dr Edwin Wong Professor Tim Goodship Professor David Kavanagh	Atypical haemolytic uraemic syndrome associated with a CD46 mutation triggered by Shigella flexneri	2014
Catriona Barker Professor David Kavanagh Professor Tim Goodship Dr Isabel Pappworth	Autoantibodies to CD59, CD55, CD46 and CD35 are not associated with aHUS	2014
Dr Edwin Wong Dr Holly Anderson Rachel Challis Dr Lisa Turnbull Gladys - et al.	Characterization of a Factor H Mutation That Perturbs the Alternative Pathway of Complement in a Family with Membranoproliferative GN	2014
Professor Tim Goodship	Complement factor H-related hybrid protein deregulates complement in dense deposit disease	2014
Professor Heather Cordell Dr Valerie Wilson Professor Judith Goodship Professor Tim Goodship	Factors determining penetrance in familial atypical haemolytic uraemic syndrome	2014
Professor Tim Goodship	How I treat thrombotic thrombocytopenic purpura and atypical haemolytic uraemic syndrome	2014
Professor Tim Goodship	Time to Improvements with Eculizumab in Patients with Atypical Haemolytic Uraemic Syndrome of Long Duration and Chronic Kidney Disease: 3-Year Update	2014
Dr Lisa Turnbull Professor Tim Goodship Dr Veronique Fremaux-Bacchi	A prevalent CFHR1/FH reverse hybrid gene in aHUS patients induces deregulation of the alternative pathway	2013
Rachel Challis Dr Holly Anderson Dr Edwin Wong Dr Lisa Turnbull Professor Kevin Marchbank et al.	Atypical haemolytic uraemic syndrome associated with a novel hybrid CFH/CFHR3 gene	2013
Professor David Kavanagh Professor Tim Goodship Dr Anna Richards	Atypical hemolytic uremic syndrome	2013
Professor Tim Goodship	Changing strategies for organ transplantation in atypical haemolytic uraemic syndrome: A tertiary case series	2013
Dr Veronique Fremaux-Bacchi Professor Tim Goodship	Combined Complement Gene Mutations in Atypical Hemolytic Uremic Syndrome Influence Clinical Phenotype	2013
Professor Tim Goodship	Complement deregulation in dense deposit disease by a novel CFHR2-CFHR5 hybrid protein	2013
Dr Edwin Wong Professor Tim Goodship Professor David Kavanagh	Complement therapy in atypical haemolytic uraemic syndrome (aHUS)	2013
Dr Lucy Holmes Dr Lisa Turnbull Dr Iain Moore Professor Kevin Marchbank Professor David Kavanagh et al.	Determining the Population Frequency of the CFHR3/CFHR1 Deletion at 1q32	2013
Professor Tim Goodship	Distribution and determinants of circulating complement factor H concentration determined by a high-throughput immunonephelometric assay	2013
Professor Tim Goodship	Eculizumab in aHUS pts with long disease duration, with or without renal transplant	2013
Dr Steven Hardy Professor Tim Goodship	Eculizumab therapy for atypical haemolytic uraemic syndrome due to a gain-of-function mutation of complement factor B	2013
Professor Tim Goodship	Efficacy and safety of Eculizumab in the treatment of atypical haemolyticuraemic syndrome: A single tertiary centre experience	2013
Professor Tim Goodship Professor Neil Sheerin	Efficacy of Eculizumab in atypical hemolytic uremic syndrome (aHUS) patients with or without prior transplant	2013
Dr Valerie Wilson Dr Rebecca Darlay Dr Katrina Wood Professor Claire Harris Dr Eva-Maria Hunze et al.	Genotype/Phenotype Correlations in Complement Factor H Deficiency Arising From Uniparental Isodisomy	2013
Professor Tim Goodship	Long-term efficacy of Eculizumab in patients with atypical haemolyticuraemic syndrome with a long disease duration and chronic kidney disease	2013
Professor Neil Sheerin Professor Tim Goodship	Terminal Complement Inhibitor Eculizumab in Atypical Hemolytic–Uremic Syndrome	2013
Professor Tim Goodship	Use of Eculizumab in atypical haemolyticuraemic syndrome associated with complement factor B variant	2013
