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Achievement of complete cytogenetic remission after two very low-dose doner leucocyte infusions in a patient with extensive cGVHD relapsing in accelerated phase post allogeneic BMT for CML

Lookup NU author(s): Dr Paul Sinclair


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We report the case of a 55-year-old female who despite having developed extensive chronic graft-versus-host disease (GVHD), relapsed 35 months after a T cell-replete sibling donor bone marrow transplant for Philadelphia-positive chronic myeloid leukaemia (Ph CML). She achieved complete cytogenetic remission after discontinuation of cyclosporin A and administration of two low-dose donor leucocyte infusions (DLI 1 ´ 106 and 5 ´ 106 CD3+ cells/kg). Eighteen months after the first infusion she remains well and in complete cytogenetic remission with a normocellular marrow and no exacerbation of GVHD.

Publication metadata

Author(s): Rahman SL, Mahendra P, Nacheva E, Sinclair P, Arno J, Marcus RE

Publication type: Article

Publication status: Published

Journal: Bone Marrow Transplantation

Year: 1998

Volume: 21

Issue: 9

Pages: 955-956

Print publication date: 01/05/1998

ISSN (print): 0268-3369

ISSN (electronic): 1476-5365

Publisher: Nature Publishing Group


DOI: 10.1038/sj.bmt.1701195


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