Publications by Professor Derek Mann - ePrints

Browsing publications by Professor Derek Mann.

Newcastle Authors	Title	Year
Lucy Rimmer Professor Derek Mann Professor Avan Sayer Dr Shoba Amarnath Dr Antoneta Granic et al.	A Silver Bullet for Ageing Medicine?: Clinical Relevance of T-Cell Checkpoint Receptors in normal Human Ageing	2024
Amy Collins Rebecca Scott Dr Caroline Wilson Dr Giuseppe Abbate Steven White et al.	UCHL1-dependent control of hypoxia-inducible factor transcriptional activity during liver fibrosis	2024
Dr Paul Brennan Dr Ahmed Elsharkawy Professor Derek Mann	Antifibrotic therapy in nonalcoholic steatohepatitis: time for a human-centric approach	2023
Hanna Salmonowicz Dr James Chapman George Kelly Dr Laura Greaves Professor Derek Mann et al.	Apoptotic stress causes mtDNA release during senescence and drives the SASP	2023
Dr Jack Leslie Dr Jill Hunter Amy Collins Amelia Rushton Lauren Russell et al.	c-Rel–dependent Chk2 signaling regulates the DNA damage response limiting hepatocarcinogenesis	2023
Bassier Zadran Daniel Wainwright Dr Yvonne Bury Dr Saimir Luli Rachel Howarth et al.	Impact of retrotransposon protein L1 ORF1p expression on oncogenic pathways in hepatocellular carcinoma: the role of cytoplasmic PIN1 upregulation	2023
Laura Sabater Jean-Baptiste Gossart Inmaculada Hernandez Lopez Dr Daniel Rico Rodriguez Dr Lee Borthwick et al.	miRNA Expression in Fibroblastic Foci within Idiopathic Pulmonary Fibrosis Lungs Reveals Novel Disease-Relevant Pathways	2023
Amy Collins Dr Glyn Nelson Professor Fiona Oakley Professor Derek Mann	Sublethal necroptosis signaling promotes inflammation and liver cancer	2023
Dr Sam Orange Dr Jack Leslie Professor Derek Mann	The exercise IL-6 enigma in cancer	2023
Adnan Ali Dr Caroline Wilson Dr Jack Leslie Professor Derek Mann	Author Correction: Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer (Nature Medicine, (2019), 25, 4, (641-655), 10.1038/s41591-019-0379-5)	2022
Dr Jack Leslie Erik Ramon Gil Kathryn Gilroy Dr Saimir Luli Maja Laszczewska et al.	CXCR2 inhibition enables NASH-HCC immunotherapy	2022
Dr Daniel Geh Dr Jack Leslie Professor Helen Reeves Professor Derek Mann	Neutrophils as potential therapeutic targets in hepatocellular carcinoma	2022
Professor Derek Mann	TREM-2 plays a protective role in cholestasis by acting as a negative regulator of inflammation	2022
Dr Jack Leslie Dr Hannah Paish Amy Collins Rebecca Scott Abi Watson et al.	A Mammalian Target of Rapamycin-Perilipin 3 (mTORC1-Plin3) Pathway is essential to Activate Lipophagy and Protects Against Hepatosteatosis	2021
Misti McCain Professor Derek Mann Professor Helen Reeves	Cell-free DNA TAPS provides multimodal information for early cancer detection	2021
Marco Zaki Dr Ahmed Mahdi Dr Gillian Patman Anna Whitehead Joao Mauricio et al.	Key features of the environment promoting liver cancer in the absence of cirrhosis	2021
Dr Arianna Bianchi Dr Letizia Marchetti Dr Hannah Paish Dr Kile Green Dr Dina Tiniakos et al.	Moderate Exercise Inhibits Age-Related Inflammation, Liver Steatosis, Senescence, and Tumorigenesis	2021
Dr Jack Leslie Dr Marie-Helene Ruchaud Amy Collins Leena Habiballa Dr Gabi Saretzki et al.	Neutrophils induce paracrine telomere dysfunction and senescence in ROS-dependent manner	2021
Professor Fiona Oakley Marco Zaki Professor Derek Mann	TREM-2 defends the liver against hepatocellular carcinoma through multifactorial protective mechanisms	2021
Dr Ed Fielder Dr Clare Tweedy Dr Caroline Wilson Professor Fiona Oakley Dr Fiona LeBeau et al.	Anti-inflammatory treatment rescues memory deficits during aging in nfkb1−/− mice	2020
Dr Julie Worrell Dr Jack Leslie Dr Graham Smith Marco Zaki Dr Hannah Paish et al.	cRel expression regulates distinct transcriptional and functional profiles driving fibroblast matrix production in systemic sclerosis	2020
Dr Jack Leslie Dr Marina Garcia Macia Dr Saimir Luli Dr Julie Worrell William Reilly et al.	c-Rel orchestrates energy-dependant epithelial and macrophage reprogramming in fibrosis	2020
Dr Jack Leslie Benjamin Millar Alicia Del Carpio Pons Rachel Burgoyne Joseph Frost et al.	FPR-1 is an important regulator of neutrophil recruitment and a tissue-specific driver of pulmonary fibrosis	2020
Stephen Ball Dr Simon Cockell Emerita Professor Janet Wilson Professor Derek Mann Professor Andrew Fisher et al.	Microarray analysis of primary epithelial and fibroblast cells in chronic rhinosinusitis without nasal polyps	2020
Professor Derek Mann Dr Lee Borthwick Professor David Deehan Dr Nicholas Kalson	Quantification of intra-articular fibrosis in patients with stiff knee arthroplasties using metal-reduction MRI	2020
Laura Sabater Dr Luigi Locatelli Professor Fiona Oakley Dr Timothy Hardy Jeremy French et al.	RNA sequencing reveals changes in the microRNAome of transdifferentiating hepatic stellate cells that are conserved between human and rat	2020
Dr Hannah Paish Lee Reed Helen Brown Mark Bryan Dr Olivier Govaere et al.	A bioreactor technology for modelling fibrosis in human and rodent precision-cut liver slices	2019
Dr Hannah Paish Dr Colin Gillespie Alicia Del Carpio Pons Professor Derek Mann Professor David Deehan et al.	Chronic, Active Inflammation in Patients with Failed Total Knee Replacements Undergoing Revision Surgery	2019
Dr Eva Moran Salvador Dr Ashwin Sivaharan Laura Sabater Marco Zaki Amber Knox et al.	Fibrogenic Activity of MECP2 is Regulated by Phosphorylation in Hepatic Stellate Cells	2019
