Publications by Professor Matthew Wright - ePrints

Browsing publications by Professor Matthew Wright.

Newcastle Authors	Title	Year
Dr Toni Pringle Erik Ramon Gil Dr Jack Leslie Professor Fiona Oakley Professor Matthew Wright et al.	Synthesis and Preclinical Evaluation of a ⁸⁹Zr-labelled Human Single Chain Antibody for Non-invasive Detection of Hepatic Myofibroblasts in Acute Liver Injury	2024
Rodrigo Figueiredo Dr Avinash Sewpaul Dr Alistair Leitch Lucy Bates Professor Matthew Wright et al.	Pregnane X Receptor Activation in Liver Perfusion	2022
Professor Matthew Wright	Scientific Guidance on the data required for the risk assessment of flavourings to be used in or on foods	2022
Dr Alistair Leitch Dr Tarek Mamdouh Abdelghany Dr Phillip Probert Dr Stephanie Meyer Dr Jeremy Palmer et al.	The toxicity of the methylimidazolium ionic liquids, with a focus on M8OI and hepatic effects	2020
Professor Matthew Wright	Ionic Liquids: New Emerging Pollutants, Similarities with Perfluorinated Alkyl Substances (PFASs)	2019
Dr Aimen Amer Gourab Sen Jeremy French Professor Colin Wilson Professor Derek Manas et al.	The association of pregnane X receptor activation with outcomes after liver transplantation—A retrospective study	2019
Dr Emma Fairhall Dr Alistair Leitch Anne Lakey Dr Phillip Probert Carol De Santis et al.	Glucocorticoid-induced pancreatic-hepatic trans-differentiation in a human cell line in vitro	2018
Dr Phillip Probert Dr Alistair Leitch Dr Michael Dunn Dr Stephanie Meyer Dr Jeremy Palmer et al.	Identification of a xenobiotic as a potential environmental trigger in primary biliary cholangitis	2018
Dr Alistair Leitch Anne Lakey will Hotham Professor Loranne Agius Professor George Kass et al.	The ionic liquid 1-octyl-3-methylimidazolium (M8OI) is an activator of the human estrogen receptor alpha	2018
Dr Alistair Leitch Philip Probert Dr Stephanie Meyer Professor George Kass Professor Matthew Wright et al.	B-13 progenitor-derived hepatocytes (B-13/H cells) model lipid dysregulation in response to drugs and chemicals	2017
Dr Stephanie Meyer Dr Phillip Probert Anne Lakey Dr Alistair Leitch Dr Lynsay Blake et al.	Environmental xenoestrogens super-activate a variant murine ER beta in cholangiocytes	2017
Dr Stephanie Meyer Dr Phillip Probert Anne Lakey Andrew Axon Dr Alistair Leitch et al.	Hepatic effects of tartrazine (E 102) after systemic exposure are independent of oestrogen receptor interactions in the mouse	2017
Dr Bushra alQuadeib Professor Lidija Siller Professor Matthew Wright Dr Ben Horrocks	Oral administration of amphotericin B nanoparticles: antifungal activity, bioavailability and toxicity in rats	2017
Dr Saimir Luli Dr Stephen Hill Helen Brown Jack Leslie Dr Helen Marshall et al.	A new fluorescence-based optical imaging method to non-invasively monitor hepatic myofibroblasts in vivo	2016
Professor Matthew Wright	Hepatic stellate cells regulate liver specific immunity to visceral leishmaniasis through p110δ dependent induction of regulatory T cells in mice	2016
Dr Emma Fairhall Dr Michelle Charles Dr Phillip Probert Dr Karen Wallace Jen Gibb et al.	Pancreatic B-13 Cell Trans-Differentiation to Hepatocytes Is Dependent on Epigenetic-Regulated Changes in Gene Expression	2016
Dr Emma Fairhall Dr Phillip Probert Professor Fiona Oakley Professor Matthew Wright	Pancreatic progenitor-derived hepatocytes are viable and functional in a 3D high density bioreactor culture system.	2016
