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Lower Ambulatory Blood Pressure in Chronic Fatigue Syndrome

Lookup NU author(s): Emerita Professor Julia Newton, Jessie Pairman, Professor David Jones


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Objective: To examine blood pressure circadian rhythm in subjects with chronic fatigue syndrome (CFS) and appropriate normal and fatigued controls to correlate parameters of blood pressure regulation with perception of fatigue in an observational cohort study. The cause of CFS remains unknown and there are no effective treatments. Methods: To address whether inactivity was a confounder, we performed a 24-hour ambulatory blood pressure monitoring in the following three subject groups: 1) CFS patients (Fukuda Diagnostic criteria) (n=38); 2) normal controls (n=120); and 3) a fatigue comparison group (n=47) with the autoimmune liver disease primary biliary cirrhosis (PBC). All patients completed a measure of fatigue severity (Fatigue Impact Scale). In view of the different demographics between the patient groups, patients were age- and sex-matched on a case-by-case basis to normal controls and blood pressure parameters were compared. Results: Compared with the control population, the CFS group had significantly lower systolic blood pressure (p

Publication metadata

Author(s): Newton JL, Sheth A, Shin J, Pairman J, Wilton K, Burt JA, Jones DEJ

Publication type: Article

Publication status: Published

Journal: Psychosomatic Medicine

Year: 2009

Volume: 71

Issue: 3

Pages: 361-365

ISSN (print): 0033-3174

ISSN (electronic): 1534-7796

Publisher: Lippincott Williams & Wilkins


DOI: 10.1097/PSY.0b013e31819ccd2a


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