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Lookup NU author(s): Dr Anita Roopun, Professor Mark Cunningham, Professor Roger Whittaker, Professor Andrew Trevelyan, Dr Andrew Russell, Professor Miles Whittington
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Many types of electrographic seizures are readily identifiable by direct visual examination of electroencephalographic or electrocorticographic recordings. This process can, however, be painstakingly slow, and much effort has been expended to automate the process using various dynamic properties of epileptiform waveforms. As methods have become more subtle and powerful they have been used for seizure Subclassification, seizure prediction, and seizure onset identification and localization. Here we concentrate on the last, with reference to seizures of neocortical origin. We briefly review some of the methods used and introduce preliminary results from a very simple dynamic model based on key electrophysiological properties found in some seizure types: Occurrence of very fast oscillations (sometimes called ripples), excess gamma frequency oscillations. electroencephalographic/electrocorticographic flattening, and changes in global synchrony. We show how this multiscale analysis may reveal features unique to seizure onset and speculate on the underlying cellular and network phenomena responsible. (C) 2008 Elsevier Inc. All rights reserved.
Author(s): Roopun AK, Traub RD, Baldeweg T, Cunningham MO, Whittaker RG, Trevelyan A, Duncan R, Russell AJC, Whittington MA
Publication type: Article
Publication status: Published
Journal: Epilepsy & Behavior
Year: 2009
Volume: 14
Issue: 1
Pages: 39-46
ISSN (print): 1525-5050
ISSN (electronic): 1525-5069
Publisher: Academic Press
URL: http://dx.doi.org/10.1016/j.yebeh.2008.09.008
DOI: 10.1016/j.yebeh.2008.09.008
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