Publications by Professor Ioakim Spyridopoulos - ePrints

Browsing publications by Professor Ioakim Spyridopoulos.

Newcastle Authors	Title	Year
Yasemin Ekinci Professor Gavin Richardson Professor Ioakim Spyridopoulos	A Phase IIa Clinical Trial of KAND567, Fractalkine Receptor Inhibitor, in Patients with ST-Elevation Acute Myocardial Infarction after Percutaneous Coronary Intervention	2024
Dr Maria Camacho Encina Laura Booth Dr Rachael Redgrave Dr Omowumi Folaranmi Professor Ioakim Spyridopoulos et al.	Cellular Senescence, Mitochondrial Dysfunction, and Their Link to Cardiovascular Disease	2024
Dr Bilal Bawamia Muntaser Omari Professor Ioakim Spyridopoulos Dr Mohammad Alkhalil	Eosinopenia in patients with acute myocardial infarction- longitudinal imaging insights from the CAPRI study	2024
Dr Rachael Redgrave Dr Esha Singh Dr Simon Tual-Chalot Dr Catherine Park Dr Darroch Hall et al.	Exogenous Transforming Growth Factor-β1 and Its Helminth-Derived Mimic Attenuate the Heart's Inflammatory Response to Ischemic Injury and Reduce Mature Scar Size	2024
Professor Ioakim Spyridopoulos	Zibotentan in Microvascular Angina: A Randomized, Placebo-Controlled, Crossover Trial	2024
Dr Bilal Bawamia Dr Luke Spray Vincent Wangsaputra Dr Karim Bennaceur Dr Sharareh Vahabi et al.	Activation of telomerase by TA-65 enhances immunity and reduces inflammation post myocardial infarction Randomized Pilot Trial	2023
Dr Ayman Al-atta Dr Luke Spray Dr Ashfaq Mohammed Professor Ioakim Spyridopoulos	Arginine Vasopressin Plays a Role in Microvascular Dysfunction After ST-Elevation Myocardial Infarction	2023
Dr Visvesh Jeyalan Professor Ioakim Spyridopoulos Professor Vijay Kunadian Dr Mohaned Egred Professor Azfar Zaman et al.	Clinical outcomes of coronary intravascular lithotripsy in patients with stent failure (COIL registry)	2023
Dr Kateryna Sopova Dr Simon Tual-Chalot Dr Nikolaos Vlachogiannis Dr Georgios Georgiopoulos Dr Luke Spray et al.	Effector T cell chemokine IP-10 predicts cardiac recovery and clinical outcomes post-myocardial infarction	2023
Shu Xian Loh Yasemin Ekinci Dr Luke Spray Dr Visvesh Jeyalan Professor Gavin Richardson et al.	Fractalkine Signalling (CX₃CL1/CX₃CR1 Axis) as an Emerging Target in Coronary Artery Disease.	2023
Dr Visvesh Jeyalan Dr David Austin Shu Xian Loh Vincent Wangsaputra Professor Ioakim Spyridopoulos et al.	Fractalkine/CX₃CR1 in Dilated Cardiomyopathy: A Potential Future Target for Immunomodulatory Therapy?	2023
Laura Booth Dr Rachael Redgrave Dr Simon Tual-Chalot Professor Ioakim Spyridopoulos Dr Helen Phillips et al.	Heart Disease and Ageing: The Roles of Senescence, Mitochondria, and Telomerase in Cardiovascular Disease	2023
Dr Mina Ghobrial Dr Bilal Bawamia Professor Ioakim Spyridopoulos Professor Vijay Kunadian Professor Azfar Zaman et al.	Microvascular Obstruction in Acute Myocardial Infarction, a Potential Therapeutic Target	2023
Dr Georgios Georgiopoulos Dr Kateryna Sopova Dr Luke Spray Dr Jose Coelho Lima Junior Dr Simon Tual-Chalot et al.	Modification of the GRACE Risk Score for Risk Prediction in Patients with Acute Coronary Syndromes	2023
Dr Rachael Redgrave Dr Emily Dookun Laura Booth Dr Maria Camacho Encina Dr Omowumi Folaranmi et al.	Senescent cardiomyocytes contribute to cardiac dysfunction following myocardial infarction	2023
Dr Aikaterini Gatsiou Dr Simon Tual-Chalot Dr Georgios Georgiopoulos Professor Kimon Stamatelopoulos Professor Ioakim Spyridopoulos et al.	The RNA editor ADAR2 promotes immune cell trafficking by enhancing endothelial responses to interleukin-6 during sterile inflammation	2023
