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Browsing publications by Dr Paul Sinclair.

Newcastle AuthorsTitleYearFull text
Emeritus Professor Amritpal Hungin
Dr Paul Sinclair
Knowledge gaps in the management of refractory reflux-like symptoms: Healthcare provider survey2022
Dr Paul Sinclair
Dr Sarra Ryan
Dr Matthew Bashton
Shaun Hollern
Rebecca Hanna
et al.
SH2B3 inactivation through CN-LOH-12q is uniquely associated with B-cell precursor ALL with iAMP21 or other chromosome 21 gain2019
Dr Ruth Cranston
Dr Paul Sinclair
Dr Matthew Bashton
Dr Matthew Selby
Professor Christine Harrison FRCPath FMedSci
et al.
A Genome-Wide CRISPR Screen Implicates MYC Dysregulation in TCF3-PBX1 B-ALL2018
Dr Paul Sinclair
Dr Helen Blair
Dr Sarra Ryan
Dr Lars Buechler
Joanna Cheng
et al.
Dynamic clonal progression in xenografts of acute lymphoblastic leukemia with intrachromosomal amplification of chromosome 212018
Zach Dixon
Dr Lindsay Nicholson
Elizabeth Matheson
Dr Paul Sinclair
Professor Christine Harrison FRCPath FMedSci
et al.
CREBBP knockdown enhances RAS/RAF/MEK/ERK signaling in Ras pathway mutated acute lymphoblastic leukemia but does not modulate chemotherapeutic response2017
Dr Alex Elder
Dr Klaus Rehe
Dr Simon Bomken
Dr Paul Sinclair
Katie Dormon
et al.
The ability to cross the blood-cerebrospinal fluid barrier is a generic property of acute lymphoblastic leukemia blasts.2016
Dr Sarra Ryan
Elizabeth Matheson
Dr Paul Sinclair
Dr Matthew Bashton
Claire Schwab
et al.
The role of the RAS pathway in iAMP21-ALL2016
Dr Paul Sinclair
Joanna Cheng
Prahlad Raninga
Rebecca Hanna
Shaun Hollern
et al.
A Targeted Functional Clone Tracking Assay for the Identification of Tumour Suppressor Genes in BCP- ALL Implicates the Transcription Factors FOXO3 and PRDM12015
Dr Klaus Rehe
Dr Simon Bomken
Dr Paul Sinclair
Dr Lisa Russell
Professor Olaf Heidenreich
et al.
Childhood pre-B acute lymphoblastic leukaemia cells capable of central nervous system engraftment are common, heterogeneous and transit the blood-cerebrospinal fluid barrier2015
Dr Jeyanthy Eswaran
Dr Paul Sinclair
Professor Olaf Heidenreich
Professor Julie Irving
Dr Lisa Russell
et al.
The pre-B-cell receptor checkpoint in acute lymphoblastic leukaemia2015
Sarra Ryan
Professor Anthony Moorman
Dr Richard McNally
Professor Bryan Young
Dr Paul Sinclair
et al.
Constitutional and somatic rearrangement of chromosome 21 in acute lymphoblastic leukaemia2014
Dr Jeyanthy Eswaran
Dr Paul Sinclair
Dr Sirintra Nakjang
Professor Christine Harrison FRCPath FMedSci
Identification of Cmtm Family Proteins As Tumor Suppressor and Membrane Regulator in B Cell Precursor Acute Lymphoblastic Leukemia2014
Jake Clayton
Joanna Cheng
Dr Sarra Ryan
Professor Christine Harrison FRCPath FMedSci
Dr Paul Sinclair
et al.
Oncogenomic Screening Strategies to Identify Tumour Suppressor Genes on Chromosome 12 in Acute Myeloid Leukaemia2014
Dr Paul Sinclair
Dr Vikki Rand
Hannah Ensor
Professor Christine Harrison FRCPath FMedSci
Analysis of a breakpoint cluster reveals insight into the mechanism of intrachromosomal amplification in a lymphoid malignancy2011
Dr Vikki Rand
Dr Lisa Russell
Claire Schwab
Hannah Ensor
Professor Julie Irving
et al.
Genomic characterization implicates iAMP21 as a likely primary genetic event in childhood B-cell precursor acute lymphoblastic leukemia2011
Dr Paul Sinclair
Dynamic plasticity of large -scale chromatin structure revealed by self-assembly of engineered chromosome regions2010
Dr Paul Sinclair
Insights into interphase large-scale chromatin structure from analysis of engineered chromosome regions2010
Dr Vikki Rand
Dr Lisa Russell
Professor Julie Irving
Lisa Jones
Dr Dino Masic
et al.
What Is the Initiating Mechanism of iAMP21 in Childhood B Cell Precursor ALL?2009
Dr Paul Sinclair
The facultative heterochromatin of the inactive X chromosome has a distinctive condensed ultrastructure2008
Dr Paul Sinclair
Professor Christine Harrison FRCPath FMedSci
Analysis of balanced rearrangements of chromosome 6 in acute leukemia: clustered breakpoints in q22-q23 and possible involvement of c-MYB in a new recurrent translocation, t(6;7)(q23;q32 through 36)2005
Dr Paul Sinclair
Professor Christine Harrison FRCPath FMedSci
A fluorescence in situ hybridization map of 6q deletions in acute lymphocytic leukemia: identification and analysis of a candidate tumor suppressor gene2004
Dr Paul Sinclair
Dr Bridget Wilkins
Identification of four new translocations involving FGFR1 in myeloid disorders2001
Dr Paul Sinclair
Transcription factor BACH2 is transcriptionally regulated by the BCR/ABL oncogene2001
Dr Paul Sinclair
Professor Christine Harrison FRCPath FMedSci
Deletion of 6q16-q21 in human lymphoid maligancies: a mapping and deletion analysis2000
Dr Paul Sinclair
Large deletions at the t(9;22) breakpoint are common and may define a poor-prognosis subgroup of patients with chronicmyeloid leukemia2000
Dr Paul Sinclair
Comparative analysis of G-banding, chromosome painting, locus specific FISH and CGH in chronic myeloid leukemia blast chrisis1999
Dr Paul Sinclair
Achievement of complete cytogenetic remission after two very low-dose doner leucocyte infusions in a patient with extensive cGVHD relapsing in accelerated phase post allogeneic BMT for CML1998
Dr Paul Sinclair
Improved sensitivity of BCR-ABL detection: a triple-probe three colour fluorescence in situ hybridisation system.1997
Dr Paul Sinclair
t(9;13)(q34;q12) chromosomal translocation persisting 4 years post autologous bone marrow transplantation for secondary AML despite morphological remission1996
Dr Paul Sinclair
Denovo ring chromosome 3: a new case with a mild phenotype1991