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NF-kappa B signalling: Embracing complexity to achieve translation

Lookup NU author(s): Professor Derek Mann


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NF-kappa B is a dimeric transcription factor that has emerged as an important regulator of liver homeostasis and is mechanistically implicated in a variety of liver pathologies including hepatitis, steatosis, fibrosis, and hepatocellular carcinoma. The question remains as to whether NF-kappa B can really be exploited for the development of therapeutics for these pathologies in the diseased human liver. This review casts a critical eye on the experimental evidence gathered to date and in particular questions the rationale for the current focus on components of the upstream IKK complex as therapeutic targets. We make the argument that translation of NF-kappa B biology to new therapies is more likely to emerge from a re-focus of basic research back to the NF-kappa B/Rel Subunit functions and the complexities of their post-translational modifications and context-dependent co-regulator interactions. (C) 2009 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.

Publication metadata

Author(s): Chakraborty JB, Mann DA

Publication type: Article

Publication status: Published

Journal: Journal of Hepatology

Year: 2010

Volume: 52

Issue: 2

Pages: 285-291

Print publication date: 01/02/2010

ISSN (print): 0168-8278

ISSN (electronic): 1600-0641

Publisher: Elsevier BV


DOI: 10.1016/j.jhep.2009.10.030


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Funder referenceFunder name
British Liver Trust
Wellcome Trust
223151European Commission