Dr Rachael Redgrave Dr Maria Camacho Encina Dr Simon Tual-Chalot Dr Omowumi Folaranmi Dr Carmen Martin-Ruiz et al.	The senescence-associated secretory phenotype as a biomarker for age-related myocardial remodelling and cardiovascular disease	2023
Dr Bilal Bawamia Professor Ioakim Spyridopoulos Dr Alan Bagnall Dr Mohaned Egred Professor Azfar Zaman et al.	Very Early Discharge After Primary Percutaneous Coronary Intervention for ST-Elevation Myocardial Infarction: Mortality Outcomes at Six Months	2023
Professor Ioakim Spyridopoulos Dr Bilal Bawamia Dr Luke Spray Vincent Wangsaputra Professor Konstantinos Stellos et al.	Activation of mitochondrial telomerase reverses relative lymphopenia post myocardial infarction: results from the randomised, double-blinded TACTIC phase IIa pilot trial	2022
Professor Kimon Stamatelopoulos Dr Georgios Georgiopoulos Dr Nikolaos Vlachogiannis Dr Kateryna Sopova Dr Simon Tual-Chalot et al.	Cathepsin S Levels and Survival Among Patients With Non-ST-Segment Elevation Acute Coronary Syndromes	2022
Dr Nikolaos Vlachogiannis Dr Ken Baker Dr Georgios Georgiopoulos Dr Ina Schim van der Loeff Dr Aidan Hanrath et al.	Clinical frailty, and not features of acute infection, is associated with late mortality in COVID-19: a retrospective cohort study	2022
Dr Antoneta Granic Dr Carmen Martin-Ruiz Lucy Rimmer Dr Richard Dodds Dr Louise Robinson et al.	Immunosenescence profiles of lymphocyte compartments and multiple long-term conditions (multimorbidity) in very old adults: The Newcastle 85+ Study	2022
Dr Anna Walaszczyk Dr Emily Dookun Dr Rachael Redgrave Dr Pawel Palmowski Dr Simon Tual-Chalot et al.	Therapeutic potential of navitoclax in age-related cardiovascular diseases	2022
Dr Jake McClements Professor Katarina Novakovic Professor Azfar Zaman Professor Ioakim Spyridopoulos Professor Marloes Peeters et al.	Immobilization of Molecularly Imprinted Polymer Nanoparticles onto Surfaces using Different Strategies: Evaluating the Influence of the Functionalised Interface on the Performance of a Thermal Assay for the Detection of Cardiac Biomarker Troponin I	2021
Jose Coelho Lima Junior Dr Georgios Georgiopoulos Dr Jannath Ahmed David Gaskin Dr Konstantinos Bakogiannis et al.	Prognostic value of admission high-sensitivity troponin in patients with ST-elevation myocardial infarction	2021
Dr Sarah Marsh Dr Catherine Park Dr Rachael Redgrave Dr Esha Singh Lilia Draganova et al.	Rapid fall in circulating non-classical monocytes in ST elevation myocardial infarction patients correlates with cardiac injury	2021
Dr Andrew Owens Dr Anna Walaszczyk Professor Ioakim Spyridopoulos Dr Emily Dookun Professor Gavin Richardson et al.	Senescence and Senolytics in Cardiovascular disease: Promise and Potential Pitfalls	2021
Jedrzej Hoffmann Professor Gavin Richardson Professor Ioakim Spyridopoulos	Telomerase As a Therapeutic Target in Cardiovascular Disease	2021
Professor Ioakim Spyridopoulos	Terminally Differentiated CD4⁺ T Cells Promote Myocardial Inflammaging	2021
Dr Luke Spray Dr Catherine Park Dr Suzanne Cormack Dr Ashfaq Mohammed Dr Stephen Boag et al.	The Fractalkine Receptor CX3CR1 Links Lymphocyte Kinetics in CMV-Seropositive Patients and Acute Myocardial Infarction With Adverse Left Ventricular Remodeling	2021
Emily Dookun Dr Anna Walaszczyk Dr Rachael Redgrave Dr Pawel Palmowski Dr Simon Tual-Chalot et al.	Clearance of senescent cells during cardiac ischemia–reperfusion injury improves recovery	2020
Dr Carmen Martin-Ruiz Professor Thomas von Zglinicki Professor Gavin Richardson Lilia Draganova Dr Rachael Redgrave et al.	CMV-independent increase in CD27−CD28+ CD8+ EMRA T cells is inversely related to mortality in octogenarians	2020