Dr Maria Perugorria Professor Fiona Oakley Professor Jelena Mann Dr Dina Tiniakos Professor Derek Mann et al.	Non-parenchymal TREM-2 protects the liver from immune-mediated hepatocellular damage	2019
Dr Caroline Wilson Dr Jack Leslie Professor Derek Mann	Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer	2019
Clara Correia Melo Dr Jodie Birch Dr Ed Fielder Dr James Chapman Dr Anthony Lagnado et al.	Rapamycin improves healthspan but not inflammaging in nfkb1-/- mice	2019
Dr Hannah Paish Dr Nicholas Kalson Dr Graham Smith Alicia Del Carpio Pons Nicholas Smith et al.	Fibroblasts Promote Inflammation and Pain via IL-1α Induction of the Monocyte Chemoattractant Chemokine (C-C Motif) Ligand 2	2018
Dr Tyrell Cartwright Dr Julie Worrell Dr Letizia Marchetti Amber Knox Professor Jelena Mann et al.	HDAC1 interacts with the p50 NF-κB subunit via its nuclear localization sequence to constrain inflammatory gene expression	2018
Dr Jane Margetts Laura Ogle Dr Anthony Chan Dr David Jamieson Dr Catherine Willoughby et al.	Neutrophils: driving progression and poor prognosis in hepatocellular carcinoma?	2018
Dr Marie Boyle Faik Tutucu Dr Timothy Hardy Professor Derek Mann Dr Mujdat Zeybel et al.	Plasma cell-free DNA methylation: a liquid biomarker of hepatic fibrosis	2018
Dr Nicholas Kalson Timothy Brock Professor Derek Mann Dr Lee Borthwick Professor David Deehan et al.	Reduced telomere length is associated with fibrotic joint disease suggesting that impaired telomere repair contributes to joint fibrosis	2018
Dr Mujdat Zeybel Dr Saimir Luli Laura Sabater Dr Timothy Hardy Professor Fiona Oakley et al.	A Proof-of-Concept for Epigenetic Therapy of Tissue Fibrosis: Inhibition of Liver Fibrosis Progression by 3-Deazaneplanocin A	2017
Professor Stuart McPherson Dr Nina Wilson Dr Dina Tiniakos Dr Jennifer Wilkinson Professor Alastair Burt et al.	A randomised controlled trial of losartan as an anti-fibrotic agent in non-alcoholic steatohepatitis	2017
Dr Mikolaj Ogrodnik Dr Satomi Miwa Dr Dina Tiniakos Dr Caroline Wilson Professor Chris Day et al.	Cellular senescence drives age-dependent hepatic steatosis	2017
Dr Caroline Wilson Professor Derek Mann Dr Lee Borthwick	Epigenetic reprogramming in liver fibrosis and cancer	2017
Dr Timothy Hardy Dr Mujdat Zeybel Professor Chris Day Dr Christian Dipper Dr Steven Masson et al.	Plasma DNA methylation: A potential biomarker for stratification of liver fibrosis in non-alcoholic fatty liver disease	2017
Professor Fiona Oakley Professor Derek Mann	The new-generation pan-peroxisome proliferator-activated receptor agonist IVA337 protects the liver from metabolic disorders and fibrosis.	2017
Dr Amy Fearn Dr Aldi Situmorang Christopher Fox Professor Fiona Oakley Rachel Howarth et al.	The NF-kB1 is a key regulator of acute but not chronic renal injury	2017
Laura Corbett Dr Pier Paoli John Casement Professor Jelena Mann Professor Derek Mann et al.	Variant Histone H2afv reprograms DNA methylation during early zebrafish development	2017
Dr Lee Borthwick Wona Suwara Dr Sonya Carnell Dr Nicola Green Dr Rahul Mahida et al.	Pseudomonas aeruginosa induced Airway Epithelial Injury Drives Fibroblast Activation: A Mechanism in Chronic Lung Allograft Dysfunction	2016
Dr Saimir Luli Dr Stephen Hill Helen Brown Jack Leslie Dr Helen Marshall et al.	A new fluorescence-based optical imaging method to non-invasively monitor hepatic myofibroblasts in vivo	2016
Dr Anna Moles Fernandez Dr Jacqueline Butterworth Dr Jill Hunter Dr Jack Leslie Helene Sellier et al.	A RelA(p65) Thr505 phospho-site mutation reveals an important mechanism regulating NF-kB dependent liver regeneration and cancer	2016
Professor Jelena Mann Professor Derek Mann	Dynamic phosphorylation of RelA on Ser42 and Ser45 in response to TNFα stimulation regulates DNA binding and transcription	2016
Dr Timothy Hardy Professor Derek Mann	Epigenetic in liver disease: from biology to therapeutics	2016
Dr Nicholas Kalson Dr Lee Borthwick Professor Derek Mann Professor David Deehan	International consensus on the definition and classification of fibrosis of the knee joint	2016
John Moir Professor Derek Mann Professor Jelena Mann Richard Charnley Professor Derek Manas et al.	Metabolic relationships within the tumour microenvironment of pancreatic ductal adenocarcinoma - pancreatic stellate cells induce glycolysis in cancer cells	2016
Dr Clara Correia Melo Francisco Marques Rhys Anderson Dr Graeme Hewitt Dr Bernadette Carroll et al.	Mitochondria are required for pro-ageing features of the senescent phenotype	2016
Dr Lee Borthwick Professor Derek Mann	Osteopontin and HMGB1: novel regulators of HSC activation	2016
Stuart Robinson Professor Derek Mann Professor Derek Manas Professor Fiona Oakley Professor Jelena Mann et al.	Response to 'Comment on 'The potential contribution of tumour-related factors to the development of FOLFOX-induced sinusoidal obstruction syndrome''	2016
John Moir Professor Derek Mann Professor Jelena Mann Richard Charnley Professor Derek Manas et al.	The effect of monocarboxylate transporter 1 inhibition in the tumour microenvironment of pancreatic ductal adenocarcinoma	2016
Dr Stephen Ball Professor Derek Mann Emerita Professor Janet Wilson Professor Andrew Fisher	The Role of the Fibroblast in Inflammatory Upper Airway Conditions	2016
Professor Fiona Oakley Dr Maria Perugorria Professor Derek Mann	TPL2 Kinase Is a Crucial Signaling Factor and Mediator of NKT Effector Cytokine Expression in Immune-Mediated Liver Injury	2016
David Dixon Jonathon Coates Joanna Horabin Andrew Walker Dr Nicole Abdul et al.	A potential mode of action for Anakinra in patients with arthrofibrosis following total knee arthroplasty	2015
