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Targeting Allograft Injury and Inflammation in the Management of Post-Lung Transplant Bronchiolitis Obliterans Syndrome

Lookup NU author(s): Dr Andrew Robertson, Professor Michael Griffin, Professor Jeffrey Pearson, Dr Ian Forrest, Professor John Dark, Emeritus Professor Nick Europe-Finner, Professor Christopher WardORCiD


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Chronic allograft dysfunction, manifesting as bronchiolitis obliterans syndrome (BOS), is the major cause of morbidity and mortality in human lung transplant recipients. While alloimmunity has a definite role, there is increasing interest in overall allograft injury and subsequent inflammation and remodeling. This review deals with nonalloimmune factors that may potentiate alloimmune injury. We discuss infection and reflux/aspiration as examples of allograft injury, which may lead to chronic loss of graft function and BOS. Surgical and nonsurgical treatments aimed at preventing these insults and improving survival are considered. The need for further evidence, including randomized-controlled trials, to evaluate the role of medical and surgical therapies is emphasized by the current literature.

Publication metadata

Author(s): Robertson AGN, Griffin SM, Murphy DM, Pearson JP, Forrest IA, Dark JH, Corris PA, Ward C

Publication type: Review

Publication status: Published

Journal: American Journal of Transplantation

Year: 2009

Volume: 9

Issue: 6

Pages: 1272-1278

ISSN (print): 1600-6135

ISSN (electronic): 1600-6143



DOI: 10.1111/j.1600-6143.2009.02648.x