Publications by Professor Miles Whittington - ePrints

Browsing publications by Professor Miles Whittington.

Newcastle Authors	Title	Year
Professor Mark Cunningham Dr Ian Schofield Dr Alistair Jenkins Professor Miles Whittington	Enhanced interlaminar excitation or reduced superficial layer inhibition in neocortex generates different spike-and-wave-like electrographic events in vitro	2018
Sabine Gretenkord Professor Adrian Rees Professor Miles Whittington Dr Sasha Gartside Dr Fiona LeBeau et al.	Dorsal vs. ventral differences in fast Up-state-associated oscillations in the medial prefrontal cortex of the urethane-anesthetized rat	2017
Natalie Adams Professor Miles Whittington Dr Fiona LeBeau	Hetereogeneity in Neuronal Intrinsic Properties: A Possible Mechanism for Hub-Like Properties of the Rat Anterior Cingulate Cortex during Network Activity	2017
Matthew Ainsworth Professor Marcus Kaiser Dr Jennifer Simonotto Professor Miles Whittington	GABA_B receptor-mediated, layer-specific synaptic plasticity reorganizes gamma-frequency neocortical response to stimulation	2016
Dr Christopher Adams Natalie Adams Professor Miles Whittington	Electrographic Waveform Structure Predicts Laminar Focus Location in a Model of Temporal Lobe Seizures In Vitro	2015
Dr Henrik Kjeldsen Professor Marcus Kaiser Professor Miles Whittington	Near-field electromagnetic holography for high-resolution analysis of network interactions in neuronal tissue	2015
Vasileios Glykos Professor Miles Whittington Dr Fiona LeBeau	Subregional differences in the generation of fast network oscillations in the rat medial prefrontal cortex (mPFC) in vitro	2015
Lucy Carracedo Dr Ian Schofield Dr Rob Forsyth Professor Miles Whittington	Unbalanced Peptidergic Inhibition in Superficial Neocortex Underlies Spike and Wave Seizure Activity	2015
Dr Richard Tomsett Matthew Ainsworth Professor Alexander Thiele Mehdi Sanayei Dr Xing Chen et al.	Virtual Electrode Recording Tool for EXtracellular potentials (VERTEX): comparing multi-electrode recordings from simulated and biological mammalian cortical tissue	2015
Professor Mark Cunningham Professor Miles Whittington	What Is a Seizure Network? Very Fast Oscillations at the Interface Between Normal and Epileptic Brain	2014
Professor Mark Cunningham Professor Miles Whittington	What is a seizure network? Very fast oscillations at the interface between normal and epileptic brain	2014
Lucy Carracedo Henrik Kjeldsen Dr Alistair Jenkins Dr Ian Schofield Professor Mark Cunningham et al.	A Neocortical Delta Rhythm Facilitates Reciprocal Interlaminar Interactions via Nested Theta Rhythms	2013
Professor Miles Whittington	Axonal properties determine somatic firing in a model of in vitro CA1 hippocampal sharp wave/ripples and persistent gamma oscillations	2012
Professor Miles Whittington	Cognitive dysfunction in psychiatric disorders: characteristics, causes and the quest for improved therapy	2012
Professor Miles Whittington	Dynamical changes in neurological diseases and anesthesia	2012
Professor Mark Cunningham Dr Anita Roopun Dr Ian Schofield Professor Roger Whittaker Dr Alistair Jenkins et al.	Glissandi: transient fast electrocorticographic oscillations of steadily increasing frequency, explained by temporally increasing gap junction conductance	2012
Professor Miles Whittington	Long-Range-Projecting GABAergic Neurons Modulate Inhibition in Hippocampus and Entorhinal Cortex	2012
Matthew Ainsworth Professor Mark Cunningham Professor Miles Whittington	Rates and Rhythms: A Synergistic View of Frequency and Temporal Coding in Neuronal Networks	2012
Dr Yevgeniya Lekomtseva Professor Miles Whittington	Reorganisation and distribution of tau protein in patients with temporal lobe epilepsy	2012
Professor Miles Whittington	Segregation of Axonal and Somatic Activity During Fast Network Oscillations	2012
Professor Mark Cunningham Professor Miles Whittington	Chemical synaptic and gap junctional interactions between principal neurons: Partners in epileptogenesis	2011
Professor Miles Whittington Dr Anita Roopun	Circuits and brain rhythms in schizophrenia: a wealth of convergent targets	2011
Matthew Ainsworth Professor Mark Cunningham Dr Anita Roopun Professor Miles Whittington	Dual Gamma Rhythm Generators Control Interlaminar Synchrony in Auditory Cortex	2011