Dr Agata Page Dr Pier Paoli Dr Stephen Hill Rachel Howarth Jeremy French et al.	Alcohol directly stimulates epigenetic modifications in hepatic stellate cells	2015
Dr Agata Page Professor Jelena Mann Professor Derek Mann	Changes in DNA methylation and hydroxymethylation during HSC activation	2015
Professor Fiona Oakley Professor Derek Mann	Chapter 15 - Stellate Cell Depletion Models	2015
Professor Derek Mann	Emerging and Disease-Specific Mechanisms of Hepatic Stellate Cell Activation	2015
Professor Jelena Mann Professor Derek Mann	Epigenetic regulation of hepatic stellate cells and liver fibrosis	2015
Dr Agata Page Professor Derek Mann	Epigenetic regulation of liver fibrosis	2015
Dr Nicole Abdul David Dixon Andrew Walker Joanna Horabin Professor David Deehan et al.	Fibrosis is a common outcome following total knee arthroplasty	2015
Dr Stephen Ball Monika Suwara Dr Lee Borthwick Emerita Professor Janet Wilson Professor Derek Mann et al.	How Reliable are Sino-Nasal Cell Lines for Studying the Pathophysiology of Chronic Rhinosinusitis?	2015
Professor Derek Mann	Importance of investigating epigenetic alterations for industry, and regulators: An appraisal of current efforts by the Health and Environmental Sciences Institute	2015
Dr Nicholas Kalson Professor Derek Mann Professor David Deehan	Joint Stiffness Is Heritable and Associated with Fibrotic Conditions and Joint Replacement	2015
Dr Timothy Hardy Victoria Sharkey Dr Mujdat Zeybel Professor John Mathers Steven White et al.	Laser capture microdissection reveals cell-specific DNA methylation signatures in key fibrosis modifier genes in chronic liver disease	2015
Dr Eva Moran Salvador Dr Pier Paoli Dr Graham Smith Dr Agata Page Rachel Howarth et al.	MeCP2 exerts global control over the myofibroblast transcriptome and reveals new regulators of fibrosis	2015
Dr Anna Moles Fernandez Dr Jacqueline Butterworth Dr Jill Hunter Professor Derek Mann Professor Fiona Oakley et al.	Mutation of Rela THR505 Enhances Liver Regeneration Following Partial Hepatectomy	2015
Dr Caroline Wilson Dr Diana Jurk Nicola Fullard Paul Banks Dr Agata Page et al.	NFkB1 is a suppressor of neutrophil-driven hepatocellular carcinoma	2015
Laura Corbett Professor Jelena Mann Professor Derek Mann	Non-Canonical Wnt Predominates in Activated Rat Hepatic Stellate Cells, Influencing HSC Survival and Paracrine Stimulation of Kupffer Cells	2015
Dr Saimir Luli Dr Daniela Di Paolo Dr Caroline Wilson Professor Matthew Wright Helen Brown et al.	Non-invasive fluorescent imaging of liver fibrosis and response to therapy in mice	2015
Dr Jess Dyson Professor Derek Mann Professor David Jones	Novel therapeutic targets in primary biliary cirrhosis	2015
Dr Luigi Locatelli Dr Pier Paoli Dr Timothy Hardy Rachel Howarth Professor Fiona Oakley et al.	Sequence Profiling of miRNAs Reveals mir-150-5p as a Regulator of Transdifferentiation	2015
Dr Anna Moles Fernandez Dr Jacqueline Butterworth Dr Jill Hunter Dr Dina Tiniakos Professor Derek Mann et al.	Thr505 RelA phosphorylation controls liver proliferative response and supresses NF-kappa B tumor-promoting activities	2015
Dr Caroline Wilson Dr Lindsay Murphy Jack Leslie Dr Stuart Kendrick Jeremy French et al.	Ubiquitin C-terminal hydrolase 1: A novel functional marker for liver myofibroblasts and a therapeutic target in chronic liver disease	2015
Dr Phillip Probert Dr Mohammed Ebrahimkhani Professor Fiona Oakley Professor Jelena Mann Professor Alastair Burt et al.	A reversible model for periportal fibrosis and a refined alternative to bile duct ligation	2014
Dr Saimir Luli Dr Stephen Hill Professor Matthew Wright Professor Derek Mann Professor Fiona Oakley et al.	A simple fluorescence based method to non-invasively image liver fibrosis	2014
Dr Anna Moles Fernandez Dr Lindsay Murphy Dr Caroline Wilson Dr Jayshree Bagchi Chakraborty Christopher Fox et al.	A TLR2/S100A9/CXCL-2 signaling network is necessary for neutrophil recruitment in acute and chronic liver injury in the mouse	2014
Laura Corbett Professor Jelena Mann Professor Derek Mann	Canonical vs non-canonical Wnt signalling	2014
Dr Diana Jurk Dr Caroline Wilson Dr Joao Passos Professor Fiona Oakley Clara Correia Melo et al.	Chronic inflammation induces telomere dysfunction and accelerates ageing in mice	2014
Dr Mujdat Zeybel Dr Timothy Hardy Christopher Fox Dr Steven Masson Professor Derek Mann et al.	Differential DNA methylation of genes involved in fibrosis progression in NAFLD and ALD	2014
Professor Derek Mann	Epigenetics in Liver Disease	2014
Professor Derek Mann	Erratum to "Clinical evidence for the regression of liver fibrosis" (vol 56, pg 1171, 2012)	2014
Professor Jelena Mann Professor Derek Manas Professor Derek Mann Steven White	Folfox induced sinusoidal obstruction syndrome (SOS) is a potentially reversible condition	2014
Wona Suwara Dr Nicola Green Dr Lee Borthwick Professor Jelena Mann Emeritus Professor Nick Europe-Finner et al.	IL-1α released from damaged epithelial cells is sufficient and essential to trigger inflammatory responses in human lung fibroblasts	2014
Dr Caroline Wilson Professor Jelena Mann Dr Meagan Walsh Professor Fiona Oakley Professor Matthew Wright et al.	Quiescent Hepatic Stellate Cells Functionally Contribute to the Hepatic Innate Immune Response via TLR3	2014
Stuart Robinson Professor Jelena Mann Professor Derek Manas Professor Derek Mann Steven White et al.	An experimental MODEL study to investigate the pathogenesis of oxaliplatin-induced liver injury	2013