Dr Suzanne Cormack Dr Alison Steel Dr Thomas Chadwick Andrew Bryant Dr Mohaned Egred et al.	Effect of ciclosporin on safety, lymphocyte kinetics and left ventricular remodelling in acute myocardial infarction	2020
Dr Mohaned Egred Dr Alan Bagnall Professor Ioakim Spyridopoulos Dr Rajiv Das Professor Azfar Zaman et al.	Effect of Pressure-controlled intermittent Coronary Sinus Occlusion (PiCSO) on infarct size in anterior STEMI: PiCSO in ACS study	2020
Dr Antoneta Granic Dr Carmen Martin-Ruiz Dr Richard Dodds Professor Dame Louise Robinson Professor Ioakim Spyridopoulos et al.	Immunosenescence profiles are not associated with muscle strength, physical performance and sarcopenia risk in very old adults: The Newcastle 85+ Study	2020
Danlin Liu Professor Gavin Richardson Dr Fehmi Benli Dr Catherine Park Joao Victor de De Souza Cunha et al.	Inflammageing in the cardiovascular system: mechanisms, emerging targets, and novel therapeutic strategies	2020
Dr Nikolaos Vlachogiannis Dr Konstantinos Bakogiannis Professor Ioakim Spyridopoulos Professor Kimon Stamatelopoulos Professor Konstantinos Stellos et al.	Involvement of cardiovascular system as the critical point in coronavirus disease 2019 (COVID-19) prognosis and recovery	2020
Jose Coelho Lima Junior Dr Ashfaq Mohammed Dr Suzanne Cormack Adnan Ali Dr Matthew Barter et al.	Kinetics Analysis of Circulating MicroRNAs Unveils Markers of Failed Myocardial Reperfusion	2020
Dr Catherine Park Dr Suzanne Cormack Dr Stephen Boag Dr Karim Bennaceur Professor Gavin Richardson et al.	Role of CMV-serostatus and CX3CR1 on lymphocyte kinetics and left ventricular remodelling in patients with acute myocardial infarction	2020
Rebecca Maier Dr Bilal Bawamia Dr Karim Bennaceur Sarah Dunn Dr Leanne Marsay et al.	Telomerase activation to reverse immunosenescence in elderly patients with acute coronary syndrome: Protocol for a randomized pilot trial	2020
Professor Konstantinos Stellos Professor Ioakim Spyridopoulos	Exercise, telomerase activity, and cardiovascular disease prevention	2019
Emily Dookun Dr Anna Walaszczyk Dr Rachael Redgrave Dr Simon Tual-Chalot Oliver Yausep et al.	Navitoclax eliminates senescence attenuating remodelling and improving outcome to cardiac ischemia-reperfusion injury	2019
Dr Anna Walaszczyk Emily Dookun Dr Rachael Redgrave Dr Simon Tual-Chalot Professor Ioakim Spyridopoulos et al.	Pharmacological clearance of senescent cells improves survival and recovery in aged mice following acute myocardial infarction.	2019
Oliver Yausep Emily Dookun Dr Anna Walaszczyk Dr Rachael Redgrave Dr Simon Tual-Chalot et al.	The Effects of Senolytics on Murine Cardiac Function and Morphology Post-Ischemia Reperfusion Injury	2019
Peter Luke Professor Christopher Eggett Professor Ioakim Spyridopoulos Dr Timothy Irvine	A comparative analysis of British and American Society of Echocardiography recommendations for the assessment of left ventricular diastolic function	2018
Emily Dookun Dr Anna Walaszczyk Dr Rachael Redgrave Dr Simon Tual-Chalot Oliver Yausep et al.	Accumulation of cardiomyocyte senescence following ischaemia-reperfusion injury (IRI); a potential therapeutic target?	2018
Emily Dookun Dr Anna Walaszczyk Dr Rachael Redgrave Dr Simon Tual-Chalot Oliver Yausep et al.	Cardiomyocyte Senescence accumulates following Myocardial Infarction and Ischaemia-Reperfusion Injury.	2018
Professor Ioakim Spyridopoulos	CDKN1B/p27 is localized in mitochondria and improves respiration-dependent processes in the cardiovascular system—New mode of action for caffeine	2018
