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Browsing publications by Professor Ioakim Spyridopoulos.

Newcastle AuthorsTitleYearFull text
Dr Nikolaos Vlachogiannis
Dr Ken Baker
Dr Georgios Georgiopoulos
Dr Ina Schim van der Loeff
Dr Aidan Hanrath
et al.
Clinical frailty, and not features of acute infection, is associated with late mortality in COVID-19: a retrospective cohort study2022
Dr Jake McClements
Dr Katarina Novakovic
Professor Azfar Zaman
Professor Ioakim Spyridopoulos
Dr Marloes Peeters
et al.
Immobilization of Molecularly Imprinted Polymer Nanoparticles onto Surfaces using Different Strategies: Evaluating the Influence of the Functionalised Interface on the Performance of a Thermal Assay for the Detection of Cardiac Biomarker Troponin I2021
Jose Coelho Lima Junior
Dr Georgios Georgiopoulos
Dr Jannath Ahmed
David Gaskin
Dr Konstantinos Bakogiannis
et al.
Prognostic value of admission high-sensitivity troponin in patients with ST-elevation myocardial infarction2021
Dr Sarah Marsh
Dr Catherine Park
Dr Rachael Redgrave
Dr Esha Singh
Lilia Draganova
et al.
Rapid fall in circulating non-classical monocytes in ST elevation myocardial infarction patients correlates with cardiac injury2021
Dr Andrew Owens
Dr Anna Walaszczyk
Professor Ioakim Spyridopoulos
Dr Emily Dookun
Dr Gavin Richardson
et al.
Senescence and Senolytics in Cardiovascular disease: Promise and Potential Pitfalls2021
Jedrzej Hoffmann
Dr Gavin Richardson
Professor Ioakim Spyridopoulos
Telomerase As a Therapeutic Target in Cardiovascular Disease2021
Professor Ioakim Spyridopoulos
Terminally Differentiated CD4+ T Cells Promote Myocardial Inflammaging2021
Dr Catherine Park
Dr Suzanne Cormack
Dr Ashfaq Mohammed
Dr Stephen Boag
Dr Karim Bennaceur
et al.
The Fractalkine Receptor CX3CR1 Links Lymphocyte Kinetics in CMV-Seropositive Patients and Acute Myocardial Infarction With Adverse Left Ventricular Remodeling2021
Emily Dookun
Dr Anna Walaszczyk
Dr Rachael Redgrave
Dr Pawel Palmowski
Dr Simon Tual-Chalot
et al.
Clearance of senescent cells during cardiac ischemia–reperfusion injury improves recovery2020
Dr Carmen Martin-Ruiz
Professor Thomas von Zglinicki
Dr Gavin Richardson
Lilia Draganova
Dr Rachael Redgrave
et al.
CMV-independent increase in CD27−CD28+ CD8+ EMRA T cells is inversely related to mortality in octogenarians2020
Dr Suzanne Cormack
Dr Alison Steel
Dr Thomas Chadwick
Andrew Bryant
Dr Mohaned Egred
et al.
Effect of ciclosporin on safety, lymphocyte kinetics and left ventricular remodelling in acute myocardial infarction2020
Dr Mohaned Egred
Dr Alan Bagnall
Professor Ioakim Spyridopoulos
Dr Rajiv Das
Professor Azfar Zaman
et al.
Effect of Pressure-controlled intermittent Coronary Sinus Occlusion (PiCSO) on infarct size in anterior STEMI: PiCSO in ACS study2020
Dr Antoneta Granic
Dr Carmen Martin-Ruiz
Dr Richard Dodds
Professor Dame Louise Robinson
Professor Ioakim Spyridopoulos
et al.
Immunosenescence profiles are not associated with muscle strength, physical performance and sarcopenia risk in very old adults: The Newcastle 85+ Study2020
Danlin Liu
Dr Gavin Richardson
Fehmi Benli
Dr Catherine Park
Joao Victor de De Souza Cunha
et al.
