Toggle Main Menu Toggle Search

Open Access padlockePrints

Browsing publications by Professor Derek Mann.

Newcastle AuthorsTitleYearFull text
Adnan Ali
Dr Caroline Wilson
Dr Jack Leslie
Professor Derek Mann
Author Correction: Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer (Nature Medicine, (2019), 25, 4, (641-655), 10.1038/s41591-019-0379-5)2022
Dr Jack Leslie
Erik Ramon Gil
Kathryn Gilroy
Dr Saimir Luli
Maja Laszczewska
et al.
CXCR2 inhibition enables NASH-HCC immunotherapy2022
Dr Daniel Geh
Dr Jack Leslie
Professor Helen Reeves
Professor Derek Mann
Neutrophils as potential therapeutic targets in hepatocellular carcinoma2022
Dr Jack Leslie
Hannah Paish
Amy Collins
Rebecca Scott
Abi Watson
et al.
A Mammalian Target of Rapamycin-Perilipin 3 (mTORC1-Plin3) Pathway is essential to Activate Lipophagy and Protects Against Hepatosteatosis2021
Misti McCain
Professor Derek Mann
Professor Helen Reeves
Cell-free DNA TAPS provides multimodal information for early cancer detection2021
Marco Zaki
Dr Ahmed Mahdi
Dr Gillian Patman
Anna Whitehead
Joao Mauricio
et al.
Key features of the environment promoting liver cancer in the absence of cirrhosis2021
Dr Arianna Bianchi
Letizia Marchetti
Hannah Paish
Dr Kile Green
Dr Dina Tiniakos
et al.
Moderate Exercise Inhibits Age-Related Inflammation, Liver Steatosis, Senescence, and Tumorigenesis2021
Dr Jack Leslie
Dr Marie-Helene Ruchaud
Amy Collins
Leena Habiballa
Dr Gabi Saretzki
et al.
Neutrophils induce paracrine telomere dysfunction and senescence in ROS-dependent manner2021
Professor Fiona Oakley
Marco Zaki
Professor Derek Mann
TREM-2 defends the liver against hepatocellular carcinoma through multifactorial protective mechanisms2021
Edward Fielder
Dr Clare Tweedy
Dr Caroline Wilson
Professor Fiona Oakley
Dr Fiona LeBeau
et al.
Anti-inflammatory treatment rescues memory deficits during aging in nfkb1−/− mice2020
Dr Julie Worrell
Dr Jack Leslie
Dr Graham Smith
Marco Zaki
Hannah Paish
et al.
cRel expression regulates distinct transcriptional and functional profiles driving fibroblast matrix production in systemic sclerosis2020
Dr Jack Leslie
Dr Marina Garcia Macia
Dr Saimir Luli
Dr Julie Worrell
William Reilly
et al.
c-Rel orchestrates energy-dependant epithelial and macrophage reprogramming in fibrosis2020
Dr Jack Leslie
Benjamin Millar
Alicia Del Carpio Pons
Rachel Burgoyne
Joseph Frost
et al.
FPR-1 is an important regulator of neutrophil recruitment and a tissue-specific driver of pulmonary fibrosis2020
Stephen Ball
Dr Simon Cockell
Emerita Professor Janet Wilson
Professor Derek Mann
Professor Andrew Fisher
et al.
Microarray analysis of primary epithelial and fibroblast cells in chronic rhinosinusitis without nasal polyps2020
Professor Derek Mann
Dr Lee Borthwick
Professor David Deehan
Dr Nicholas Kalson
Quantification of intra-articular fibrosis in patients with stiff knee arthroplasties using metal-reduction MRI2020
Laura Sabater
Dr Luigi Locatelli
Professor Fiona Oakley
Dr Timothy Hardy
Jeremy French
et al.
RNA sequencing reveals changes in the microRNAome of transdifferentiating hepatic stellate cells that are conserved between human and rat2020
Hannah Paish
Lee Reed
Helen Brown
Mark Bryan
Dr Olivier Govaere
et al.
A bioreactor technology for modelling fibrosis in human and rodent precision-cut liver slices2019
Hannah Paish
Dr Colin Gillespie
Alicia Del Carpio Pons
Professor Derek Mann
Professor David Deehan
et al.
Chronic, Active Inflammation in Patients with Failed Total Knee Replacements Undergoing Revision Surgery2019
Dr Eva Moran Salvador
Dr Ashwin Sivaharan
Laura Sabater
Marco Zaki
Amber Knox
et al.
Fibrogenic Activity of MECP2 is Regulated by Phosphorylation in Hepatic Stellate Cells2019
Dr Maria Perugorria
Professor Fiona Oakley
Professor Jelena Mann
Dr Dina Tiniakos
Professor Derek Mann
et al.
Non-parenchymal TREM-2 protects the liver from immune-mediated hepatocellular damage2019
Dr Caroline Wilson
Dr Jack Leslie
Professor Derek Mann
Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer2019
Clara Correia Melo
Dr Jodie Birch
Edward Fielder
Dr James Chapman
Dr Anthony Lagnado
et al.
Rapamycin improves healthspan but not inflammaging in nfkb1-/- mice2019
Hannah Paish
Dr Nicholas Kalson
Dr Graham Smith
Alicia Del Carpio Pons
Nicholas Smith
et al.
Fibroblasts Promote Inflammation and Pain via IL-1α Induction of the Monocyte Chemoattractant Chemokine (C-C Motif) Ligand 22018
Dr Tyrell Cartwright
Dr Julie Worrell
Letizia Marchetti
Amber Knox
Professor Jelena Mann
et al.
HDAC1 interacts with the p50 NF-κB subunit via its nuclear localization sequence to constrain inflammatory gene expression2018
Dr Jane Margetts
Laura Ogle
Dr Anthony Chan
Dr David Jamieson
Dr Catherine Willoughby
et al.
Neutrophils: driving progression and poor prognosis in hepatocellular carcinoma?2018
Dr Marie Boyle
Faik Tutucu
Dr Timothy Hardy
Professor Derek Mann
Dr Mujdat Zeybel
et al.
Plasma cell-free DNA methylation: a liquid biomarker of hepatic fibrosis2018
Dr Nicholas Kalson
Timothy Brock
Professor Derek Mann
Dr Lee Borthwick
Professor David Deehan
et al.