Professor David Kavanagh Dr Lisa Turnbull Professor Kevin Marchbank Professor Claire Harris Professor Tim Goodship et al.	A novel hybrid CFH/CFHR3 gene generated by a microhomology-mediated deletion in familial atypical hemolytic uremic syndrome	2012
Dr Luca Ermini Professor Tim Goodship Dr Lisa Turnbull Professor Heather Cordell Dr Veronique Fremaux-Bacchi et al.	Common genetic variants in complement genes other than CFH, CD46 and the CFHRs are not associated with aHUS.	2012
Dr Luca Ermini Dr Ian Wilson Professor Tim Goodship Professor Neil Sheerin	Complement polymorphisms: Geographical distribution and relevance to disease	2012
Dr Lisa Turnbull Professor Tim Goodship	Dense deposits disease (DDD): Favorable long-term outcome on enalapril despite persistence of complement activation	2012
Professor Tim Goodship	Eculizumab (ECU) Safety and Efficacy in Atypical Hemolytic Uremic Syndrome (aHUS) Patients with Long Disease Duration and Chronic Kidney Disease (CKD): 2-Year Results	2012
Professor Tim Goodship	Eculizumab Is an Effective Treatment for Atypical Hemolytic Uremic Syndrome in Patients with or without Identified Genetic Complement Mutations or Complement Factor H Auto-Antibodies	2012
Professor Tim Goodship Dr Isabel Pappworth Dr Iain Moore Dr Eva-Maria Hunze James Staniforth et al.	Factor H autoantibodies in membranoproliferative glomerulonephritis	2012
Professor David Kavanagh Dr Isabel Pappworth Christine Hayes Dr Iain Moore Dr Eva-Maria Hunze et al.	Factor I Autoantibodies in Patients with Atypical Hemolytic Uremic Syndrome: Disease-Associated or an Epiphenomenon?	2012
Dr Edwin Wong Dr Holly Anderson Rachel Challis Professor Kevin Marchbank Professor David Kavanagh et al.	Familial membranoproliferative glomerulonephritis type I associated with a functionally significant mutation in complement factor H	2012
Dr Karim Bennaceur Dr Eva-Maria Hunze James Staniforth Dr Lisa Turnbull Dr Valerie Wilson et al.	MCP (CD46) autoantibodies are associated with atypical hemolytic uremic syndrome	2012
Dr Valerie Wilson Dr Iain Moore Dr Lisa Turnbull Professor Kevin Marchbank Professor Neil Sheerin et al.	Postpartum aHUS Secondary to a Genetic Abnormality in Factor H Acquired Through Liver Transplantation	2012
Professor Tim Goodship Professor Claire Harris	Sensitive and specific assays for C3 nephritic factors clarify mechanisms underlying complement dysregulation	2012
Dr Lisa Turnbull Professor Tim Goodship	The European MPGN Registry: Novel genetic- and autoimmune-factors allow a differentiation between MPGN subtype I and subtype II	2012
Professor Tim Goodship	Association of Genetic Variants in Complement Factor H and Factor H-Related Genes with Systemic Lupus Erythematosus Susceptibility	2011
Professor Tim Goodship	Eculizumab Is An Effective Long-Term Treatment In Patients with Atypical Hemolytic Uremic Syndrome (aHUS) Previously Receiving Chronic Plasma Exchange/Infusion (PE/PI): Extension Study Results	2011
Professor Tim Goodship	Eculizumab is an effective treatment for patients with atypical hemolytic syndrome (aHUS) receiving chronic plasma therapy (PT)	2011
Dr Luca Ermini Professor Tim Goodship Dr Lisa Turnbull Professor Heather Cordell Dr Veronique Fremaux-Bacchi et al.	Genetic variants in CFH and CD46 are the major susceptibility factors for aHUS-An association study of multiple complement genes	2011
Professor David Kavanagh Professor Tim Goodship	Haemolytic Uraemic Syndrome	2011
Dr Roslyn Simms Professor John Sayer Dr Richard Quinton Professor Mark Walker Professor Tim Goodship et al.	Monogenic diabetes, renal dysplasia and hypopituitarism: a patient with a HNF1A mutation	2011
