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Browsing publications by Professor David Jones.

Newcastle AuthorsTitleYearFull text
Professor David Jones
Dr David Sheridan
A phase II, randomized, open-label, 52-week study of seladelpar in patients with primary biliary cholangitis2022
Professor David Jones
Ten years of NIHR research training: who got an award? A retrospective cohort study2022
Colette Kirk
Laura Haigh
Dr Nicholas Thompson
Professor Mark Pearce
Professor David Jones
et al.
The effects of different parenteral nutrition lipid formulations on clinical and laboratory endpoints in patients receiving home parenteral nutrition: A systematic review2022
Professor David Jones
UK-PBC National Audit: A collaborative success in identifying critical shortfalls2022
Professor Heather Cordell
James Fryett
Dr Rebecca Darlay
Professor David Jones
An international genome-wide meta-analysis of primary biliary cholangitis: Novel risk loci and candidate drugs2021
Dr Jess Dyson
Professor David Jones
Bezafibrate for the Treatment of Cholestatic Pruritus: Time for a Change in Management?2021
Professor Heather Cordell
Dr Rebecca Darlay
Professor David Jones
Corrigendum to ‘An international genome-wide meta-analysis of primary biliary cholangitis: Novel risk loci and candidate drugs’ [J Hepatol 2021;75(3):572–581] (Journal of Hepatology (2021) 75(3) (572–581), (S0168827821003342), (10.1016/j.jhep.2021.04.055))2021
Stephen Rice
Dr Viviana Albani
Dr Dimitrios Minos
Dr Gulnar Fattakhova
Dr Mark Shirley
et al.
Effects of Primary Biliary Cholangitis on Quality of Life and Health Care Costs in the United Kingdom2021
Dr April Phaw
Dr Jess Leighton
Dr Jess Dyson
Professor David Jones
Managing cognitive symptoms and fatigue in cholestatic liver disease2021
Dr Jess Leighton
Dr Jess Dyson
Professor David Jones
Patient ownership of primary biliary cholangitis long-Term management2021
Dr Laura Jopson
Professor David Jones
Quality of life in patients with primary biliary cholangitis: A cross-geographical comparison2021
Dr Aaron Wetten
Professor David Jones
Dr Jess Dyson
Specific considerations for the management of primary biliary cholangitis: are the drug treatment options good enough?2021
Dr Alistair Leitch
Dr Ibrahim Ibrahim
Dr Tarek Mamdouh Abdelghany
Dr Alex Charlton
Clair Roper
et al.
The methylimidazolium ionic liquid M8OI is detectable in human sera and is subject to biliary excretion in perfused human liver2021
Dr Ben Barron-Millar
Dr Laura Ogle
Professor John Kirby
Dr Jeremy Palmer
Dr Laura Jopson
et al.
The Serum Proteome and Ursodeoxycholic Acid Response in Primary Biliary Cholangitis2021
Dr April Phaw
Dr Jess Dyson
Professor David Jones
Understanding Fatigue in Primary Biliary Cholangitis2021
Professor David Jones
Widespread gaps in the quality of care for primary biliary cholangitis in UK2021
Professor Heather Cordell
Professor David Jones
Dr Harumasa Nakamura
X Chromosome Contribution to the Genetic Architecture of Primary Biliary Cholangitis2021
Dr Helen Bosomworth
Professor David Jones
Editorial: rapid assessment of health-related quality of life in primary biliary cholangitis—no excuse not to ask. Authors' reply2020
Dr April Phaw
Dr Jess Dyson
Professor David Jones
Emerging drugs for the treatment of primary biliary cholangitis2020
Professor David Jones
Letter: histology is relevant for risk stratification in primary biliary cholangitis2020
Dr Dennis Lendrem
Dr Clare Lendrem
Dr Arthur Pratt
Professor John Isaacs
Professor David Jones
et al.
Schrödinger's pipeline and the outsourcing of pharmaceutical innovation2020
Dr John Brain
Professor David Jones
TGF-β2 silencing to target biliary-derived liver diseases2020
Dr Alistair Leitch
Dr Tarek Mamdouh Abdelghany
Dr Phillip Probert
Dr Stephanie Meyer
Dr Jeremy Palmer
et al.
The toxicity of the methylimidazolium ionic liquids, with a focus on M8OI and hepatic effects2020
Dr Jess Dyson
Professor David Jones
UDCA prophylaxis for post-transplant PBC recurrence prevention: Time to change practice2020
Dr Vinod Hegade
Dr Stuart Kendrick
Professor David Jones
Autotaxin, bile acid profile and effect of ileal bile acid transporter inhibition in primary biliary cholangitis patients with pruritus2019
Dr Jess Dyson
Professor David Jones
British Society of Gastroenterology and UK-PSC guidelines for the diagnosis and management of primary sclerosing cholangitis2019
Dr Vinod Hegade
Professor David Jones
Complications of cholestasis2019
Professor David Jones
Development and adaptation of patient-reported outcome measures for patients who experience itch associated with primary biliary cholangitis2019
Professor David Jones
Fatigue in chronic liver disease: New insights and therapeutic approaches2019
Dr Amardeep Khanna
Dr Vinod Hegade
Professor David Jones
Management of Fatigue in Primary Biliary Cholangitis2019
Dr April Phaw
Professor David Jones
PBC: Better Solutions to Beat Feeling Beat2019
Professor David Jones
Position statement on access to care in rare liver diseases: Advancements of the European reference network (ERN) RARE-LIVER2019
Dr Vinod Hegade
Dr Holly Fisher
Dr Stuart Kendrick
Professor David Jones
Pruritus Is Common and Undertreated in Patients With Primary Biliary Cholangitis in the United Kingdom2019
Dr Amaani Hussain
Robert Samuel
Dr Vinod Hegade
Professor David Jones
Professor Nick Reynolds
et al.
Pruritus secondary to primary biliary cholangitis: a review of the pathophysiology and management with phototherapy2019
Dr Amardeep Khanna
Dr Laura Jopson
Denise Howel
Andrew Bryant
Professor Andrew Blamire
et al.
Rituximab is Ineffective for Treatment of Fatigue in Primary Biliary Cholangitis: A Phase-2 Randomised Controlled Trial2019
Matthew Simcock
Dr Sirintra Nakjang
Dr Richard Heath
Dr Lauren Walker
Dr Craig Robson
et al.
The Pioneering Role of GATA2 in Androgen Receptor Variant Regulation Is Controlled by Bromodomain and Extraterminal Proteins in Castrate-Resistant Prostate Cancer2019
Professor David Jones
Access to care in rare liver diseases: New challenges and new opportunities2018
Dr Rebecca Darlay
Dr Kristin Ayers
Dr Lynsey Hall
Professor David Jones
Professor Heather Cordell
et al.
Amino acid residues in five separate HLA genes can explain most of the known associations between the MHC and Primary Biliary Cholangitis2018
Dr Laura Jopson
Dr Amardeep Khanna
Professor David Jones
Are Clinicians Ready for Safe Use of Stratified Therapy in Primary Biliary Cholangitis (PBC)? A Study of Educational Awareness2018
Professor David Jones
Dr Vinod Hegade
Bezafibrate in primary biliary cholangitis2018
Dr Phillip Probert
Dr Alistair Leitch
Dr Michael Dunn
Dr Stephanie Meyer
Dr Jeremy Palmer
et al.
Identification of a xenobiotic as a potential environmental trigger in primary biliary cholangitis2018
Professor David Jones
Increased sensitivity of Treg cells from patients with PBC to low dose IL-12 drives their differentiation into IFN-γ secreting cells2018
Dr Jess Dyson
Dr Lin Lee Wong
Dr Theophile Bigirumurame
Dr Stuart Kendrick
Professor David Jones
et al.
Inequity of care provision and outcome disparity in autoimmune hepatitis in the United Kingdom2018
Dr Jess Dyson
Professor David Jones
Dr Mark Hudson
Primary sclerosing cholangitis2018
Dr Amardeep Khanna
Dr Laura Jopson
Denise Howel
Andrew Bryant
Professor Andrew Blamire
et al.
Rituximab for the Treatment of Fatigue in Primary Biliary Cholangitis (formerly Primary Biliary Cirrhosis) A Randomised Controlled Trial2018
Dr Amardeep Khanna
Dr Jess Leighton
Dr Lin Lee Wong
Professor David Jones
Symptoms of PBC – Pathophysiology and management2018
Dr Jess Dyson
Dr Dina Tiniakos
Professor David Jones
The British Society of Gastroenterology/UK-PBC primary biliary cholangitis treatment and management guidelines2018
Dr Lin Lee Wong
Dr Holly Fisher
Dr Deborah Stocken
Stephen Rice
Dr Amardeep Khanna
et al.
