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DNA damage in horticultural farmers: a pilot study showing an association with organophosphate pesticide exposure

Lookup NU author(s): Dr Kathryn Atherton, Professor Faith Williams, Professor Stephen Rushton, Professor Peter Blain, Dr Elaine Mutch

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Abstract

A study of horticultural farmers exposed to organophosphate pesticides (OPs) and controls investigated the relationships between OP exposure, DNA damage and oxidative stress. Blood acetylcholinesterase (AChE) and urinary dialkylphosphate (DAP) levels determined exposure and 8-hydroxy-2'-deoxyguanosine (8OHdG) indicated oxidative stress status. The farmers had approximately 30% lower AChE activity and increased DAP levels compared with the controls, reflecting moderate OP exposure. They had higher DNA damage than the controls and there was a significant positive relationship between DAP and DNA damage with greater than 95% power. The farmers also had a significant positive relationship between urinary DAP and 8OHdG levels.

Publication metadata

Author(s): Atherton KM, Williams FM, Gonzalez FJE, Glass R, Rushton S, Blain PG, Mutch E

Publication type: Article

Publication status: Published

Journal: Biomarkers

Year: 2009

Volume: 14

Issue: 7

Pages: 443-451

Print publication date: 01/01/2009

Date deposited: 25/01/2010

ISSN (print): 1354-750X

ISSN (electronic): 1366-5804

Publisher: Informa Healthcare

URL: http://dx.doi.org/10.3109/13547500903137265

DOI: 10.3109/13547500903137265

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