Inflammageing in the cardiovascular system: mechanisms, emerging targets, and novel therapeutic strategies2020
Dr Nikolaos Vlachogiannis
Dr Konstantinos Bakogiannis
Professor Ioakim Spyridopoulos
Professor Kimon Stamatelopoulos
Professor Konstantinos Stellos
et al.
Involvement of cardiovascular system as the critical point in coronavirus disease 2019 (COVID-19) prognosis and recovery2020
Jose Coelho Lima Junior
Dr Ashfaq Mohammed
Dr Suzanne Cormack
Adnan Ali
Dr Matthew Barter
et al.
Kinetics Analysis of Circulating MicroRNAs Unveils Markers of Failed Myocardial Reperfusion2020
Dr Catherine Park
Dr Suzanne Cormack
Dr Stephen Boag
Dr Karim Bennaceur
Dr Gavin Richardson
et al.
Role of CMV-serostatus and CX3CR1 on lymphocyte kinetics and left ventricular remodelling in patients with acute myocardial infarction2020
Rebecca Maier
Dr Bilal Bawamia
Dr Karim Bennaceur
Sarah Dunn
Dr Leanne Marsay
et al.
Telomerase activation to reverse immunosenescence in elderly patients with acute coronary syndrome: Protocol for a randomized pilot trial2020
Professor Konstantinos Stellos
Professor Ioakim Spyridopoulos
Exercise, telomerase activity, and cardiovascular disease prevention2019
Emily Dookun
Dr Anna Walaszczyk
Dr Rachael Redgrave
Dr Simon Tual-Chalot
Oliver Yausep
et al.
Navitoclax eliminates senescence attenuating remodelling and improving outcome to cardiac ischemia-reperfusion injury2019
Dr Anna Walaszczyk
Emily Dookun
Dr Rachael Redgrave
Dr Simon Tual-Chalot
Professor Ioakim Spyridopoulos
et al.
Pharmacological clearance of senescent cells improves survival and recovery in aged mice following acute myocardial infarction.2019
Oliver Yausep
Emily Dookun
Dr Anna Walaszczyk
Dr Rachael Redgrave
Dr Simon Tual-Chalot
et al.
The Effects of Senolytics on Murine Cardiac Function and Morphology Post-Ischemia Reperfusion Injury2019
Peter Luke
Dr Christopher Eggett
Professor Ioakim Spyridopoulos
Dr Timothy Irvine
A comparative analysis of British and American Society of Echocardiography recommendations for the assessment of left ventricular diastolic function2018
Emily Dookun
Dr Anna Walaszczyk
Dr Rachael Redgrave
Dr Simon Tual-Chalot
Oliver Yausep
et al.
Accumulation of cardiomyocyte senescence following ischaemia-reperfusion injury (IRI); a potential therapeutic target?2018
Emily Dookun
Dr Anna Walaszczyk
Dr Rachael Redgrave
Dr Simon Tual-Chalot
Oliver Yausep
et al.
Cardiomyocyte Senescence accumulates following Myocardial Infarction and Ischaemia-Reperfusion Injury.2018
Professor Ioakim Spyridopoulos
CDKN1B/p27 is localized in mitochondria and improves respiration-dependent processes in the cardiovascular system—New mode of action for caffeine2018
Professor Ioakim Spyridopoulos
Interventions to slow cardiovascular aging: Dietary restriction, drugs and novel molecules2018
Professor Ioakim Spyridopoulos
Molecular mechanisms and therapy of cardiovascular ageing2018
Professor Ioakim Spyridopoulos
Non-coding RNA regulation of T cell biology: Implications for age-associated cardiovascular diseases2018
Dr Suzanne Cormack
Samuel Jones
Dr Rajiv Das
Dr Mohaned Egred
Professor Simi Ali
et al.
