Toggle Main Menu Toggle Search

Open Access padlockePrints

Browsing publications by Dr Arthur Pratt.

Newcastle AuthorsTitleYearFull text
Dr Arthur Pratt
Professor John Isaacs
Dr Elena Nikiphorou
Association between social deprivation and disease activity in rheumatoid arthritis: a systematic literature review2022
Dr Faye Cooles
Dr Jessica Tarn
Dr Dennis Lendrem
Najib Naamane
Alice Lin
et al.
Interferon-α-mediated therapeutic resistance in early rheumatoid arthritis implicates epigenetic reprogramming2022
Dr Arthur Pratt
Prospective Studies on the Risk of Rheumatoid Arthritis: The European Risk RA Registry2022
Professor James Wason
Dr Arthur Pratt
Professor John Isaacs
The role of comorbidities alongside patient and disease characteristics on long-term disease activity in RA using UK inception cohort data2022
Dr Richard Howey
Alex Clark
Najib Naamane
Dr Louise Reynard
Dr Arthur Pratt
et al.
A Bayesian network approach incorporating imputation of missing data enables exploratory analysis of complex causal biological relationships2021
Dr Fiona Rayner
Dr Amy Anderson
Dr Ken Baker
Professor Christopher Buckley
Dr Bernard Dyke
et al.
BIOlogical Factors that Limit sustAined Remission in rhEumatoid arthritis (the BIO-FLARE study): protocol for a non-randomised longitudinal cohort study2021
Abigail Gault
Dr Christopher Stewart
Dr Arthur Pratt
Dr Neil Rajan
Cutaneous immune‐related adverse events in patients with melanoma treated with checkpoint inhibitors2021
Leonie Schittenhelm
Dr Arthur Pratt
Professor Catharien Hilkens
Dendritic cell integrin expression patterns regulate inflammation in the rheumatoid arthritis joint2021
Dr Ken Baker
Dr Arthur Pratt
Professor John Isaacs
Half-Dose vs Stable-Dose Conventional Synthetic Disease-Modifying Antirheumatic Drugs and Disease Flare in Patients with Rheumatoid Arthritis2021
Dr Nicola Maney
Dr Ben Barron-Millar
Dr Christopher Carey
Ian Herron
Dr Amy Anderson
et al.
Pim Kinases as Therapeutic Targets in Early Rheumatoid Arthritis2021
Professor James Wason
Dr Arthur Pratt
Professor John Isaacs
Dr Elena Nikiphorou
Predictors of poor function in RA based on two prospective UK inception cohorts. Do comorbidities matter?2021
Professor John Isaacs
Dr Arthur Pratt
Rituximab versus tocilizumab in anti-TNF inadequate responder patients with rheumatoid arthritis (R4RA): 16-week outcomes of a stratified, biopsy-driven, multicentre, open-label, phase 4 randomised controlled trial2021
Dr Arthur Pratt
Dr Stefan Siebert
Mike Cole
Dr Deborah Stocken
Amy Cranston
et al.
Targeting synovial fibroblast proliferation in rheumatoid arthritis (TRAFIC): an open-label, dose-finding, phase 1b trial2021
Dr Arthur Pratt
Professor John Isaacs
Dr Elena Nikiphorou
The use and context of the term 'multimorbidity' in rheumatoid arthritis: A systematic literature review2021
Mike Cole
Professor Fai Ng
Dr Stefan Siebert
Dr Arthur Pratt
Professor John Isaacs
et al.
TRAFIC: statistical design and analysis plan for a pragmatic early phase 1/2 Bayesian adaptive dose escalation trial in rheumatoid arthritis2021
Dr Ken Baker
Benjamin Thompson
Dr Dennis Lendrem
Adam Scadeng
Dr Arthur Pratt
et al.
Lack of association between clinical and ultrasound measures of disease activity in rheumatoid arthritis remission2020
Alex Clark
Dr Amy Anderson
Dr Nishanthi Thalayasingam
Najib Naamane
Julie Diboll
et al.
Lymphocyte DNA methylation mediates genetic risk at shared immune-mediated disease loci2020
Dr Dennis Lendrem
Dr Clare Lendrem
Dr Arthur Pratt
Professor John Isaacs
Professor David Jones
et al.