Dr Phillip Probert Dr Jeremy Palmer Dr Aimen Amer Steven White Professor David Jones et al.	Progenitor-derived hepatocyte-like (B-13/H) cells metabolise 1′-hydroxyestragole to a genotoxic species via a SULT2B1-dependent mechanism	2016
Aimen Amer Professor Matthew Wright Steven White	Activation of the pregnane X receptor (PXR) reduces the risk of early allograft dysfunction following liver transplantation	2015
Dr Phillip Probert Dr Stephanie Meyer Fouzeyyah Alsaeedi Andrew Axon Dr Emma Fairhall et al.	An expandable donor-free supply of functional hepatocytes for toxicology	2015
Dr Saimir Luli Dr Daniela Di Paolo Dr Caroline Wilson Professor Matthew Wright Helen Brown et al.	Non-invasive fluorescent imaging of liver fibrosis and response to therapy in mice	2015
Aimen Amer Dr Abigail Vallance Professor Matthew Wright Steven White	Reducing the risk of early allograft dysfunction in liver transplant recipients by activation of the pregnane x receptor (PXR)	2015
Dr Bushra alQuadeib Professor Lidija Siller Dr Ben Horrocks Professor Matthew Wright	Stealth Amphotericin B nanoparticles for oral drug delivery: In vitro optimization	2015
Aimen Amer Dr Phillip Probert Dr Michael Dunn Margaret Knight Dr Abigail Vallance et al.	Sustained Isoprostane E2 Elevation, Inflammation and Fibrosis after Acute Ischaemia-Reperfusion Injury Are Reduced by Pregnane X Receptor Activation	2015
Ashleigh McConnell Dr Graeme O'Boyle Professor Matthew Wright Professor Penny Lovat	Targeting mitogen-activated protein kinase kinase to prevent CXCR₄-CXCL₁₂ chemotaxis in cutaneous melanoma	2015
Dr Phillip Probert Dr Mohammed Ebrahimkhani Professor Fiona Oakley Professor Jelena Mann Professor Alastair Burt et al.	A reversible model for periportal fibrosis and a refined alternative to bile duct ligation	2014
Dr Saimir Luli Dr Stephen Hill Professor Matthew Wright Professor Derek Mann Professor Fiona Oakley et al.	A simple fluorescence based method to non-invasively image liver fibrosis	2014
Dr Emma Fairhall Dr Karen Wallace Professor Matthew Wright	Co-culture of B-13 hepatocyte progenitors with liver myofibroblasts promotes progenitor WNT signalling repression in response to glucocorticoids and enhances their transdifferentiation towards hepatocyte-like cells	2014
Dr Phillip Probert Professor Fiona Oakley Professor Matthew Wright	Improving expression levels of transporters in progenitor-derived hepatocyte-like (B-13/H) cells	2014
Dr Phillip Probert Professor Matthew Wright	Progenitor-derived hepatocyte-like (B-13/H) cells metabolise 1 ' hydroxyestragole to a genotoxic species - An animal donor-free in vitro screen for phase II activated genotoxins	2014
Dr Caroline Wilson Professor Jelena Mann Dr Meagan Walsh Professor Fiona Oakley Professor Matthew Wright et al.	Quiescent Hepatic Stellate Cells Functionally Contribute to the Hepatic Innate Immune Response via TLR3	2014
Professor Matthew Wright	SMAC mimetics in combination with the pro-inflammatory cytokine TNF alpha augment cell death in B-13 progenitor-derived hepatocytes	2014
Dr Jamie Fernandez Professor Matthew Wright	Survivin expression promotes VEGF-induced tumor angiogenesis via PI3K/Akt enhanced β-catenin/Tcf-Lef dependent transcription	2014
Dr Stephanie Meyer Andrew Axon Dr Paul Jowsey Emeritus Professor Faith Williams Professor Peter Blain et al.	Tartrazine is not an activator of the mouse oestrogen ER alpha and ER beta receptors	2014