The Impact of Autoimmune Hepatitis and Its Treatment on Health Utility2018
Dr James Orr
Dr Dave Houghton
Professor David Jones
A novel method for continuous, non-invasive, cuff-less measurement of blood pressure: Evaluation in patients with non-alcoholic fatty liver disease2017
Dr Chris Lamb
Dr John Mansfield
Anna Long
Maria Price
Dr Graeme O'Boyle
et al.
aEß7 Integrin Identifies Subsets of Pro-Inflammatory Colonic CD4+ T Lymphocytes in Ulcerative Colitis2017
Dr Vinod Hegade
Professor David Jones
Apical Sodium-Dependent Transporter Inhibitors in Primary Biliary Cholangitis and Primary Sclerosing Cholangitis2017
Dr Vinod Hegade
Dr Stuart Kendrick
Professor David Jones
Effect of ileal bile acid transporter inhibitor GSK2330672 on pruritus in primary biliary cholangitis: a double-blind, randomised, placebo-controlled, crossover, phase 2a study2017
Dr Amardeep Khanna
Professor David Jones
Novel strategies and therapeutic options for the management of primary biliary cholangitis2017
Professor David Jones
Seladelpar (MBX-8025), a selective PPAR-δ agonist, in patients with primary biliary cholangitis with an inadequate response to ursodeoxycholic acid: a double-blind, randomised, placebo-controlled, phase 2, proof-of-concept study2017
Professor David Jones
Stratified medicine and primary biliary cholangitis2017
Dr Lin Lee Wong
Dr Vinod Hegade
Professor David Jones
What Comes after Ursodeoxycholic Acid in Primary Biliary Cholangitis?2017
Professor David Jones
A phase 2 proof of concept study of MBX-8025 in patients with Primary Biliary Cholangitis (PBC) who are inadequate responders to ursodeoxycholic acid (UDCA)2016
Dr Vinod Hegade
Dr Stuart Kendrick
Professor David Jones
A Phase 2 Randomised Crossover Trial of Ileal Bile Acid Transporter Inhibitor GSK2330672 in Patients with Primary Biliary Cholangitis and Symptoms of Pruritus2016
Dr Vinod Hegade
Dr Stuart Kendrick
Professor David Jones
A systematic approach to the management of cholestatic pruritus in primary biliary cirrhosis2016
Dr Gary Reynolds
Dr Lin Lee Wong
Professor David Jones
Dr Jess Dyson
Balance between exhausted regulatory T cells and CD161(+) NK cells is crucial in acute AIH pathogenesis2016
Dr Vinod Hegade
Dr Stuart Kendrick
Professor David Jones
BAT117213: Ileal bile acid transporter (IBAT) inhibition as a treatment for pruritus in primary biliary cirrhosis: study protocol for a randomised controlled trial2016
Professor Luke Vale
Dr Diarmuid Coughlan
Professor David Jones
Clinician Confidence in Stratifying Risk in Primary Biliary Cirrhosis - A UK-PBC Survey2016
Stephen Rice
Dr Viviana Albani
Dr Gulnar Fattakhova
Professor Stephen Rushton
Dr Diarmuid Coughlan
et al.
Cost and utility estimates for patients at different stages in the natural history of Primary Biliary Cirrhosis (PBC) from the UK-PBC Cohort2016
Kile Green
Dr Laura Jopson
Dr Ben Barron-Millar
Barbara Innes
Sarah Pagan
et al.
Early Molecular Stratification of High-risk Primary Biliary Cholangitis2016
Dr Jess Dyson
Professor David Jones
Early Primary Biliary Cholangitis is Characterised by Brain Abnormalities on Cerebral Magnetic Resonance Imaging2016
Professor David Jones
Editorial: fenofibrate as second-line therapy in high risk PBC - more answers or more questions?2016
Professor David Jones
Efficacy and Safety of Obeticholic Acid (OCA) in PBC Patients with Advanced Disease as Evidenced by Abnormal Bilirubin: An Integrated Analysis2016
Professor David Jones
Efficacy of Obeticholic Acid Treatment in Patients with Primary Biliary Cholangitis with Cirrhosis2016
Dr James Orr
Dr Daniel Stow
Professor Fiona Matthews
Professor Barbara Hanratty
Professor David Jones
et al.
Eleven-year mortality and referral practices associated with abnormal alanine aminotransferase (ALT) results2016
Professor Luke Vale
Professor David Jones
Hospitalisation for PBC: a UK-PBC analysis of hospital episodes2016
Dr Vinod Hegade
Dr Amardeep Khanna
Dr Lucy Walker
Dr Lin Lee Wong
Dr Jess Dyson
et al.
Long-Term Fenofibrate Treatment in Primary Biliary Cholangitis Improves Biochemistry but Not the UK-PBC Risk Score2016
Dr Vinod Hegade
Dr Richard Speight
Rachel Etherington
Professor David Jones
Novel bile acid therapeutics for the treatment of chronic liver diseases2016
Professor David Jones
Obeticholic acid for the treatment of primary biliary cirrhosis2016
Professor David Jones
POISE: A Placebo-Controlled Trial of Obeticholic Acid in Primary Biliary Cholangitis2016
Professor David Jones
Predicted Risk of End Stage Liver Disease with Continued Standard of Care and Subsequent Addition of Obeticholic Acid in Patients with PBC2016
Dr Phillip Probert
Dr Jeremy Palmer
Dr Aimen Amer
Steven White
Professor David Jones
et al.
Progenitor-derived hepatocyte-like (B-13/H) cells metabolise 1′-hydroxyestragole to a genotoxic species via a SULT2B1-dependent mechanism2016
Dr Jess Dyson
Dr Nina Wilson
Dr Laura Jopson
Samantha Ducker
Dr Deborah Stocken
et al.
The inter-relationship of symptom severity and quality of life in 2055 patients with primary biliary cholangitis2016
Dr Vinod Hegade
Professor David Jones
The safety and efficacy of nasobiliary drainage in the treatment of refractory cholestatic pruritus: a multicentre European study2016
Professor Heather Cordell
Professor David Jones
The UK-PBC Risk Scores: Derivation and Validation of a Scoring System for Long-Term Prediction of End-Stage Liver Disease in Primary Biliary Cholangitis2016
Dr Lin Lee Wong
Dr Stuart Kendrick
Professor David Jones
Dr Jess Dyson
UK-AIH - Highlighting the need for standardization of treatment in autoimmune hepatitis2016
Dr Laura Jopson
Dr Jess Dyson
Professor David Jones
Understanding and Treating Fatigue in Primary Biliary Cirrhosis and Primary Sclerosing Cholangitis2016
Dr Jess Dyson
Dr Jeremy Palmer
Dr Lin Lee Wong
Dr Stuart Kendrick
Professor David Jones
et al.
Understanding the importance of pro- and anti-inflammatory cytokines in autoimmune hepatitis2016
Dr Lin Lee Wong
Dr Stuart Kendrick
Dr Jess Dyson
Professor David Jones
Understanding the unmet need in Autoimmune Hepatitis - The United Kingdom AIH Study (UK-AIH)2016
Dr Vinod Hegade
Dr Stuart Kendrick
Professor David Jones
A Comparative Study of Pruritus in PBC Cohorts from UK, USA and Italy2015
Professor David Jones
A phase 3B, double blind, placebo controlled study evaluating the effect of obeticholic acid on clinical outcomes in subjects with primary biliary cirrhosis at elevated risk of progression to liver transplant or death2015
Dr Vinod Hegade
Dr Stuart Kendrick
Professor David Jones
A study to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of repeat doses of GSK2330672 administration in subjects with primary biliary cirrhosis and symptoms of pruritus2015
Dr Katherine James
Shereen Al-Ali
Dr Jessica Tarn
Dr Simon Cockell
Dr Colin Gillespie
et al.
A Transcriptional Signature of Fatigue Derived from Patients with Primary Sjögren’s Syndrome2015
Professor David Jones
Changing nomenclature for PBC: From "cirrhosis' to "cholangitis'2015
Professor David Jones
Changing nomenclature for PBC: from 'cirrhosis' to 'cholangitis'2015
Professor David Jones
Changing Nomenclature for PBC: From 'Cirrhosis' to 'Cholangitis'2015
Professor David Jones
Changing nomenclature for PBC: From 'cirrhosis' to 'cholangitis'2015
Professor David Jones
Changing nomenclature for PBC: From 'cirrhosis' to 'cholangitis'2015
Professor David Jones
Changing Nomenclature for PBC: From 'Cirrhosis' to 'Cholangitis'2015
Professor David Jones
Changing nomenclature for PBC: From 'cirrhosis' to 'cholangitis'2015
Professor David Jones
Changing Nomenclature for PBC: From 'Cirrhosis' to 'Cholangitis'2015
Professor David Jones
Cholestatic liver disease and liver transplantation in the UK: a twenty year review2015
Professor Luke Vale
Dr Diarmuid Coughlan
Professor David Jones
Clinician confidence in stratifying risk in primary biliary cirrhosis - a UK-PBC survey2015
Dr Vinod Hegade
Professor David Jones
Complications of cholestasis2015
Professor David Jones
Convergence of Two Predictive Models of Risk Reduction in Patients with Primary Biliary Cirrhosis (PBC)2015
Greta Pells
Professor David Jones
Professor Luke Vale
Cost-effectiveness of current therapies in primary biliary cirrhosis: a systematic review of economic evidence2015
Dr Vinod Hegade
Dr Stuart Kendrick
Professor David Jones
Drug treatment of pruritus in liver diseases2015
Professor David Jones
Efficacy and Safety of Obeticholic Acid (OCA) in PBC Patients with Advanced Disease as Evidenced by Abnormal Bilirubin: An Integrated Analysis2015
Dr Laura Jopson
Professor David Jones
Fatigue in Primary Biliary Cirrhosis: Prevalence, Pathogenesis and Management2015
Dr Jess Dyson
Dr Ahmed Elsharkawy
Dr Chris Lamb
Dr Ahmad Al-Rifai
Professor Julia Newton
et al.
