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Telomere length-heterogeneity among myeloid cells is a predictor for chronological ageing

Lookup NU author(s): Professor Ioakim Spyridopoulos

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Abstract

We have previously shown that mean telomere length (TL) of granulocytes reflects TL of myeloid bone marrow cells extremely well. Here we analysed the distribution of TL from peripheral blood granulocytes and lymphocytes in 61 female and 68 age-matched male healthy volunteers. We show that the age-dependent decline in TL occurs more rapid in peripheral blood lymphocytes (53 bp/year) than in granulocytes (39 bp/year; p


Publication metadata

Author(s): Hoffmann J, Erben Y, Zeiher AM, Dimmeler S, Spyridopoulos I

Publication type: Article

Publication status: Published

Journal: Experimental Gerontology

Year: 2009

Volume: 44

Issue: 5

Pages: 363-366

ISSN (print): 0531-5565

ISSN (electronic): 1873-6815

Publisher: Elsevier Inc.

URL: http://dx.doi.org/10.1016/j.exger.2009.02.006

DOI: 10.1016/j.exger.2009.02.006


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