Schrödinger's pipeline and the outsourcing of pharmaceutical innovation2020
Dr Lilian Nwosu
Dr Arthur Pratt
Professor John Isaacs
Single-cell sequencing reveals clonal expansions of pro-inflammatory synovial CD8 T cells expressing tissue-homing receptors in psoriatic arthritis2020
Dr Stefan Siebert
Dr Arthur Pratt
Dr Deborah Stocken
Dr Miranda Morton
Amy Cranston
et al.
Targeting the rheumatoid arthritis synovial fibroblast via cyclin dependent kinase inhibition: An early phase trial2020
Professor John Isaacs
Dr Arthur Pratt
Arthritis prevention in the pre-clinical phase of RA with abatacept (the APIPPRA study): a multi-centre, randomised, double-blind, parallel-group, placebo-controlled clinical trial protocol2019
Dr Clare Lendrem
Dr Dennis Lendrem
Dr Arthur Pratt
Najib Naamane
Dr Peter McMeekin
et al.
Between a ROC and a hard place: Teaching prevalence plots to understand real world biomarker performance in the clinic2019
Dr Amy Anderson
Dr Nicola Maney
Dr Dennis Lendrem
Julie Diboll
Dr Philip Brown
et al.
Expression of STAT3-regulated genes in circulating CD4+ T cells discriminates rheumatoid arthritis independently of clinical parameters in early arthritis2019
Laura Ridgley
Dr Amy Anderson
Dr Nicola Maney
Najib Naamane
Andrew Skelton
et al.
IL-6 Mediated Transcriptional Programming of Naïve CD4+ T Cells in Early Rheumatoid Arthritis Drives Dysregulated Effector Function2019
Dr Matthew Wood
Adam Leckenby
Dr Gary Reynolds
Dr Rachel Spiering
Dr Arthur Pratt
et al.
Macrophage proliferation distinguishes 2 subgroups of knee osteoarthritis patients2019
Dr Ken Baker
Andrew Skelton
Dr Dennis Lendrem
Adam Scadeng
Dr Ben Thompson
et al.
Predicting drug-free remission in rheumatoid arthritis: A prospective interventional cohort study2019
Kundan Iqbal
Dr Dennis Lendrem
Ben Hargreaves
Professor John Isaacs
Dr Ben Thompson
et al.
Routine musculoskeletal ultrasound findings impact diagnostic decisions maximally in autoantibody-seronegative early arthritis patients2019
Dr Rachel Spiering
Matthew Wood
Anshor Fath
Oliver Eltherington
Dr Amy Anderson
et al.
Targeting of tolerogenic dendritic cells to heat-shock proteins in inflammatory arthritis2019
Dr Nishanthi Thalayasingam
Andrew Skelton
Dr Amy Anderson
Alex Clark
Julie Diboll
et al.
CD4+ and B lymphocyte expression quantitative traits at rheumatoid arthritis risk loci in untreated early arthritis: implications for causal gene identification2018
Dr Ken Baker
Dr Ben Thompson
Dr Dennis Lendrem
Dr Arthur Pratt
Professor John Isaacs
et al.
Lack of association between clinical and ultrasound measures of disease activity in rheumatoid arthritis clinical remission: a cross-sectional analysis2018
Dr Arthur Pratt
Patient-reported outcomes and safety in patients undergoing synovial biopsy: Comparison of ultrasound-guided needle biopsy, ultrasound-guided portal and forceps and arthroscopic-guided synovial biopsy techniques in five centres across Europe2018
Dr Faye Cooles
Dr Amy Anderson
Andrew Skelton
Dr Arthur Pratt
Professor Iain McInnes
et al.
Phenotypic and transcriptomic analysis of peripheral blood plasmacytoid and conventional dendritic cells in early drug naïve rheumatoid arthritis2018
Dr Ken Baker
Dr Dennis Lendrem
Dr Ben Thompson
Dr Arthur Pratt
Professor John Isaacs
et al.
Predictors of drug-free remission in rheumatoid arthritis: results from the prospective Biomarkers of Remission in Rheumatoid Arthritis (BioRRA) Study2018
Laura Ridgley
Dr Amy Anderson
Dr Arthur Pratt
What are the dominant cytokines in early rheumatoid arthritis?2018
Professor Karim Raza
Dr Arthur Pratt
Helen Hanson
Dr Stefan Siebert
Professor John Isaacs
et al.