Stuart Robinson Professor Jelena Mann Professor Derek Manas Professor Derek Mann Steven White et al.	An experimental study to identify the potential role of pharmacogenomics in determining the occurrence of oxaliplatin-induced liver injury	2013
Stuart Robinson Professor Jelena Mann Professor Derek Manas Professor Derek Mann Steven White et al.	Antioxidant therapy is able to prevent the development of oxaliplatin induced sinusoidal obstruction syndrome	2013
Dr Lindsay Murphy Dr Jayshree Bagchi Chakraborty Professor Jelena Mann Professor Fiona Oakley Professor Derek Mann et al.	Deficient Neutrophil Recruitment into the Liver Parenchyma after an Acute CCl₄ Challenge does not affect Fibrogenesis	2013
Dr Claire Troakes Professor Johannes Attems Annette King Professor Derek Mann	Diagnostic approach to Argyrophilic Grain Disease (AGD): an UK BDR trial	2013
Dr Mujdat Zeybel Professor Derek Mann Professor Jelena Mann	Epigenetic modifications as new targets for liver disease therapies	2013
Professor Jelena Mann Professor Derek Mann	Epigenetic regulation of wound healing and fibrosis	2013
Professor Derek Mann Professor Jelena Mann	Ethanol Stimulates Production of Extracellular Matrix Proteins in Hepatic Stellate Cells	2013
Stuart Robinson Professor Jelena Mann Professor Derek Manas Professor Derek Mann Steven White et al.	Identification of molecular pathways implicated in the pathogenesis of oxaliplatin induced sinusoidal obstruction syndrome	2013
Dr Lindsay Murphy Dr Saimir Luli Dr Lee Borthwick Dr Steven O'Reilly Professor Neil Perkins et al.	Inhibition of RelA-Ser536 phosphorylation by a competing peptide reduces mouse liver fibrosis without blocking the innate immune response	2013
Stuart Robinson Professor Jelena Mann Professor Derek Manas Professor Derek Mann Steven White et al.	Is FOLFOX induced sinusoidal obstruction syndrome (SOS) a potentially reversible condition?	2013
Dr Phillip Probert Dr Mohammed Ebrahimkhani Professor Fiona Oakley Professor Alastair Burt Professor Derek Mann et al.	Methapyrilene Treatment is a Refined Alternative to Bile Duct Ligation as a Model of Reproducible and Reversible Periportal Fibrosis in the Rat	2013
Dr Gillian Patman Dr Despina Televantou Anna Whitehead Professor Chris Day Professor Fiona Oakley et al.	Mild Steatosis and Impaired Glucose Tolerance are Associated with Liver Cancer Development, While Progression to Nash Increases Number/Size in an Animal Model of NAFLD	2013
Stuart Robinson Professor Jelena Mann Professor John Mathers Professor Alastair Burt Professor Fiona Oakley et al.	Pathogenesis of FOLFOX induced sinusoidal obstruction syndrome in a murine chemotherapy model	2013
Professor Derek Mann Professor Fiona Oakley	Serotonin paracrine signaling in tissue fibrosis	2013
Dr Gillian Patman Dr Despina Televantou Anna Whitehead Professor Chris Day Professor Alastair Burt et al.	Sulfatase-2 (SULF2) Expressed in Hepatocytes and Stromal Cells Contributes to the Development of Steatosis, the Progression of NAFLD to Fibrosis and the Advancement of Cancer	2013
Dr Nicola Fullard Dr Steven O'Reilly Professor Jaap Van Laar David Faini Julie Diboll et al.	The c-Rel Subunit of NF-κB Regulates Epidermal Homeostasis and Promotes Skin Fibrosis in Mice	2013
Stuart Robinson Professor Derek Mann Professor Derek Manas Professor Fiona Oakley Professor Jelena Mann et al.	The potential contribution of tumour-related factors to the development of FOLFOX-induced sinusoidal obstruction syndrome	2013
Laura Corbett Professor Jelena Mann Professor Derek Mann	The Wnt Pathway in Hepatic Stellate Cells: Canonical vs. Non-Canonical Signalling	2013
Dr Lee Borthwick Emeritus Professor Nick Europe-Finner Dr Rahul Mahida Andrew Walker Aaron Gardner et al.	TNFα From Classically Activated Macrophages Accentuates Epithelial to Mesenchymal Transition in Obliterative Bronchiolitis	2013
Dr Maria Perugorria Dr Lindsay Murphy Dr Nicola Fullard Dr Caroline Wilson Professor Fiona Oakley et al.	Tumor progression locus 2/Cot is required for activation of extracellular regulated kinase in liver injury and toll-like receptor-induced TIMP-1 gene transcription in hepatic stellate cells in mice	2013
Stuart Robinson Professor Jelena Mann Professor Derek Manas Professor Alastair Burt Professor Derek Mann et al.	An experimental study to determine the pathogenesis of oxaliplatin induced sinusoidal obstruction syndrome	2012
Professor Derek Mann	Clinical evidence for the regression of liver fibrosis	2012
Shilu Amin Dr Meagan Walsh Dr Caroline Wilson Dr Elaine Willmore Professor Derek Mann et al.	Cross-talk between DNA methylation and active histone modifications regulates aberrant expression of ZAP70 in CLL	2012
Stuart Robinson Professor Jelena Mann Professor Alastair Burt Professor Derek Manas Professor Derek Mann et al.	Does a pro-thrombotic environment contribute to the development of chemotherapy associated liver injury in patients with colorectal liver metastases?	2012
Dr Mujdat Zeybel Dr Meagan Walsh Professor Derek Mann Professor Jelena Mann	DZNep attenuates liver fibrosis by blocking EZH2 and H3K27me3	2012
Stuart Robinson Professor Jelena Mann Professor Derek Manas Professor Derek Mann Steven White et al.	Expression of the copper export transporter atpase 7B correlates with tissue specific injury in a murine model of colorectal liver metastases	2012
Stuart Robinson Professor Jelena Mann Professor Derek Manas Professor Derek Mann Steven White et al.	Gene expression in oxaliplatin related sinusoidal obstruction syndrome	2012