Overcoming Heparin-Associated RT-qPCR Inhibition and Normalization Issues for microRNA Quantification in Patients with Acute Myocardial Infarction2018
Dr Anna Walaszczyk
Emily Dookun
Dr Rachael Redgrave
Dr Simon Tual-Chalot
Rhys Anderson
et al.
Senescence as a therapeutic target for myocardial ageing2018
Dr Anna Walaszczyk
Emily Dookun
Dr Rachael Redgrave
Professor Ioakim Spyridopoulos
Professor Helen Arthur
et al.
Senescence contributes age related cardiac dysfunction2018
Dr Anna Walaszczyk
Emily Dookun
Dr Rachael Redgrave
Professor Ioakim Spyridopoulos
Professor Helen Arthur
et al.
Senescence contributes to reduced survival and impaired cardiac function following myocardial infraction in aged mice.2018
Dr Gavin Richardson
Dr Karim Bennaceur
Emily Dookun
Lilia Draganova
Dr Gabriele Saretzki
et al.
Telomerase Mediates Lymphocyte Proliferation but Not the Atherosclerosis-Suppressive Potential of Regulatory T-Cells2018
Dr Stephen Boag
Dr Emanuele Andreano
Professor Ioakim Spyridopoulos
Lymphocyte Communication in Myocardial Ischemia/Reperfusion Injury2017
Professor Ioakim Spyridopoulos
Professor Helen Arthur
Microvessels of the heart: Formation, regeneration and dysfunction2017
Professor Ioakim Spyridopoulos
Telomere length in cardiovascular disease2017
Professor Ioakim Spyridopoulos
Telomeres and cardiovascular diseases: Facts, controversies and limitations2017
Dr Sarah Marsh
Professor Helen Arthur
Professor Ioakim Spyridopoulos
The secret life of nonclassical monocytes2017
Professor Ioakim Spyridopoulos
Dr Carmen Martin-Ruiz
Dr Catharien Hilkens
Mohammad Yadegarfar
Professor John Isaacs
et al.
CMV-seropositivity and T-cell senescence predict increased cardiovascular mortality in octogenarians - results from the Newcastle 85+ study2016
Dr Evgeniya Shmeleva
Dr Stephen Boag
Santosh Murali
Dr Karim Bennaceur
Dr Rajiv Das
et al.
Differences in immune responses between CMV-seronegative and -seropositive patients with myocardial ischemia and reperfusion2015
Jedrzej Hoffmann
Dr Evgeniya Shmeleva
Dr Stephen Boag
Dr Karel Fiser
Dr Alan Bagnall
et al.
Myocardial Ischemia and Reperfusion Leads to Transient CD8 Immune Deficiency and Accelerated Immunosenescence in CMV-Seropositive Patients2015
Jedrzej Hoffmann
Professor Ioakim Spyridopoulos
Senescent cytotoxic T cells in acute myocardial infarction: innocent bystanders or the horsemen of apocalypse?2015
Professor Ioakim Spyridopoulos
Dr Javed Ahmed
Dr Rajiv Das
Dr Richard Edwards
Dr Alan Bagnall
et al.
Shock-index as a novel predictor of long-term outcome following primary percutaneous coronary intervention2015
Dr Stephen Boag
Dr Rajiv Das
Dr Evgeniya Shmeleva
Dr Alan Bagnall
Dr Mohaned Egred
et al.
T lymphocytes and fractalkine contribute to myocardial ischemia/reperfusion injury in patients2015
Dr Karim Bennaceur
Mark Atwill
Nayef Al Zhrany
Jedrzej Hoffmann
Professor Bernard Keavney
et al.
Atorvastatin induces T cell proliferation by a telomerase reverse transcriptase (TERT) mediated mechanism2014
Nouf Al-Ajmi
Dr Gabriele Saretzki
Dr Colin Miles
Professor Ioakim Spyridopoulos
Dietary restriction ameliorates haematopoietic ageing independent of telomerase, whilst lack of telomerase and short telomeres exacerbate the ageing phenotype2014
Dr Stephen Boag
Dr Rajiv Das
Dr Mohaned Egred
Professor Azfar Zaman
Dr Alan Bagnall
et al.