Patient and researcher perspectives on facilitating patient and public involvement in rheumatology research2017
Dr Ken Baker
Dr Arthur Pratt
Dr Ben Thompson
Professor John Isaacs
Response to: 'Let's stop fooling ourselves. In RA, only ACR/EULAR criteria define remission and equate with absence of disease!' by Boers2017
Professor John Isaacs
Dr Arthur Pratt
Synovial tissue research: A state-of-the-art review2017
Dr Faye Cooles
Dr Amy Anderson
Dr Dennis Lendrem
Julie Norris
Dr Arthur Pratt
et al.
The interferon gene signature is increased in patients with early treatment-naive rheumatoid arthritis and predicts a poorer response to initial therapy2017
Dr Amy Anderson
Dr David Swan
Oliver Eltherington
Dr Arthur Pratt
Dr Gary Reynolds
et al.
Tolerogenic dendritic cells generated with dexamethasone and vitamin D3 regulate rheumatoid arthritis CD4+ T-cells partly via TGF-β12017
Dr Arthur Pratt
Dr Amy Anderson
Professor John Isaacs
Bcl-3 in CD4+ T Cell–Mediated Rheumatoid Arthritis Pathogenesis: Comment on the Article by Meguro et al2016
Dr Arthur Pratt
Dr Amy Anderson
Professor John Isaacs
Julie Diboll
Dr Nishanthi Thalayasingam
et al.
Capture Hi-C identifies a novel causal gene, IL20RA, in the pan-autoimmune genetic susceptibility region 6q232016
Dr Arthur Pratt
Dr Dennis Lendrem
Ben Hargreaves
Professor John Isaacs
Components of treatment delay in rheumatoid arthritis differ according to autoantibody status: validation of a single-centre observation using national audit data2016
Helen Hanson
Professor John Isaacs
Dr Lesley Kay
Dr Dennis Lendrem
Dr Nicola O'Brien
et al.
Experiences of staff and patients in relation to clinical research recruitment and involvement: a qualitative study2016
Dr Arthur Pratt
Dr Amy Anderson
Julie Diboll
Andrew Skelton
Dr Dennis Lendrem
et al.
Identification of novel expression quantitative trait loci in CD4+ T cells of untreated early arthritis patients2016
Dr Amy Anderson
Dr Arthur Pratt
Dr John Doran
Christine Routledge
Ben Hargreaves
et al.
IL-6-driven STAT signalling in circulating CD4+ lymphocytes is a marker for early anti-citrullinated peptide antibody-negative rheumatoid arthritis2016
Dr Philip Brown
Dr Arthur Pratt
Professor John Isaacs
Mechanism of action of methotrexate in rheumatoid arthritis, and the search for biomarkers2016
Dr Gary Reynolds
Dr Arthur Pratt
Dr David Coady
Dr Graham Raftery
Dr Alice Lorenzi
et al.
Synovial CD4+ T-cell-derived GM-CSF supports the differentiation of an inflammatory dendritic cell population in rheumatoid arthritis2016
Dr Ken Baker
Benjamin Thompson
Dr Dennis Lendrem
Dr Arthur Pratt
Professor John Isaacs
et al.
Ultrasound measures of synovitis are independent of clinical parameters in the setting of rheumatoid arthritis remission: a cross-sectional analysis.2016
Dr Arthur Pratt
Ben Hargreaves
Dr Dennis Lendrem
Professor John Isaacs
Components of treatment delay in rheumatoid arthritis differ according to autoantibody status2015
Dr Arthur Pratt
Professor John Isaacs
Genotyping in rheumatoid arthritis: a game changer in clinical management?2015
Dr Arthur Pratt
Ben Hargreaves
Christine Routledge
Lesley Tiffin
Julie Norris
et al.
Reasons for Treatment Delay in Early Rheumatoid Arthritis Differ According to Autoantibody Status2015
Dr Faye Cooles
Dr Arthur Pratt
Dr Dennis Lendrem
Professor Fai Ng
Dr Terry Aspray
et al.
Retrospective analysis of the role of serum vitamin D in early rheumatic disease2015
Dr Arthur Pratt
Dr Amy Anderson
Dr Dennis Lendrem
Julie Diboll
Ben Hargreaves
et al.
STAT3-regulated gene expression in circulating CD4+ T cells discriminates RA patients independently of clinical parameters in early arthritis: a validation study.2015
Dr Arthur Pratt
Dr Amy Anderson
Julie Diboll
Andrew Skelton
Ben Hargreaves
et al.
The Importance of IL-6-STAT3 Mediated Activation of Circulating CD4+ T Cells in the Pathogenesis of Early Seronegative Rheumatoid Arthritis: A Validation Study2015
Sophie Noblett
Dr Arthur Pratt
Ben Hargreaves
Christine Routledge
Phil Mawson
et al.