Dr Maria Perugorria Dr Mujdat Zeybel Mark Walsh Shilu Amin Professor Alastair Burt et al.	Histone methyltransferase ASH1 orchestrates fibrogenic gene transcription during myofibroblast transdifferentiation	2012
Professor Derek Mann Professor Fiona Oakley	Inhibition of 536 phosphorylation site in NF-kappa B (RELA) reduces liver fibrosis in mouse progressive liver disease, but does not block the innate immune response	2012
Wona Suwara Dr Lee Borthwick Dr Rahul Mahida Dr Nicola Green Aaron Gardner et al.	Interleukin-1 Alpha (IL-1α) Released from Injured Lung Epithelium is a Critical Alarmin Driving Activation of a Potent Inflammatory Phenotype in Lung Fibroblasts	2012
Dr Nicola Green Wona Suwara Dr Lee Borthwick Professor Derek Mann Professor Andrew Fisher et al.	Interleukin-33 in Chronic Lung Disease	2012
Dr Mujdat Zeybel Dr Timothy Hardy Frances Wong Professor John Mathers Christopher Fox et al.	Multigenerational epigenetic adaptation of the hepatic wound-healing response	2012
Dr Caroline Wilson Professor Fiona Oakley Professor Jelena Mann Professor Derek Mann	NF-kappa B1-/- suppresses ageing and carcinogen-induced hepatocellular carcinoma by limiting neutrophil accumulation and ROS production	2012
Professor Fiona Oakley Professor Derek Mann Dr Neil Hanley	Osteopontin is a novel downstream target of SOX9 with diagnostic implications for progression of liver fibrosis in humans	2012
Professor Derek Mann	Reply to: "Regression of fibrosis: The need for quantitative methods of assessment"	2012
Professor Derek Mann Professor Jelena Mann	Rosmarinic acid and baicalin epigenetically derepress peroxisomal proliferator-activated receptor gamma in hepatic stellate cells for their antifibrotic effect	2012
Professor Derek Mann	Seamless replacement of Autographa californica multiple nucleopolyhedrovirus gp64 with each of five novel type II alphabaculovirus fusion sequences generates pseudotyped virus that fails to transduce mammalian cells	2012
Dr Aaron Ions Gardner Professor Andrew Fisher Christine Richter Grace Johnson Dr Elizabeth Moisey et al.	The Critical Role of TAK1 in Accentuated Epithelial to Mesenchymal Transition in Obliterative Bronchiolitis after Lung Transplantation	2012
Silvia Gaspar Pereira Dr Nicola Fullard Aidan Maxwell Dr Lindsay Murphy Dr Ralf Bauer et al.	The NF-κB Subunit c-Rel Stimulates Cardiac Hypertrophy and Fibrosis	2012
Christine Richter Professor Derek Mann Dr Anja Krippner-Heidenreich	The Tumor Necrosis Factor Receptor Stalk Regions Define Responsiveness to Soluble versus Membrane-Bound Ligand	2012
Dr Lee Borthwick Aaron Gardner Professor Anthony De Soyza Professor Derek Mann Professor Andrew Fisher et al.	Transforming Growth Factor-β1 (TGF-β1) Driven Epithelial to Mesenchymal Transition (EMT) is Accentuated by Tumour Necrosis Factor α (TNFα) via Crosstalk Between the SMAD and NF-κB Pathways	2012
Dr Lee Borthwick Dr Aaron Ions Gardner Professor Anthony De Soyza Professor Derek Mann Professor Andrew Fisher et al.	Transforming Growth Factor-β1 (TGF-β1) Driven Epithelial to Mesenchymal Transition (EMT) is Accentuated by Tumour Necrosis Factor α (TNFα) via Crosstalk Between the SMAD and NF-κB Pathways	2012
Dr Anna Moles Fernandez Professor Fiona Oakley Professor Derek Mann	A peptide mimetic of the functional SER536 phosphorylation site in NF-kappa B (RELA) inhibits liver fibrosis	2011
Dr Rahul Mahida Monika Suwara Dr Gavin Johnson Professor Derek Mann Emeritus Professor Nick Europe-Finner et al.	Alarmins in bronchiolitis obliterans syndrome after lung transplantation	2011
Professor Derek Mann Professor Jelena Mann	Epigenetic cell fate regulation of hepatic stellate cells	2011
Dr Maria Perugorria Dr Caroline Wilson Dr Mujdat Zeybel Shilu Amin Professor Fiona Oakley et al.	Expression profiling of epigenetic regulators identifies ASH1 as a key activator of pro-fibrogenic genes	2011
Professor Derek Mann	Human T-cell leukemia virus type 1 Tax transactivates the matrix metalloproteinase 7 gene via JunD/AP-1 signaling	2011
Stuart Robinson Professor Jelena Mann Professor Alastair Burt Professor Derek Manas Professor Derek Mann et al.	Pathogenesis of chemotherapy associated liver injury prior to major hepatic resection	2011
Dr Mujdat Zeybel Professor Fiona Oakley Professor Alastair Burt Professor Derek Mann Professor Jelena Mann et al.	Protective adaptation to liver fibrosis in a single generation by heritable epigenetic modifications	2011
Dr Mohammed Ebrahimkhani Professor Fiona Oakley Dr Lindsay Murphy Professor Jelena Mann Dr Maria Perugorria et al.	Stimulating healthy tissue regeneration by targeting the 5-HT_2B receptor in chronic liver disease	2011
Professor Fiona Oakley Dr Lindsay Murphy Professor Matthew Wright Professor Derek Mann	Stimulation of liver regeneration and amelioration of fibrosis by antagonism of a 5-HT2B/ERK/JUND/TGF beta 1 signally pathway in hepatic stellate cell	2011
Stuart Robinson Professor Derek Manas Professor Derek Mann Steven White	Systemic chemotherapy and its implications for resection of colorectal liver metastasis	2011
Monika Suwara Dr Rahul Mahida Dr Lee Borthwick Professor Jelena Mann Emeritus Professor Nick Europe-Finner et al.	The Epithelial Alarmin, Interleukin 1 alpha (IL-1 alpha), Is a Potential Fibrogenic Factor in Bronchiolitis Obliterans Syndrome (BOS)	2011
Dr Maria Perugorria Professor Fiona Oakley Professor Jelena Mann Professor Derek Mann	TREM-2 expression is induced during the regeneration phase of liver injury and acts as a negative regulator of neutrophillic infiltration and hepatocyte proliferation	2011