Reduced telomere length is associated with fibrotic joint disease suggesting that impaired telomere repair contributes to joint fibrosis2018
Dr Mujdat Zeybel
Dr Saimir Luli
Laura Sabater
Dr Timothy Hardy
Professor Fiona Oakley
et al.
A Proof-of-Concept for Epigenetic Therapy of Tissue Fibrosis: Inhibition of Liver Fibrosis Progression by 3-Deazaneplanocin A2017
Dr Stuart McPherson
Dr Nina Wilson
Dr Dina Tiniakos
Dr Jennifer Wilkinson
Professor Alastair Burt
et al.
A randomised controlled trial of losartan as an anti-fibrotic agent in non-alcoholic steatohepatitis2017
Dr Mikolaj Ogrodnik
Dr Satomi Miwa
Dr Dina Tiniakos
Dr Caroline Wilson
Professor Chris Day
et al.
Cellular senescence drives age-dependent hepatic steatosis2017
Dr Caroline Wilson
Professor Derek Mann
Dr Lee Borthwick
Epigenetic reprogramming in liver fibrosis and cancer2017
Dr Timothy Hardy
Dr Mujdat Zeybel
Professor Chris Day
Dr Christian Dipper
Dr Steven Masson
et al.
Plasma DNA methylation: A potential biomarker for stratification of liver fibrosis in non-alcoholic fatty liver disease2017
Professor Fiona Oakley
Professor Derek Mann
The new-generation pan-peroxisome proliferator-activated receptor agonist IVA337 protects the liver from metabolic disorders and fibrosis.2017
Dr Amy Fearn
Dr Aldi Situmorang
Christopher Fox
Professor Fiona Oakley
Rachel Howarth
et al.
The NF-kB1 is a key regulator of acute but not chronic renal injury2017
Laura Corbett
Dr Pier Paoli
John Casement
Professor Jelena Mann
Professor Derek Mann
et al.
Variant Histone H2afv reprograms DNA methylation during early zebrafish development2017
Dr Lee Borthwick
Wona Suwara
Dr Sonya Carnell
Dr Nicola Green
Dr Rahul Mahida
et al.
Pseudomonas aeruginosa induced Airway Epithelial Injury Drives Fibroblast Activation: A Mechanism in Chronic Lung Allograft Dysfunction2016
Dr Saimir Luli
Dr Stephen Hill
Helen Brown
Jack Leslie
Dr Helen Marshall
et al.
A new fluorescence-based optical imaging method to non-invasively monitor hepatic myofibroblasts in vivo2016
Dr Anna Moles Fernandez
Dr Jacqueline Butterworth
Dr Jill Hunter
Dr Jack Leslie
Helene Sellier
et al.
A RelA(p65) Thr505 phospho-site mutation reveals an important mechanism regulating NF-kB dependent liver regeneration and cancer2016
Professor Jelena Mann
Professor Derek Mann
Dynamic phosphorylation of RelA on Ser42 and Ser45 in response to TNFα stimulation regulates DNA binding and transcription2016
Dr Timothy Hardy
Professor Derek Mann
Epigenetic in liver disease: from biology to therapeutics2016
Dr Nicholas Kalson
Dr Lee Borthwick
Professor Derek Mann
Professor David Deehan
International consensus on the definition and classification of fibrosis of the knee joint2016
John Moir
Professor Derek Mann
Professor Jelena Mann
Richard Charnley
Professor Derek Manas
et al.
Metabolic relationships within the tumour microenvironment of pancreatic ductal adenocarcinoma - pancreatic stellate cells induce glycolysis in cancer cells2016
Dr Clara Correia Melo
Francisco Marques
Rhys Anderson
Dr Graeme Hewitt
Dr Bernadette Carroll
et al.
Mitochondria are required for pro-ageing features of the senescent phenotype2016
Dr Lee Borthwick
Professor Derek Mann
Osteopontin and HMGB1: novel regulators of HSC activation2016
Stuart Robinson
Professor Derek Mann
Professor Derek Manas
Professor Fiona Oakley
Professor Jelena Mann
et al.
Response to 'Comment on 'The potential contribution of tumour-related factors to the development of FOLFOX-induced sinusoidal obstruction syndrome''2016
John Moir
Professor Derek Mann
Professor Jelena Mann
Richard Charnley
Professor Derek Manas
et al.
The effect of monocarboxylate transporter 1 inhibition in the tumour microenvironment of pancreatic ductal adenocarcinoma2016
Dr Stephen Ball
Professor Derek Mann
Emerita Professor Janet Wilson
Professor Andrew Fisher
The Role of the Fibroblast in Inflammatory Upper Airway Conditions2016
Professor Fiona Oakley
Dr Maria Perugorria
Professor Derek Mann
TPL2 Kinase Is a Crucial Signaling Factor and Mediator of NKT Effector Cytokine Expression in Immune-Mediated Liver Injury2016
David Dixon
Jonathon Coates
Joanna Horabin
Andrew Walker
Dr Nicole Abdul
et al.
A potential mode of action for Anakinra in patients with arthrofibrosis following total knee arthroplasty2015
Dr Agata Page
Dr Pier Paoli
Dr Stephen Hill
Rachel Howarth
Jeremy French
et al.
Alcohol directly stimulates epigenetic modifications in hepatic stellate cells2015
Dr Agata Page
Professor Jelena Mann
Professor Derek Mann
Changes in DNA methylation and hydroxymethylation during HSC activation2015
Professor Fiona Oakley
Professor Derek Mann
Chapter 15 - Stellate Cell Depletion Models2015
Professor Derek Mann
Emerging and Disease-Specific Mechanisms of Hepatic Stellate Cell Activation2015
Professor Jelena Mann
Professor Derek Mann
Epigenetic regulation of hepatic stellate cells and liver fibrosis2015
Dr Agata Page
Professor Derek Mann
Epigenetic regulation of liver fibrosis2015
Dr Nicole Abdul
David Dixon
Andrew Walker
Joanna Horabin
Professor David Deehan
et al.
Fibrosis is a common outcome following total knee arthroplasty2015
Dr Stephen Ball
Monika Suwara
Dr Lee Borthwick
Emerita Professor Janet Wilson
Professor Derek Mann
et al.