Fatigue in primary sclerosing cholangitis is associated with sympathetic over-activity and increased cardiac output2015
Kile Green
Sarah Pagan
Dr Jess Dyson
Dr Lucy Walker
Dr Laura Jopson
et al.
High-risk primary biliary cirrhosis has a distinct molecular signature opening the way for a molecular approach to stratified therapeutics2015
Professor Luke Vale
Professor David Jones
Hospitalisation for primary biliary cirrhosis: a UK-PBC analysis of hospital episodes2015
Dr Rebecca Darlay
Dr Kristin Ayers
Professor David Jones
Dr Peter Donaldson
Professor Heather Cordell
et al.
Immunochip analysis identifies amino acid residues in five separate HLA genes driving the association between the MHC and primary biliary cirrhosis2015
Dr Vinod Hegade
Dr Stuart Kendrick
Professor David Jones
Itch and liver: management in primary care2015
Dr James Orr
Professor David Jones
Dr Mark Hudson
Minimally deranged serum alanine transferase identified in the community: referral practices, prevalence of liver pathology and long term mortality2015
Dr Laura Jopson
Dr Vinod Hegade
Professor David Jones
Natural history of fatigue and pruritus in primary biliary cirrhosis: Implications for the role of pruritus in the aetiology and treatment of fatigue2015
Dr Jess Dyson
Professor Derek Mann
Professor David Jones
Novel therapeutic targets in primary biliary cirrhosis2015
Dr Laura Jopson
Professor Julia Newton
Denise Howel
Dr Jeremy Palmer
Professor John Isaacs
et al.
RITPBC: B-cell depleting therapy (RITUXIMAB) as a treatment for fatigue in primary biliary cirrhosis: study protocol for a randomised controlled trial2015
Dr James Orr
Dr Mark Hudson
Emeritus Professor Calum McNeil
Professor David Jones
The home study (home monitoring in encephalopathy): Rationale and study design2015
Dr Jess Dyson
Professor David Jones
Unmet clinical need in autoimmune liver diseases2015
Professor David Jones
Validation of an alkaline phosphatase and bilirubin response criterion as biomarker for transplant-free2015
Dr Jess Dyson
Dr Laura Jopson
Samantha Ducker
Professor David Jones
Age at Presentation and Gender are Predictors of Increased Mortality Over Long-Term Follow-Up in Primary Biliary Cirrhosis (PBC)2014
Professor Kofi Oppong
Professor David Jones
Richard Charnley
Professor Derek Manas
Bryon Jaques
et al.
Autoimmune Pancreatitis - Diagnosis, Management and Longterm Follow-up2014
Dr James Orr
Dr Mark Hudson
Professor David Jones
Development and validation of The Newcastle Patient Reported Ascites Measure2014
Dr Jess Dyson
Professor David Jones
Diagnosis and Management of Patients with primary biliary cirrchosis2014
Dr Imran Patanwala
Dr Maria King
Dr John Rose
Professor David Jones
Folic acid handling by the human gut: implications for food fortification and supplementation2014
Professor David Jones
Dr Chris Vincent
FXR Agonist Obeticholic Acid: Pruritus, A Common Side Effect Ameliorated by Dose Titration2014
Dr James Orr
Tara Homer
Dr Laura Ternent
Professor Julia Newton
Emeritus Professor Calum McNeil
et al.
Health related quality of life in people with advanced chronic liver disease2014
Dr James Orr
Tara Homer
Dr Laura Ternent
Professor Julia Newton
Emeritus Professor Calum McNeil
et al.
'Health Related Quality of Life in People with Advanced Chronic Liver Disease'2014
Dr James Frith
Professor Fai Ng
Professor Chris Day
Dr Brendan Payne
Professor Neil Sheerin
et al.
Orthostatic intolerance is common in chronic disease - A clinical cohort study2014
Dr Laura Jopson
Professor David Jones
Pathogenesis of Primary Biliary Cirrhosis and Its Fatigue2014
Dr Vinod Hegade
Dr Stuart Kendrick
Professor David Jones
Patient Experience and Characteristics of Cholestatic Pruritus in the UK-PBC Research Cohort2014
Professor David Jones
PBC management among clinicians: Gaps in clinical competence and practice performance - Survey findings2014
Professor David Jones
Reply to: "Fatigue and liver transplantation in patients with primary biliary cirrhosis"2014
Dr Laura Jopson
Professor David Jones
Professor Heather Cordell
Risk stratification in primary biliary cirrhosis using the UK-PBC Research Cohort2014
Dr Jess Dyson
Dr Laura Jopson
Samantha Ducker
Professor David Jones
The Impact of Age at Presentation on Symptoms in Primary Biliary Cirrhosis2014
Dr Laura Jopson
Dr Jess Dyson
Professor David Jones
The New Epidemiology of Primary Biliary Cirrhosis2014
Dr Chris Lamb
Dr John Mansfield
Dr Graeme O'Boyle
Professor David Jones
Jennifer Kirby
et al.
Ulcerative colitis: The alpha E beta 7 integrin is associated with a high frequency of Th17, Th1 and Th17/Th1 CD4 lymphocytes2014
Dr Chris Lamb
Dr John Mansfield
Dr Graeme O'Boyle
Professor David Jones
Dr Michael Keir
et al.
Ulcerative Colitis: The Alpha-e-beta-7 Integrin Is Associated With A High Frequency Of Th17, Th1 And Th17/th1 Cd4 Lymphocytes2014
Dr Jeremy Palmer
Professor David Jones
Dr Jess Dyson
Professor John Kirby
Understanding the Mechanisms Underpinning Treatment Non-Response in Primary Biliary Cirrhosis: A Tool for Treatment Stratification2014
Dr Jeremy Palmer
Dr Jess Dyson
Professor David Jones
Professor John Kirby
Understanding the mechanisms underpinning treatment non-response in Primary Biliary Cirrhosis: a tool for treatment stratification2014
Dr Laura Jopson
Professor David Jones
Dr Jess Dyson
Younger patients presenting with Primary Biliary Cirrhosis are more likely to have cognitive impairment2014
Dr Imran Patanwala
Dr Peter McMeekin
Professor Julia Newton
Professor David Jones
A validated clinical tool for the prediction of varices in PBC: The Newcastle Varices in PBC Score2013
Greta Pells
Professor Julia Newton
Professor David Jones
Age at Diagnosis Predicts Treatment Response in Primary Biliary Cirrhosis (PBC)2013
Chris Elliott
Dr James Frith
Professor Chris Day
Professor David Jones
Professor Julia Newton
et al.
Functional Impairment in Alcoholic Liver Disease and Non-alcoholic Fatty Liver Disease Is Significant and Persists over 3 Years of Follow-Up2013
Professor David Jones
Dr James Frith
Professor Julia Newton
Reduced thoracic fluid content in early-stage primary biliary cirrhosis that associates with impraired cardiac inotropy2013
Dr Kirstie Anderson
Professor David Jones
Katharine Wilton
Professor Julia Newton
Restless leg syndrome is a treatable cause of sleep disturbance and fatigue in primary biliary cirrhosis2013
Greta Pells
Professor Julia Newton
Samantha Ducker
Professor David Jones
Sex and Age Are Determinants of the Clinical Phenotype of Primary Biliary Cirrhosis and Response to Ursodeoxycholic Acid2013
Dr Laura Jopson
Professor David Jones
The effect of liver transplantation on fatigue in patients with primary biliary cirrhosis: A prospective study2013
Greta Pells
Professor Julia Newton
Samantha Ducker
Professor David Jones
The impact of liver transplantation on the phenotype of primary biliary cirrhosis patients in the UK-PBC cohort2013
Professor Julia Newton
Samantha Ducker
Professor David Jones
The impact of primary biliary cirrhosis on perceived quality of life: The UK-PBC national study2013
Dr Chris Lamb
Dr Graeme O'Boyle
Professor David Jones
Dr John Mansfield
Professor John Kirby
et al.
Blockade of the B7 integrin prevents adherence of t lymphocytes to MAdCAM-1 in an in vitro model of vascular microcirculation post-capillary shear flow2012
Dr Kieren Hollingsworth
Dr Guy MacGowan
Dr Matt Bates
Professor Roy Taylor
Professor David Jones
et al.
Cardiac torsion-strain relationships in fatigued primary biliary cirrhosis patients show accelerated aging: a pilot cross-sectional study2012
Dr James Frith
Professor David Jones
Professor Chris Day
Professor Julia Newton
Cognitive impairment in non-cirrhotic chronic liver disease is unrelated to liver disease severity but associated with ineffective baroreflex function2012
Professor Heather Cordell
Samantha Ducker
Dr Peter Donaldson
Professor David Jones
Dense fine-mapping study identifies new susceptibility loci for primary biliary cirrhosis2012
Professor Heather Cordell
Samantha Ducker
Dr Peter Donaldson
Professor David Jones
Dense fine-mapping study identifies novel disease loci and implicates coding and non-coding variation in primary Mary cirrhosis risk2012
Dr James Frith
Sandra Kerr
Dr Lisa Robinson
Chris Elliott
Katharine Wilton
et al.