Dynamic Changes in T-Lymphocyte Counts Following Primary Percutaneous Coronary Intervention Predict Infarct Size and Microvascular Obstruction2014
Dr Evgeniya Shmeleva
Dr Stephen Boag
Santosh Murali
Dr Karim Bennaceur
Dr Stephen Todryk
et al.
Effect of CMV-seropositivity on acute outcome of acute myocardial infarction2014
Professor Ioakim Spyridopoulos
Dr Javed Ahmed
Dr Mohaned Egred
Shock-Index as a Novel Predictor of Longterm Outcome Following Primary Percutaneous Coronary Intervention2014
Professor Ioakim Spyridopoulos
Professor Thomas von Zglinicki
Telomere length predicts cardiovascular disease2014
Dr Alan Bagnall
Professor Ioakim Spyridopoulos
The evidence base for revascularisation of chronic total occlusions2014
Professor Ioakim Spyridopoulos
Comparison of the Seattle Heart Failure Model and Cardiopulmonary Exercise Capacity for Prediction of Death in Patients With Chronic Ischemic Heart Failure and Intracoronary Progenitor Cell Application2013
Professor Ioakim Spyridopoulos
Prognostic impact of using drug-eluting-stents on outcome and strategy in multivessel PCI: data from the Frankfurt MV-PCI registry2013
Professor Azfar Zaman
Dr Javed Ahmed
Dr Mohaned Egred
Professor Ioakim Spyridopoulos
Professor Bernard Keavney
et al.
Provision of Gastroprotective Medication and Bleeding Risk Following Acute Coronary Syndrome2013
Professor Azfar Zaman
Dr Javed Ahmed
Dr Mohaned Egred
Dr Richard Edwards
Professor Ioakim Spyridopoulos
et al.
Provision of Gastroprotective Medication and Bleeding Risk Following Acute Coronary Syndrome2013
Professor Ioakim Spyridopoulos
Randomized trial of preventive angioplasty in myocardial infarction2013
Professor Ioakim Spyridopoulos
Risk Stratification Following Complex PCI: Clinical Versus Anatomical Risk Stratification Including "Post PCI Residual SYNTAX-Score" as Quantification of Incomplete Revascularization2013
Jedrzej Hoffmann
Dr Karel Fiser
Dr Jolanta Weaver
Ian Dimmick
Monika Loeher
et al.
High-Throughput 13-Parameter Immunophenotyping Identifies Shifts in the Circulating T-Cell Compartment Following Reperfusion in Patients with Acute Myocardial Infarction2012
Professor Ioakim Spyridopoulos
Impact of interventional strategy for unprotected left main coronary artery percutaneous coronary intervention on long-term survival2012
Dr Mohaned Egred
Dr Alan Bagnall
Professor Ioakim Spyridopoulos
Sheila Jamieson
Dr Javed Ahmed
et al.