How Reliable are Sino-Nasal Cell Lines for Studying the Pathophysiology of Chronic Rhinosinusitis?2015
Professor Derek Mann
Importance of investigating epigenetic alterations for industry, and regulators: An appraisal of current efforts by the Health and Environmental Sciences Institute2015
Dr Nicholas Kalson
Professor Derek Mann
Professor David Deehan
Joint Stiffness Is Heritable and Associated with Fibrotic Conditions and Joint Replacement2015
Dr Timothy Hardy
Victoria Sharkey
Dr Mujdat Zeybel
Professor John Mathers
Steven White
et al.
Laser capture microdissection reveals cell-specific DNA methylation signatures in key fibrosis modifier genes in chronic liver disease2015
Dr Eva Moran Salvador
Dr Pier Paoli
Dr Graham Smith
Dr Agata Page
Rachel Howarth
et al.
MeCP2 exerts global control over the myofibroblast transcriptome and reveals new regulators of fibrosis2015
Dr Anna Moles Fernandez
Dr Jacqueline Butterworth
Dr Jill Hunter
Professor Derek Mann
Professor Fiona Oakley
et al.
Mutation of Rela THR505 Enhances Liver Regeneration Following Partial Hepatectomy2015
Dr Caroline Wilson
Dr Diana Jurk
Nicola Fullard
Paul Banks
Dr Agata Page
et al.
NFkB1 is a suppressor of neutrophil-driven hepatocellular carcinoma2015
Laura Corbett
Professor Jelena Mann
Professor Derek Mann
Non-Canonical Wnt Predominates in Activated Rat Hepatic Stellate Cells, Influencing HSC Survival and Paracrine Stimulation of Kupffer Cells2015
Dr Saimir Luli
Dr Daniela Di Paolo
Dr Caroline Wilson
Professor Matthew Wright
Helen Brown
et al.
Non-invasive fluorescent imaging of liver fibrosis and response to therapy in mice2015
Dr Jess Dyson
Professor Derek Mann
Professor David Jones
Novel therapeutic targets in primary biliary cirrhosis2015
Dr Luigi Locatelli
Dr Pier Paoli
Dr Timothy Hardy
Rachel Howarth
Professor Fiona Oakley
et al.
Sequence Profiling of miRNAs Reveals mir-150-5p as a Regulator of Transdifferentiation2015
Dr Anna Moles Fernandez
Dr Jacqueline Butterworth
Dr Jill Hunter
Dr Dina Tiniakos
Professor Derek Mann
et al.
Thr505 RelA phosphorylation controls liver proliferative response and supresses NF-kappa B tumor-promoting activities2015
Dr Caroline Wilson
Dr Lindsay Murphy
Jack Leslie
Dr Stuart Kendrick
Jeremy French
et al.
Ubiquitin C-terminal hydrolase 1: A novel functional marker for liver myofibroblasts and a therapeutic target in chronic liver disease2015
Dr Phillip Probert
Dr Mohammed Ebrahimkhani
Professor Fiona Oakley
Professor Jelena Mann
Professor Alastair Burt
et al.
A reversible model for periportal fibrosis and a refined alternative to bile duct ligation2014
Dr Saimir Luli
Dr Stephen Hill
Professor Matthew Wright
Professor Derek Mann
Professor Fiona Oakley
et al.
A simple fluorescence based method to non-invasively image liver fibrosis2014
Dr Anna Moles Fernandez
Dr Lindsay Murphy
Dr Caroline Wilson
Dr Jayshree Bagchi Chakraborty
Christopher Fox
et al.
A TLR2/S100A9/CXCL-2 signaling network is necessary for neutrophil recruitment in acute and chronic liver injury in the mouse2014
Laura Corbett
Professor Jelena Mann
Professor Derek Mann
Canonical vs non-canonical Wnt signalling2014
Dr Diana Jurk
Dr Caroline Wilson
Dr Joao Passos
Professor Fiona Oakley
Clara Correia Melo
et al.
Chronic inflammation induces telomere dysfunction and accelerates ageing in mice2014
Dr Mujdat Zeybel
Dr Timothy Hardy
Christopher Fox
Dr Steven Masson
Professor Derek Mann
et al.
Differential DNA methylation of genes involved in fibrosis progression in NAFLD and ALD2014
Professor Derek Mann
Epigenetics in Liver Disease2014
Professor Derek Mann
Erratum to "Clinical evidence for the regression of liver fibrosis" (vol 56, pg 1171, 2012)2014
Professor Jelena Mann
Professor Derek Manas
Professor Derek Mann
Steven White
Folfox induced sinusoidal obstruction syndrome (SOS) is a potentially reversible condition2014
Wona Suwara
Dr Nicola Green
Dr Lee Borthwick
Professor Jelena Mann
Emeritus Professor Nick Europe-Finner
et al.
IL-1α released from damaged epithelial cells is sufficient and essential to trigger inflammatory responses in human lung fibroblasts2014
Dr Caroline Wilson
Professor Jelena Mann
Dr Meagan Walsh
Professor Fiona Oakley
Professor Matthew Wright
et al.
Quiescent Hepatic Stellate Cells Functionally Contribute to the Hepatic Innate Immune Response via TLR32014
Stuart Robinson
Professor Jelena Mann
Professor Derek Manas
Professor Derek Mann
Steven White
et al.
An experimental MODEL study to investigate the pathogenesis of oxaliplatin-induced liver injury2013
Stuart Robinson
Professor Jelena Mann
Professor Derek Manas
Professor Derek Mann
Steven White
et al.
An experimental study to identify the potential role of pharmacogenomics in determining the occurrence of oxaliplatin-induced liver injury2013
Stuart Robinson
Professor Jelena Mann
Professor Derek Manas
Professor Derek Mann
Steven White
et al.
Antioxidant therapy is able to prevent the development of oxaliplatin induced sinusoidal obstruction syndrome2013
Dr Lindsay Murphy
Dr Jayshree Bagchi Chakraborty
Professor Jelena Mann
Professor Fiona Oakley
Professor Derek Mann
et al.