Falls and Fall-Related Injury Are Common in Older People with Chronic Liver Disease2012
Dr Marie Hale
Professor Julia Newton
Professor David Jones
Fatigue in primary biliary cirrhosis2012
Professor David Jones
Dr Sally Stephens
Dr Laura Yates
Dr Amanda Greenall
Professor Simon Thomas
et al.
Fetal Outcomes Following Dosulepin Overdose in Pregnancy2012
Professor David Jones
Dr Sally Stephens
Dr Laura Yates
Dr Amanda Greenall
Professor Simon Thomas
et al.
Fetal Outcomes Following Fentanyl Exposure in Pregnancy2012
Professor David Jones
Dr Kieren Hollingsworth
Professor Djordje Jakovljevic
Dr Gulnar Fattakhova
Jessie Pairman
et al.
Loss of capacity to recover from acidosis on repeat exercise in chronic fatigue syndrome: A case control study2012
Professor David Jones
Out-patient' albumin dialysis for cholestatic patients with intractable pruritus2012
Professor David Jones
Pathogenesis of cholestatic itch: Old questions, new answers, and future opportunities2012
Professor David Jones
Professor Heather Cordell
Pathway analysis of the UK GWAS dataset implicates key immunoregulatory pathways in the pathogenesis of primary biliary cirrhosis2012
Dr Michael Prentis
Professor Mike Trenell
Professor David Jones
Tim Lees
Dr Christopher Snowden
et al.
Submaximal exercise testing predicts perioperative hospitalization after aortic aneurysm repair2012
Dr Imran Patanwala
Professor Julia Newton
Professor David Jones
The clinical impact of varices and a new externally validated non-invasive inexpensive tool to predict their presence in patients with PBC2012
Dr Imran Patanwala
Professor Julia Newton
Dr Mark Hudson
Professor David Jones
The clinical impact of varices and a new externally validated non-invasive inexpensive tool to predict their presence in patients with PBC2012
Professor David Jones
The Farnesoid X receptor (FXR) agoinst obeticholic acid (OCA) increases plasma FGF-19 concentrations and decreases bile acid synthesis in primary biliary cirrhosis (PBC)2012
Professor David Jones
A potential retroviral aetiology for mouse PBC: More answers or more questions?2011
Dr Imran Patanwala
Dr Simon Kometa
Professor Julia Newton
Dr Mark Hudson
Professor David Jones
et al.
An externally-validated clinical tool for the prediction of gastro-oesophageal varices in patients with PBC - the Newcastle varices in PBC (NVP) score2011
Professor David Jones
An international study evaluating the farnesoid X receptor agonist obeticholic acid as montherapy in PBC2011
Professor David Jones
Dr Imran Patanwala
Professor Julia Newton
Comparison of the PBC-40 and PBC-27 tools for quality of life assessment in English speaking primary biliary cirrhosis patients2011
Professor David Jones
Jo Gray
Dr James Frith
Professor Julia Newton
Fatigue severity remains stable over time and independently associated with orthostatic symptoms in chronic fatigue syndrome: a longitudinal study2011
Professor Julia Newton
Dr James Frith
Jessie Pairman
Professor David Jones
Functional capacity is significantly impaired in primary biliary cirrhosis and is related to orthostatic symptoms2011
Professor Heather Cordell
Dr Peter Donaldson
Samantha Ducker
Professor David Jones
Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis2011
Dr James Prentis
Professor David Jones
Professor Mike Trenell
Dr Christopher Snowden
Impaired cardiorespiratory reserve in primary biliary cirrhosis patients undergoing liver transplant assessment2011
Professor Julia Newton
Dr Mark Hudson
Professor David Jones
Morbidity and mortality associated with varices in patients with primary biliary cirrhosis2011
Emeritus Professor Nick Miller
Dr Katherine Deane
Professor David Jones
Emma Noble
National survey of speech and language therapy provision for people with Parkinson’s disease in the United Kingdom: therapists’ practices2011
Dr Chris Lamb
Maria Price
Professor David Jones
Dr John Mansfield
Patients with Crohn's Disease report high levels of fatigue during a symptomatic disease flare2011
Chris Elliott
Dr James Frith
Jessie Pairman
Professor David Jones
Professor Julia Newton
et al.
Reduction in functional ability is significant postliver transplantation compared with matched liver disease and community dwelling controls2011
Professor David Jones
Professor Julia Newton
Reply to: Do fatigue and UDCA therapy truly have independent effects on mortality in PBC?2011
Emeritus Professor Nick Miller
Emma Noble
Professor David Jones
Dr Katherine Deane
Survey of speech and language therapy provision for people with Parkinson’s disease in the United Kingdom: patients’ and carers’ perspectives2011
Professor David Jones
Professor Julia Newton
The Complexity of Fatigue2011
Professor David Jones
Dr Ahmad Al-Rifai
Dr James Frith
Dr Imran Patanwala
Professor Julia Newton
et al.
The independent effects of fatigue and UDCA therapy on mortality in primary biliary cirrhosis: Results of a 9 year cohort follow-up (vol 53, pg 911, 2010) [Corrigendum]2011
Dr Timothy Hardy
Dr Claire McDonald
Professor David Jones
Professor Julia Newton
A follow-up study of modafinil for the treatment of daytime somnolence and fatigue in primary biliary cirrhosis2010
Professor David Jones
Dr Kieren Hollingsworth
Professor Roy Taylor
Professor Andrew Blamire
Professor Julia Newton
et al.
Abnormalities in pH handling by peripheral muscle and potential regulation by the autonomic nervous system in chronic fatigue syndrome2010
Dr Stuart Kendrick
Dr Graeme O'Boyle
Professor Jelena Mann
Dr Mujdat Zeybel
Dr Jeremy Palmer
et al.
Acetate, the Key Modulator of Inflammatory Responses in Acute Alcoholic Hepatitis2010
Dr Jeremy Palmer
Dr Imran Patanwala
Elsbeth Henderson
Professor Chris Day
Professor David Jones
et al.
Allo- and auto-antibody responses in ALD as biomarkers of prognosis2010
Dr Claire McDonald
Professor Julia Newton
Professor Stuart Baker
Professor David Jones
Central nervous system dysfunction in primary biliary cirrhosis and its relationship to symptoms2010
Professor Heather Cordell
Dr Peter Donaldson
Professor David Jones
Genome-wide association study identifies more than 10 primary biliary cirrhosis risk loci2010
Professor David Jones
Dr Kieren Hollingsworth
Dr Gulnar Fattakhova
Dr Guy MacGowan
Professor Roy Taylor
et al.
Impaired cardiovascular function in primary biliary cirrhosis2010
Dr Kieren Hollingsworth
Professor David Jones
Professor Roy Taylor
Professor Andrew Blamire
Professor Julia Newton
et al.
Impaired cardiovascular response to standing in Chronic Fatigue Syndrome2010
Dr Kieren Hollingsworth
Professor David Jones
Professor Roy Taylor
Dr James Frith
Professor Andrew Blamire
et al.
Impaired cerebral autoregulation in primary biliary cirrhosis: implications for the pathogenesis of cognitive decline2010
Dr Kieren Hollingsworth
Professor Julia Newton
Dr Imran Patanwala
Professor Roy Taylor
Professor Andrew Blamire
et al.
Impaired subendocardial myofibre in primary biliary cirrhosis2010
Dr James Frith
Chris Elliott
Jessie Pairman
Dr Imran Patanwala
Professor David Jones
et al.
Liver transplantation is not associated with significant improvement in functional ability or symptoms2010
Dr Kieren Hollingsworth
Professor Julia Newton
Professor Roy Taylor
Professor Andrew Blamire
Professor David Jones
et al.
Loss of capacity to recover from acidosis in repeat exercise is strongly associated with fatigue in primary biliary cirrhosis2010
Professor Julia Newton
Professor David Jones
Making sense of fatigue2010
Dr James Frith
Professor Chris Day
Chris Elliott
Professor David Jones
Professor Julia Newton
et al.
Potential strategies to improve uptake of exercise interventions in non-alcoholic fatty liver disease2010
Dr James Frith
Sandra Kerr
Dr Lisa Robinson
Chris Elliott
Katharine Wilton
et al.
Primary biliary cirrhosis is associated with falls and significant fall related injury2010
Dr James Frith
Dr Simon Kerr
Dr Lisa Robinson
Katharine Wilton
Jessie Pairman
et al.
Primary biliary cirrhosis is associated with falls and significant fall related injury2010
Professor Julia Newton
Professor David Jones
Reply2010
Dr Karolina Rygiel
Dr Helen Robertson
Dr Joe Willet
Dr John Brain
Professor Alastair Burt
et al.
T Cell-Mediated Biliary Epithelial-to-Mesenchymal Transition in Liver Allograft Rejection2010
Professor David Jones
Dr Ahmad Al-Rifai
Dr James Frith
Dr Imran Patanwala
Professor Julia Newton
et al.
The independent effects of fatigue and UDCA therapy on mortality in primary biliary cirrhosis: Results of a 9 year follow-up2010
Professor David Jones
Professor Chris Day
The significance of autoantibodies in non-alcoholic fatty liver disease2010
Dr Stuart Kendrick
Elsbeth Henderson
Dr Jeremy Palmer
Professor David Jones
Professor Chris Day
et al.