Professor David Kavanagh Professor Tim Goodship Dr Veronique Fremaux-Bacchi	Mutations in Complement Regulatory Proteins Predispose to Preeclampsia: A Genetic Analysis of the PROMISSE Cohort	2011
Professor Tim Goodship	Plasma therapy for atypical haemolytic uraemic syndrome associated with heterozygous factor H mutations	2011
Professor Tim Goodship	Prevention of large-vessel stenoses in atypical hemolytic uremic syndrome associated with complement dysregulation	2011
Aisling Stewart Professor Heather Cordell Professor Judith Goodship Professor Tim Goodship	Primary, Nonsyndromic Vesicoureteric Reflux and Nephropathy in Sibling Pairs: A United Kingdom Cohort for a DNA Bank	2011
Dr Colin Wilson Dr Nicholas Torpey Bryon Jaques Dr Lisa Turnbull David Talbot et al.	Successful Simultaneous Liver-Kidney Transplant in an Adult With Atypical Hemolytic Uremic Syndrome Associated With a Mutation in Complement Factor H	2011
Dr Alison Brown Professor Tim Goodship Professor Neil Sheerin Professor Derek Manas	Successful Treatment of De Novo Posttransplant Thrombotic Microangiopathy With Eculizumab	2011
Professor David Kavanagh Dr Lisa Turnbull Professor Kevin Marchbank Professor Tim Goodship	A novel hybrid complement gene associated with familial haemolytic uraemic syndrome	2010
Dr Iain Moore Dr Lisa Turnbull Dr Isabel Pappworth Professor David Kavanagh James Staniforth et al.	Association of factor H autoantibodies with deletions of CFHR1, CFHR3, CFHR4, and with mutations in CFH, CFI, CD46, and C3 in patients with atypical hemolytic uremic syndrome	2010
Professor Heather Cordell Professor Tim Goodship	Associations of CFHR1-CFHR3 deletion and a CFH snp to age-related macular degeneration are not independent reply	2010
Dr Lisa Turnbull Professor Tim Goodship	Atypical haemolytic uraemic syndrome in one large kindred predisposed by factor H mutation penetrance data based on mutation testing and family history	2010
Professor David Kavanagh Professor Tim Goodship	Atypical hemolytic uremic syndrome	2010
Professor Tim Goodship	Clinical Practice Guidelines for the management of atypical Haemolytic Uraemic Syndrome in the United Kingdom	2010
Dr Isabel Pappworth Dr Iain Moore Dr Lisa Turnbull Professor David Kavanagh James Staniforth et al.	Complement Factor H Autoantibodies and Age-Related Macular Degeneration	2010
Professor Tim Goodship	Early Intensive Plasma Exchange (PEX) for Atypical Haemolytic Uraemic Syndrome (aHUS) May Slow Progression to End-Stage Renal Failure (ESRF) [meeting abstract]	2010
Professor David Kavanagh Dr Isabel Pappworth Dr John Tapson Dr Iain Moore Dr Lisa Turnbull et al.	Factor I autoantibodies are associated with atypical haemolytic uraemic syndrome	2010
Professor David Kavanagh Dr Lisa Turnbull Professor Kevin Marchbank Professor Tim Goodship	Functional characterisation of a novel hybrid complement factor H protein associated with atypical haemolytic uraemic	2010
Professor David Kavanagh Professor Tim Goodship	Genetics and complement in atypical HUS	2010
Professor Kevin Marchbank Professor Tim Goodship	Impact of compound heterozygous complement factor H mutations on development of atypical hemolytic uremic syndrome-A pedigree revisited	2010
Dr Lisa Turnbull Professor Tim Goodship	Maintenance of Kidney Function Following Treatment With Eculizumab and Discontinuation of Plasma Exchange After a Third Kidney Transplant for Atypical Hemolytic Uremic Syndrome Associated With a CFH Mutation	2010
Professor David Kavanagh Professor Tim Goodship Dr Veronique Fremaux-Bacchi	Mutations in complement regulatory proteins predispose to preeclampsia	2010
Professor Tim Goodship	Non-atheromatous arterial stenoses in atypical haemolytic uraemic syndrome associated with complement dysregulation	2010