Deficient Neutrophil Recruitment into the Liver Parenchyma after an Acute CCl4 Challenge does not affect Fibrogenesis2013
Dr Claire Troakes
Professor Johannes Attems
Annette King
Professor Derek Mann
Diagnostic approach to Argyrophilic Grain Disease (AGD): an UK BDR trial2013
Dr Mujdat Zeybel
Professor Derek Mann
Professor Jelena Mann
Epigenetic modifications as new targets for liver disease therapies2013
Professor Jelena Mann
Professor Derek Mann
Epigenetic regulation of wound healing and fibrosis2013
Professor Derek Mann
Professor Jelena Mann
Ethanol Stimulates Production of Extracellular Matrix Proteins in Hepatic Stellate Cells2013
Stuart Robinson
Professor Jelena Mann
Professor Derek Manas
Professor Derek Mann
Steven White
et al.
Identification of molecular pathways implicated in the pathogenesis of oxaliplatin induced sinusoidal obstruction syndrome2013
Dr Lindsay Murphy
Dr Saimir Luli
Dr Lee Borthwick
Dr Steven O'Reilly
Professor Neil Perkins
et al.
Inhibition of RelA-Ser536 phosphorylation by a competing peptide reduces mouse liver fibrosis without blocking the innate immune response2013
Stuart Robinson
Professor Jelena Mann
Professor Derek Manas
Professor Derek Mann
Steven White
et al.
Is FOLFOX induced sinusoidal obstruction syndrome (SOS) a potentially reversible condition?2013
Dr Phillip Probert
Dr Mohammed Ebrahimkhani
Professor Fiona Oakley
Professor Alastair Burt
Professor Derek Mann
et al.
Methapyrilene Treatment is a Refined Alternative to Bile Duct Ligation as a Model of Reproducible and Reversible Periportal Fibrosis in the Rat2013
Dr Gillian Patman
Dr Despina Televantou
Anna Whitehead
Professor Chris Day
Professor Fiona Oakley
et al.
Mild Steatosis and Impaired Glucose Tolerance are Associated with Liver Cancer Development, While Progression to Nash Increases Number/Size in an Animal Model of NAFLD2013
Stuart Robinson
Professor Jelena Mann
Professor John Mathers
Professor Alastair Burt
Professor Fiona Oakley
et al.
Pathogenesis of FOLFOX induced sinusoidal obstruction syndrome in a murine chemotherapy model2013
Professor Derek Mann
Professor Fiona Oakley
Serotonin paracrine signaling in tissue fibrosis2013
Dr Gillian Patman
Dr Despina Televantou
Anna Whitehead
Professor Chris Day
Professor Alastair Burt
et al.
Sulfatase-2 (SULF2) Expressed in Hepatocytes and Stromal Cells Contributes to the Development of Steatosis, the Progression of NAFLD to Fibrosis and the Advancement of Cancer2013
Dr Nicola Fullard
Dr Steven O'Reilly
Professor Jaap Van Laar
David Faini
Julie Diboll
et al.
The c-Rel Subunit of NF-κB Regulates Epidermal Homeostasis and Promotes Skin Fibrosis in Mice2013
Stuart Robinson
Professor Derek Mann
Professor Derek Manas
Professor Fiona Oakley
Professor Jelena Mann
et al.
The potential contribution of tumour-related factors to the development of FOLFOX-induced sinusoidal obstruction syndrome2013
Laura Corbett
Professor Jelena Mann
Professor Derek Mann
The Wnt Pathway in Hepatic Stellate Cells: Canonical vs. Non-Canonical Signalling2013
Dr Lee Borthwick
Emeritus Professor Nick Europe-Finner
Dr Rahul Mahida
Andrew Walker
Aaron Gardner
et al.
TNFα From Classically Activated Macrophages Accentuates Epithelial to Mesenchymal Transition in Obliterative Bronchiolitis2013
Dr Maria Perugorria
Dr Lindsay Murphy
Dr Nicola Fullard
Dr Caroline Wilson
Professor Fiona Oakley
et al.
Tumor progression locus 2/Cot is required for activation of extracellular regulated kinase in liver injury and toll-like receptor-induced TIMP-1 gene transcription in hepatic stellate cells in mice2013
Stuart Robinson
Professor Jelena Mann
Professor Derek Manas
Professor Alastair Burt
Professor Derek Mann
et al.
An experimental study to determine the pathogenesis of oxaliplatin induced sinusoidal obstruction syndrome2012
Professor Derek Mann
Clinical evidence for the regression of liver fibrosis2012
Shilu Amin
Dr Meagan Walsh
Dr Caroline Wilson
Dr Elaine Willmore
Professor Derek Mann
et al.
Cross-talk between DNA methylation and active histone modifications regulates aberrant expression of ZAP70 in CLL2012
Stuart Robinson
Professor Jelena Mann
Professor Alastair Burt
Professor Derek Manas
Professor Derek Mann
et al.
Does a pro-thrombotic environment contribute to the development of chemotherapy associated liver injury in patients with colorectal liver metastases?2012
Dr Mujdat Zeybel
Dr Meagan Walsh
Professor Derek Mann
Professor Jelena Mann
DZNep attenuates liver fibrosis by blocking EZH2 and H3K27me32012
Stuart Robinson
Professor Jelena Mann
Professor Derek Manas
Professor Derek Mann
Steven White
et al.
Expression of the copper export transporter atpase 7B correlates with tissue specific injury in a murine model of colorectal liver metastases2012
Stuart Robinson
Professor Jelena Mann
Professor Derek Manas
Professor Derek Mann
Steven White
et al.
Gene expression in oxaliplatin related sinusoidal obstruction syndrome2012
Dr Maria Perugorria
Dr Mujdat Zeybel
Mark Walsh
Shilu Amin
Professor Alastair Burt
et al.
Histone methyltransferase ASH1 orchestrates fibrogenic gene transcription during myofibroblast transdifferentiation2012
Professor Derek Mann
Professor Fiona Oakley
Inhibition of 536 phosphorylation site in NF-kappa B (RELA) reduces liver fibrosis in mouse progressive liver disease, but does not block the innate immune response2012
Wona Suwara
Dr Lee Borthwick
Dr Rahul Mahida
Dr Nicola Green
Aaron Gardner
et al.