Theophylline improves steroid sensitivity in acute alcoholic hepatitis2010
Professor Heather Cordell
Samantha Ducker
Dr Peter Donaldson
Professor David Jones
Validation of the north american genome-wide association study of primary biliary cirrhosis and identification of additional genetic susceptibility loci in a British cohort2010
Professor Julia Newton
Professor David Jones
Variability of perceived fatigue in primary biliary cirrhosis: implications for symptom assessment2010
Professor Alastair Burt
Professor David Jones
1001 Cytochome P450 2E1 (CYP2E1) autoreactivity in alcoholic liver disease: No evidence for a pathogenetic role2009
Dr Jeremy Palmer
Dr Hannah Walden
Professor John Kirby
Professor David Jones
680: Incorporation of 6-bromohexanoic acid (6BH) into cellular pyruvate dehydrogenase complex (PDC): Further evidence for generation of an autoimmunogenic neoantigen in primary billary cirrhosis (PBC)2009
Professor David Jones
Dr Claire McDonald
Professor Julia Newton
A Efficacy and Tolerability of Modafinil for the Treatment of Daytime Somnolence and Fatigue in Primary Biliary Cirrhosis2009
Dr James Frith
Professor David Jones
Professor Julia Newton
Chronic liver disease in an ageing population2009
Dr Lucy Walker
Professor Julia Newton
Professor David Jones
Professor Margaret Bassendine
Comment on Biochemical Response to Ursodeoxycholic Acid and Long-Term Prognosis in Primary Biliary Cirrhosis2009
Professor Julia Newton
Jessie Pairman
Katharine Wilton
Professor David Jones
Professor Chris Day
et al.
Fatigue and autonomic dysfunction in non-alcoholic fatty liver disease2009
Dr Kieren Hollingsworth
Professor David Jones
Dr Benjamin Aribisala
Professor Peter Thelwall
Professor Roy Taylor
et al.
Globus pallidus magnetisation transfer ratio, T1 and T2 in primary biliary cirrhosis: relationship with disease stage and age2009
Dr Kieren Hollingsworth
Professor Julia Newton
Professor Andrew Blamire
Professor Roy Taylor
Professor David Jones
et al.
Loss of Capacity to Recover from Acidosis on Repeat Exercise is Strongly Associated with Fatigue in Primary Biliary Cirrhosis (PBC)2009
Professor Julia Newton
Jessie Pairman
Professor David Jones
Lower Ambulatory Blood Pressure in Chronic Fatigue Syndrome2009
Sam Stevens
Professor John Allen
Emeritus Professor Alan Murray
Professor David Jones
Professor Julia Newton
et al.
Microvascular optical assessment confirms the presence of peripheral autonomic dysfunction in primary biliary cirrhosis2009
Professor David Jones
Dr Janine Gray
Professor Julia Newton
Perceived fatigue is comparable between different disease groups2009
Dr James Frith
Professor David Jones
Professor Julia Newton
Regulation of Cerebral Blood Flow is Significantly Impaired in Primary Biliary Cirrhosis2009
Professor Julia Newton
Professor David Jones
Serum anti-mitochondrial antibodies and fatigue in primary biliary cirrhosis2009
Professor Julia Newton
Jessie Pairman
Katharine Wilton
Professor David Jones
A Predictive Model for Fatigue and Its Etiologic Associations in Primary Biliary Cirrhosis2008
Professor David Jones
Jessie Pairman
Katharine Wilton
Professor Julia Newton
An integrated care pathway improves quality of life in Primary Biliary Cirrhosis2008
Professor Julia Newton
Dr James Frith
Dr Lisa Robinson
Professor David Jones
Appreciation of the benefits of exercise programmes in non-alcoholic liver disease: implications of fatigue and impact upon activities of daily living2008
Professor Julia Newton
Dr Kieren Hollingsworth
Professor Andrew Blamire
Professor Roy Taylor
Ruth Pearce
et al.
Autonomic dysfunction: A potential modifiable risk factor for cognitive decline in primary biliary cirrhosis2008
Dr Helen Marshall
Dr Helen Robertson
Professor Alastair Burt
Professor David Jones
Professor John Kirby
et al.
Biliary epithelial to mesenchymal transition contributes to portal tract fibrogenesis in primary sclerosing cholangitis2008
Professor Julia Newton
Dr Kieren Hollingsworth
Professor Roy Taylor
Ruth Pearce
Professor Andrew Blamire
et al.
Cognitive impairment in primary biliary cirrhosis: Symptom impact and potential etiology2008
Dr Stuart Kendrick
Dr Graeme O'Boyle
Dr Jeremy Palmer
Professor David Jones
Enhanced inflammatory responses in alcoholic liver disease: is acetate the key?2008
Professor John Kirby
Dr Helen Robertson
Dr Helen Marshall
Dr Karolina Rygiel
Dr Mark Hudson
et al.
Epithelial to mesenchymal transition in primary sclerosing cholangitis2008
Professor John Kirby
Dr Helen Robertson
Helen Marshall
Dr Karolina Rygiel
Dr Mark Hudson
et al.
Epithelial to mesenchymal transition in primary sclerosing cholangitis2008
Dr Karolina Rygiel
Dr Helen Robertson
Dr Helen Marshall
Marcin Pekalski
Liena Zhao
et al.
Epithelial-mesenchymal transition contributes to portal tract fibrogenesis during human chronic liver disease2008
Professor David Jones
Professor Lynn Rochester
Every day walking with Parkinson’s disease: Understanding personal challenges and strategies2008
Dr James Frith
Dr Lisa Robinson
Jessie Pairman
Katharine Wilton
Professor David Jones
et al.
Falls are common in primary biliary cirrhosis and associate with dysautonomia and distal lower limb weakness2008
Professor Julia Newton
Jessie Pairman
Katharine Wilton
Professor David Jones
Fatigue in non-alcoholic fatty liver disease (NAFLD) associates with hypotension and autonomic dysfunction2008
Professor Julia Newton
Professor David Jones
Katharine Wilton
Professor Alastair Burt
Professor Chris Day
et al.
Fatigue in non-alcoholic fatty liver disease (NAFLD) is significant and associates with inactivity and excessive daytime sleepiness but not with liver disease severity or insulin resistance2008
Dr Kieren Hollingsworth
Professor David Jones
Dr Benjamin Aribisala
Professor Roy Taylor
Professor Andrew Blamire
et al.
Globus pallidus abnormalities in MRI T2 relaxation time in primary biliary cirrhosis are associated with impaired cerebral autoregulation: implications for the pathogenesis of cognitive decline2008
Dr Jeremy Palmer
Professor David Jones
Professor John Kirby
Human Th17 cells: investigation of T cell differentiation in the presence of TGF-beta and a range of pro-inflammatory cytokines2008
Professor David Jones
Professor Lynn Rochester
Victoria Hetherington
Identifying fallers with Parkinson's disease using home-based tests: Who is at risk?2008
Professor Julia Newton
Dr Kieren Hollingsworth
Dr Jeremy Palmer
Professor Roy Taylor
Professor Andrew Blamire
et al.
Mitochondrial dysfunction and muscle PH abnormality post-exercise: A two-hit mechanism for fatigue pathogenesis in primary biliary cirrhosis2008
Dr James Frith
Professor Dame Louise Robinson
Jessie Pairman
Katharine Wilton
Professor David Jones
et al.
Orthostatic grading scale is better than timed up and go at identifying fallers with primary biliary cirrhosis2008
Professor David Jones
Pathogenesis of Primary Biliary Cirrhosis2008
Professor David Jones
Pathogenesis of primary biliary cirrhosis2008
Dr Kieren Hollingsworth
Professor Julia Newton
Professor Roy Taylor
Dr Claire McDonald
Dr Jeremy Palmer
et al.
Pilot Study of Peripheral Muscle Function in Primary Biliary Cirrhosis: Potential Implications for Fatigue Pathogenesis2008
Professor David Jones
Dr Jeremy Palmer
Professor Alastair Burt
Professor John Kirby
The specificity of liver inflammation in mouse models of primary biliary cirrhosis2008
Sam Stevens
Emeritus Professor Alan Murray
Professor David Jones
Professor Julia Newton
Vascular optical assessment of peripheral autonomic dysfunctino (AD) in primary biliary cirrhosis2008
Dr Hannah Walden
Professor John Kirby
Emeritus Professor Steve Yeaman
Dr Joseph Gray
Professor David Jones
et al.
Xenobiotic Incorporation into Pyruvate Dehydrogenase Complex Can Occur Via the Exogenous Lipoylation Pathway2008
Dr Martin Prince
Professor Margaret Bassendine
Dr Mark Hudson
Emeritus Professor Oliver James
Professor David Jones
et al.