Professor Tim Goodship Professor David Kavanagh	Pulling the Trigger in Atypical Hemolytic Uremic Syndrome: The Role of Pregnancy	2010
Professor Tim Goodship	Relative Role of Genetic Complement Abnormalities in Sporadic and Familial aHUS and Their Impact on Clinical Phenotype	2010
Professor Heather Cordell Professor Tim Goodship	Reply to “Associations of CFHR1–CFHR3 deletion and a CFH SNP to age-related macular degeneration are not independent”	2010
Professor Tim Goodship	Successful Isolated Liver Transplantation in a Child with Atypical Hemolytic Uremic Syndrome and a Mutation in Complement Factor H	2010
Dr Isabel Pappworth Professor Kevin Marchbank Dr Lisa Turnbull Professor Tim Goodship	Successful Renal Transplantation in Factor H Autoantibody Associated HUS with CFHR1 and 3 Deficiency and CFH Variant G2850T	2010
Professor David Kavanagh Professor Tim Goodship	Transplantation in Atypical Hemolytic Uremic Syndrome	2010
Professor Kevin Marchbank Professor David Kavanagh Dr Lisa Turnbull Professor Tim Goodship	Triggering of atypical hemolytic uremic syndrome by influenza A (H1N1)	2010
Professor Heather Cordell Dr Rebecca Darlay Dr Heather Lambert Professor Tim Goodship Dr Rajko Kenda et al.	Whole-Genome Linkage and Association Scan in Primary, Nonsyndromic Vesicoureteric Reflux	2010
Dr Lisa Turnbull Professor Tim Goodship	Eculizumab allows plasma exchange iscontinuation after a third kidney transplantation in a patient with plasma dependent atypical HUS due to CFH mutation	2009
Dr Lisa Turnbull Professor Tim Goodship	Eculizumab allows plasma exchnage discontinuation after a third kidney transplantation in a patient with plasma dependent atypical hus due to CFH mutation	2009
Professor Kevin Marchbank Dr Lisa Turnbull Dr Veronique Fremaux-Bacchi James Staniforth Professor David Kavanagh et al.	Genomic disorders associated with aHUS	2009
Dr Lisa Turnbull Professor Tim Goodship	In atypical HUS (aHUS), the EKZ-AMC protocol of plasma therapy (PT) prevents a chronic renal failure, allows successful kidney transplantation and avoid cerebral arteries stenosis	2009
Dr Matthew Edey Dr Lisa Turnbull Professor Tim Goodship	Is complement factor H a susceptibility factor for IgA nephropathy?	2009
Dr Veronique Fremaux-Bacchi Professor Tim Goodship	Liver-kidney transplantation to cure atypical hemolytic uremic syndrome	2009
Dr Lisa Turnbull Professor Tim Goodship	Prophylactic plasma exchange in CD46-associated atypical haemolytic uremic syndrome	2009
James Staniforth Professor David Kavanagh Dr Lisa Turnbull Professor Tim Goodship Professor Kevin Marchbank et al.	Towards a highly specific Factor H ELISA for rapid screening of patient sera	2009
Professor Tim Goodship	Uromodulin mutations causing familial juvenile hyperuricaemic nephropathy lead to protein maturation defects and retention in the endoplasmic reticulum	2009
Dr Matthew Edey Professor David Kavanagh Dr Anne Lampe Professor Judith Goodship Dr Lisa Turnbull et al.	A Novel Non-Synonymous Polymorphism (p.Arg240His) in C4b-Binding Protein Is Associated with Atypical Hemolytic Uremic Syndrome and Leads to Impaired Alternative Pathway Cofactor Activity	2008
Dr Iain Moore Dr Lisa Turnbull Professor Tim Goodship Professor Kevin Marchbank	Anti-factor H autoantibodies in aHUS - Is there an association with CFHR1/3 copy number?	2008
Dr Matthew Edey Dr Lisa Turnbull Professor Tim Goodship Dr Suren Kanagasundaram	Association of a Factor H Mutation With Hemolytic Uremic Syndrome Following a Diarrheal Illness	2008
Professor Tim Goodship	Chapter 14 Hemolytic Uremic Syndrome/Thrombotic Thrombocytopenic Purpura	2008
Dr Lisa Turnbull Professor Tim Goodship	Effect of plasma exchanges (PEs) in 2 cases of dense deposit disease (DDD)	2008