Interleukin-1 Alpha (IL-1α) Released from Injured Lung Epithelium is a Critical Alarmin Driving Activation of a Potent Inflammatory Phenotype in Lung Fibroblasts2012
Dr Nicola Green
Wona Suwara
Dr Lee Borthwick
Professor Derek Mann
Professor Andrew Fisher
et al.
Interleukin-33 in Chronic Lung Disease2012
Dr Mujdat Zeybel
Dr Timothy Hardy
Frances Wong
Professor John Mathers
Christopher Fox
et al.
Multigenerational epigenetic adaptation of the hepatic wound-healing response2012
Dr Caroline Wilson
Professor Fiona Oakley
Professor Jelena Mann
Professor Derek Mann
NF-kappa B1-/- suppresses ageing and carcinogen-induced hepatocellular carcinoma by limiting neutrophil accumulation and ROS production2012
Professor Fiona Oakley
Professor Derek Mann
Dr Neil Hanley
Osteopontin is a novel downstream target of SOX9 with diagnostic implications for progression of liver fibrosis in humans2012
Professor Derek Mann
Reply to: "Regression of fibrosis: The need for quantitative methods of assessment"2012
Professor Derek Mann
Professor Jelena Mann
Rosmarinic acid and baicalin epigenetically derepress peroxisomal proliferator-activated receptor gamma in hepatic stellate cells for their antifibrotic effect2012
Professor Derek Mann
Seamless replacement of Autographa californica multiple nucleopolyhedrovirus gp64 with each of five novel type II alphabaculovirus fusion sequences generates pseudotyped virus that fails to transduce mammalian cells2012
Dr Aaron Ions Gardner
Professor Andrew Fisher
Christine Richter
Grace Johnson
Dr Elizabeth Moisey
et al.
The Critical Role of TAK1 in Accentuated Epithelial to Mesenchymal Transition in Obliterative Bronchiolitis after Lung Transplantation2012
Silvia Gaspar Pereira
Dr Nicola Fullard
Aidan Maxwell
Dr Lindsay Murphy
Dr Ralf Bauer
et al.
The NF-κB Subunit c-Rel Stimulates Cardiac Hypertrophy and Fibrosis2012
Christine Richter
Professor Derek Mann
Dr Anja Krippner-Heidenreich
The Tumor Necrosis Factor Receptor Stalk Regions Define Responsiveness to Soluble versus Membrane-Bound Ligand2012
Dr Lee Borthwick
Aaron Gardner
Professor Anthony De Soyza
Professor Derek Mann
Professor Andrew Fisher
et al.
Transforming Growth Factor-β1 (TGF-β1) Driven Epithelial to Mesenchymal Transition (EMT) is Accentuated by Tumour Necrosis Factor α (TNFα) via Crosstalk Between the SMAD and NF-κB Pathways2012
Dr Lee Borthwick
Dr Aaron Ions Gardner
Professor Anthony De Soyza
Professor Derek Mann
Professor Andrew Fisher
et al.
Transforming Growth Factor-β1 (TGF-β1) Driven Epithelial to Mesenchymal Transition (EMT) is Accentuated by Tumour Necrosis Factor α (TNFα) via Crosstalk Between the SMAD and NF-κB Pathways2012
Dr Anna Moles Fernandez
Professor Fiona Oakley
Professor Derek Mann
A peptide mimetic of the functional SER536 phosphorylation site in NF-kappa B (RELA) inhibits liver fibrosis2011
Dr Rahul Mahida
Monika Suwara
Dr Gavin Johnson
Professor Derek Mann
Emeritus Professor Nick Europe-Finner
et al.
Alarmins in bronchiolitis obliterans syndrome after lung transplantation2011
Professor Derek Mann
Professor Jelena Mann
Epigenetic cell fate regulation of hepatic stellate cells2011
Dr Maria Perugorria
Dr Caroline Wilson
Dr Mujdat Zeybel
Shilu Amin
Professor Fiona Oakley
et al.
Expression profiling of epigenetic regulators identifies ASH1 as a key activator of pro-fibrogenic genes2011
Professor Derek Mann
Human T-cell leukemia virus type 1 Tax transactivates the matrix metalloproteinase 7 gene via JunD/AP-1 signaling2011
Stuart Robinson
Professor Jelena Mann
Professor Alastair Burt
Professor Derek Manas
Professor Derek Mann
et al.
Pathogenesis of chemotherapy associated liver injury prior to major hepatic resection2011
Dr Mujdat Zeybel
Professor Fiona Oakley
Professor Alastair Burt
Professor Derek Mann
Professor Jelena Mann
et al.
Protective adaptation to liver fibrosis in a single generation by heritable epigenetic modifications2011
Dr Mohammed Ebrahimkhani
Professor Fiona Oakley
Dr Lindsay Murphy
Professor Jelena Mann
Dr Maria Perugorria
et al.
Stimulating healthy tissue regeneration by targeting the 5-HT2B receptor in chronic liver disease2011
Professor Fiona Oakley
Dr Lindsay Murphy
Professor Matthew Wright
Professor Derek Mann
Stimulation of liver regeneration and amelioration of fibrosis by antagonism of a 5-HT2B/ERK/JUND/TGF beta 1 signally pathway in hepatic stellate cell2011
Stuart Robinson
Professor Derek Manas
Professor Derek Mann
Steven White
Systemic chemotherapy and its implications for resection of colorectal liver metastasis2011
Monika Suwara
Dr Rahul Mahida
Dr Lee Borthwick
Professor Jelena Mann
Emeritus Professor Nick Europe-Finner
et al.
The Epithelial Alarmin, Interleukin 1 alpha (IL-1 alpha), Is a Potential Fibrogenic Factor in Bronchiolitis Obliterans Syndrome (BOS)2011
Dr Maria Perugorria
Professor Fiona Oakley
Professor Jelena Mann
Professor Derek Mann
TREM-2 expression is induced during the regeneration phase of liver injury and acts as a negative regulator of neutrophillic infiltration and hepatocyte proliferation2011
Dr Caroline Wilson
Professor Fiona Oakley
Professor Derek Mann
UCH-L1: A novel and functional marker for activated hepatic stellate cells2011
Professor Derek Mann
Dr Meagan Walsh
A DDX5 S480A Polymorphism Is Associated with Increased Transcription of Fibrogenic Genes in Hepatic Stellate Cells2010
Professor Jelena Mann
Professor Derek Mann
Allele-Specific Regulation of Matrix Metalloproteinase-3 Gene by Transcription Factor NF kappa B2010
Dr Kate Potter
Professor Heather Cordell
Professor Ann Daly
Professor Derek Mann
Professor John Isaacs
et al.