Dr Michelle Charles Dr Karen Wallace Dr Phillip Probert Professor Fiona Oakley Professor Matthew Wright et al.	THE glucocorticoid-dependent conversion of the B-13 progenitor cell into hepatocyte-like (B-13/H) cells is dependent on a short exposure to glucocorticoid and epigenetic alterations	2014
Dr Bushra alQuadeib Professor Lidija Siller Dr Elaine Mutch Dr Ben Horrocks Professor Matthew Wright et al.	Therapeutic monitoring of amphotericin B in Saudi ICU patients using UPLC MS/MS assay	2014
Dr Phillip Probert Git Chung Dr Simon Cockell Professor Loranne Agius Steven White et al.	Utility of B-13 Progenitor-Derived Hepatocytes in Hepatotoxicity and Genotoxicity Studies	2014
Dr Emma Fairhall Professor Matthew Wright	Dexamethasone induced hepatic differentiation of rat pancreatic progenitor cells (B-13) in a 3D multicompartment bioreactor system	2013
Mohamed Noormohamed Professor Matthew Wright Dr David Cowie Susan Stamp David Talbot et al.	Extracorporeal membrane oxygenation for resuscitation of deceased cardiac donor livers for hepatocyte isolation	2013
Dr Graeme O'Boyle Isabella Swidenbank Dr Helen Marshall Catriona Barker Dr Jane Renwick et al.	Inhibition of CXCR4-CXCL12 chemotaxis in melanoma by AMD11070	2013
Dr Phillip Probert Dr Mohammed Ebrahimkhani Professor Fiona Oakley Professor Alastair Burt Professor Derek Mann et al.	Methapyrilene Treatment is a Refined Alternative to Bile Duct Ligation as a Model of Reproducible and Reversible Periportal Fibrosis in the Rat	2013
Dr Emma Fairhall Dr Michelle Charles Karen Wallace Claire Schwab Professor Christine Harrison FRCPath FMedSci et al.	The B-13 hepatocyte progenitor cell resists pluripotency induction and differentiation to non-hepatocyte cells.	2013
Dr Emma Fairhall Claire Schwab Professor Christine Harrison FRCPath FMedSci Dr Karen Wallace Professor Matthew Wright et al.	The Hepatic Progenitor B-13 Cell Line Engrafts into the Mouse Liver and Transdifferentiates in Vivo	2013
Professor Matthew Wright	Guidance for submission for food additive evaluations	2012
Andrew Axon Dr Felicity May Dr Luke Gaughan Professor Faith Williams Professor Peter Blain et al.	Tartrazine and sunset yellow are xenoestrogens in a new screening assay to identify modulators of human oestrogen receptor transcriptional activity	2012
Dr Aimen Amer Professor Derek Manas Professor Matthew Wright Steven White	The effect of hypoxic stress on activated hepatic stellate cell chemotaxis in-vitro	2012
Dr Karen Wallace Professor James Shaw Professor Alastair Burt Professor Matthew Wright	Prolonged glucocorticoid exposure results in the appearance of hepatocytes in the adult pancreas	2011
Dr Karen Wallace QUAN LONG Dr Emma Fairhall Professor Matthew Wright	Serine/threonine protein kinase SGK1 in glucocorticoid-dependent transdifferentiation of pancreatic acinar cells to hepatocytes	2011
Dr Karen Wallace Emma Fairhall Professor Matthew Wright	Serum- and glucorticoid-induced kinase 1 (SGK1) plays a key role in the glucocorticoid dependent trans-differentiation of a pancreatic progenitor cell to hepatocytes	2011
Dr Mohammed Ebrahimkhani Professor Fiona Oakley Dr Lindsay Murphy Professor Jelena Mann Dr Maria Perugorria et al.	Stimulating healthy tissue regeneration by targeting the 5-HT_2B receptor in chronic liver disease	2011
Professor Fiona Oakley Dr Lindsay Murphy Professor Matthew Wright Professor Derek Mann	Stimulation of liver regeneration and amelioration of fibrosis by antagonism of a 5-HT2B/ERK/JUND/TGF beta 1 signally pathway in hepatic stellate cell	2011