Dr Caroline Wilson Professor Fiona Oakley Professor Derek Mann	UCH-L1: A novel and functional marker for activated hepatic stellate cells	2011
Professor Derek Mann Dr Meagan Walsh	A DDX5 S480A Polymorphism Is Associated with Increased Transcription of Fibrogenic Genes in Hepatic Stellate Cells	2010
Professor Jelena Mann Professor Derek Mann	Allele-Specific Regulation of Matrix Metalloproteinase-3 Gene by Transcription Factor NF kappa B	2010
Dr Kate Potter Professor Heather Cordell Professor Ann Daly Professor Derek Mann Professor John Isaacs et al.	Association between anti-tumour necrosis factor treatment response and genetic variants within the TLR and NFĸB signalling pathways	2010
Professor Derek Mann	Counter-selection recombineering of the baculovirus genome: a strategy for seamless modification of repeat-containing BACs	2010
Professor Jelena Mann Professor Fiona Oakley Professor Alastair Burt Professor Derek Mann	Epigenetic regulation of pro-fibrogenic genes involved in hepatic stellate cell activation and liver fibrosis	2010
Mohamed Noormohamed Professor Matthew Wright Dr David Cowie Susan Stamp Professor Derek Mann et al.	Extracorporeal membranous oxygenation in a porcine non-heart beating liver model - a valuable tool for improving hepatocyte viability	2010
Professor Derek Mann	Fibrogenic signalling in hepatic stellate cells	2010
Professor Fiona Oakley Professor Derek Mann Dr Neil Hanley	Identification of SOX9 as a novel mechanism to explain aspects of liver fibrosis	2010
Monika Suwara Dr Lee Borthwick Professor Jelena Mann Professor Andrew Fisher Professor Derek Mann et al.	IL-1 IS A KEY EPITHELIAL ALARMIN WHICH PROMOTES FIBROBLAST ACTIVATION	2010
Professor Jelena Mann Aidan Maxwell Professor Fiona Oakley Professor Derek Mann	MeCP2 Controls an Epigenetic Pathway That Promotes Myofibroblast Transdifferentiation and Fibrosis	2010
Professor Derek Mann	NF-kappa B signalling: Embracing complexity to achieve translation	2010
Professor Jelena Mann Professor Fiona Oakley Professor Alastair Burt Professor Derek Mann	NF-KB1 (p50) protects against growth of hepatocellular carcinoma by suppressing ROS, inhibiting hepatic phospho-Stat3 and stimulating Phospho-p38 alpha	2010
Dr Stuart Atkinson Professor Lyle Armstrong Professor Derek Mann Professor Majlinda Lako	Opposing Putative Roles for Canonical and Noncanonical NF kappa B Signaling on the Survival, Proliferation, and Differentiation Potential of Human Embryonic Stem Cells	2010
Stuart Robinson Professor Derek Mann	Role of nuclear factor kappa B in liver health and disease	2010
Professor Derek Mann Professor Jelena Mann	Rosmarinic acid lifts PPAR gamma epigenetic repression and restores stellate cell quiescence via induction of MIR132 and MIR137 and suppression of MeCP2 and EZH2	2010
Dr Roben Gieling Dr Ahmed Elsharkawy Dr David Cowie Professor Matthew Wright Dr Mohammed Ebrahimkhani et al.	The c-Rel Subunit of Nuclear Factor-κB Regulates Murine Liver Inflammation, Wound-Healing, and Hepatocyte Proliferation	2010
Dr Ahmed Elsharkawy Professor Fiona Oakley Professor Derek Mann Professor Jelena Mann	The NF-κB p50:p50:HDAC-1 repressor complex orchestrates transcriptional inhibition of multiple pro-inflammatory genes	2010
Dr Karen Wallace Dr David Cowie Stephen Hill Andy Axon Steven White et al.	The PXR is a drug target for chronic inflammatory liver disease	2010
Dr Aaron Ions Gardner Dr Malcolm Brodlie Professor Derek Mann Dr Lee Borthwick Professor Andrew Fisher et al.	The role of transforming growth factor-beta activated kinase-1 (TAK-1) in the development of airway fibrosis	2010
Dr Maria Perugorria Professor Fiona Oakley Professor Jelena Mann Professor Derek Mann	TREM-2 is induced in liver injury and is a suppressor of neutrophillic inflammation and hepatocyte proliferation	2010
Dr Ramesh Menon Dr Evelyn Jaros Professor Derek Mann	What's in a name? Neuronal intermediate filament inclusion disease (NIFID), frontotemporal lobar degeneration-intermediate filament (FTLD-IF) or frontotemporal lobar degeneration-fused in sarcoma (FTLD-FUS)?	2010
Stephen Hartland Professor Derek Mann	Active matrix metalloproteinase-2 promotes apoptosis of hepatic stellate cells via the cleavage of cellular N-cadherin	2009
Professor Fiona Oakley Dr Martha Watson Professor Derek Manas Professor Derek Mann	Angiotensin II Activates IκB Kinase Phosphorylation of RelA at Ser⁵³⁶ to Promote Myofibroblast Survival and Liver Fibrosis	2009
Professor Jelena Mann Professor Derek Mann	Epigenetic Relay Controls Expression of the Master Fibrogenic and Metabolic Regulator PPAR Gamma and is Essential for Actovation of Hepatic Stellate Cells	2009
Professor Jelena Mann Xin Xu Professor Fiona Oakley Aidan Maxwell Dr Ahmed Elsharkawy et al.	Epigenetically Inherited Resistance to Liver Fibrosis	2009
Aidan Maxwell Professor Derek Mann Professor Jelena Mann	Innate Immune Functions for Hepatic Stellate	2009
Dr Lindsay Murphy Dr Mohammed Ebrahimkhani Professor Derek Mann Professor Fiona Oakley	Pharmacological Blockade of 5HT 2B Receptor Stimulates Liver Growth	2009
Professor Derek Mann	Telmisartan attenuates progression of steatohepatitis in mice: role of hepatic macrophage infiltration and effects on adipose tissue	2009
Dr Roben Gieling Vidya Rajasekaran Dr Diana Jurk Dr Ahmed Elsharkawy Professor Alastair Burt et al.	The Anti-Inflammatory and Anti-Proliferative Properties of the NFKB1 (P50) Gene Protect Against Hepatocellular Carcinoma	2009
