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Lookup NU author(s): Dr Judith Bulmer,
Dr Roger Searle,
Professor Steve RobsonORCiD
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Alterations in the balance of leucocyte populations in uterine decidua may lead to the generation of an unfavourable cytokine environment that is associated with unsuccessful pregnancy. Single and double immunohistochemical labelling was used to examine leucocyte populations in decidua from normal third trimester, foetal growth-restricted and pre-eclamptic pregnancies. Placental bed biopsies from 12 women undergoing elective Caesarean section with no hypertension or foetal growth restriction (FGR), 8 women with FGR without maternal hypertension and 12 women with pre-eclampsia (PE) were used to quantify decidual CD56+ uterine NK cells, CD14+ macrophages, CD3+T-lymphocytes and CD8+ lymphocytes. CD3+CD56+, CD8+CD56+ and CD161+CD3+ double-labelled cells in decidua were compared in PE and control decidua. Decidual CD3+T-lymphocytes (P
Author(s): Williams PJ, Bulmer JN, Searle RF, Innes BA, Robson SC
Publication type: Article
Publication status: Published
ISSN (print): 1470-1626
ISSN (electronic): 1741-7899
Publisher: BioScientifica Ltd.
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