Toggle Main Menu Toggle Search

Open Access padlockePrints

Responses to Interaural Time Delay in Human Cortex

Lookup NU author(s): Dr Katherina von Kriegstein, Professor Tim GriffithsORCiD


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


von Kriegstein K, Griffiths TD, Thompson SK, McAlpine D. Responses to interaural time delay in human cortex. J Neurophysiol 100: 2712-2718, 2008. First published September 17, 2008; doi:10.1152/jn.90210.2008. Humans use differences in the timing of sounds at the two ears to determine the location of a sound source. Various models have been posited for the neural representation of these interaural time differences (ITDs). These models make opposing predictions about the lateralization of ITD processing in the human brain. The weighted-image model predicts that sounds leading in time at one ear activate maximally the opposite brain hemisphere for all values of ITD. In contrast, the pi-limit model assumes that ITDs beyond half the period of the stimulus center frequency are not explicitly encoded in the brain and that such "long" ITDs activate maximally the side of the brain to which the sound is heard. A previous neuroimaging study revealed activity in the human inferior colliculus consistent with the pi-limit. Here we show that cortical responses to sounds with ITDs within the pi-limit are in line with the predictions of both models. However, contrary to the immediate predictions of both models, neural activation is bilateral for "long" ITDs, despite these being perceived as clearly lateralized. Furthermore, processing of long ITDs leads to higher activation in cortex than processing of short ITDs. These data show that coding of ITD in cortex is fundamentally different from coding of ITD in the brain stem. We discuss these results in the context of the two models.

Publication metadata

Author(s): von Kriegstein K, Griffiths TD, Thompson SK, McAlpine D

Publication type: Article

Publication status: Published

Journal: Journal of Neurophysiology

Year: 2008

Volume: 100

Issue: 5

Pages: 2712-2718

ISSN (print): 0022-3077

ISSN (electronic): 1522-1598

Publisher: American Physiological Society


DOI: 10.1152/jn.90210.2008


Altmetrics provided by Altmetric