Impact of thrombus aspiration during primary percutaneous coronary intervention on mortality in ST-segment elevation myocardial infarction2012
Professor Ioakim Spyridopoulos
Microvascular dysfunction and pulse wave reflection characterize different vascular pathologies in patients at cardiovascular risk2012
Dr Javed Ahmed
Professor Ioakim Spyridopoulos
Dr Alan Bagnall
Dr Mohaned Egred
Mortality outcome of out-of-hours primary percutaneous coronary intervention in the current era2012
Professor Ioakim Spyridopoulos
Is telomerase a potential target for vascular rejuvenation?2011
Dr Vijay Kunadian
Professor Azfar Zaman
Professor Ioakim Spyridopoulos
Sodium bicarbonate for the prevention of contrast induced nephropathy: A meta-analysis of published clinical trials2011
Professor Ioakim Spyridopoulos
Augmentation indices recorded from the radial artery and from the digital arteries provide the same information in patients under cardiovascular risk2010
Professor Ioakim Spyridopoulos
Clinical Risk Stratification is a Better Determinant of Long-Term Survival Following Multivessel PCI Compared to Anatomic Risk Stratification Using the SYNTAX-Score2010
Professor Ioakim Spyridopoulos
Comparison of the Seattle Heart Failure Model (SHFM) and Cardiopulmonary Exercise Testing (CPET) for Predicting Mortality of Patients With Ischemic Heart Failure2010
Professor Ioakim Spyridopoulos
Complete Revascularization in Patients Undergoing Multivessel PCI is an Independent Predictor of Improved Long-term Survival2010
Professor Ioakim Spyridopoulos
Idiopathic (unexplained) pulmonary embolism is associated with an impaired prognosis compared to other entities of pulmonary embolism2010
Professor Ioakim Spyridopoulos
Intracoronary beta-radiation therapy for in-stent restenosis: long-term success rate and prediction of failure2010
Professor Ioakim Spyridopoulos
Accelerated Telomere Shortening in CD8+T-lymphocytes From Patients With Coronary Heart Disease Links Cytomegalovirus-Induced T Cell Response and Deterioration of Myocardial Function2009
Professor Ioakim Spyridopoulos
Accelerated Telomere Shortening in Leukocyte Subpopulations of Patients With Coronary Heart Disease: Role of Cytomegalovirus Seropositivity2009
Professor Ioakim Spyridopoulos
Cardiac 31P-MRS compared to echocardiographic findings in patients with hypertensive heart disease without overt systolic dysfunction - preliminary results2009
Professor Ioakim Spyridopoulos
Downregulation of ETS rescues diabetes-induced reduction of endothelial progenitor cells2009
Professor Ioakim Spyridopoulos
Favorable Long-Term Survival in Patients Undergoing Multivessel-PCI Compared to Predicted Prognosis of CABG Estimated by EuroSCORE: Procedural and Clinical Determinants of Long-Term Outcome2009
Professor Ioakim Spyridopoulos
Favorable long-term survival in patients undergoing stent PCI of unprotected left main coronary artery compared to predicted short-term prognosis of CABG estimated by EuroSCORE: clinical determinants of long-term outcome2009
Professor Ioakim Spyridopoulos
Incidence, clinical characteristics, and long-term prognosis of travel-associated pulmonary embolism2009
Professor Ioakim Spyridopoulos
Mitochondrial telomerase reverse transcriptase binds to and protects mitochondrial DNA and function from damage2009
Professor Ioakim Spyridopoulos
Radial augmentation index unmasks premature coronary artery disease in younger males2009
Professor Ioakim Spyridopoulos
Role of N-Terminal Pro-Brain Natriuretic Peptide and Cystatin C to Estimate Renal Function in Patients With and Without Heart Failure2009
Professor Ioakim Spyridopoulos
Telomere length-heterogeneity among myeloid cells is a predictor for chronological ageing2009
Professor Ioakim Spyridopoulos
Caffeine enhances endothelial repair by an AMPK-dependent mechanism2008
Professor Ioakim Spyridopoulos
Mitochondrial p27 Is Required For Endothelial Energy Metabolism And Cell Migration2008
Professor Ioakim Spyridopoulos
Nuclear Protein Tyrosine Phosphatase Shp-2 Is One Important Negative Regulator of Nuclear Export of Telomerase Reverse Transcriptase2008
Professor Ioakim Spyridopoulos
Telomere gap between granulocytes and lymphocytes is a determinant for hematopoetic progenitor cell impairment in patients with previous myocardial infarction2008
Professor Ioakim Spyridopoulos
The initial slope of the VCO2/VO2-curve (s1) in cardiopulmonary exercise testing is a strong and independent predictor of outcome in patients with previous myocardial infarction2008