Dr Veronique Fremaux-Bacchi Professor Tim Goodship	Efficacy of plasma therapy in atypical hemolytic uremic syndrome with complement factor H mutations	2008
Dr Lisa Turnbull Professor Tim Goodship	Failure of prophylactic plasma exchanges (PEs) to prevent end-stage renal failure (ESRF) in MCP mutation-related atypical hemolytic uremic syndrome (aHUS)	2008
Dr Veronique Fremaux-Bacchi Professor Tim Goodship	Membrane cofactor protein mutations in atypical hemolytic uremic syndrome (aHUS), fatal Stx-HUS, C3 glomerulonephritis, and the HELLP syndrome	2008
Dr Veronique Fremaux-Bacchi Dr Lisa Turnbull Dr Alison Brown Dr Nadeem Moghal Professor Tim Goodship et al.	Mutations in complement C3 predispose to development of atypical hemolytic uremic syndrome	2008
Dr Lisa Turnbull Professor Tim Goodship	Plasma therapy in atypical haemolytic uremic syndrome: Lessons from a family with a factor H mutation	2008
Dr Lisa Turnbull Dr Veronique Fremaux-Bacchi Professor Tim Goodship	The complement factor H R1210C mutation is associated with atypical hemolytic uremic syndrome	2008
Dr Lisa Turnbull Professor Tim Goodship	The European MPGN registry	2008
Professor David Kavanagh Dr Matthew Edey Dr Lisa Turnbull Professor Judith Goodship Dr Anne Lampe et al.	A non-synonymous polymorphism (arg240his) in C4b-binding protein is associated with atypical haemolytic uraemic syndrome and leads to impaired alternative pathway cofactor activity	2007
Professor Tim Goodship	Anguish over angiopathy: Hemolytic uremic syndrome	2007
Professor Tim Goodship	Complement factor H and the hemolytic uremic syndrome	2007
Dr Matthew Edey Dr Lisa Turnbull Professor Judith Goodship Professor Tim Goodship	Deletion of complement factor H-related genes CFHR1 and CFHR3 is associated with atypical hemolytic uremic syndrome	2007
Dr Matthew Edey Dr Lisa Turnbull Professor Judith Goodship Professor Tim Goodship	Factor H autoantibodies in atypical hemolytic uremic syndrome correlate with CFHR1/CFHR3 deficiency and affect recognition functions	2007
Professor Tim Goodship	Genetics of HUS	2007
Professor David Kavanagh Dr Veronique Fremaux-Bacchi Professor Tim Goodship	Implications of the initial mutations in membrane cofactor protein (MCP; CD46) leading to atypical hemolytic uremic syndrome	2007
Dr Veronique Fremaux-Bacchi Professor Tim Goodship	Membrane cofactor protein mutations in atypical hemolytic uremic syndrome (aHUS), fatal Stx-HUS, C3 glomerulonephritis and the HELLP syndrome	2007
Professor Tim Goodship	Microangiopathies	2007
Professor Tim Goodship	Modeling how CD46 deficiency predisposes to atypical hemolytic uremic syndrome	2007
Dr Veronique Fremaux-Bacchi Professor Tim Goodship	Mutations in complement C3 predispose to development of atypical haemolytic uraemic syndrome	2007
Professor Tim Goodship	Nutritional Screening in Patients on Hemodialysis: Is Subjective Global Assessment an Appropriate Tool?	2007
Professor David Kavanagh Dr Veronique Fremaux-Bacchi Professor Tim Goodship	Screening for complement system abnormalities in patients with atypical hemolytic uremic syndrome	2007
Professor David Kavanagh Rachel Burgess Professor Judith Goodship Professor Tim Goodship	The decay accelerating factor mutation I197V found in hemolytic uraemic syndrome does not impair complement regulation	2007
Dr Veronique Fremaux-Bacchi Professor Tim Goodship	The factor H-aHUS mutation database and website: Update and integration of MCP and FI mutations with structural models	2007
Dr Veronique Fremaux-Bacchi Professor Tim Goodship	The interactive factor H-atypical hemolytic uremic syndrome mutation database and website: Update and integration of membrane cofactor protein and factor I mutations with structural models	2007
Professor David Kavanagh Professor Tim Goodship	Update on evaluating complement in hemolytic uremic syndrome	2007