Professor Ioakim Spyridopoulos	Interventions to slow cardiovascular aging: Dietary restriction, drugs and novel molecules	2018
Professor Ioakim Spyridopoulos	Molecular mechanisms and therapy of cardiovascular ageing	2018
Professor Ioakim Spyridopoulos	Non-coding RNA regulation of T cell biology: Implications for age-associated cardiovascular diseases	2018
Dr Suzanne Cormack Samuel Jones Dr Rajiv Das Dr Mohaned Egred Professor Simi Ali et al.	Overcoming Heparin-Associated RT-qPCR Inhibition and Normalization Issues for microRNA Quantification in Patients with Acute Myocardial Infarction	2018
Dr Anna Walaszczyk Emily Dookun Dr Rachael Redgrave Dr Simon Tual-Chalot Rhys Anderson et al.	Senescence as a therapeutic target for myocardial ageing	2018
Dr Anna Walaszczyk Emily Dookun Dr Rachael Redgrave Professor Ioakim Spyridopoulos Professor Helen Arthur et al.	Senescence contributes age related cardiac dysfunction	2018
Dr Anna Walaszczyk Emily Dookun Dr Rachael Redgrave Professor Ioakim Spyridopoulos Professor Helen Arthur et al.	Senescence contributes to reduced survival and impaired cardiac function following myocardial infraction in aged mice.	2018
Professor Gavin Richardson Dr Karim Bennaceur Emily Dookun Lilia Draganova Dr Gabriele Saretzki et al.	Telomerase Mediates Lymphocyte Proliferation but Not the Atherosclerosis-Suppressive Potential of Regulatory T-Cells	2018
Dr Stephen Boag Dr Emanuele Andreano Professor Ioakim Spyridopoulos	Lymphocyte Communication in Myocardial Ischemia/Reperfusion Injury	2017
Professor Ioakim Spyridopoulos Professor Helen Arthur	Microvessels of the heart: Formation, regeneration and dysfunction	2017
Professor Ioakim Spyridopoulos	Telomere length in cardiovascular disease	2017
Professor Ioakim Spyridopoulos	Telomeres and cardiovascular diseases: Facts, controversies and limitations	2017
Dr Sarah Marsh Professor Helen Arthur Professor Ioakim Spyridopoulos	The secret life of nonclassical monocytes	2017
Professor Ioakim Spyridopoulos Dr Carmen Martin-Ruiz Professor Catharien Hilkens Mohammad Yadegarfar Professor John Isaacs et al.	CMV-seropositivity and T-cell senescence predict increased cardiovascular mortality in octogenarians - results from the Newcastle 85+ study	2016
Dr Evgeniya Shmeleva Dr Stephen Boag Santosh Murali Dr Karim Bennaceur Dr Rajiv Das et al.	Differences in immune responses between CMV-seronegative and -seropositive patients with myocardial ischemia and reperfusion	2015
Jedrzej Hoffmann Dr Evgeniya Shmeleva Dr Stephen Boag Dr Karel Fiser Dr Alan Bagnall et al.	Myocardial Ischemia and Reperfusion Leads to Transient CD8 Immune Deficiency and Accelerated Immunosenescence in CMV-Seropositive Patients	2015
Jedrzej Hoffmann Professor Ioakim Spyridopoulos	Senescent cytotoxic T cells in acute myocardial infarction: innocent bystanders or the horsemen of apocalypse?	2015
Professor Ioakim Spyridopoulos Dr Javed Ahmed Dr Rajiv Das Dr Richard Edwards Dr Alan Bagnall et al.	Shock-index as a novel predictor of long-term outcome following primary percutaneous coronary intervention	2015
Dr Stephen Boag Dr Rajiv Das Dr Evgeniya Shmeleva Dr Alan Bagnall Dr Mohaned Egred et al.	T lymphocytes and fractalkine contribute to myocardial ischemia/reperfusion injury in patients	2015
Dr Karim Bennaceur Mark Atwill Nayef Al Zhrany Jedrzej Hoffmann Professor Bernard Keavney et al.	Atorvastatin induces T cell proliferation by a telomerase reverse transcriptase (TERT) mediated mechanism	2014
