Browse by author
Lookup NU author(s): Professor Darren Wilkinson
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
Two related developments are currently changing traditional approaches to computational systems biology modelling. First, stochastic models are being used increasingly in preference to deterministic models to describe biochemical network dynamics at the single-cell level. Second, sophisticated statistical methods and algorithms are being used to fit both deterministic and stochastic models to time course and other experimental data. Both frameworks are needed to adequately describe observed noise, variability and heterogeneity of biological systems over a range of scales of biological organization.
Author(s): Wilkinson DJ
Publication type: Review
Publication status: Published
Journal: Nature Reviews: Genetics
ISSN (print): 1471-0056
ISSN (electronic): 1471-0064