A randomized trial of antioxidant therapy alone or with corticosteroids in acute alcoholic hepatitis2007
Professor David Jones
Professor Julia Newton
An open study of modafinil for the treatment of daytime somnolence and fatigue in primary biliary cirrhosis2007
Professor David Jones
Professor Julia Newton
An open study of modafinil for the treatment of daytime somnolence and fatigue in primary biliary cirrhosis2007
Professor David Jones
Professor Julia Newton
Association between fatigue and decreased survival in primary biliary cirrhosis - Reply2007
Professor David Jones
Professor Julia Newton
Authors' reply [2]2007
Professor Julia Newton
Dr Simon Kerr
Jessie Pairman
Professor David Jones
Autonomic dysfunction in primary biliary cirrhosis correlates with fatigue severity2007
Dr Helen Robertson
Professor John Kirby
Professor David Jones
Professor Alastair Burt
Biliary epithelial-mesenchymal transition in posttransplantation recurrence of primary biliary cirrhosis2007
Dr Claire McDonald
Professor David Jones
Professor Julia Newton
Central cerebral activation is reduced in primary biliary cirrhosis and associated with excessive daytime sleepiness2007
Professor David Jones
Complications of cholestasis2007
Dr Peter Donaldson
Professor David Jones
Dr John Taylor
Professor Julia Newton
Professor Margaret Bassendine
et al.
Cytotoxic T-Lymphocyte-Associated Antigen-4 Single Nucleotide Polymorphisms and Haplotypes in Primary Biliary Cirrhosis2007
Dr Graeme O'Boyle
Professor David Jones
Professor Chris Day
Effects of ethanol on endotoxin-mediated cytokine release: Sensitisation via TLR4 but normal tolerance2007
Dr Stuart Kendrick
Dr Graeme O'Boyle
Professor Jelena Mann
Professor David Jones
Professor Chris Day
et al.
Ethanol-induced histone acetylation: A novel mechanism for enhancement of inflammation in alcoholic hepatitis?2007
Professor David Jones
Fatigue in cholestatic liver disease: Is it all in the mind?2007
Professor Julia Newton
Professor David Jones
Elsbeth Henderson
Jessie Pairman
Katharine Wilton
et al.
Fatigue in NAFLD is severe and associates with excessive daytime somnolence but not with liver disease severity or insulin resistance2007
Professor David Jones
Professor Julia Newton
Fatigue-associated mortality in Primary Biliary Cirrosis is principally a problem of the over 65’s.2007
Dr Stuart Kendrick
Dr Jeremy Palmer
Professor David Jones
Professor Chris Day
Lymphocyte steroid sensitivity in severe alcoholic hepatitis2007
Dr Stuart Kendrick
Professor David Jones
Mechanisms of Innate Immunity in Sepsis2007
Professor David Jones
Pathogenesis of primary biliary cirrhosis2007
Professor Julia Newton
Dr Mark Hudson
Jessie Pairman
Professor David Jones
Population prevalence and symptom associations of autonomic dysfunction in primary biliary cirrhosis2007
Professor Julia Newton
Professor David Jones
Population prevalence of autonomic dysfunction in Primary Biliary Cirrhosis2007
Dr Hannah Walden
Dr Jeremy Palmer
Professor John Kirby
Dr Stuart Kendrick
Professor David Jones
et al.
Substrate promiscuity in the pyruvate dehydrogenase complex (PDC) lipoylation pathway: Xenobiotic incorporation as a potential mechanism for the pathogenesis of primary biliary cirrhosis (PBC)2007
Professor Julia Newton
Professor David Jones
Symptoms of autonomic dysfunction in chronic fatigue syndrome2007
Professor Julia Newton
Professor David Jones
Symptoms of autonomic dysfunction in chronic fatigue syndrome2007
Professor Mark Freeston
Dr Christine Baker
Professor David Jones
Professor Julia Newton
The role of psychological factors in the fatigue of primary biliary cirrhosis2007
Professor David Jones
Dr Amanda Robe
Dr Jeremy Palmer
Professor John Kirby
Adoptive transfer of self-PDC reactive T-cells into naive mice induces portal tract and bile duct changes characteristic of primary biliary cirrhosis (PBC)2006
Professor David Jones
Anaesthesia for patients with chronic liver disease2006
Professor Julia Newton
Professor David Jones
Katharine Wilton
Jessie Pairman
Dr Steve Parry
et al.
Calcaneal bone mineral density in older patients who have fallen2006
Professor Julia Newton
Professor David Jones
Katharine Wilton
Jessie Pairman
Dr Steve Parry
et al.
Calcaneal bone mineral density in older patients who have fallen2006
Professor Julia Newton
Professor David Jones
Characterisation of the associations and impact of symptoms in primary biliary cirrhosis using a disease specific quality of life measure2006
Professor David Jones
Professor Julia Newton
Cognitive impairment in primary biliary cirrhosis (PBC) is related to sympathetic autonomic nervous system dysfunction2006
Dr Karolina Rygiel
Dr Helen Robertson
Professor Alastair Burt
Professor David Jones
Professor John Kirby
et al.
Demonstration of the transition of intrahepatic biliary epithelial cells to fibroblasts during chronic inflammatory liver diseases2006
Professor Julia Newton
Emeritus Professor John Gibson
Katharine Wilton
Professor David Jones
Fatigue in primary biliary cirrhosis is associated with excessive daytime somnolence2006
Professor Julia Newton
Jessie Pairman
Professor David Jones
Fatigue in Primary Biliary Cirrhosis is Associated with Symptomatic Abnormalities in Blood Pressure Regulation2006
Dr Jenny Milner
Professor David Jones
Professor David Young
Emeritus Professor Drew Rowan
Emeritus Professor Tim Cawston
et al.
Fibroblast activation protein alpha is expressed by chondrocytes following a pro-inflammatory stimulus and is elevated in osteoarthritis2006
Professor David Jones
Dr Martin Prince
Professor Julia Newton
Four year follow up of fatigue in a geographically defined primary biliary cirrhosis patient cohort2006
Dr Peter Donaldson
Dr Anna Baragiotta
Professor David Jones
Emeritus Professor Oliver James
Professor Margaret Bassendine
et al.
HLA class II alleles, genotypes, haplotypes, and amino acids in primary biliary cirrhosis: A large-scale study2006
Professor Julia Newton
Professor David Jones
Modafinil is an effective treatment for excessive daytime somnolence and fatigue in primary biliary cirrhosis (PBC)2006
Anna McHugh
Dr Amanda Robe
Dr Jeremy Palmer
Professor David Jones
PDC-E3BP is not a dominant T-cell autoantigen in primary biliary cirrhosis2006
Professor David Jones
Professor Julia Newton
Primary biliary cirrhosis2006
Professor Julia Newton
Professor David Jones
Reduced heart rate variability and baroreflex sensitivity in primary biliary cirrhosis2006
Professor David Jones
Professor Julia Newton
Reflections on therapeutic trials in primary biliary cirrhosis: A qualify of life oriented counter-view2006
Professor Christopher Ward
Dr Ian Forrest
Professor David Jones
Dr Gary Pritchard
Rachel Stovold
et al.
The phosphodiesterase type IV (PDE IV) inhibitor cilomilast decreases pro-inflammatory cytokine production from primary bronchial epithelial cells derived from lung transplant recipients2006
Dr Anna Broad
Professor David Jones
Professor John Kirby
Toll-like receptor (TLR) response tolerance: A key physiological "damage limitation" Effect and an important potential opportunity for therapy2006
Dr Anna Broad
Professor John Kirby
Professor David Jones
Toll-like receptor interactions: Tolerance of MyD88-dependent cytokines but enhancement of MyD88-independent interferon-β production2006
Dr Amanda Robe
Professor John Kirby
Professor David Jones
Dr Jeremy Palmer
A key role for autoreactive B cells in the breakdown of T-cell tolerance to pyruvate dehydrogenase complex in the mouse2005
Dr Amanda Robe
Professor John Kirby
Professor David Jones
Dr Jeremy Palmer
A key role for autoreactive B cells in the breakdown of T-cell tolerance to pyruvate dehydrogenase complex in the mouse2005
Dr Mark Hudson
Joanne Newton
Dr Martin Prince
Professor David Jones
An evidence-based model for the targeting of varices screening in PBC2005
Dr Ann Jacoby
Professor Julia Newton
Emeritus Professor Oliver James
Professor David Jones
Development, validation, and evaluation of the PBC-40, a disease specific health related quality of life measure for primary biliary cirrhosis2005
Dr Ian Forrest
Dr James Lordan
Dr Gary Pritchard
Professor David Jones
Dr Helen Robertson
et al.
Epithelial to mesenchymal transition in clinically stable lung transplant recipients2005
Liena Zhao
Dr Helen Robertson
Professor John Kirby
Professor David Jones
Professor Alastair Burt
et al.
Epithelial-mesenchymal transition in portal fibrosis2005
Professor David Jones
Fat is an immuno-regulatory issue2005
Dr Martin Prince
Professor Margaret Bassendine
Professor David Jones
Fatigue in primary biliary cirrhosis [1]2005
Professor Julia Newton
Professor David Jones
Fatigue in primary biliary cirrhosis is associated with symptoms of autonomic dysfunction2005
Professor David Young
Dr Rachel Lakey
Professor David Jones
Emeritus Professor Tim Cawston
Histone deacetylase inhibitors modulate metalloproteinase gene expression in chondrocytes and block cartilage resorption2005
Professor Christopher Ward
Dr Helen Robertson
Dr Ian Forrest
Dr James Lordan
Denis Murphy
et al.