Elise Andrews Professor Matthew Wright Professor Chris Day Professor Ann Daly	A Role for the Pregnane X Receptor in Flucloxacillin-Induced Liver Injury	2010
Andy Axon Dr David Cowie Professor Fiona Oakley Professor Faith Williams Professor Peter Blain et al.	Acute oestradiol (E2) administration to mice results in liver portal tract inflammation	2010
Dr Karen Wallace Dr Emma Fairhall Professor Matthew Wright	AR42J-B-13 cell: An expandable progenitor to generate an unlimited supply of functional hepatocytes	2010
Professor Matthew Wright	British Toxicology Society Special Reviews 2010	2010
Steven White Professor James Shaw Emeritus Professor Paul Flecknell Professor Alastair Burt Professor Matthew Wright et al.	Chronic elevated systemic glucocorticoid results in widespread pancreatic-hepatic trans-differentiation in vivo	2010
Dr Karen Wallace Professor Matthew Wright	Corrigendum to "Antibody-targeted myofibroblast apoptosis reduces fibrosis during sustained liver injury" [J Hepatol 49 (2008) 88-98] (DOI:10.1016/j.jhep.2008.01.032)	2010
Dr Karen Wallace Emeritus Professor Paul Flecknell Professor Alastair Burt Professor Matthew Wright	Disrupted Pancreatic Exocrine Differentiation and Malabsorption in Response to Chronic Elevated Systemic Glucocorticoid	2010
Mohamed Noormohamed Professor Matthew Wright Dr David Cowie Susan Stamp Professor Derek Mann et al.	Extracorporeal membranous oxygenation in a porcine non-heart beating liver model - a valuable tool for improving hepatocyte viability	2010
Mohamed Noormohamed Dr David Cowie Steven White Professor Matthew Wright	Extracorporeal membranous oxygenation in a porcine non-heart beating liver model of organ preservation - A tool for improved hepatocyte isolation	2010
Dr Karen Wallace Dr Carlyn Marek Professor Matthew Wright	Glucocorticoid-dependent transdifferentiation of pancreatic progenitor cells into hepatocytes is dependent on transient suppression of WNT signalling	2010
Stephen Hill Professor Matthew Wright	Hepatic myofibroblasts are pro-inflammatory and activate NF-kappa B in monocytes via a soluble factor	2010
Mohamed Noormohamed Dr David Cowie Susan Stamp Professor Derek Manas Professor Matthew Wright et al.	Hepatoycte isolation a surrogate for liver transplant- extracorporeal membranous oxygenation a valuable tool for improved hepatocyte viability in a non-heart beating porcine model	2010
Professor Matthew Wright Dr Karen Wallace Professor James Shaw Professor Alastair Burt Steven White et al.	Long term glucocorticoid therapy leads to pancreatic acinar trans-differentiation into hepatocyte-like cells	2010
Dr Mario Abinun Professor Matthew Wright	Molecular and clinical heterogeneity in CLCN7-dependent osteopetrosis: Report of 20 novel mutations	2010
Dr Helen Marshall Professor Fiona Oakley Professor Matthew Wright	Myofibroblast depletion does not inhibit liver regeneration after partial hepatectomy	2010
Dr Andrew Douglass Dr Helen Marshall Professor Matthew Wright	Myofibroblast depletion during acute CCl4 injury delays hepatocyte injury and promotes liver regeneration	2010
Dr Roben Gieling Dr Ahmed Elsharkawy Dr David Cowie Professor Matthew Wright Dr Mohammed Ebrahimkhani et al.	The c-Rel Subunit of Nuclear Factor-κB Regulates Murine Liver Inflammation, Wound-Healing, and Hepatocyte Proliferation	2010