Dr Veronique Fremaux-Bacchi Professor Tim Goodship	Where next with atypical hemolytic uremic syndrome?	2007
Professor Tim Goodship	A common CFH haplotype, with deletion of CFHR1 and CFHR3, is associated with lower risk of age-related macular degeneration	2006
Professor Tim Goodship	An interactive web database of Factor H-associated haemolytic ureamic syndrome mutations: Insights into the structural consequences of disease-associated mutations	2006
Professor Tim Goodship	An interactive web database of factor H-associated hemolytic uremic syndrome mutations: Insights into the structural consequences of disease-associated mutations	2006
Professor David Kavanagh Professor Tim Goodship Dr Anna Richards	Atypical haemolytic uraemic syndrome	2006
Dr Julian Venables Dr Lisa Turnbull Dr David Bourn Dr Martha Lucia Diaz Torres Dr Michael Jackson et al.	Atypical haemolytic uraemic syndrome associated with a hybrid complement gene	2006
Professor Tim Goodship	Atypical HUS and complement dysregulation	2006
Dr Lisa Turnbull Professor Tim Goodship	Complement factor H-associated atypical hemolytic uremic syndrome in monozygotic twins: Concordant presentation, discordant response to treatment	2006
Dr Michael Jackson Dr Lisa Turnbull Professor Judith Goodship Dr Liz Kemp Professor Tim Goodship et al.	De novo gene conversion in the RCA gene cluster (1q32) causes mutations in complement factor H associated with atypical hemolytic uremic syndrome	2006
Professor David Kavanagh Dr Anna Richards Rachel Burgess Professor Judith Goodship Professor Tim Goodship et al.	Does complement factor B have a role in the pathogenesis of atypical HUS?	2006
Professor Tim Goodship	Factor H genotype-phenotype correlations: Lessons from aHUS, MPGN II, and AMD	2006
Dr Lisa Turnbull Professor Tim Goodship	Favorable long-term outcome after liver-kidney transplant for recurrent hemolytic uremic syndrome associated with a factor H mutation	2006
Professor David Kavanagh Professor Tim Goodship	Membrane cofactor protein and factor I: Mutations and transplantation	2006
Professor Tim Goodship	No association betiveen 2 functional single nucleolide polymorphisms (SNPs) in complement factor H (CFR) and SLE	2006
Professor Tim Goodship	Outcome of renal transplantation in patients with non-Shiga toxin-associated hemolytic uremic syndrome: Prognostic significance-of genetic background	2006
Dr Mark Boxall Professor Tim Goodship Dr Alison Brown Professor Thomas von Zglinicki	Telomere shortening and haemodialysis	2006
Professor Judith Goodship Dr Lisa Turnbull Dr Julian Venables Daniel Routledge Professor Kevin Marchbank et al.	The genomic organisation of the RCA cluster, including CFH, predisposes to gene conversion and nonhomologous recombination as a cause of atypical haemolytic uraemic syndrome	2006
Professor David Kavanagh Dr Liz Kemp Professor Judith Goodship Professor Tim Goodship	Mutations in complement factor I predispose to development of atypical hemolytic uremic syndrome	2005
Professor Tim Goodship Dr Lisa Turnbull	Posttransplantation cytomegalovirus-induced recurrence of atypical hemolytic uremic syndrome associated with a factor H mutation: Successful treatment with intensive plasma exchanges and ganciclovir	2005
Dr Veronique Fremaux-Bacchi Professor Judith Goodship Dr Lisa Turnbull Professor Tim Goodship	The development of atypical haemolytic-uraemic syndrome is influenced by susceptibility factors in factor H and membrane cofactor protein: Evidence from two independent cohorts	2005
Dr Lisa Turnbull Professor Judith Goodship Professor Tim Goodship	The development of atypical hemolytic uremic syndrome is not influenced by thrombophilia susceptibility factors [15]	2005
