Toggle Main Menu Toggle Search

Open Access padlockePrints

Exocrine pancreas trans-differentiation to hepatocytes-A physiological response to elevated glucocorticoid in vivo

Lookup NU author(s): Dr Karen Wallace, Dr Carlyn Marek, Professor Matthew Wright


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Damage or ectopic expression of some growth factors can lead to the appearance of hepatocyte-like cells within the pancreas. Since glucocorticoids promote liver hepatocyte phenotype in vitro, the effect of glucocorticoid on pancreatic differentiation in vivo was examined. Treatment of rats with glucocorticoid for 25 days at levels that significantly inhibited weight gain resulted in the appearance of acinar cells expressing cytokeratin 7 and hepatocyte markers glutamine synthetase, carbamoyl phosphate synthetase and cytochrome P450 2E (the nomenclature employed is that given at Using a plastic pancreatic acinar cell line, this response was shown to be associated with changes in the regulation of WNT signalling-related gene expression and a repression of WNT signalling activity. These data suggest that a pathological response of the pancreas in vivo to elevated glucocorticoid is a differentiation of exocrine pancreatic cells or pancreatic progenitor cells to an hepatocyte-like phenotype. (C) 2009 Elsevier Ltd. All rights reserved.

Publication metadata

Author(s): Wallace K, Marek CJ, Currie RA, Wright MC

Publication type: Article

Publication status: Published

Journal: Journal of Steroid Biochemistry and Molecular Biology

Year: 2009

Volume: 116

Issue: 1-2

Pages: 76-85

ISSN (print): 0960-0760

ISSN (electronic): 1879-1220

Publisher: Pergamon


DOI: 10.1016/j.jsbmb.2009.05.002


Altmetrics provided by Altmetric