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Clinical Practice Guidelines for the management of atypical Haemolytic Uraemic Syndrome in the United Kingdom

Lookup NU author(s): Professor Tim Goodship

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Abstract

P>Atypical haemolytic uraemic syndrome (aHUS) is associated with a poor prognosis with regard to survival at presentation, recovery of renal function and transplantation. It is now established that aHUS is a disease of complement dysregulation with mutations in the genes encoding both complement regulators and activators, and autoantibodies against the complement regulator factor H. Identification of the underlying molecular abnormality in an individual patient can now help to guide their future management. In these guidelines we make recommendations for the investigation and management of aHUS patients both at presentation and in the long-term. We particularly address the role of renal transplantation alone and combined liver-kidney transplantation.

Publication metadata

Author(s): Taylor CM, Machin S, Wigmore SJ, Goodship THJ, Renal Association, British Committee for Standards in Haematology, British Transplantation Society

Publication type: Article

Publication status: Published

Journal: British Journal of Haematology

Year: 2010

Volume: 148

Issue: 1

Pages: 37-47

ISSN (print): 0007-1048

ISSN (electronic): 1365-2141

Publisher: Wiley-Blackwell Publishing Ltd.

URL: http://dx.doi.org/10.1111/j.1365-2141.2009.07916.x

DOI: 10.1111/j.1365-2141.2009.07916.x

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