Professor Miles Whittington Professor Mark Cunningham	Fast oscillatory activity induced by kainate receptor activation in the rat basolateral amygdala in vitro	2011
Dr Yevgeniya Lekomtseva Professor Miles Whittington	Immunofluorescence staining of axonal microtuble-associated protein tau on temporal human epileptic brain	2011
Professor Roger Whittaker Emeritus Professor Doug Turnbull Professor Miles Whittington Professor Mark Cunningham	Impaired mitochondrial function abolishes gamma oscillations in the hippocampus through an effect on fast-spiking interneurons	2011
Professor Miles Whittington Professor Mark Cunningham Dr Fiona LeBeau Dr Claudia Racca	Multiple origins of the cortical gamma rhythm	2011
Professor Miles Whittington	Neuronal assembly dynamics in the beta1 frequency range permits short-term memory	2011
Dr Anita Roopun Dr Jennifer Simonotto Dr Michelle Pierce Dr Alistair Jenkins Dr Ian Schofield et al.	A nonsynaptic mechanism underlying interictal discharges in human epileptic neocortex	2010
Professor Miles Whittington	Are different rhythms good for different functions?	2010
Dr Anita Roopun Dr Fiona LeBeau Professor Mark Cunningham Professor Miles Whittington	Cholinergic neuromodulation controls directed temporal communication in neocortex in vitro	2010
Professor Miles Whittington Professor Mark Cunningham	Epileptic fast oscillations and synchrony in vitro	2010
Professor Andrew Trevelyan Dr Denise Kirby Dr Tora Smulders-Srinivasan Marco Nooteboom Professor Miles Whittington et al.	Mitochondrial DNA mutations affect calcium handling in differentiated neurons	2010
Professor Mark Cunningham Professor Miles Whittington	Spatiotemporal patterns of electrocorticographic very fast oscillations (> 80 Hz) consistent with a network model based on electrical coupling between principal neurons	2010
Dr Denise Kirby Dr Kate Rennie Dr Tora Smulders-Srinivasan Professor Miles Whittington Professor Andrew Trevelyan et al.	Transmitochondrial embryonic stem cells containing pathogenic mtDNA mutations are compromised in neuronal differentiation	2009
Dr Anita Roopun Dr Jennifer Simonotto Dr Michelle Pierce Dr Alistair Jenkins Dr Ian Schofield et al.	A non-synaptic mechanism underlying interictal discharges in human epileptic neocortex	2009
Dr Michelle Pierce Dr Anita Roopun Dr Alistair Jenkins Dr Ian Schofield Professor Miles Whittington et al.	Characterisation of very fast oscillations (VFOs) in human frontal cortical slices in vitro	2009
Dr Anita Roopun Professor Mark Cunningham Professor Roger Whittaker Professor Andrew Trevelyan Dr Andrew Russell et al.	Detecting seizure origin using basic, multiscale population dynamic measures: Preliminary findings	2009
Dr Michelle Pierce Professor Miles Whittington Professor Mark Cunningham	Transient cortical gamma oscillations: a role for GluK1-containing kainate receptors	2009
Dr Michelle Pierce Professor Miles Whittington Professor Mark Cunningham	Transient cortical gamma oscillations: a role for GluK1-containing kainate receptors	2009
Professor Miles Whittington	Can Brain Rhythms Inform on Underlying Pathology in Schizophrenia?	2008
Dr Anita Roopun Professor Miles Whittington	Characterization of a CNS penetrant, selective M1 muscarinic receptor agonist, 77-LH-28-1	2008
Dr Steven Middleton Professor Miles Whittington Professor Thomas Knopfel	DHPG induced high frequency oscillations in cerebellar cortex in vivo	2008
Professor Mark Cunningham Professor Miles Whittington	Fast oscillations in activated neocortical brain slices: An in vitro continuation of the pioneering in vivo studies of Mircea Steriade and colleagues	2008
Dr Steven Middleton Dr Claudia Racca Professor Mark Cunningham Professor Thomas Knopfel Dr Ian Schofield et al.	High-Frequency Network Oscillations in Cerebellar Cortex	2008
Dr Steven Middleton Professor Thomas Knopfel Professor Miles Whittington	Model of very fast (> 75 Hz) network oscillations generated by electrical coupling between the proximal axons of cerebellar Purkinje cells	2008
Dr Steven Middleton Dr Fiona LeBeau Dr Anita Roopun Professor Miles Whittington Professor Mark Cunningham et al.	NMDA receptor-dependent switching between different gamma rhythm-generating microcircuits in entorhinal cortex	2008