Dr Lisa Turnbull Professor Tim Goodship	Atypical relapse of hemolytic uremic syndrome after transplantation	2004
Dr Lisa Turnbull Professor Tim Goodship	Challenges in the management if infantile factor H associated hemolytic uremic syndrome	2004
Claire Lambert Professor Tim Goodship	Familial hemolytic uremic syndrome: a privileged observation	2004
Professor Tim Goodship	Inherited dysregulation of the complement system	2004
Professor Judith Goodship Professor Tim Goodship	Lack of major involvement of human uroplakin genes in vesicoureteral reflux: Implications for disease heterogeneity	2004
Dr Liz Kemp Professor Tim Goodship	Modeling how deficiency of membrane cofactor protein (MCP; CD46) predisposes to atypical hemolytic uremic syndrome	2004
Professor Tim Goodship Dr Liz Kemp	Mutations in CD46, a complement regulatory protein, predispose to atypical HUS	2004
Professor John Sayer Dr Georgina Carr Professor Simon Pearce Professor Tim Goodship Professor Nicholas Simmons et al.	Disordered calcium crystal handling in antisense CLC-5-treated collecting duct cells	2003
Dr Chris Redfern Professor Tim Goodship	Effect of insulin upon protein degradation in cultured human myocytes	2003
Professor Judith Goodship Professor Tim Goodship	Familial haemolytic uraemic syndrome and mutations in membrane cofactor protein (MCP; CD46) of the complement system	2003
Professor Judith Goodship Dr Anne Lampe Professor Tim Goodship	Familial hemolytic uremic syndrome and mutations in membrane cofactor protein (MCP; CD46) of the complement system	2003
Professor Tim Goodship	Fibrinogen in hemodialysis: The worst of both worlds?	2003
Dr Anna Richards Professor Judith Goodship Dr Anne Lampe Professor Tim Goodship	Mutations in human complement regulator, membrane cofactor protein (CD46), predispose to development of familial hemolytic uremic syndrome	2003
Dr Mark Boxall Barbara Keys Professor Thomas von Zglinicki Professor Tim Goodship	Peripheral blood mononuclear cell telomere length is unaltered in hemodialysis despite increased oxidative stress.	2003
Professor Tim Goodship	Anodipsia nervosa a variant of anorexia in patients with end-stage renal disease	2002
Professor John Sayer Dr Georgina Carr Professor Nicholas Simmons Professor Tim Goodship	Antisense CLC-5 disrupts acidic endosomes and endocytosis in murine collecting duct cells	2002
Dr Jonathan Louden Professor Kim Bartlett Dr David Reaich Professor Tim Goodship	Effects of feeding on albumin synthesis in hypoalbuminemic hemodialysis patients	2002
Professor Tim Goodship Dr Nicholas Hoenich Timothy Hawkins Dr Peter Fawcett Dr John Tapson et al.	Is decreased treatment time in hemodialysis patients harmful if solute clearance is maintained?	2002
Professor Tim Goodship	Molecular modelling of the C-terminal domains of factor H of human complement: A correlation between haemolytic uraemic syndrome and a predicted heparin binding site	2002
Dr Rosemary Donne Dr Margaret Little Professor Tim Goodship	Recurrence of hemolytic uremic syndrome after live related renal transplantation associated with subsequent de novo disease in the donor	2002
Dr Chris Redfern Professor Tim Goodship	Skeletal muscle mRNA levels for cathepsin B, but not components of the ubiquitin-proteasome pathway, are increased in patients with lung cancer referred for thoracotomy	2002
Dr Chris Redfern Professor Kim Bartlett Professor Robert Wilkinson Professor Tim Goodship	Sodium bicarbonate treatment and ubiquitin gene expression in acidotic human subjects with chronic renal failure	2002
Professor Judith Goodship Professor Tim Goodship Anne Hattersley	Solitary functioning kidney and diverse genital tract malformations associated with hepatocyte nuclear factor-1 beta mutations	2002