Dr Karen Wallace Dr David Cowie Stephen Hill Andy Axon Steven White et al.	The PXR is a drug target for chronic inflammatory liver disease	2010
Professor Matthew Wright	The trans-differentiation of pancreatic acinar cells into hepatocytes is mediated by a suppression of WNT signalling	2010
Dr Karen Wallace Professor James Shaw Professor Alastair Burt Professor Matthew Wright	Chronic Elevated Systemic Glucocorticocoid Results in Widespread Pancreatic-Hepatic Trans-Differentiation In Vivo	2009
Dr Karen Wallace Dr Carlyn Marek Professor Matthew Wright	Exocrine pancreas trans-differentiation to hepatocytes-A physiological response to elevated glucocorticoid in vivo	2009
Dr Carlyn Marek Dr Karen Wallace Professor Matthew Wright	Low affinity glucocorticoid binding site ligands as potential anti-fibrogenics	2009
Professor Matthew Wright	Myofibroblast Depletion During Acute CCL4 Injury Delays Hypatocyte Injury and Promotes Liver Regeneration	2009
Professor Quentin Anstee Professor Matthew Wright	Parenchymal extinction: coagulation and hepatic fibrogenesis	2009
Dr Karen Wallace Dr Carlyn Marek Professor Matthew Wright	The Trans-Differentiation of Pancreatic Acinar Cells into Hepatocytes is Mediated by a Suppression of WNT Signalling Activity	2009
Dr David Cowie Professor Matthew Wright	A functional PXR inhibits portal tract inflammation in a mouse model of cholangiopathy	2008
Dr David Cowie Professor Derek Mann Professor Matthew Wright	A mechanism for the anti-fibrogenic effects of the pregnane X receptor (PXR) in the liver: Inhibition of NF-κB?	2008
Dr Karen Wallace Professor Matthew Wright	Antibody-targeted myofibroblast apoptosis reduces fibrosis during sustained liver injury	2008
Dr Andrew Douglass Dr Karen Wallace Professor Matthew Wright	C1-3 recombinant antibody targeting myofibroblasts - Specific apoptosis reverses fibrosis in a sustained injury mouse model	2008
Professor Derek Mann Professor Matthew Wright	Cellular targeting of the apoptosis-inducing compound gliotoxin to fibrotic rat livers	2008
Professor Quentin Anstee Professor Matthew Wright	Coagulation status modulates murine hepatic fibrogenesis: implications for the development of novel therapies	2008
Dr Karen Wallace Professor Alastair Burt Professor Matthew Wright	Liver fibrosis	2008
Professor Matthew Wright	New technologies for toxicology: Meeting future challenges in drug safety	2008
Dr Karen Wallace Dr David Cowie Dr Carlyn Marek Professor Derek Mann Professor Matthew Wright et al.	PXR activation reduces hepatic TNF-alpha levels - A mechanism for inhibiting liver fibrosis	2008
Elise Andrews Professor Matthew Wright Professor Chris Day Professor Ann Daly	Relevance of PXR to Flucloxacillin-induced Liver Injury	2008
Dr Karen Wallace Professor Muzlifah Haniffa Professor Matthew Collin Professor Matthew Wright	Skin Derived Fibroblasts Can Differentiate Into Hepatocyte-Like Cells	2008
Dr Karen Wallace Professor Matthew Wright	Targeting liver myofibroblasts: a novel approach in anti-fibrogenic therapy	2008
Dr Roben Gieling Dr Ahmed Elsharkawy Dr David Cowie Professor Matthew Wright Professor Fiona Oakley et al.	The c-Rel subunit of NF-κB is a regulator of hepatocytes proliferation during recovery from chronic liver injury and regeneration in mice	2008
Dr Andrew Douglass Dr Karen Wallace Professor Matthew Wright	A human recombinant antibody for targeting anti-fibrogenic therapeutics to myofibroblasts in vivo	2007