IL-6 Driven Stat3 Phophorylation in Circulating Lymphocytes is Specifiv for CD4+ T Cells in Early Rheumatoid Arthritis2014
Dr Amy Anderson
Christine Routledge
Professor John Isaacs
Dr Arthur Pratt
Investigation of interleukin-6-driven STAT3 signalling in circulating lymphocytes of patients with early rheumatoid arthritis as a route to biomarker discovery2014
Dr Amy Anderson
Dr Arthur Pratt
Ben Hargreaves
Philip Brown
Professor John Isaacs
et al.
Phospho-STAT1/3 and Gene Expression Measurement in Circulating CD4+ T Cells As Diagnostic Tools in Early Autoantibody-Negative Rheumatoid Arthritis2014
Dr Amy Anderson
Dr Arthur Pratt
Ben Hargreaves
Philip Brown
Professor John Isaacs
et al.
Phospho-STAT1/3 measurement in circulating CD4+T-cells as a diagnostic tool in early autoantibody-negative rheumatoid arthritis2014
Dr Faye Cooles
Dr Arthur Pratt
Dr Dennis Lendrem
Professor Fai Ng
Dr Terry Aspray
et al.
Retrospective analysis of the role of serum vitamin D in early rheumatic disease2014
Dr Arthur Pratt
Professor John Isaacs
Seronegative rheumatoid arthritis: Pathogenetic and therapeutic aspects2014
Dr Arthur Pratt
Dr Philip Brown
Dr Simon Cockell
Gillian Wilson
Professor John Isaacs
et al.
A CD4+T-Cell Gene Expression Signature Predicts Drug Survival on Methotrexate Monotherapy in Early Rheumatoid Arthritis2013
Dr Amy Anderson
Christine Routledge
Phil Mawson
Professor John Isaacs
Dr Arthur Pratt
et al.
Interleukin-6 driven STAT3 phosphorylation in circulating lymphocytes is specific for CD4 T cells in early rheumatoid arthritis2013
Dr Amy Anderson
Christine Routledge
Phil Mawson
Professor John Isaacs
Dr Arthur Pratt
et al.
Interleukin-6 Driven STAT3 Phosphorylation In Circulating Lymphocytes Is Specific For CD4+ T Cells In Early Rheumatoid Arthritis2013
Dr Arthur Pratt
Dr Alice Lorenzi
Gillian Wilson
Professor John Isaacs
Predicting persistent inflammatory arthritis amongst early arthritis clinic patients in the UK: is musculoskeletal ultrasound required?2013
Dr Faye Cooles
Dr Arthur Pratt
Professor Fai Ng
Dr Terry Aspray
Professor John Isaacs
et al.
The Effect Of Vitamin D On Early Rheumatoid Arthritis: A Retrospective Cohort Analysis2013
Dr Arthur Pratt
Dr Daniel Swan
Dr Sarah Richardson
Gillian Wilson
Professor Catharien Hilkens
et al.
A CD4 T cell gene signature for early rheumatoid arthritis implicates interleukin 6-mediated STAT3 signalling, particularly anti-citrullinated peptide antibody-negative disease2012
Dr Arthur Pratt
Dr Philip Brown
Dr Simon Cockell
Gillian Wilson
Professor John Isaacs
et al.
A CD4+T-Cell Gene Expression Signature Predicts Drug Survival On Methotrexate Monotherapy in Early Rheumatoid Arthritis.2012
Dr Arthur Pratt
Dr Alice Lorenzi
Gillian Wilson
Professor John Isaacs
A Pragmatic Musculoskeletal Ultrasound Screening Protocol Does Not Add to a Predictive Algorithm for Persistent Inflammatory Arthritis in a UK Early Arthritis Clinic2012
Dr Amy Anderson
Dr Alice Lorenzi
Dr Arthur Pratt
Thomas Wooldridge
Julie Diboll
et al.
Immunity 12 years after alemtuzumab in RA: CD5+ B-cell depletion, thymus-dependent T-cell reconstitution and normal vaccine responses2012
Dr Arthur Pratt
Professor Jaap Van Laar
Rheumatoid arthritis: Pathogenesis and clinical aspects2012
Dr Arthur Pratt
Dr Sarah Richardson
Gillian Wilson
Professor Catharien Hilkens
Professor David Young
et al.