Association between anti-tumour necrosis factor treatment response and genetic variants within the TLR and NFĸB signalling pathways2010
Professor Derek Mann
Counter-selection recombineering of the baculovirus genome: a strategy for seamless modification of repeat-containing BACs2010
Professor Jelena Mann
Professor Fiona Oakley
Professor Alastair Burt
Professor Derek Mann
Epigenetic regulation of pro-fibrogenic genes involved in hepatic stellate cell activation and liver fibrosis2010
Mohamed Noormohamed
Professor Matthew Wright
Dr David Cowie
Susan Stamp
Professor Derek Mann
et al.
Extracorporeal membranous oxygenation in a porcine non-heart beating liver model - a valuable tool for improving hepatocyte viability2010
Professor Derek Mann
Fibrogenic signalling in hepatic stellate cells2010
Professor Fiona Oakley
Professor Derek Mann
Dr Neil Hanley
Identification of SOX9 as a novel mechanism to explain aspects of liver fibrosis2010
Monika Suwara
Dr Lee Borthwick
Professor Jelena Mann
Professor Andrew Fisher
Professor Derek Mann
et al.
IL-1 IS A KEY EPITHELIAL ALARMIN WHICH PROMOTES FIBROBLAST ACTIVATION2010
Professor Jelena Mann
Aidan Maxwell
Professor Fiona Oakley
Professor Derek Mann
MeCP2 Controls an Epigenetic Pathway That Promotes Myofibroblast Transdifferentiation and Fibrosis2010
Professor Derek Mann
NF-kappa B signalling: Embracing complexity to achieve translation2010
Professor Jelena Mann
Professor Fiona Oakley
Professor Alastair Burt
Professor Derek Mann
NF-KB1 (p50) protects against growth of hepatocellular carcinoma by suppressing ROS, inhibiting hepatic phospho-Stat3 and stimulating Phospho-p38 alpha2010
Dr Stuart Atkinson
Professor Lyle Armstrong
Professor Derek Mann
Professor Majlinda Lako
Opposing Putative Roles for Canonical and Noncanonical NF kappa B Signaling on the Survival, Proliferation, and Differentiation Potential of Human Embryonic Stem Cells2010
Stuart Robinson
Professor Derek Mann
Role of nuclear factor kappa B in liver health and disease2010
Professor Derek Mann
Professor Jelena Mann
Rosmarinic acid lifts PPAR gamma epigenetic repression and restores stellate cell quiescence via induction of MIR132 and MIR137 and suppression of MeCP2 and EZH22010
Dr Roben Gieling
Dr Ahmed Elsharkawy
Dr David Cowie
Professor Matthew Wright
Dr Mohammed Ebrahimkhani
et al.
The c-Rel Subunit of Nuclear Factor-κB Regulates Murine Liver Inflammation, Wound-Healing, and Hepatocyte Proliferation2010
Dr Ahmed Elsharkawy
Professor Fiona Oakley
Professor Derek Mann
Professor Jelena Mann
The NF-κB p50:p50:HDAC-1 repressor complex orchestrates transcriptional inhibition of multiple pro-inflammatory genes2010
Dr Karen Wallace
Dr David Cowie
Stephen Hill
Andy Axon
Steven White
et al.
The PXR is a drug target for chronic inflammatory liver disease2010
Dr Aaron Ions Gardner
Dr Malcolm Brodlie
Professor Derek Mann
Dr Lee Borthwick
Professor Andrew Fisher
et al.
The role of transforming growth factor-beta activated kinase-1 (TAK-1) in the development of airway fibrosis2010
Dr Maria Perugorria
Professor Fiona Oakley
Professor Jelena Mann
Professor Derek Mann
TREM-2 is induced in liver injury and is a suppressor of neutrophillic inflammation and hepatocyte proliferation2010
Dr Ramesh Menon
Dr Evelyn Jaros
Professor Derek Mann
What's in a name? Neuronal intermediate filament inclusion disease (NIFID), frontotemporal lobar degeneration-intermediate filament (FTLD-IF) or frontotemporal lobar degeneration-fused in sarcoma (FTLD-FUS)?2010
Stephen Hartland
Professor Derek Mann
Active matrix metalloproteinase-2 promotes apoptosis of hepatic stellate cells via the cleavage of cellular N-cadherin2009
Professor Fiona Oakley
Dr Martha Watson
Professor Derek Manas
Professor Derek Mann
Angiotensin II Activates IκB Kinase Phosphorylation of RelA at Ser536 to Promote Myofibroblast Survival and Liver Fibrosis2009
Professor Jelena Mann
Professor Derek Mann
Epigenetic Relay Controls Expression of the Master Fibrogenic and Metabolic Regulator PPAR Gamma and is Essential for Actovation of Hepatic Stellate Cells2009
Professor Jelena Mann
Xin Xu
Professor Fiona Oakley
Aidan Maxwell
Dr Ahmed Elsharkawy
et al.
Epigenetically Inherited Resistance to Liver Fibrosis2009
Aidan Maxwell
Professor Derek Mann
Professor Jelena Mann
Innate Immune Functions for Hepatic Stellate2009
Dr Lindsay Murphy
Dr Mohammed Ebrahimkhani
Professor Derek Mann
Professor Fiona Oakley
Pharmacological Blockade of 5HT 2B Receptor Stimulates Liver Growth2009
Professor Derek Mann
Telmisartan attenuates progression of steatohepatitis in mice: role of hepatic macrophage infiltration and effects on adipose tissue2009
Dr Roben Gieling
Vidya Rajasekaran
Dr Diana Jurk
Dr Ahmed Elsharkawy
Professor Alastair Burt
et al.
The Anti-Inflammatory and Anti-Proliferative Properties of the NFKB1 (P50) Gene Protect Against Hepatocellular Carcinoma2009
Dr Roben Gieling
Dr Ahmed Elsharkawy
Dr David Cowie
Professor Fiona Oakley
Professor Derek Mann
et al.
