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Faecal calprotectin or lactoferrin can identify postoperative recurrence in Crohn's disease

Lookup NU author(s): Professor Chris LambORCiD, Mohamed Mohiuddin, Fintan Bergin, Dr Jonathan Hanson, Dr John Mansfield

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Abstract

Background: Identifying Crohn's disease recurrence in symptomatic patients after ileocaecal resection is difficult. The aim of this study was to evaluate faecal concentrations of granulocyte degradation products in this setting. Methods: A postoperative cohort of 13 patients was followed prospectively for 1 year with regular faecal calprotectin (FC) and lactoferrin (FL) measurements. A second postoperative cohort (median 24 months after resection) of 104 patients provided a single stool sample. Faecal measurements were compared with symptom diaries, the Harvey Bradshaw Index, endoscopic examination, C-reactive protein and platelet measurement. Results: In the uncomplicated course, both markers normalized within 2 months. Both FC and FL correlated significantly with Harvey Bradshaw Index (P

Publication metadata

Author(s): Lamb CA, Mohiuddin MK, Gicquel J, Neely D, Bergin FG, Hanson JM, Mansfield JC

Publication type: Article

Publication status: Published

Journal: British Journal of Surgery

Year: 2009

Volume: 96

Issue: 6

Pages: 663-674

ISSN (print): 0007-1323

ISSN (electronic): 1365-2168

Publisher: John Wiley & Sons Ltd.

URL: http://dx.doi.org/10.1002/bjs.6593

DOI: 10.1002/bjs.6593

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