Nouf Al-Ajmi Dr Gabriele Saretzki Dr Colin Miles Professor Ioakim Spyridopoulos	Dietary restriction ameliorates haematopoietic ageing independent of telomerase, whilst lack of telomerase and short telomeres exacerbate the ageing phenotype	2014
Dr Stephen Boag Dr Rajiv Das Dr Mohaned Egred Professor Azfar Zaman Dr Alan Bagnall et al.	Dynamic Changes in T-Lymphocyte Counts Following Primary Percutaneous Coronary Intervention Predict Infarct Size and Microvascular Obstruction	2014
Dr Evgeniya Shmeleva Dr Stephen Boag Santosh Murali Dr Karim Bennaceur Dr Stephen Todryk et al.	Effect of CMV-seropositivity on acute outcome of acute myocardial infarction	2014
Professor Ioakim Spyridopoulos Dr Javed Ahmed Dr Mohaned Egred	Shock-Index as a Novel Predictor of Longterm Outcome Following Primary Percutaneous Coronary Intervention	2014
Professor Ioakim Spyridopoulos Professor Thomas von Zglinicki	Telomere length predicts cardiovascular disease	2014
Dr Alan Bagnall Professor Ioakim Spyridopoulos	The evidence base for revascularisation of chronic total occlusions	2014
Professor Ioakim Spyridopoulos	Comparison of the Seattle Heart Failure Model and Cardiopulmonary Exercise Capacity for Prediction of Death in Patients With Chronic Ischemic Heart Failure and Intracoronary Progenitor Cell Application	2013
Professor Ioakim Spyridopoulos	Prognostic impact of using drug-eluting-stents on outcome and strategy in multivessel PCI: data from the Frankfurt MV-PCI registry	2013
Professor Azfar Zaman Dr Javed Ahmed Dr Mohaned Egred Professor Ioakim Spyridopoulos Professor Bernard Keavney et al.	Provision of Gastroprotective Medication and Bleeding Risk Following Acute Coronary Syndrome	2013
Professor Azfar Zaman Dr Javed Ahmed Dr Mohaned Egred Dr Richard Edwards Professor Ioakim Spyridopoulos et al.	Provision of Gastroprotective Medication and Bleeding Risk Following Acute Coronary Syndrome	2013
Professor Ioakim Spyridopoulos	Randomized trial of preventive angioplasty in myocardial infarction	2013
Professor Ioakim Spyridopoulos	Risk Stratification Following Complex PCI: Clinical Versus Anatomical Risk Stratification Including "Post PCI Residual SYNTAX-Score" as Quantification of Incomplete Revascularization	2013
Jedrzej Hoffmann Dr Karel Fiser Dr Jolanta Weaver Ian Dimmick Monika Loeher et al.	High-Throughput 13-Parameter Immunophenotyping Identifies Shifts in the Circulating T-Cell Compartment Following Reperfusion in Patients with Acute Myocardial Infarction	2012
Professor Ioakim Spyridopoulos	Impact of interventional strategy for unprotected left main coronary artery percutaneous coronary intervention on long-term survival	2012
Dr Mohaned Egred Dr Alan Bagnall Professor Ioakim Spyridopoulos Sheila Jamieson Dr Javed Ahmed et al.	Impact of thrombus aspiration during primary percutaneous coronary intervention on mortality in ST-segment elevation myocardial infarction	2012
Professor Ioakim Spyridopoulos	Microvascular dysfunction and pulse wave reflection characterize different vascular pathologies in patients at cardiovascular risk	2012
Dr Javed Ahmed Professor Ioakim Spyridopoulos Dr Alan Bagnall Dr Mohaned Egred	Mortality outcome of out-of-hours primary percutaneous coronary intervention in the current era	2012
Professor Ioakim Spyridopoulos	Is telomerase a potential target for vascular rejuvenation?	2011
Professor Vijay Kunadian Professor Azfar Zaman Professor Ioakim Spyridopoulos	Sodium bicarbonate for the prevention of contrast induced nephropathy: A meta-analysis of published clinical trials	2011
Professor Ioakim Spyridopoulos	Augmentation indices recorded from the radial artery and from the digital arteries provide the same information in patients under cardiovascular risk	2010