The NF-Kappa B Subunit C-Rel is Involved in Hepatocyte Proliferation in Chronic Injured and Regenerating Liver2009
Professor Jelena Mann
Professor Derek Mann
Transcriptional regulation of hepatic stellate cells2009
Dr Amy Fearn
Professor Fiona Oakley
Professor Derek Mann
Professor Neil Sheerin
Tubulointerstitial inflammation and fibrosis is not influenced by deficiency of the regulatory transcription factor NFκB12009
Dr Amy Fearn
Professor Fiona Oakley
Professor Derek Mann
Professor Neil Sheerin
Tubulointerstitial inflammation and fibrosis is not influenced by deficiency of the regulatory transcription factor NFκB12009
Dr David Cowie
Professor Derek Mann
Professor Matthew Wright
A mechanism for the anti-fibrogenic effects of the pregnane X receptor (PXR) in the liver: Inhibition of NF-κB?2008
Professor Derek Mann
Mark Walsh
A single nucleotide polymorphism of DDX5 that confers more rapid fibrosis progression is associated with reduced transcriptional repression of key fibrogenic genes in hepatic stellate cells2008
Dr Ahmed Elsharkawy
Dr Roben Gieling
Professor Fiona Oakley
Professor Alastair Burt
Professor Derek Mann
et al.
Attenuated inflammatory response in fibrotic livers of mice lacking the c-Rel subunit of NF-kB2008
Professor Derek Mann
Professor Matthew Wright
Cellular targeting of the apoptosis-inducing compound gliotoxin to fibrotic rat livers2008
Professor Fiona Oakley
Dr David Wilson
Professor Derek Mann
Dr Neil Hanley
Ectopic SOX9 Mediates Extracellular Matrix Deposition Characteristic of Organ Fibrosis2008
Professor Derek Mann
Professor Jelena Mann
Epigenetic regulation of hepatic stellate cell activation2008
Dr Roben Gieling
Professor Alastair Burt
Professor Derek Mann
Fibrosis and Cirrhosis Reversibility – Molecular Mechanisms2008
Professor Fiona Oakley
Dr Ahmed Elsharkawy
Professor Derek Mann
Hepatic nuclear factor κB regulates neutrophil recruitment to the injured brain2008
Dr Roben Gieling
Dr Martha Watson
Professor Fiona Oakley
Professor Derek Mann
Highly specific inhibitors define a conserved function for NF-kB as a regulator of apoptosis in both human and rodent hepatic stellate cells2008
Dr Martha Watson
Dr Karen Wallace
Dr Roben Gieling
Professor Derek Manas
Professor Derek Mann
et al.
NF-κB is a critical regulator of the survival of rodent and human hepatic myofibroblasts2008
Dr Ahmed Elsharkawy
Professor Jelena Mann
Professor Derek Mann
Phosphorylation of serine 343 on the NF-kappa B P50 subunit is a pivotal regulator of inflammation2008
Dr Karen Wallace
Dr David Cowie
Dr Carlyn Marek
Professor Derek Mann
Professor Matthew Wright
et al.
PXR activation reduces hepatic TNF-alpha levels - A mechanism for inhibiting liver fibrosis2008
Professor Fiona Oakley
Professor Derek Mann
RelA serine 536 phosphorylation could be a biomarker for fibrosis that may be susceptible to regression following attenuatino of renin-angiotensin signaling2008
Dr Mohammed Ebrahimkhani
Professor Derek Mann
Professor Fiona Oakley
Serotonin 2B receptor: A novel negative regulator of liver growth2008
Dr Roben Gieling
Dr Ahmed Elsharkawy
Dr David Cowie
Professor Matthew Wright
Professor Fiona Oakley
et al.
The c-Rel subunit of NF-κB is a regulator of hepatocytes proliferation during recovery from chronic liver injury and regeneration in mice2008
Professor Derek Mann
The function of serotonin within the liver2008
Professor Derek Mann
The function of serotonin within the liver2008
Professor Fiona Oakley
Dr Martha Watson
Professor Derek Mann
The renin angiotensin system as an activator of NF-KB and a survival signal for rat and human hepatic myofibroblasts2008
Dr Mohammed Ebrahimkhani
Dr Ahmed Elsharkawy
Professor Derek Mann
Wound healing and local neuroendocrine regulation in the injured liver2008
Professor Derek Mann
Professor Jelena Mann
Epigenetic regulation of hepatic stellate cell activation2007
Dr Ahmed Elsharkawy
Professor Derek Mann
Nuclear factor-κB and the hepatic inflammation-fibrosis-cancer axis2007
Professor Jelena Mann
Professor Fiona Oakley
Dr Ahmed Elsharkawy
Professor Derek Mann
Regulation of myofibroblast transdifferentiation by DNA methylation and MeCP2: implications for wound healing and fibrogenesis2007
Dr Ahmed Elsharkawy
Professor Derek Mann
Resolving fibrosis in the diseased liver: Translating the scientific promise to the clinic2007
Professor Fiona Oakley
Professor Derek Mann
A role for serotonin (5-HT) in hepatic stellate cell function and liver fibrosis2006
Professor Derek Mann
Professor Fiona Oakley
An explanation for the apparent cell-selectivity of sulfasalazine as an inducer of hepatic myofibroblast apoptosis2006
Professor Fiona Oakley
Professor Jelena Mann
Professor Derek Mann
JunD is a profibrogenic transcription factor regulated by Jun N-terminal kinase-independent phosphorylation2006
Dr Mohammed Ebrahimkhani
Professor Fiona Oakley
Professor Derek Mann
Naltrexone, an opioid receptor antagonist, attenuates liver fibrosis in bile duct ligated rats2006
Professor Derek Mann
Pharmacological inhibitors of NF-κB accelerate apoptosis in chronic lymphocytic leukaemia cells2006
Dr Carlyn Marek
Professor Derek Mann
Professor Matthew Wright
Pregnane X Receptor Activators Inhibit Human Hepatic Stellate Cell Transdifferentiation In Vitro2006
Professor Derek Mann
Professor Fiona Oakley
Real-time in vivo analysis of NF-kappaB activation reveals a role for the liver as a regulator of acute brain inflammation2006
Professor Jelena Mann
Professor Derek Mann