A Transcriptional Profile Present in CD4+T-Cells of Patients with Undifferentiated Arthritis Predicts the Future Development of Seronegative Rheumatoid Arthritis and Implicates IL-6 in Disease Evolution2011
Dr Arthur Pratt
Dr Alice Lorenzi
Dr Philip Platt
Professor John Isaacs
Does routine musculoskeletal ultrasound use add value to the diagnosis of a RA among early and undifferentiated arthritis patients?2011
Dr Arthur Pratt
Professor John Isaacs
Does testing for circulating autoantibodies against disease-relevant citrullinated antigens add value to the CCP2 assay in diagnosing RA among early undifferenitated arthritis patients?2011
Dr Arthur Pratt
Professor John Isaacs
Does testing for circulating autoantibodies against disease-relevant citrullinated antigens add value to the CCP2 assay in diagnosing RA among early undifferentiated arthritis patients?2011
Dr Faye Cooles
Dr Arthur Pratt
Dr Gillian Wilson
Professor John Isaacs
Professor Fai Ng
et al.
Prevalence and diagnostic outcome relating to vitamin D deficiency in new patients presenting to an early arthritis clinic over 12 months2011
Dr Arthur Pratt
Professor John Isaacs
Serotyping for an extended anti-citrullinated peptide autoantibody panel does not add value to CCP2 testing for diagnosing RA in an early undifferentiated arthritis cohort2011
Dr Arthur Pratt
Dr Daniel Swan
Dr Sarah Richardson
Professor Catharien Hilkens
Professor David Young
et al.
Peripheral Blood CD4 T Cell Gene Expression Profiles as Predictive Biomarkers in Early Arthritis2010
Dr Susan Tudhope
Dr Alexei von Delwig
Dr Jane Falconer
Dr Arthur Pratt
Professor John Isaacs
et al.
Profound invariant natural killer T-cell deficiency in inflammatory arthritis2010
Dr Arthur Pratt
Dr Daniel Swan
Professor David Young
Professor Catharien Hilkens
Professor John Isaacs
et al.
A High-Throughput Transcriptomics Approach to Biomarker Discover in Early Arthritis2009
Dr Alice Lorenzi
Dr Angela Patterson
Dr Arthur Pratt
Dr Matthew Jefferson
Professor John Isaacs
et al.
Corrigendum to "Determination of thymic function directly from peripheral blood: A validated modification to an established method" [J. Immunol. Methods 2008 339(2):185-94] (DOI:10.1016/j.jim.2008.09.013)2009
Dr Arthur Pratt
Professor John Isaacs
Current concepts in the pathogenesis of early rheumatoid arthritis2009
Dr Arthur Pratt
Professor John Isaacs
The clinical utility of a rule for predicting rheumatoid arthritis in patients with early undifferentiated arthritis: comment on the article by van der Helm-van Mil et al2009
Emeritus Professor Mike Sir Michael Rawlins
Dr Angela Patterson
Dr Arthur Pratt
Dr Matthew Jefferson
Professor John Isaacs
et al.
Determination of thymic function directly from peripheral blood: a validated modification to an established method2008
Dr Alexei von Delwig
Dr Arthur Pratt
Dr Susan Tudhope
Professor John Isaacs
Professor Fai Ng
et al.
Invariant natural killer T (iNKT) cells in early rheumatoid arthritis (RA)2008
Dr Alexei von Delwig
Dr Susan Tudhope
Dr Arthur Pratt
Professor John Isaacs
Dr Desa Lilic
et al.
The role of invariant natural killer T (iNKT) cells in rheumatoid arthritis2008
Dr Arthur Pratt
Dr Lesley Kay
Comment on: Use of the QuantiFERON-TB® Gold test as part of a screening programme in patients with RA under consideration for treatment with anti-TNF-α agents: The Newcastle (UK) experience: Reply [7]2007
Dr Arthur Pratt
Dr Lesley Kay
Pamidronate infusions for Ankylosing Spondylitis give significant benefit to only a minority of patients2007
Dr Arthur Pratt
Dr Lesley Kay
Use of the QuantiFERON TB Gold test as part of a screening programme in patients with RA under consideration for treatment with anti-TNF-α agents: The Newcastle (UK) experience2007
Dr Arthur Pratt
Dr Lesley Kay
Use of the quantiFERON-TB gold test in pre-anti-TNF-alpha screening of rheumatoid arthritis patients: The newcastle experience2006