Dr Roben Gieling Dr Ahmed Elsharkawy Dr David Cowie Professor Fiona Oakley Professor Derek Mann et al.	The NF-Kappa B Subunit C-Rel is Involved in Hepatocyte Proliferation in Chronic Injured and Regenerating Liver	2009
Professor Jelena Mann Professor Derek Mann	Transcriptional regulation of hepatic stellate cells	2009
Dr Amy Fearn Professor Fiona Oakley Professor Derek Mann Professor Neil Sheerin	Tubulointerstitial inflammation and fibrosis is not influenced by deficiency of the regulatory transcription factor NFκB1	2009
Dr Amy Fearn Professor Fiona Oakley Professor Derek Mann Professor Neil Sheerin	Tubulointerstitial inflammation and fibrosis is not influenced by deficiency of the regulatory transcription factor NFκB1	2009
Dr David Cowie Professor Derek Mann Professor Matthew Wright	A mechanism for the anti-fibrogenic effects of the pregnane X receptor (PXR) in the liver: Inhibition of NF-κB?	2008
Professor Derek Mann Mark Walsh	A single nucleotide polymorphism of DDX5 that confers more rapid fibrosis progression is associated with reduced transcriptional repression of key fibrogenic genes in hepatic stellate cells	2008
Dr Ahmed Elsharkawy Dr Roben Gieling Professor Fiona Oakley Professor Alastair Burt Professor Derek Mann et al.	Attenuated inflammatory response in fibrotic livers of mice lacking the c-Rel subunit of NF-kB	2008
Professor Derek Mann Professor Matthew Wright	Cellular targeting of the apoptosis-inducing compound gliotoxin to fibrotic rat livers	2008
Professor Fiona Oakley Dr David Wilson Professor Derek Mann Dr Neil Hanley	Ectopic SOX9 Mediates Extracellular Matrix Deposition Characteristic of Organ Fibrosis	2008
Professor Derek Mann Professor Jelena Mann	Epigenetic regulation of hepatic stellate cell activation	2008
Dr Roben Gieling Professor Alastair Burt Professor Derek Mann	Fibrosis and Cirrhosis Reversibility – Molecular Mechanisms	2008
Professor Fiona Oakley Dr Ahmed Elsharkawy Professor Derek Mann	Hepatic nuclear factor κB regulates neutrophil recruitment to the injured brain	2008
Dr Roben Gieling Dr Martha Watson Professor Fiona Oakley Professor Derek Mann	Highly specific inhibitors define a conserved function for NF-kB as a regulator of apoptosis in both human and rodent hepatic stellate cells	2008
Dr Martha Watson Dr Karen Wallace Dr Roben Gieling Professor Derek Manas Professor Derek Mann et al.	NF-κB is a critical regulator of the survival of rodent and human hepatic myofibroblasts	2008
Dr Ahmed Elsharkawy Professor Jelena Mann Professor Derek Mann	Phosphorylation of serine 343 on the NF-kappa B P50 subunit is a pivotal regulator of inflammation	2008
Dr Karen Wallace Dr David Cowie Dr Carlyn Marek Professor Derek Mann Professor Matthew Wright et al.	PXR activation reduces hepatic TNF-alpha levels - A mechanism for inhibiting liver fibrosis	2008
Professor Fiona Oakley Professor Derek Mann	RelA serine 536 phosphorylation could be a biomarker for fibrosis that may be susceptible to regression following attenuatino of renin-angiotensin signaling	2008
Dr Mohammed Ebrahimkhani Professor Derek Mann Professor Fiona Oakley	Serotonin 2B receptor: A novel negative regulator of liver growth	2008
Dr Roben Gieling Dr Ahmed Elsharkawy Dr David Cowie Professor Matthew Wright Professor Fiona Oakley et al.	The c-Rel subunit of NF-κB is a regulator of hepatocytes proliferation during recovery from chronic liver injury and regeneration in mice	2008
Professor Derek Mann	The function of serotonin within the liver	2008
Professor Derek Mann	The function of serotonin within the liver	2008
Professor Fiona Oakley Dr Martha Watson Professor Derek Mann	The renin angiotensin system as an activator of NF-KB and a survival signal for rat and human hepatic myofibroblasts	2008
Dr Mohammed Ebrahimkhani Dr Ahmed Elsharkawy Professor Derek Mann	Wound healing and local neuroendocrine regulation in the injured liver	2008
Professor Derek Mann Professor Jelena Mann	Epigenetic regulation of hepatic stellate cell activation	2007
Dr Ahmed Elsharkawy Professor Derek Mann	Nuclear factor-κB and the hepatic inflammation-fibrosis-cancer axis	2007
Professor Jelena Mann Professor Fiona Oakley Dr Ahmed Elsharkawy Professor Derek Mann	Regulation of myofibroblast transdifferentiation by DNA methylation and MeCP2: implications for wound healing and fibrogenesis	2007
Dr Ahmed Elsharkawy Professor Derek Mann	Resolving fibrosis in the diseased liver: Translating the scientific promise to the clinic	2007
Professor Fiona Oakley Professor Derek Mann	A role for serotonin (5-HT) in hepatic stellate cell function and liver fibrosis	2006
Professor Derek Mann Professor Fiona Oakley	An explanation for the apparent cell-selectivity of sulfasalazine as an inducer of hepatic myofibroblast apoptosis	2006
Professor Fiona Oakley Professor Jelena Mann Professor Derek Mann	JunD is a profibrogenic transcription factor regulated by Jun N-terminal kinase-independent phosphorylation	2006
Dr Mohammed Ebrahimkhani Professor Fiona Oakley Professor Derek Mann	Naltrexone, an opioid receptor antagonist, attenuates liver fibrosis in bile duct ligated rats	2006
Professor Derek Mann	Pharmacological inhibitors of NF-κB accelerate apoptosis in chronic lymphocytic leukaemia cells	2006
Dr Carlyn Marek Professor Derek Mann Professor Matthew Wright	Pregnane X Receptor Activators Inhibit Human Hepatic Stellate Cell Transdifferentiation In Vitro	2006
Professor Derek Mann Professor Fiona Oakley	Real-time in vivo analysis of NF-kappaB activation reveals a role for the liver as a regulator of acute brain inflammation	2006