Professor Ioakim Spyridopoulos	Clinical Risk Stratification is a Better Determinant of Long-Term Survival Following Multivessel PCI Compared to Anatomic Risk Stratification Using the SYNTAX-Score	2010
Professor Ioakim Spyridopoulos	Comparison of the Seattle Heart Failure Model (SHFM) and Cardiopulmonary Exercise Testing (CPET) for Predicting Mortality of Patients With Ischemic Heart Failure	2010
Professor Ioakim Spyridopoulos	Complete Revascularization in Patients Undergoing Multivessel PCI is an Independent Predictor of Improved Long-term Survival	2010
Professor Ioakim Spyridopoulos	Idiopathic (unexplained) pulmonary embolism is associated with an impaired prognosis compared to other entities of pulmonary embolism	2010
Professor Ioakim Spyridopoulos	Intracoronary beta-radiation therapy for in-stent restenosis: long-term success rate and prediction of failure	2010
Professor Ioakim Spyridopoulos	Accelerated Telomere Shortening in CD8+T-lymphocytes From Patients With Coronary Heart Disease Links Cytomegalovirus-Induced T Cell Response and Deterioration of Myocardial Function	2009
Professor Ioakim Spyridopoulos	Accelerated Telomere Shortening in Leukocyte Subpopulations of Patients With Coronary Heart Disease: Role of Cytomegalovirus Seropositivity	2009
Professor Ioakim Spyridopoulos	Cardiac ³¹P-MRS compared to echocardiographic findings in patients with hypertensive heart disease without overt systolic dysfunction - preliminary results	2009
Professor Ioakim Spyridopoulos	Downregulation of ETS rescues diabetes-induced reduction of endothelial progenitor cells	2009
Professor Ioakim Spyridopoulos	Favorable Long-Term Survival in Patients Undergoing Multivessel-PCI Compared to Predicted Prognosis of CABG Estimated by EuroSCORE: Procedural and Clinical Determinants of Long-Term Outcome	2009
Professor Ioakim Spyridopoulos	Favorable long-term survival in patients undergoing stent PCI of unprotected left main coronary artery compared to predicted short-term prognosis of CABG estimated by EuroSCORE: clinical determinants of long-term outcome	2009
Professor Ioakim Spyridopoulos	Incidence, clinical characteristics, and long-term prognosis of travel-associated pulmonary embolism	2009
Professor Ioakim Spyridopoulos	Mitochondrial telomerase reverse transcriptase binds to and protects mitochondrial DNA and function from damage	2009
Professor Ioakim Spyridopoulos	Radial augmentation index unmasks premature coronary artery disease in younger males	2009
Professor Ioakim Spyridopoulos	Role of N-Terminal Pro-Brain Natriuretic Peptide and Cystatin C to Estimate Renal Function in Patients With and Without Heart Failure	2009
Professor Ioakim Spyridopoulos	Telomere length-heterogeneity among myeloid cells is a predictor for chronological ageing	2009
Professor Ioakim Spyridopoulos	Caffeine enhances endothelial repair by an AMPK-dependent mechanism	2008
Professor Ioakim Spyridopoulos	Mitochondrial p27 Is Required For Endothelial Energy Metabolism And Cell Migration	2008
Professor Ioakim Spyridopoulos	Nuclear Protein Tyrosine Phosphatase Shp-2 Is One Important Negative Regulator of Nuclear Export of Telomerase Reverse Transcriptase	2008
Professor Ioakim Spyridopoulos	Telomere gap between granulocytes and lymphocytes is a determinant for hematopoetic progenitor cell impairment in patients with previous myocardial infarction	2008
Professor Ioakim Spyridopoulos	The initial slope of the VCO2/VO2-curve (s1) in cardiopulmonary exercise testing is a strong and independent predictor of outcome in patients with previous myocardial infarction	2008