Functional Analysis of HIV Type 1 Nef Reveals a Role for PAK2 as a Regulator of Cell Phenotype and Function in the Murine Dendritic Cell Line, DC2.42005
Peter Smith
Professor Fiona Oakley
Professor Derek Mann
Herpesvirus saimiri-based vector biodistribution using noninvasive optical imaging2005
Professor Fiona Oakley
Dr Carlyn Marek
Professor Matthew Wright
Professor Derek Mann
Inhibition of Inhibitor of κB Kinases Stimulates Hepatic Stellate Cell Apoptosis and Accelerated Recovery From Rat Liver Fibrosis2005
Professor Derek Mann
Professor Fiona Oakley
NF-kappaB: a signal for cancer2005
Professor Fiona Oakley
Professor Derek Mann
Novel sulfasalazine analogues with enhanced NF-kB inhibitory and apoptosis promoting activity2005
Professor Fiona Oakley
Professor Jelena Mann
Professor Simi Ali
Professor Derek Mann
Nuclear Factor-κB1 (p50) Limits the Inflammatory and Fibrogenic Responses to Chronic Injury2005
Professor Derek Mann
RNA interference mediated in human primary cells via recombinant baculoviral vectors2005
Dr Ahmed Elsharkawy
Professor Fiona Oakley
Professor Derek Mann
The role and regulation of hepatic stellate cell apoptosis in reversal of liver fibrosis2005
Professor Jelena Mann
Professor Derek Mann
A failure of transforming growth factor-beta1 negative regulation maintains sustained NF-kappaB activation in gut inflammation2004
Professor Fiona Oakley
Professor Derek Mann
Induction of myofibroblast MMP-9 transcription in three-dimensional collagen I gel cultures: regulation by NF-kappaB, AP-1 and Sp12004
Professor Derek Mann
N-Cadherin cleavage during activated hepatic stellate cell apoptosis is inhibited by tissue inhibitor of metalloproteinase-12004
Professor Derek Mann
Oxidant regulation of the bivalent cation transporter Nramp12004
Professor Derek Mann
Regulation of Tissue Inhibitor of Metalloproteinase 1 Gene Transcription by RUNX1 and RUNX22004
Professor Fiona Oakley
Professor Jelena Mann
Professor Derek Mann
Basal Expression of IκBα Is Controlled by the Mammalian Transcriptional Repressor RBP-J (CBF1) and Its Activator Notch12003
Professor Derek Mann
Characterization of the murine Nramp1 promoter: requirements for transactivation by Miz-12003
Professor Fiona Oakley
Professor Derek Mann
Hepatocytes Express Nerve Growth Factor during Liver Injury: Evidence for Paracrine Regulation of Hepatic Stellate Cell Apoptosis2003
Professor Jelena Mann
Professor Fiona Oakley
Professor Derek Mann
CD40 Induces Interleukin-6 Gene Transcription in Dendritic Cells REGULATION BY TRAF2, AP-1, NF-κB, AND CBF12002
Professor Derek Mann
c-Myc represses and Miz-1 activates the murine natural resistance-associated protein 1 promoter2002
Professor Derek Mann
c-Myc represses the murine Nramp1 promoter2002
Clare McCormick
Professor Fiona Oakley
Professor Derek Mann
High efficiency gene transfer into cultured primary rat and human hepatic stellate cells using baculovirus vectors2002
Professor Derek Mann
Transcriptional regulation of hepatic stellate cell activation2002
Professor Matthew Wright
Professor Derek Mann
Gliotoxin Stimulates the Apoptosis of Human and Rat Hepatic Stellate Cells and Enhances the Resolution of Liver Fibrosis in Rats2001
Professor Jelena Mann
Professor Derek Mann
JunD Regulates Transcription of the Tissue Inhibitor of Metalloproteinases-1 and Interleukin-6 Genes in Activated Hepatic Stellate Cells2001
Professor Matthew Wright
Professor Derek Mann
Regulation of E-box DNA binding during in vivo and in vitro activation of rat and human hepatic stellate cells2001
Professor Derek Mann
Attenuation and augmentation of ischaemia-related neuronal death by tumour necrosis factor-alpha in vitro2000
Dr Heather Bigg
Emeritus Professor Drew Rowan
Professor Derek Mann
Emeritus Professor Tim Cawston
Regulation of human TIMP-1 Gene Expression2000
Professor Matthew Wright
Mark McAuley
Professor Derek Mann
Upstream tissue inhibitor of metalloproteinases-1 (TIMP-1) element-1, a novel and essential regulatory DNA motif in the human TIMP-1 gene promoter, directly interacts with a 30-kDa nuclear protein2000
Professor Derek Mann
A bi-functional activator/repressor element required for transcriptional activity of the human UCH-L1 gene assembles a neuron-specific protein: single-strand DNA complex1999
Professor Derek Mann
A soluble factor produced by macrophages mediates the neurotoxic effects of HIV-1 Tat in vitro1999
Professor Matthew Wright
Professor Derek Mann
Control of the tissue inhibitor of metalloproteinases-1 promoter in culture-activated rat hepatic stellate cells: regulation by activator protein-1 DNA binding proteins1999
Professor Derek Mann
Identification of the Nef-associated kinase as p21-activated kinase 21999
Professor Derek Mann
Induction of activator protein 1 (AP-1) in macrophages by human immunodeficiency virus type-1 NEF is a cell-type-specific response that requires both hck and MAPK signaling events1999
Dr Ahmed Elsharkawy
Professor Matthew Wright
Professor Derek Mann
Persistent activation of nuclear factor-kappaB in cultured rat hepatic stellate cells involves the induction of potentially novel Rel-like factors and prolonged changes in the expression of IkappaB family proteins1999
Professor Derek Mann
Tissue inhibitors of metalloproteinases: role in liver fibrosis and alcoholic liver disease1999
Emeritus Professor Drew Rowan
Professor Derek Mann
Emeritus Professor Tim Cawston
Transcriptional activity of the human tissue inhibitor of metalloproteinases 1 (TIMP-1) gene in fibroblasts involves elements in the promoter, exon 1 and intron 11997