Hypothesis: Epithelial-to-mesenchymal transition is a common cause of chronic allograft failure2005
Dr Stephen Stewart
Dr Beate Haugk
Professor Alastair Burt
Professor David Jones
Professor Chris Day
et al.
Anti-cytochrome P4502E1 autoantibody titre associates with immune liver histology in advanced alcoholic liver disease2004
Dr Jeremy Palmer
Professor John Kirby
Professor David Jones
Apoptosis as a mechanism for cell surface expression of the autoantigen pyruvate dehydrogenase complex2004
Dr Deborah Buck
Professor David Jones
Emeritus Professor Oliver James
Dr Ann Jacoby
Assessing quality of life in primary biliary cirrhosis2004
Dr Amanda Robe
Dr Jeremy Palmer
Professor John Kirby
Professor David Jones
Breakdown of T-cell tolerance to the primary biliary cirrhosis (PBC) autoantigen pyruvate dehydrogenase complex is a B-cell driven process2004
Dr Amanda Robe
Dr Jeremy Palmer
Professor John Kirby
Professor David Jones
Breakdown of T-cell tolerance to the primary biliary cirrhosis (PBC) autoantigen pyruvate dehydrogenase complex is a B-cell driven process2004
Dr Anna Baragiotta
Dr Kaushik Agarwal
Dr Alison Sutherland
Professor David Jones
Dr Peter Donaldson
et al.
Chemokine receptor 5 and primary biliary cirrhosis: A two-centre genetic association study2004
Dr Stephen Stewart
Professor David Jones
Dr Beate Haugk
Professor Alastair Burt
Professor Chris Day
et al.
Correlation between anti-CYP2E1 titre and lymphocyte infiltration in ALD - An autoimmune disease in some patients?2004
Dr Jeremy Palmer
Dr Amanda Robe
Professor Alastair Burt
Professor John Kirby
Professor David Jones
et al.
Covalent modification as a mechanism for the breakdown of immune tolerance to pyruvate dehydrogenase complex in the mouse2004
Professor Margaret Bassendine
Professor David Jones
Fatigue and primary biliary cirrhosis: Association of globus pallidus magnetisation transfer ratio measurements with fatigue severity and blood manganese levels2004
Dr Anna Baragiotta
Dr Kaushik Agarwal
Professor David Jones
Dr Peter Donaldson
Professor Margaret Bassendine
et al.
No evidence for involvement of the CCR5 (chemokine receptor-5) delta 32 mutation in primary biliary cirrhosis2004
Dr Stephen Stewart
Professor Chris Day
Professor David Jones
Oxidative Stress as a Trigger for Cellular Immune Responses in Patients with Alcoholic Liver Disease2004
Emeritus Professor Oliver James
Professor David Jones
Patterns of Autoimmunity in PBC Patients and Their Families: a Population-Based Cohort Study2004
Emeritus Professor Oliver James
Professor David Jones
Patterns of autoimmunity in primary biliary cirrhosis patients and their families: A population-based cohort study2004
Professor David Jones
Primary biliary cirrhosis2004
Professor David Jones
Professor Margaret Bassendine
Primary biliary cirrhosis: Report of a focus study group2004
Professor Julia Newton
Professor David Jones
Risk factors for sudden cardiac death in primary biliary cirrhosis.2004
Dr Martin Prince
Dr Denis Burke
Matthew Edwards
Dr Michael Bramble
Emeritus Professor Oliver James
et al.
A placebo controlled randomised crossover trial of oral antioxidant supplementation for fatigue in primary biliary cirrhosis (PBC)2003
Professor David Jones
Addison's other disease: Primary biliary cirrhosis as a model autoimmune disease2003
Dr John Taylor
Emeritus Professor Oliver James
Professor Margaret Bassendine
Professor David Jones
Dr Peter Donaldson
et al.
Caspase 8 gene polymorphism is associated with primary biliary cirrhosis2003
Professor David Jones
Professor John Kirby
Cell-surface expression of PDC during apoptosis: A possible route for autoantigen presentation in PBC?2003
Professor David Jones
Discussion on the true impact of fatigue in primary biliary cirrhosis: A population study [1] (multiple letters)2003
Professor Ann Daly
Julian Leathart
Dr Beate Haugk
Professor David Jones
Professor Alastair Burt
et al.
Evidence that alcoholic liver disease is due to immune mechanisms in genetically susceptible drinkers2003
Dr Martin Prince
Professor David Jones
Fatigue in anti-mitochondrial antibody positive patients with normal liver function tests2003
Professor David Jones
Fatigue in PBC2003
Dr Stephen Stewart
Professor Ann Daly
Professor David Jones
Julian Leathart
Professor Chris Day
et al.
Genetic and epigenetic factors in autoimmune reactions toward cytochrome P4502E1 in alcoholic liver disease2003
Professor David Jones
Dr Peter Donaldson
Genetic factors in the pathogenesis of primary biliary cirrhosis2003
Anna McHugh
Dr Jeremy Palmer
Emeritus Professor Steve Yeaman
Professor David Jones
Is PDC-E3BP (protein X) a T-cell autoantigen in primary biliary cirrhosis?2003
Professor Chris Day
Professor David Jones
Neo-antigen specific T-cell responses are closely associated with the presence of liver disease in heavy drinkers2003
Dr Martin Prince
Emeritus Professor Oliver James
Professor David Jones
Oral antioxidant supplementation for fatigue associated with primary biliary cirrhosis2003
Dr Martin Prince
Dr Nia Edwards
Dr Michael Bramble
Emeritus Professor Oliver James
Professor David Jones
et al.
Oral antioxidant supplementation for fatigue associated with primary biliary cirrhosis: Results of a multicentre, randomized, placebo-controlled, cross-over trial2003
Dr Martin Prince
Emeritus Professor Oliver James
Professor Chris Day
Dr Mark Hudson
Professor David Jones
et al.
Pain as a complication of opiate antagonist therapy in cholestasis: A single centre experience2003
Dr Martin Prince
Dr Mark Hudson
Professor Chris Day
Emeritus Professor Oliver James
Professor David Jones
et al.
Pain as a complication of use of opiate antagonists for symptom control in cholestasis2003
Professor David Jones
Pathogenesis of primary biliary cirrhosis2003
Professor David Jones
Dr Martin Prince
Dr Mark Hudson
The Mayo prognostic score fails to predict increased mortality associated with portal hypertension in primary biliary cirrhosis (PBC)2003
Professor John Kirby
Michael Bone
Dr Helen Robertson
Dr Mark Hudson
Professor David Jones
et al.
The number of intraepithelial T cells decreases from ascending colon to rectum [1]2003
Dr Amanda Robe
Dr Jeremy Palmer
Professor John Kirby
Professor Margaret Bassendine
Professor David Jones
et al.
[abstract] Characterisation of liver infiltrating T-cell antigen specificity in a mouse model of primary biliary cirrhosis (PBC)2002
Dr Martin Prince
Dr Denis Burke
Matthew Edwards
Dr Michael Bramble
Emeritus Professor Oliver James
et al.
A placebo controlled randomised crossover trial of oral antioxidant supplementation for fatigue in primary biliary cirrhosis (PBC)2002
Professor David Jones
Dr Jeremy Palmer
Professor Alastair Burt
Dr Amanda Robe
Professor John Kirby
et al.
Bacterial motif DNA as an adjuvant for the breakdown of immune self-tolerance to pyruvate dehydrogenase complex2002
Dr Jeremy Palmer
Professor John Kirby
Professor David Jones
Breakdown of tolerance is seen to both PDC-E2 and PDC-E3BP, individual antigens in primary biliary cirrhosis, in a mouse model of PDC autoreactivity2002
Dr John Taylor
Emeritus Professor Oliver James
Professor Margaret Bassendine
Professor David Jones
Dr Peter Donaldson
et al.
Caspase 8 gene polymorphism is associated with primary biliary cirrhosis2002
Dr Pamela MacDonald
Professor John Kirby
Professor David Jones
Cell-surface expression of pyruvate dehydrogenase complex during apoptosis: A possible route for autoantigen presentation in primary biliary cirrhosis2002
Dr Amanda Robe
Dr Jeremy Palmer
Professor John Kirby
Professor David Jones
Characterisation of liver infiltrating T-cell antigen specificity in a mouse model of primary biliary cirrhosis (PBC)2002
Professor David Jones
Complications of cholestasis2002
Professor Ann Daly
Julian Leathart
Dr Beate Haugk
Professor David Jones
Professor Alastair Burt
et al.
Evidence that alcoholic liver disease is due to immune mechanisms in genetically susceptible drinkers2002
Dr Martin Prince
Professor David Jones
Fatigue in anti-mitochondrial antibody positive patients with normal liver function tests2002
Dr Kaushik Agarwal
Professor David Jones
Professor Alastair Burt
Dr Mark Hudson
Emeritus Professor Oliver James
et al.