Professor Tim Goodship	Solution structures of complement components by X-ray and neutron scattering and analytical ultracentrifugation	2002
Professor Judith Goodship Professor Tim Goodship	The genetics and pathogenesis of haemolytic uraemic syndrome and thrombotic thrombocytopenic purpura	2002
Dr Mark Buddles Dr Rosemary Donne Professor Judith Goodship Professor Tim Goodship	Factor H mutations in hemolytic uremic syndrome cluster in exons 18-20, a domain important for host cell recognition	2001
Professor Tim Goodship	Genotypic and phenotypic spectrum in tricho-rhino-phalangeal syndrome types I and III	2001
Professor Tim Goodship Emeritus Professor John Gibson	Nutritional status of patients undergoing lung cancer operations	2001
Professor Tim Goodship Emeritus Professor John Gibson	The influence of nutritional status on complications after operations for lung cancer	2001
Professor John Sayer Dr Gavin Stewart Dr Stefan Boese Dr Michael Gray Professor Simon Pearce et al.	The voltage-dependent of Cl- channel ClC-5 and plasma membrane Cl- conductances of mouse renal collecting duct cells (mIMCD-3)	2001
Dr Jonathan Louden Professor Tim Goodship	Acid-Base in Renal Failure: What have isotope studies in humans told us about the nutritional effects of acidosis in dialysis?	2000
Dr Jonathan Louden Professor Tim Goodship	An assessment of the methods available to determine nutritional equilibrium in patients with chronic renal failure	2000
Dr Mark Buddles Dr Rosemary Donne Amy Richards Professor Judith Goodship Professor Tim Goodship et al.	Complement factor H gene mutation associated with autosomal recessive atypical hemolytic uremic syndrome	2000
Professor Tim Goodship Janet Stoddart Dr Alison Brown Dr Michael Ward Dr John Owen et al.	Long-term follow-up of patients presenting to adult nephrologists with chronic pyelonephritis and 'normal' renal function	2000
Professor Tim Goodship Professor Judith Goodship	Primary, nonsyndromic vesicoureteric reflux and its nephropathy is genetically heterogeneous, with a locus on chromosome 1	2000
Professor Tim Goodship Professor Judith Goodship	A major locus for vesicoureteric reflux and its nephropathy	1999
Dr Jonathan Louden Professor Tim Goodship	Acidosis and nutrition	1999
Professor Tim Goodship Dr Peter Fawcett Dr John Tapson	Adequacy of haemodialysis - the long and the short of it	1999
Professor Tim Goodship	Angiotensin converting enzyme inhibitors (ACE-I) and bilateral nephrectomy in the treatment of hypertension in non-diarrhoeal haemolytic uraemic syndrome (d-HUS) - a retrospective study.	1999
Professor Tim Goodship Dr Michael Ward	Audit of hospital haemodialysis delivery	1999
Professor Tim Goodship Dr John Owen Jan Stoddart Dr Michael Ward Professor Robert Wilkinson et al.	Chronic pyelonephritis. A re-evaluation of prognostic factors for the development of renal impairment	1999
Professor Tim Goodship Professor Kim Bartlett	Does clenbuterol affect whole body protein turnover in adults with end-stage renal failure managed by CAPD?	1999
Dr Rosemary Donne Professor Judith Goodship Professor Tim Goodship	Familial relapsing haemolytic uraemic syndrome and complement factor H deficiency	1999
Professor Judith Goodship Professor Tim Goodship	von Willebrand factor-cleaving protease in thrombotic thrombocytopenic purpura and the hemolytic-uremic syndrome	1999
Dr Nicholas Hoenich Dr Chris Redfern Professor Tim Goodship	Production of interleukin 1 receptor antagonist and interleukin 1 during haemodialysis with cellulose membranes	1994
Professor Stephen Proctor Professor Tim Goodship	Immune complex glomerulonephritis, myasthenia gravis and compensated hypothyroidism in a patient following allogeneic bone marrow transplantation	1993