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Altered decidual leucocyte populations in the placental bed in pre-eclampsia and foetal growth restriction: a comparison with late normal pregnancy

Lookup NU author(s): Dr Judith Bulmer, Dr Roger Searle, Barbara Innes, Professor Steve RobsonORCiD

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Abstract

Alterations in the balance of leucocyte populations in uterine decidua may lead to the generation of an unfavourable cytokine environment that is associated with unsuccessful pregnancy. Single and double immunohistochemical labelling was used to examine leucocyte populations in decidua from normal third trimester, foetal growth-restricted and pre-eclamptic pregnancies. Placental bed biopsies from 12 women undergoing elective Caesarean section with no hypertension or foetal growth restriction (FGR), 8 women with FGR without maternal hypertension and 12 women with pre-eclampsia (PE) were used to quantify decidual CD56+ uterine NK cells, CD14+ macrophages, CD3+T-lymphocytes and CD8+ lymphocytes. CD3+CD56+, CD8+CD56+ and CD161+CD3+ double-labelled cells in decidua were compared in PE and control decidua. Decidual CD3+T-lymphocytes (P

Publication metadata

Author(s): Williams PJ, Bulmer JN, Searle RF, Innes BA, Robson SC

Publication type: Article

Publication status: Published

Journal: Reproduction

Year: 2009

Volume: 138

Issue: 1

Pages: 177-184

ISSN (print): 1470-1626

ISSN (electronic): 1741-7899

Publisher: BioScientifica Ltd.

URL: http://dx.doi.org/10.1530/REP-09-0007

DOI: 10.1530/REP-09-0007

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