Metastatic breast carcinoma presenting as acute liver failure and portal hypertension2002
Professor Chris Day
Professor David Jones
Neo-antigen specific T-cell responses are closely associated with the presence of liver disease in heavy drinkers2002
Professor David Jones
Dr Jeremy Palmer
Dr Amanda Robe
Professor John Kirby
Oral tolerisation to pyruvate dehydrogenase complex as a potential therapy for primary biliary cirrhosis2002
Professor Julia Newton
Professor David Jones
Osteoporosis in primary biliary cirrhosis2002
Professor Julia Newton
Emeritus Professor Oliver James
Professor Margaret Bassendine
Professor David Jones
Osteoporosis is not a specific complication of primary biliary cirrhosis2002
Dr Martin Prince
Emeritus Professor Oliver James
Professor Chris Day
Dr Mark Hudson
Professor David Jones
et al.
Pain as a complication of opiate antagonist therapy in cholestasis: A single centre experience2002
Dr Martin Prince
Professor Margaret Bassendine
Professor David Jones
Reduced pallidal magnetisation transfer ratios are associated with fatigue in pre-cirrhotic patients with primary biliary cirrhosis (PBC)2002
Professor Margaret Bassendine
Professor David Jones
Reduced pallidal magnetisation transfer ratios are associated with fatigue in pre-cirrhotic patients with primary biliary cirrhosis [abstract]2002
Dr Jeremy Palmer
Professor John Kirby
Professor David Jones
The immunology of primary biliary cirrhosis: The end of the beginning?2002
Professor David Jones
Dr Martin Prince
Dr Mark Hudson
The impact of portal hypertension in primary biliary cirrhosis (PBC)2002
Professor David Jones
Dr Martin Prince
Dr Mark Hudson
The mayo prognostic score fails to predict increased mortality associated with portal hypertension in primary biliary cirrhosis2002
Professor David Jones
Dr Martin Prince
Dr Mark Hudson
The prevalence of portal hypertension (PHT) in primary biliary cirrhosis (PBC) [abstract]2002
Dr Martin Prince
Dr Anna Baragiotta
Professor Margaret Bassendine
Emeritus Professor Oliver James
Professor David Jones
et al.
The true impact of fatigue in primary biliary cirrhosis: A population study2002
Dr Stephen Stewart
Professor Ann Daly
Julian Leathart
Professor David Jones
Professor Chris Day
et al.
A polymorphism in CTLA-4 is associated with the presence of anti-CYP2E1 antibody titres in patients with alcoholic liver disease2001
Dr Stephen Stewart
Professor David Jones
Professor Chris Day
Alcoholic liver disease: New insights into mechanisms and preventative strategies2001
Dr Jeremy Palmer
Emeritus Professor Steve Yeaman
Professor David Jones
Epitope specificity of anti-PDC E1 alpha antibodies in primary biliary cirrhosis (PBC)2001
Emeritus Professor Oliver James
Professor David Jones
Failure to sustain peripheral muscle activity as an aetiological factor for fatigue in primary biliary cirrhosis (PBC)2001
Professor David Jones
Professor Julia Newton
Fatigue in primary biliary cirrhosis is associated with early autonomic failure2001
Dr Anna Baragiotta
Professor David Jones
Dr Kaushik Agarwal
Emeritus Professor Oliver James
Professor Margaret Bassendine
et al.
Genetic susceptibility to primary biliary cirrhosis (PBC): Analysis of chemokine receptor 5 (CCR5) delta32 deletion2001
Emeritus Professor Oliver James
Professor David Jones
Grip strength and subjective fatigue in patients with primary biliary cirrhosis [4]2001
Dr Peter Donaldson
Dr Kaushik Agarwal
Emeritus Professor Oliver James
Professor David Jones
HLA and interleukin 1 gene polymorphisms in primary biliary cirrhosis: associations with disease progression and disease susceptibility2001
Dr Martin Prince
Professor David Jones
Measuring fatigue in medically unwell and distressed patients2001
Dr David Neill
David Hughes
Alan Leake
Louise Ward
Professor David Jones
et al.
Neuritogenic-neurotoxic effects of membrane-associated forms of amyloid precursor protein2001
Professor Julia Newton
Emeritus Professor Roger Francis
Emeritus Professor Oliver James
Professor Margaret Bassendine
Professor David Jones
et al.
Osteoporosis in primary biliary cirrhosis revisited2001
Professor John Isaacs
Professor David Jones
The ninety-fifth annual general meeting of the association of physicians of Great Britain and Ireland 20012001
Dr Kaushik Agarwal
Dr John Rose
Dr Mark Hudson
Professor David Jones
TIPSS in PBC: Lessons regarding the role played by variceal bleeding in disease prognosis2001
Dr Anna Baragiotta
Emeritus Professor Oliver James
Professor David Jones
Joanne Newton
Professor Margaret Bassendine
et al.
Vitamin D receptor (VDR) TaqI polymorphism in primary biliary cirrhosis (PBC)2001
Professor David Jones
Autoantigens in primary biliary cirrhosis2000
Emeritus Professor Steve Yeaman
Professor John Kirby
Professor David Jones
Autoreactive responses to pyruvate dehydrogenase complex in the pathogenesis of primary biliary cirrhosis2000
Professor David Jones
Professor Ann Daly
Emeritus Professor Oliver James
Dr Bijayeswar Vaidya
Professor Simon Pearce
et al.
CTLA-4 gene polymorphism confers susceptibility to primary biliary cirrhosis2000
Dr Kaushik Agarwal
Professor David Jones
Dr Peter Donaldson
Cytotoxic T lymphocyte antigen-4 (CTLA-4) gene polymorphisms and susceptibility to type 1 autoimmune hepatitis2000
Dr Kaushik Agarwal
Professor David Jones
Dr Peter Donaldson
Cytotoxic T lymphocyte antigen-4 gene polymorphisms and susceptibility to type 1 autoimmune hepatitis2000
Professor David Jones
Fetal microchimerism: an aetiological factor in primary biliary cirrhosis?2000
Dr Martin Prince
Professor David Jones
Primary biliary cirrhosis: New perspectives in diagnosis and treatment2000
Professor David Jones
Recent advances in autoimmune diseases2000
Dr Jeremy Palmer
Professor John Kirby
Emeritus Professor Steve Yeaman
Professor Margaret Bassendine
Professor David Jones
et al.
Secretory autoantibodies in primary biliary cirrhosis (PBC)2000
Dr Martin Prince
Emeritus Professor Oliver James
Professor David Jones
Validation of a fatigue impact score in primary biliary cirrhosis: towards a standard for clinical and trial use2000
Denise Howel
Dr Jane Metcalf
Professor David Jones
Emeritus Professor Oliver James
Cancer risk in primary biliary cirrhosis: A study in northern England1999
Professor David Jones
Emeritus Professor Oliver James
Dr Michael Bramble
Case report: Oral antioxidant therapy for the treatment of primary biliary cirrhosis: A pilot study1999
Dr Jeremy Palmer
Professor David Jones
Professor Janet Quinn
Anna McHugh
Emeritus Professor Steve Yeaman
et al.
Characterization of the autoantibody responses to recombinant E3 binding protein (protein X) of pyruvate dehydrogenase in primary biliary cirrhosis1999
Professor David Jones
Co-sensitisation with self- and homologous foreign-antigen as a mechanism of breakdown of self-tolerance in primary biliary cirrhosis (PBC)1999
Dr Kaushik Agarwal
Professor David Jones
Professor Ann Daly
Professor Margaret Bassendine
CTLA-4 gene polymorphism and chronicity in viral hepatitis1999
Dr Kaushik Agarwal
Professor David Jones
Dr Peter Donaldson
CTLA-4 gene polymorphism and susceptibility to autoimmune hepatitis1999
Dr Kaushik Agarwal
Professor David Jones
Professor Ann Daly
Professor Margaret Bassendine
Dr Mark Hudson
et al.
CTLA-4 gene polymorphism and susceptibility to inflammatory bowel disease (IBD)1999
Professor David Jones
Emeritus Professor Oliver James
Professor Alastair Burt
Dr Mark Hudson
Development of autoimmune hepatitis following liver transplantation for primary biliary cirrhosis1999
Professor David Jones
Professor Margaret Bassendine
Emeritus Professor Oliver James
Familial primary hiliary cirrhosis reassessed: A geographically-based population study1999
Dr Kaushik Agarwal
Professor David Jones
Professor Margaret Bassendine
Genetic susceptibility to primary biliary cirrhosis [Review]1999
Dr Jeremy Palmer
Professor John Kirby
Emeritus Professor Steve Yeaman
Professor David Jones
Persistence of secretory autoantibodies in PBC patients post-liver transplant: a potential mechanism for disease recurrence?1999
Dr Jeremy Palmer
Emeritus Professor Steve Yeaman
Professor Margaret Bassendine
Professor David Jones
T cell responses to the putative dominant autoepitope in primary biliary cirrhosis (PBC)1999
Dr Martin Prince
Lorna Ingoe
Professor David Jones
Dr Irving Cobden
Professor Roger Barton
et al.
The CLO test in the UK: inappropriate reading and missed results1999
Dr Kaushik Agarwal
Professor David Jones
Treatment of hepatitis C infection - Review underplayed important public health issues1999
Professor David Jones
Professor Julia Newton
Professor Ann Daly
Professor Chris Day
Emeritus Professor Oliver James
et al.
Tumour necrosis factor-α promoter polymorphisms in primary biliary cirrhosis1999
Professor David Jones
Emeritus Professor Oliver James
Professor Margaret Bassendine
Primary biliary cirrhosis: clinical and associated autoimmune features and natural history1998