danny boy, haggis, shagger, dan Haggerty Professor Miles Whittington	P.1.c.018: beta 1-adrenergic receptor activation evokes a long-lasting increase in hippocampal theta (4-15Hz) rhythm in vitro	2008
Dr Anita Roopun Lucy Carracedo Professor Marcus Kaiser Professor Miles Whittington	Period concatenation underlies interactions between gamma and beta rhythms in neocortex	2008
Dr Anita Roopun Professor Mark Cunningham Dr Claudia Racca Dr Kai Alter Professor Miles Whittington et al.	Region-specific changes in gamma and beta2 rhythms in NMDA receptor dysfunction models of schizophrenia	2008
Dr Anita Roopun Lucy Carracedo Professor Miles Whittington	Rhythm generation through period concatenation in rat somatosensory cortex	2008
Dr Anita Roopun Lucy Carracedo Professor Marcus Kaiser Professor Miles Whittington	Temporal interactions between cortical rhythms	2008
Dr Steven Middleton Dr Claudia Racca Dr Helen Garner Dr Fiona LeBeau Professor Miles Whittington et al.	Beta rhythms (15-20 Hz) generated by nonreciprocal communication in hippocampus	2007
Professor Miles Whittington	Gap junctions on hippocampal mossy fiber axons demonstrated by thin-section electron microscopy and freeze-fracture replica immunogold labeling	2007
Dr Claudia Racca Professor Mark Cunningham Professor Miles Whittington Dr Fiona LeBeau	Impairment of hippocampal gamma (γ)-frequency oscillations in vitro in mice overexpressing human amyloid precursor protein (APP)	2007
Professor Miles Whittington Dr Claudia Racca	Loss of parvalbumin-positive interneurons predicts deficits in cortical gamma rhythm generation in animal models of schizophrenia-like cognitive dysfunction	2007
Professor Mark Cunningham Dr Steven Middleton Dr Fiona LeBeau Professor Miles Whittington	Recruitment of Parvalbumin-Positive Interneurons Determines Hippocampal Function and Associated Behavior	2007
Professor Leslie Smith Stephen Baker Terri Jackson Professor Marcus Kaiser Professor Evelyne Sernagor et al.	The CARMEN e-Science pilot project: Neuroinformatics work packages	2007
Professor Andrew Trevelyan Professor Miles Whittington	The source of afterdischarge activity in neocortical tonic-clonic epilepsy	2007
Dr Anita Roopun Dr Steven Middleton Professor Mark Cunningham Dr Fiona LeBeau Professor Miles Whittington et al.	A beta2-frequency (20-30 Hz) oscillation in nonsynaptic networks of somatosensory cortex	2006
Professor Mark Cunningham Professor Miles Whittington	Low-dimensional maps encoding dynamics in entorhinal cortex and hippocampus	2006
Professor Mark Cunningham Dr Claudia Racca Professor Miles Whittington	Neuronal metabolism governs cortical network response state	2006
Professor Mark Cunningham Judith Hunt Dr Steven Middleton Dr Fiona LeBeau Professor Miles Whittington et al.	Region-specific reduction in entorhinal gamma oscillations and parvalbumin-immunoreactive neurons in animal models of psychiatric illness	2006
Dr Claudia Racca Professor Mark Cunningham Judith Hunt Dr Steven Middleton Dr Fiona LeBeau et al.	Region-specific reduction in entorhinal gamma oscillations and parvalbumin-immunoreactive neurons in animal models of psychiatric illness	2006
Professor Miles Whittington	Combined experimental/simulation studies of cellular and network mechanisms of epileptogenesis in vitro and in vivo	2005
Professor Miles Whittington	Differential involvement of oriens/pyramidale interneurones in hippocampal network oscillations in vitro	2005
Dr Helen Garner Professor Miles Whittington	Induction by kainate of theta frequency rhythmic activity in the rat medial septum-diagonal band complex in vitro	2005
Professor Miles Whittington	Orthogonal arrangement of rhythm-generating microcircuits in the hippocampus	2005
Dr Fiona LeBeau Professor Miles Whittington	Oscillatory activity within rat substantia gelatinosa in vitro: a role for chemical and electrical neurotransmission	2005
Dr Fiona LeBeau Professor Mark Cunningham Professor Miles Whittington	Persistent gamma oscillations in superficial layers of rat auditory neocortex: experiment and model	2005
Professor Mark Cunningham Dr Fiona LeBeau Dr Anita Roopun Professor Miles Whittington	Single-Column Thalamocortical Network Model Exhibiting Gamma Oscillations, Sleep Spindles, and Epileptogenic Bursts	2005