Professor Jelena Mann Professor Derek Mann	Functional Analysis of HIV Type 1 Nef Reveals a Role for PAK2 as a Regulator of Cell Phenotype and Function in the Murine Dendritic Cell Line, DC2.4	2005
Peter Smith Professor Fiona Oakley Professor Derek Mann	Herpesvirus saimiri-based vector biodistribution using noninvasive optical imaging	2005
Professor Fiona Oakley Dr Carlyn Marek Professor Matthew Wright Professor Derek Mann	Inhibition of Inhibitor of κB Kinases Stimulates Hepatic Stellate Cell Apoptosis and Accelerated Recovery From Rat Liver Fibrosis	2005
Professor Derek Mann Professor Fiona Oakley	NF-kappaB: a signal for cancer	2005
Professor Fiona Oakley Professor Derek Mann	Novel sulfasalazine analogues with enhanced NF-kB inhibitory and apoptosis promoting activity	2005
Professor Fiona Oakley Professor Jelena Mann Professor Simi Ali Professor Derek Mann	Nuclear Factor-κB1 (p50) Limits the Inflammatory and Fibrogenic Responses to Chronic Injury	2005
Professor Derek Mann	RNA interference mediated in human primary cells via recombinant baculoviral vectors	2005
Dr Ahmed Elsharkawy Professor Fiona Oakley Professor Derek Mann	The role and regulation of hepatic stellate cell apoptosis in reversal of liver fibrosis	2005
Professor Jelena Mann Professor Derek Mann	A failure of transforming growth factor-beta1 negative regulation maintains sustained NF-kappaB activation in gut inflammation	2004
Professor Fiona Oakley Professor Derek Mann	Induction of myofibroblast MMP-9 transcription in three-dimensional collagen I gel cultures: regulation by NF-kappaB, AP-1 and Sp1	2004
Professor Derek Mann	N-Cadherin cleavage during activated hepatic stellate cell apoptosis is inhibited by tissue inhibitor of metalloproteinase-1	2004
Professor Derek Mann	Oxidant regulation of the bivalent cation transporter Nramp1	2004
Professor Derek Mann	Regulation of Tissue Inhibitor of Metalloproteinase 1 Gene Transcription by RUNX1 and RUNX2	2004
Professor Fiona Oakley Professor Jelena Mann Professor Derek Mann	Basal Expression of IκBα Is Controlled by the Mammalian Transcriptional Repressor RBP-J (CBF1) and Its Activator Notch1	2003
Professor Derek Mann	Characterization of the murine Nramp1 promoter: requirements for transactivation by Miz-1	2003
Professor Fiona Oakley Professor Derek Mann	Hepatocytes Express Nerve Growth Factor during Liver Injury: Evidence for Paracrine Regulation of Hepatic Stellate Cell Apoptosis	2003
Professor Jelena Mann Professor Fiona Oakley Professor Derek Mann	CD40 Induces Interleukin-6 Gene Transcription in Dendritic Cells REGULATION BY TRAF2, AP-1, NF-κB, AND CBF1	2002
Professor Derek Mann	c-Myc represses and Miz-1 activates the murine natural resistance-associated protein 1 promoter	2002
Professor Derek Mann	c-Myc represses the murine Nramp1 promoter	2002
Clare McCormick Professor Fiona Oakley Professor Derek Mann	High efficiency gene transfer into cultured primary rat and human hepatic stellate cells using baculovirus vectors	2002
Professor Derek Mann	Transcriptional regulation of hepatic stellate cell activation	2002
Professor Matthew Wright Professor Derek Mann	Gliotoxin Stimulates the Apoptosis of Human and Rat Hepatic Stellate Cells and Enhances the Resolution of Liver Fibrosis in Rats	2001
Professor Jelena Mann Professor Derek Mann	JunD Regulates Transcription of the Tissue Inhibitor of Metalloproteinases-1 and Interleukin-6 Genes in Activated Hepatic Stellate Cells	2001
Professor Matthew Wright Professor Derek Mann	Regulation of E-box DNA binding during in vivo and in vitro activation of rat and human hepatic stellate cells	2001
Professor Derek Mann	Attenuation and augmentation of ischaemia-related neuronal death by tumour necrosis factor-alpha in vitro	2000
Dr Heather Bigg Emeritus Professor Drew Rowan Professor Derek Mann Emeritus Professor Tim Cawston	Regulation of human TIMP-1 Gene Expression	2000
Professor Matthew Wright Mark McAuley Professor Derek Mann	Upstream tissue inhibitor of metalloproteinases-1 (TIMP-1) element-1, a novel and essential regulatory DNA motif in the human TIMP-1 gene promoter, directly interacts with a 30-kDa nuclear protein	2000
Professor Derek Mann	A bi-functional activator/repressor element required for transcriptional activity of the human UCH-L1 gene assembles a neuron-specific protein: single-strand DNA complex	1999
Professor Derek Mann	A soluble factor produced by macrophages mediates the neurotoxic effects of HIV-1 Tat in vitro	1999
Professor Matthew Wright Professor Derek Mann	Control of the tissue inhibitor of metalloproteinases-1 promoter in culture-activated rat hepatic stellate cells: regulation by activator protein-1 DNA binding proteins	1999
Professor Derek Mann	Identification of the Nef-associated kinase as p21-activated kinase 2	1999
Professor Derek Mann	Induction of activator protein 1 (AP-1) in macrophages by human immunodeficiency virus type-1 NEF is a cell-type-specific response that requires both hck and MAPK signaling events	1999
Dr Ahmed Elsharkawy Professor Matthew Wright Professor Derek Mann	Persistent activation of nuclear factor-kappaB in cultured rat hepatic stellate cells involves the induction of potentially novel Rel-like factors and prolonged changes in the expression of IkappaB family proteins	1999
Professor Derek Mann	Tissue inhibitors of metalloproteinases: role in liver fibrosis and alcoholic liver disease	1999
Emeritus Professor Drew Rowan Professor Derek Mann Emeritus Professor Tim Cawston	Transcriptional activity of the human tissue inhibitor of metalloproteinases 1 (TIMP-1) gene in fibroblasts involves elements in the promoter, exon 1 and intron 1	1997