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Current concepts in the pathogenesis of early rheumatoid arthritis

Lookup NU author(s): Dr Arthur Pratt, Professor John IsaacsORCiD


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Rheumatoid arthritis (RA) is a systemic inflammatory disease with a predilection for symmetrically distributed diarthroidal joints. It is clinically heterogeneous, with particular disease phenotypes defined according to a complex interplay of genes and the environment. In this chapter we first summarize current knowledge of RA genetic susceptibility, a field which has been transformed in recent years by powerful modern genotyping technologies. The importance of a recently described subclassification for the disease based upon the presence or absence of circulating autoantibodies to citrullinated peptides has further informed genetic studies, and we consider the implications for our understanding of RA pathogenesis. We then review the cellular and molecular processes that initiate and perpetuate joint destruction.

Publication metadata

Author(s): Pratt AG, Isaacs JD, Mattey DL

Publication type: Review

Publication status: Published

Journal: Best Practice & Research: Clinical Rheumatology

Year: 2009

Volume: 23

Issue: 1

Pages: 37-48

ISSN (electronic): 1532-1770


DOI: 10.1016/j.berh.2008.08.002