Professor Miles Whittington	Slow and fast inhibition and an H-current interact to create a theta rhythm in a model of CA1 interneuron network	2005
Dr Fiona LeBeau Professor Miles Whittington	Transient Depression of Excitatory Synapses on Interneurons Contributes to Epileptiform Bursts During Gamma Oscillations in the Mouse Hippocampal Slice	2005
Professor Mark Cunningham Professor Miles Whittington Dr Anita Roopun Dr Fiona LeBeau	A role for fast rhythmic bursting neurons in cortical gamma oscillations in vitro	2004
Dr Fiona LeBeau Professor Miles Whittington	Cellular mechanisms of neuronal population oscillations in the hippocampus in vitro	2004
Professor Mark Cunningham Professor Miles Whittington	Coexistence of gamma and high-frequency oscillations in rat medial entorhinal cortex in vitro	2004
Professor Miles Whittington	Interneuron diversity series: inhibitory interneurons and network oscillations in vitro	2004
Professor Miles Whittington	A novel network of multipolar bursting interneurons generates theta frequency oscillations in neocortex	2003
Dr Fiona LeBeau Professor Miles Whittington	Contrasting roles of axonal (pyramidal cell) and dendritic (interneuron) electrical coupling in the generation of neuronal network oscillations	2003
Professor Miles Whittington	Fast rhythmic bursting can be induced in layer 2/3 cortical neurons by enhancing persistent Na+ conductance or by blocking BK channels	2003
Professor Mark Cunningham Dr Fiona LeBeau Professor Miles Whittington	GABA-enhanced collective behavior in neuronal axons underlies persistent gamma-frequency oscillations	2003
Professor Mark Cunningham Professor Miles Whittington	Gamma Oscillations Induced by Kainate Receptor Activation in the Entorhinal Cortex In Vitro	2003
Professor Miles Whittington Dr Fiona LeBeau	Sharp Wave-Like Activity in the Hippocampus In Vitro in Mice Lacking the Gap Junction Protein Connexin 36	2003
Professor Miles Whittington	The effects of general anaesthetics on carbachol-evoked gamma oscillations in the rat hippocampus in vitro	2003
Dr Fiona LeBeau Professor Miles Whittington	The role of electrical signalling via gap junctions in the generation of fast network oscillations	2003
Professor Miles Whittington	A comparison of the efficacy of carbamazepine and the novel anti-epileptic drug levetiracetam in the tetanus toxin model of focal complex partial epilepsy	2002
Dr Fiona LeBeau Professor Miles Whittington	A model of atropine-resistant theta oscillations in rat hippocampal area CA1	2002
Professor Miles Whittington	Altered dentate filtering during the transition to seizure in the rat tetanus toxin model of epilepsy	2002
Dr Fiona LeBeau Professor Miles Whittington	Fast network oscillations in the rat dentate gyrus in vitro	2002
Dr Fiona LeBeau Professor Miles Whittington	Fast network oscillations induced by potassium transients in the rat hippocampus in vitro	2002
Dr Fiona LeBeau Professor Miles Whittington	Fast network oscillations induced by potassium transients in the rat hippocampus in vitro	2002
Professor Miles Whittington	Long-range synchronisation of gamma and beta oscillations and the plasticity of excitatory and inhibitory synapses: A network model	2002
Professor Miles Whittington	New roles for the gamma rhythm: population tuning and preprocessing for the Beta rhythm	2002
Professor Miles Whittington Dr Fiona LeBeau	A possible role for gap junctions in generation of very fast EEG oscillations preceding the onset of, and perhaps initiating, seizures	2001
Professor Miles Whittington Dr Fiona LeBeau	Differential expression of synaptic and non-synaptic mechanisms underlying stimulus-induced gamma oscillations in vitro	2001
Dr Fiona LeBeau Professor Miles Whittington	Gap junctions between interneuron dendrites can enhance synchrony of gamma oscillations in distributed networks	2001
Dr Fiona LeBeau Professor Miles Whittington	Impaired Electrical Signaling Disrupts Gamma Frequency Oscillations in Connexin 36-Deficient Mice	2001
Professor Miles Whittington	Self-organised synaptic plasticity contributes to the shaping of gamma and beta oscillations in vitro	2001
Dr Fiona LeBeau Professor Miles Whittington	A model of gamma-frequency network oscillations induced in the rat CA3 region by carbachol in vitro	2000