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Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey

Lookup NU author(s): Professor Mark Pearce, Professor Caroline Relton

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Abstract

Telomere shortening is a biomarker of cellular senescence and is associated with a wide range of age-related disease. Oxidative stress is also associated with physiological aging and several age-related diseases. Non-human studies suggest that variants in oxidative stress genes nay contribute to both telomere shortening and biological aging. We sought to test whether oxidative stress-related gene polymorphisms contribute to variance in both telomere length and physical biomarkers of aging in humans. Telomere lengths were calculated for 190 (82 men, 108 women) participants aged 79 years and associations with 384 SNPs. from 141 oxidative stress genes, identified 9 significant SNPS, of which those from 5 genes (GSTZ1, MSRA NDUFA3, NDUFA8, VIM) had robust associations with physical aging biomarkers, respiratory function or grip strength. Replication of associations in a sample of 318 (120 males, 198 females) participants aged 50 years confirmed significant associations for two of the five SNPs (MSRA rs4841322, p = 0.008: NDUFAS rs6822, p = 0.048) on telomere length. These data indicate that oxidative stress genes may be involved in pathways that lead to both telomere shortening and physiological aging in humans. Oxidative stress may explain, at least in part, associations between telomere shortening and physiological aging. (C) 2008 Elsevier Ireland Ltd. All rights reserved.


Publication metadata

Author(s): Starr JM, Shiels PG, Harris SE, Pattie A, Pearce MS, Relton CL, Deary IJ

Publication type: Article

Publication status: Published

Journal: Mechanisms of Ageing and Development

Year: 2008

Volume: 129

Issue: 12

Pages: 745-751

ISSN (print): 0047-6374

ISSN (electronic): 1872-6216

Publisher: Elsevier Ireland Ltd.

URL: http://dx.doi.org/10.1016/j.mad.2008.09.020

DOI: 10.1016/j.mad.2008.09.020


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