Dr Carlyn Marek Dr Karen Wallace Professor Matthew Wright	Expression of CYP2S1 in human hepatic stellate cells	2007
Dr Carlyn Marek Professor Derek Mann Professor Matthew Wright	Pregnane X Receptor Activators Inhibit Human Hepatic Stellate Cell Transdifferentiation In Vitro	2006
Professor Matthew Wright	The impact of pregnane X receptor activation on liver fibrosis	2006
Professor Matthew Wright	Common complications in the chondrodysplasias	2005
Professor Matthew Wright	Generation of a monoclonal human single chain antibody fragment to hepatic stellate cells - a potential mechanism for targeting liver anti-fibrotic therapeutics	2005
Professor Fiona Oakley Dr Carlyn Marek Professor Matthew Wright Professor Derek Mann	Inhibition of Inhibitor of κB Kinases Stimulates Hepatic Stellate Cell Apoptosis and Accelerated Recovery From Rat Liver Fibrosis	2005
Dr Carlyn Marek Professor Matthew Wright	Pregnenolone 16α carbonitrile inhibits rodent liver fibrogenesis via PXR-dependent and PXR-independent mechanisms	2005
Professor Matthew Wright Professor Margaret Bassendine	Treatment of histologically mild hepatitis C virus infection with interferon and ribavirin: A multicentre randomized controlled trial	2005
Professor Matthew Wright	Identification of a truncated ratp28-related protein expressed in kidney	2004
Dr Carlyn Marek Professor Matthew Wright	Mechanism of Action of the Antifibrogenic Compound Gliotoxin in Rat Liver Cells	2004
Professor Quentin Anstee Professor Matthew Wright	The factor V Leiden mutation accelerates disease progression in a mouse model of hepatic fibrosis induced by chronic carbon tetrachloride exposure	2004
Dr Carlyn Marek Professor Matthew Wright	Generation of hepatocytes expressing functional cytochromes P450 from a pancreatic progenitor cell line in vitro	2003
Professor Matthew Wright Professor Derek Mann	Gliotoxin Stimulates the Apoptosis of Human and Rat Hepatic Stellate Cells and Enhances the Resolution of Liver Fibrosis in Rats	2001
Professor Matthew Wright Professor Derek Mann	Regulation of E-box DNA binding during in vivo and in vitro activation of rat and human hepatic stellate cells	2001
Professor Judith Goodship Dr Miranda Splitt Professor Matthew Wright	Autozygosity mapping of a Seckel Syndrome Locus to chromosome 3q22.1-q24	2000
Professor Matthew Wright	Effect of the Adrenal 11-beta Hydroxylase Inhibitor Metyrapone on Human Hepatic Cytochrome P-450 gene Expression: Induction of Cytochrome P-450 3A4	2000
Professor Matthew Wright	Fibronectin mediated hepatocyte shape change reprograms cytochrome P450 2C11 gene expression via an integrin signalled induction of ribonuclease activity	2000
Professor Matthew Wright Mark McAuley Professor Derek Mann	Upstream tissue inhibitor of metalloproteinases-1 (TIMP-1) element-1, a novel and essential regulatory DNA motif in the human TIMP-1 gene promoter, directly interacts with a 30-kDa nuclear protein	2000
Professor Matthew Wright Professor Derek Mann	Control of the tissue inhibitor of metalloproteinases-1 promoter in culture-activated rat hepatic stellate cells: regulation by activator protein-1 DNA binding proteins	1999
Dr Ahmed Elsharkawy Professor Matthew Wright Professor Derek Mann	Persistent activation of nuclear factor-kappaB in cultured rat hepatic stellate cells involves the induction of potentially novel Rel-like factors and prolonged changes in the expression of IkappaB family proteins	1999